Neural correlates of processing valence and arousal in affective words

Psychological frameworks conceptualize emotion along 2 dimensions, "valence" and "arousal." Arousal invokes a single axis of intensity increasing from neutral to maximally arousing. Valence can be described variously as a bipolar continuum, as independent positive and negative dimensions, or as hedonic value (distance from neutral). In this study, we used functional magnetic resonance imaging to characterize neural activity correlating with arousal and with distinct models of valence during presentation of affective word stimuli. Our results extend observations in the chemosensory domain suggesting a double dissociation in which subregions of orbitofrontal cortex process valence, whereas amygdala preferentially processes arousal. In addition, our data support the physiological validity of descriptions of valence along independent axes or as absolute distance from neutral but fail to support the validity of descriptions of valence along a bipolar continuum

Renormalization group flow and parallel transport with non-metric compatible connections

A family of connections on the space of couplings for a renormalizable field theory is defined. The connections are obtained from a Levi-Civita connection, for a metric which is a generalisation of the Zamolodchikov metric in two dimensions, by adding a family of tensors which are solutions of the renormalization group equation for the operator product expansion co-efficients. The connections are torsion free, but not metric compatible in general. The renormalization group flows of N=2 supersymmetric Yang-Mills theory in four dimensions and the O(N)-model in three dimensions, in the large $N$ limit, are analysed in terms of parallel transport under these connections

Noncommutativity in a Time-Dependent Background

We compute a time-dependent noncommutativity parameter in a model with a time-dependent background, a space-time metric of the plane wave type supported by a Neveu-Schwarz two-form potential. This model is an open string version of the WZW model based on a non-semi-simple group previously studied by Nappi and Witten. The background we study is not conformally invariant. We consider a light-cone action for the sigma-model, compute the worldsheet propagator, and use it to derive a time-dependent noncommutativity parameter.Comment: 12 pages; v3: statement corrected and references adde

U.S. Spacesuit Knowledge Capture

The ability to learn from both the mistakes and successes of the past is vital to assuring success in the future. Due to the close physical interaction between spacesuit systems and human beings as users, spacesuit technology and usage lends itself rather uniquely to the benefits realized from the skillful organization of historical information; its dissemination; the collection and identification of artifacts; and the education of individuals and groups working in the field. The National Aeronautics and Space Administration (NASA), other organizations and individuals have been performing United States (U.S.) spacesuit knowledge capture since the beginning of space exploration. Avenues used to capture the knowledge have included publication of reports; conference presentations; specialized seminars; and classes usually given by veterans in the field. Recently, the effort has been more concentrated and formalized whereby a new avenue of spacesuit knowledge capture has been added to the archives through which videotaping occurs, engaging both current and retired specialists in the field presenting technical scope specifically for education and preservation of knowledge. Now with video archiving, all these avenues of learning can be brought to life with the real experts presenting their wealth of knowledge on screen for future learners to enjoy. U.S. spacesuit knowledge capture topics have included lessons learned in spacesuit technology, experience from the Gemini, Apollo, Skylab and Shuttle programs, hardware certification, design, development and other program components, spacesuit evolution and experience, failure analysis and resolution, and aspects of program management. Concurrently, U.S. spacesuit knowledge capture activities have progressed to a level where NASA, the National Air and Space Museum (NASM), Hamilton Sundstrand (HS) and the spacesuit community are now working together to provide a rather closed-looped spacesuit knowledge capture system which includes specific attention to spacesuit system artifacts as well. A NASM report has recently been created that allows the cross reference of history to the artifacts and the artifacts to the history including spacesuit manufacturing details with current condition and location. NASA has examined spacesuits in the NASM collection for evidence of wear during their operational life. NASA s formal spacesuit knowledge capture efforts now make use of both the NASM spacesuit preservation collection and report to enhance its efforts to educate NASA personnel and contribute to spacesuit history. Be it archiving of human knowledge or archiving of the actual spacesuit legacy hardware with its rich history, the joining together of spacesuit system artifact history with that of development and use during past programs will provide a wealth of knowledge which will greatly enhance the chances for the success of future and more ambitious spacesuit system programs

