A qualitative exploration of parenting representations and experiences amongst mothers at risk of parenting difficulties and care proceedings

Mothers who are at risk of losing custody of their children represent a vulnerable and stigmatised population, whose voices are seldom heard. Exploring their perspectives of parenting, their child and the relationship with their child – their ‘parenting representations’ – can improve our understandings of their struggles and inform interventions seeking to interrupt cycles of transgenerational trauma. Research in this area so far has been predominantly quantitative, meaning valuable information about subjective experiences is often lost. The present study sought to address this gap by thematically analysing interviews with eight mothers with under-3-year-olds on the edge of Local Authority care, completed at the beginning of a specialist therapeutic intervention. Results are reported around five themes: ‘Idealistic portrayal of the child and relationship’, ‘Struggling as a parent’, ‘Shadows of the past’, ‘The child and motherhood as comfort’ and ‘Anxiety about loss and fighting for the child’. The parenting struggles of mothers in this population are complex and multi-faceted, fuelled by ongoing relational trauma, fears of further pain, adversity, and difficulties in accessing and trusting support. Successful interventions are likely to require comprehensive, long-term approaches which holistically address mothers’ unmet physical and emotional needs, and begin with building relational trust

High energy blazars spectroscopy with X-Shooter on the VLT

We present results of observations in the UV to near-IR range for eight blazars, three of which have been recently discovered at Very High Energies (VHE) and five appearing as interesting candidates for VHE {\gamma}-ray detection. We focus in this paper on the search for their redshifts, which are unknown or considered as uncertain.Comment: 4 pages, 8 figures, to appear in the proceedings of the 5th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2012), July 9-13, 2012, Heidelberg, German

Spectroscopy of High Energy BL Lac Objects with X-shooter on the VLT

Context. The study of BL Lac objects (BLL) detected in gamma-rays gives insights on the acceleration mechanisms in play in such systems and is also a valuable tool to constrain the density of the extragalactic background light. As their spectra are dominated by the non-thermal emission of the jet and the spectral features are weak and narrow in the optical domain, measuring their redshift is challenging. However such a measure is fundamental as it allows a firm determination of the distance and luminosity of the source, and therefore a consistent model of its emission. Aims. Measurement of the redshift of BLL detected in gamma-rays and determination of global properties of their host galaxies. Methods. We observed a sample of eight BLL (KUV 00311-1938, PKS 0447-439, PKS 0301-243, BZB J0238-3116, BZB J0543-5532, BZB J0505+0415, BZB J0816-1311 and RBS 334) with the X-shooter spectrograph installed at the ESO Very Large Telescope in order to take advantage of its unprecedented wavelength coverage and of its resolution about 5 times higher than generally used in such studies. We extracted UVB to NIR spectra that we then corrected for telluric absorption and calibrated in flux. We systematically searched for spectral features. When possible, we determined the contribution of the host galaxy to the overall emission. Results. Of the eight BLL, we measured the redshift of five of them and determined lower limits for two through the detection of intervening systems. All seven of these objects have redshifts greater than 0.2. In two cases, we refuted redshift values reported in other publications. Through careful modelling, we determined the magnitude of the host galaxies. In two cases, the detection of emission lines allowed to provide hints on the overall properties of the gas in the host galaxies.Comment: 19 pages, 10 figures, 7 tables, in press on A&

A Role of the Fast ATP-gated P2X1 Cation Channel in Thrombosis of Small Arteries In Vivo

The P2X1 receptor is a fast ATP-gated cation channel expressed in blood platelets, where its role has been difficult to assess due to its rapid desensitization and the lack of pharmacological tools. In this paper, we have used P2X1−/− and wild-type mouse platelets, treated with apyrase to prevent desensitization, to demonstrate the function of P2X1 in the response to thrombogenic stimuli. In vitro, the collagen-induced aggregation and secretion of P2X1-deficient platelets was decreased, as was adhesion and thrombus growth on a collagen-coated surface, particularly when the wall shear rate was elevated. In vivo, the functional role of P2X1 could be demonstrated using two models of platelet-dependent thrombotic occlusion of small arteries, in which blood flow is characterized by a high shear rate. The mortality of P2X1−/− mice in a model of systemic thromboembolism was reduced and the size of mural thrombi formed after a laser-induced vessel wall injury was decreased as compared with normal mice, whereas the time for complete thrombus removal was shortened. Overall, the P2X1 receptor appears to contribute to the formation of platelet thrombi, particularly in arteries in which shear forces are high

