87 research outputs found
Linear Field Dependence of the Normal-State In-Plane Magnetoresistance of Sr2RuO4
The transverse and longitudinal in-plane magnetoresistances in the normal
state of superconducting Sr2RuO4 single crystals have been measured. At low
temperatures, both of them were found to be positive with a linear
magnetic-field dependence above a threshold field, a result not expected from
electronic band theory. We argue that such behavior is a manifestation of a
novel coherent state characterized by a spin pseudo gap in the quasi-particle
excitation spectrum in Sr2RuO4.Comment: 4 pages + 5 figure
Semiclassical relativistic strings in S^5 and long coherent operators in N=4 SYM theory
We consider the low energy effective action corresponding to the 1-loop,
planar, dilatation operator in the scalar sector of N=4 SU(N) SYM theory. For a
general class of non-holomorphic ``long'' operators, of bare dimension L>>1, it
is a sigma model action with 8-dimensional target space and agrees with a limit
of the phase-space string sigma model action describing generic fast-moving
strings in the S^5 part of AdS_5 x S^5. The limit of the string action is taken
in a way that allows for a systematic expansion to higher orders in the
effective coupling . This extends previous work on rigid rotating
strings in S^5 (dual to operators in the SU(3) sector of the dilatation
operator) to the case when string oscillations or pulsations in S^5 are
allowed. We establish a map between the profile of the leading order string
solution and the structure of the corresponding coherent, ``locally BPS'', SYM
scalar operator. As an application, we explicitly determine the form of the
non-holomorphic operators dual to the pulsating strings. Using action--angle
variables, we also directly compute the energy of pulsating solutions,
simplifying previous treatments.Comment: LaTeX, 50 pages, 1 figure. v2: References added, minor corrections.
54 pages. v3: Few changes. One paragraph added at the end of section 3. 55
page
Chiral Dynamics of the Two \Lambda(1405) States
Using a chiral unitary approach for the meson--baryon interactions, we show
that two octets of J^{\pi}=1/2^- baryon states, which are degenerate in the
limit of exact SU(3) symmetry, and a singlet are generated dynamically. The
SU(3) breaking produces the splitting of the two octets, resulting in the case
of strangeness S=-1 in two poles of the scattering matrix close to the nominal
\Lambda(1405) resonance. These poles are combinations of the singlet state and
the octets. We show how actual experiments see just one effective resonance
shape, but with properties which change from one reaction to another.Comment: 21 pages, 5 figure
Relativistic Calculation of the Meson Spectrum: a Fully Covariant Treatment Versus Standard Treatments
A large number of treatments of the meson spectrum have been tried that
consider mesons as quark - anti quark bound states. Recently, we used
relativistic quantum "constraint" mechanics to introduce a fully covariant
treatment defined by two coupled Dirac equations. For field-theoretic
interactions, this procedure functions as a "quantum mechanical transform of
Bethe-Salpeter equation". Here, we test its spectral fits against those
provided by an assortment of models: Wisconsin model, Iowa State model,
Brayshaw model, and the popular semi-relativistic treatment of Godfrey and
Isgur. We find that the fit provided by the two-body Dirac model for the entire
meson spectrum competes with the best fits to partial spectra provided by the
others and does so with the smallest number of interaction functions without
additional cutoff parameters necessary to make other approaches numerically
tractable. We discuss the distinguishing features of our model that may account
for the relative overall success of its fits. Note especially that in our
approach for QCD, the resulting pion mass and associated Goldstone behavior
depend sensitively on the preservation of relativistic couplings that are
crucial for its success when solved nonperturbatively for the analogous
two-body bound-states of QED.Comment: 75 pages, 6 figures, revised content
Mass Splitting and Production of and Measured in N Interactions
From a sample of decaying to the
final state, we have observed, in the hadroproduction experiment E791 at
Fermilab, and through
their decays to . The mass difference ) is measured to be ; for
, we find .
The rate of production from decays of the triplet is
(22\pm 2\pm 3) {%} of the total production assuming equal rate
of production from all three, as measured for and .
We do not observe a statistically significant baryon-antibaryon
production asymmetry. The and spectra of from
decays are observed to be similar to those for all 's
produced.Comment: 15 pages, uuencoded postscript 3 figures uuencoded, tar-compressed
fil
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
Track D Social Science, Human Rights and Political Science
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd
Integrative molecular characterization of malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity. We also report strong expression of the immune-checkpoint gene VISTA in epithelioid MPM, strikingly higher than in other solid cancers, with implications for the immune response to MPM and for its immunotherapy. Our findings highlight new avenues for further investigation of MPM biology and novel therapeutic options. SIGNIFICANCE: Through a comprehensive integrated genomic study of 74 MPMs, we provide a deeper understanding of histology-independent determinants of aggressive behavior, define a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity, and discovered strong expresssion of the immune-checkpoint gene VISTA in epithelioid MPM
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
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