The influence of gravitational lensing on the spectra of lensed QSOs

We consider the influence of (milli/micro)lensing on the spectra of lensed QSOs. We propose a method for the observational detection of microlensing in the spectra of lensed QSOs and apply it to the spectra of the three lensed QSOs (PG 1115+080, QSO 1413+117 and QSO 0957+561) observed with Hubble Space Telescope (HST). We find that the flux ratio between images A1 and A2 of PG 1115+080 is wavelength-dependent and shows differential magnification between the emission lines and the continuum. We interpret this magnification as arising from millilensing. We also find that the temporal variations in the continuum of image C of QSO 1413+117 may be caused by microlensing, while the temporal variation observed in QSO 0957+561 was probably an intrinsic one.Comment: 11 pages, accepted for publication in MNRA

Contamination and exclusion in the sigma Orionis young group

We present radial velocities for 38 low-mass candidate members of the sigma Orionis young group. We have measured their radial velocities by cross-correlation of high resolution (R~6000) AF2/WYFFOS spectra of the gravity sensitive NaI doublet at 8183, 8195Angstroms. The total sample contained 117 objects of which 54 have sufficient signal-to-noise to detect NaI at an equivalent width of 3Angstroms, however we only detect NaI in 38 of these. This implies that very low-mass members of this young group display weaker NaI absorption than similarly aged objects in the Upper Scorpius OB association. We develop a technique to assess membership using radial velocities with a range of uncertainties that does not bias the selection when large uncertainties are present. The resulting membership probabilities are used to assess the issue of exclusion in photometric selections, and we find that very few members are likely to be excluded by such techniques. We also assess the level of contamination in the expected pre-main sequence region of colour-magnitude space brighter than I = 17. We find that contamination by non-members in the expected PMS region of the colour-magnitude diagram is small. We conclude that although radial velocity alone is insufficient to confirm membership, high signal-to-noise observations of the NaI doublet provide the opportunity to use the strength of NaI absorption in concert with radial velocities to asses membership down to the lowest masses, where Lithium absorption no longer distinguishes youth.Comment: 11 pages, MNRAS accepted. Online data available from: http://www.astro.ex.ac.uk/people/timn/Catalogues/service.htm

Genomes as geography: using GIS technology to build interactive genome feature maps

BACKGROUND: Many commonly used genome browsers display sequence annotations and related attributes as horizontal data tracks that can be toggled on and off according to user preferences. Most genome browsers use only simple keyword searches and limit the display of detailed annotations to one chromosomal region of the genome at a time. We have employed concepts, methodologies, and tools that were developed for the display of geographic data to develop a Genome Spatial Information System (GenoSIS) for displaying genomes spatially, and interacting with genome annotations and related attribute data. In contrast to the paradigm of horizontally stacked data tracks used by most genome browsers, GenoSIS uses the concept of registered spatial layers composed of spatial objects for integrated display of diverse data. In addition to basic keyword searches, GenoSIS supports complex queries, including spatial queries, and dynamically generates genome maps. Our adaptation of the geographic information system (GIS) model in a genome context supports spatial representation of genome features at multiple scales with a versatile and expressive query capability beyond that supported by existing genome browsers. RESULTS: We implemented an interactive genome sequence feature map for the mouse genome in GenoSIS, an application that uses ArcGIS, a commercially available GIS software system. The genome features and their attributes are represented as spatial objects and data layers that can be toggled on and off according to user preferences or displayed selectively in response to user queries. GenoSIS supports the generation of custom genome maps in response to complex queries about genome features based on both their attributes and locations. Our example application of GenoSIS to the mouse genome demonstrates the powerful visualization and query capability of mature GIS technology applied in a novel domain. CONCLUSION: Mapping tools developed specifically for geographic data can be exploited to display, explore and interact with genome data. The approach we describe here is organism independent and is equally useful for linear and circular chromosomes. One of the unique capabilities of GenoSIS compared to existing genome browsers is the capacity to generate genome feature maps dynamically in response to complex attribute and spatial queries

Large UK retailers' initiatives to reduce consumers' emissions: a systematic assessment