The P2Y1 receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice

Pancreatic β cells express several P2 receptors including P2Y1 and the modulation of insulin secretion by extracellular nucleotides has suggested that these receptors may contribute to the regulation of glucose homeostasis. To determine whether the P2Y1 receptor is involved in this process, we performed studies in P2Y1 mice. In baseline conditions, P2Y1-mice exhibited a 15% increase in glycemia and a 40% increase in insulinemia, associated with a 10% increase in body weight, pointing to a role of the P2Y1 receptor in the control of glucose metabolism. Dynamic experiments further showed that P2Y1-mice exhibited a tendency to glucose intolerance. These features were associated with a decrease in the plasma levels of free fatty acid and triglycerides. When fed a lipids and sucrose enriched diet for 15 weeks, the two genotypes no longer displayed any significant differences. To determine whether the P2Y1 receptor was directly involved in the control of insulin secretion, experiments were carried out in isolated Langerhans islets. In the presence of high concentrations of glucose, insulin secretion was significantly greater in islets from P2Y1-mice. Altogether, these results show that the P2Y1 receptor plays a physiological role in the maintenance of glucose homeostasis at least in part by regulating insulin secretion

Gammapy: A Python package for gamma-ray astronomy

In this article, we present Gammapy, an open-source Python package for the analysis of astronomical $\gamma$-ray data, and illustrate the functionalities of its first long-term-support release, version 1.0. Built on the modern Python scientific ecosystem, Gammapy provides a uniform platform for reducing and modeling data from different $\gamma$-ray instruments for many analysis scenarios. Gammapy complies with several well-established data conventions in high-energy astrophysics, providing serialized data products that are interoperable with other software packages. Starting from event lists and instrument response functions, Gammapy provides functionalities to reduce these data by binning them in energy and sky coordinates. Several techniques for background estimation are implemented in the package to handle the residual hadronic background affecting $\gamma$-ray instruments. After the data are binned, the flux and morphology of one or more $\gamma$-ray sources can be estimated using Poisson maximum likelihood fitting and assuming a variety of spectral, temporal, and spatial models. Estimation of flux points, likelihood profiles, and light curves is also supported. After describing the structure of the package, we show, using publicly available $\gamma$-ray data, the capabilities of Gammapy in multiple traditional and novel $\gamma$-ray analysis scenarios, such as spectral and spectro-morphological modeling and estimations of a spectral energy distribution and a light curve. Its flexibility and power are displayed in a final multi-instrument example, where datasets from different instruments, at different stages of data reduction, are simultaneously fitted with an astrophysical flux model.Comment: 26 pages, 16 figure

Altimetry for the future: Building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ‘‘Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Altimetry for the future: building on 25 years of progress

In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion

Gamma radiation from active galactic nuclei observed at very high energies with H.E.S.S. : multiwavelength studies and radiative modeling

PARIS-Observatoire (751142302) / SudocSudocFranceF

SSC Scenario for Tev Emission from Non-Blazar AGNs

International audienceM 87 is the first extragalactic source detected in the TeV gamma-ray domain that is not a blazar, its large scale jet not being aligned to the line of sight. We present here a multi-blob synchrotron self-Compton model accounting explicitly for large viewing angles and moderate Lorentz factors as inferred from magnetohydrodynamic simulations of jet formation, motivated by the detection of M 87 at very high energies (VHE; E > 100 GeV). Predictions are presented for the very high-energy emission of active galactic nuclei with extended optical or X-ray jet, which could be misaligned blazars but still show some moderate beaming. We include predictions for 3C 273, Cen A and PKS 0521-36