Semi-automatic semantic enrichment of raw sensor data

One of the more recent sources of large volumes of generated data is sensor devices, where dedicated sensing equipment is used to monitor events and happenings in a wide range of domains, including monitoring human biometrics. In recent trials to examine the effects that key moments in movies have on the human body, we fitted fitted with a number of biometric sensor devices and monitored them as they watched a range of dierent movies in groups. The purpose of these experiments was to examine the correlation between humans' highlights in movies as observed from biometric sensors, and highlights in the same movies as identified by our automatic movie analysis techniques. However,the problem with this type of experiment is that both the analysis of the video stream and the sensor data readings are not directly usable in their raw form because of the sheer volume of low-level data values generated both from the sensors and from the movie analysis. This work describes the semi-automated enrichment of both video analysis and sensor data and the mechanism used to query the data in both centralised environments, and in a peer-to-peer architecture when the number of sensor devices grows to large numbers. We present and validate a scalable means of semi-automating the semantic enrichment of sensor data, thereby providing a means of large-scale sensor management

Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library

The application of a tandem condensation/cyclisation/[3+2]-cycloaddition/elimination reaction gives an sp3-rich tricyclic pyrazoline scaffold with two ethyl esters in a single step from a simple linear starting material. The successive hydrolysis and cyclisation (with Boc anhydride) of these 3-dimensional architectures, generates unprecedented 16-membered macrocyclic bisanhydrides (characterised by XRD). Selective amidations could then be achieved by ring opening with a primary amine followed by HATU-promoted amide coupling to yield an sp3-rich natural product-like library

In vivo comparison of the proangiogenic properties of chlordecone and three of its dechlorinated derivatives formed by in situ chemical reduction

In situ chemical reduction (ISCR) has been identified as a possible way for the remediation of soils contaminated by chlordecone (CLD). Evidences provided by the literature indicate an association between the development of prostate cancer and CLD exposure (Multigner et al. 2010). In a previous in vitro study, we demonstrated that the two main dechlorinated CLD derivatives formed by ISCR, CLD-1Cl, and CLD-3Cl have lower cytotoxicity and proangiogenic properties than CLD itself (Legeay et al. 2017). By contrast, nothing is known on the in vivo proangiogenic effect of these dechlorinated derivatives. Based on in vitro data, the aims of this study were therefore to evaluate the in vivo influence of CLD and three of its dechlorinated metabolites in the control of neovascularization in a mice model of prostate cancer. The proangiogenic effect of CLD and three of its dechlorinated derivatives, CLD-1Cl, CLD-3Cl, and CLD-4Cl, was evaluated on a murine model of human prostate tumor (PC-3) treated, at two exposure levels: 33 μg/kg and 1.7 μg/kg respectively reflecting acute and chronic toxic exposure in human. The results of serum measurements show that, for the same ingested dose, the three metabolite concentrations were significantly lower than that of CLD. Dechlorination of CLD lead therefore to molecules that are biologically absorbed or metabolized, or both, faster than the parent molecule. Prostate tumor growth was lower in the groups treated by the three metabolites compared to the one treated by CLD. The vascularization measured on the tumor sections was inversely proportional to the rate of dechlorination, the treatment with CLD-4Cl showing no difference with control animals treated with only the vehicle oil used for all substances tested. We can therefore conclude that the proangiogenic effect of CLD is significantly decreased following the ISCR-resulting dechlorination. Further investigations are needed to elucidate the molecular mechanisms by which dechlorination of CLD reduces proangiogenic effects in prostate tumor

Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced

Élections de 1842. Électeurs, que demandez-vous ?... [Signé : E.-M. L....y (Legeay).]

Appartient à l’ensemble documentaire : LangRous1Avec mode text

Minibasins and salt canopy in foreland fold-and-thrust belts: The central Sivas Basin, Turkey

ACLInternational audienceThe Sivas Basin in the Central Anatolian Plateau (Turkey), which formed in the context of a foreland fold-and-thrust belt (FTB), exhibits a typical wall and basin (WAB) province characterized by symmetric minibasins separated by continuous steep-flanked walls and diapirs. Extensive fieldwork including regional and detailed local mapping of the contacts and margins of minibasins, and interpretation of a set of 2-D regional seismic lines, provide evidence for the development of a shallow evaporite level separating two generations of minibasins within the WAB province. Here beds of symmetric exposed minibasins along diapir flank are younger than minibasins observed over autochthonous evaporites. Laterally away from the WAB province, increase in wavelength of the tectonic structures suggests a deepening of the decollement level. We interpret that a shallower evaporite level developed in the form of an evaporite canopy, triggered by significant lateral shortening. The Upper Eocene-Lower Oligocene autochthonous Tuzhisar evaporite level was remobilized by the northward migrating sedimentary load and the tilting of the southern basin margin during propagation of the foreland fold-and-thrust belt. Asymmetric and symmetric primary minibasins were overrun by an allochthonous sheet forming a canopy. A second generation of salt withdrawal minibasins subsided into the allochthonous salt sheet. The polygonal pattern of the WAB province influences the growing fold-and-thrust belt system during the late stage of the secondary minibasins development. The Sivas FTB basin is the result of the interaction between fold-and-thrust belt propagation, evaporite remobilization, and interaction between evaporite flow and sedimentation in the minibasins. ©2016. American Geophysical Union. All Rights Reserved

Transition from marine deep slope deposits to evaporitic facies of an isolated shallow water hypersaline basin: case study of the Sivas foreland basin (Turkey)

AFFInternational audienc

Transition from marine deep slope deposits to evaporitic facies of an isolated shallow water hypersaline basin: case study of the Sivas foreland basin (Turkey)

AFFInternational audienc