In the interest of climate change mitigation, policy makers, businesses and non-governmental organisations have devised initiatives designed to reduce in-use emissions whilst, at the same time, the number of energy-consuming products in homes, and household energy consumption, is increasing. Retailers are important because they are at the interface between manufacturers of products and consumers and they supply the vast majority of consumer goods in developed countries like the UK, including energy using products. Large retailers have a consistent history of corporate responsibility reporting and have included plans and actions to influence consumer emissions within them. This paper adapts two frameworks to use them for systematically assessing large retailers’ initiatives aimed at reducing consumers’ carbon emissions. The Framework for Strategic Sustainable Development (FSSD) is adapted and used to analyse the strategic scope and coherence of these initiatives in relation to the businesses’ sustainability strategies. The ISM ‘Individual Social Material’ framework is adapted and used to analyse how consumer behaviour change mechanisms are framed by retailers. These frameworks are used to analyse eighteen initiatives designed to reduce consumer emissions from eight of the largest UK retail businesses, identified from publicly available data. The results of the eighteen initiatives analysed show that the vast majority were not well planned nor were they strategically coherent. Secondly, most of these specific initiatives relied solely on providing information to consumers and thus deployed a rather narrow range of consumer behaviour change mechanisms. The research concludes that leaders of retail businesses and policy makers could use the FSSD to ensure processes, and measurements are comprehensive and integrated, in order to increase the materiality and impact of their initiatives to reduce consumer emissions in use. Furthermore, retailers could benefit from exploring different models of behaviour change from the ISM framework in order to access a wider set of tools for transformative system change

Cosmogenic ^(10)Be and ^(36)Cl geochronology of offset alluvial fans along the northern Death Valley fault zone: Implications for transient strain in the eastern California shear zone

The northern Death Valley fault zone (NDVFZ) has long been recognized as a major right-lateral strike-slip fault in the eastern California shear zone (ECSZ). However, its geologic slip rate has been difficult to determine. Using high-resolution digital topographic imagery and terrestrial cosmogenic nuclide dating, we present the first geochronologically determined slip rate for the NDVFZ. Our study focuses on the Red Wall Canyon alluvial fan, which exposes clean dextral offsets of seven channels. Analysis of airborne laser swath mapping data indicates ∼297 ± 9 m of right-lateral displacement on the fault system since the late Pleistocene. In situ terrestrial cosmogenic ^(10)Be and ^(36)Cl geochronology was used to date the Red Wall Canyon fan and a second, correlative fan also cut by the fault. Beryllium 10 dates from large cobbles and boulders provide a maximum age of 70 +22/−20 ka for the offset landforms. The minimum age of the alluvial fan deposits based on ^(36)Cl depth profiles is 63 ± 8 ka. Combining the offset measurement with the cosmogenic ^(10)Be date yields a geologic fault slip rate of 4.2 +1.9/−1.1 mm yr^(−1), whereas the ^(36)Cl data indicate 4.7 +0.9/−0.6 mm yr^(−1) of slip. Summing these slip rates with known rates on the Owens Valley, Hunter Mountain, and Stateline faults at similar latitudes suggests a total geologic slip rate across the northern ECSZ of ∼8.5 to 10 mm yr^(−1). This rate is commensurate with the overall geodetic rate and implies that the apparent discrepancy between geologic and geodetic data observed in the Mojave section of the ECSZ does not extend north of the Garlock fault. Although the overall geodetic rates are similar, the best estimates based on geology predict higher strain rates in the eastern part of the ECSZ than to the west, whereas the observed geodetic strain is relatively constant

A genome-wide view of Caenorhabditis elegans base-substitution mutation processes

Knowledge of mutation processes is central to understanding virtually all evolutionary phenomena and the underlying nature of genetic disorders and cancers. However, the limitations of standard molecular mutation detection methods have historically precluded a genome-wide understanding of mutation rates and spectra in the nuclear genomes of multicellular organisms. We applied two high-throughput DNA sequencing technologies to identify and characterize hundreds of spontaneously arising base-substitution mutations in 10 Caenorhabditis elegans mutation-accumulation (MA)-line nuclear genomes. C. elegans mutation rate estimates were similar to previous calculations based on smaller numbers of mutations. Mutations were distributed uniformly within and among chromosomes and were not associated with recombination rate variation in the MA lines, suggesting that intragenomic variation in genetic hitchhiking and/or background selection are primarily responsible for the chromosomal distribution patterns of polymorphic nucleotides in C. elegans natural populations. A strong mutational bias from G/C to A/T nucleotides was detected in the MA lines, implicating oxidative DNA damage as a major endogenous mutagenic force in C. elegans. The observed mutational bias also suggests that the C. elegans nuclear genome cannot be at equilibrium because of mutation alone. Transversions dominate the spectrum of spontaneous mutations observed here, whereas transitions dominate patterns of allegedly neutral polymorphism in natural populations of C. elegans and many other animal species; this observation challenges the assumption that natural patterns of molecular variation in noncoding regions of the nuclear genome accurately reflect underlying mutation processes