155 research outputs found
Understanding patient views and experiences of the IDENTIfication of PALLiative care needs (IDENTI-Pall) : a qualitative interview study protocol
Introduction: More people are living with multimorbidity, defined as two or more long-term physical or mental health conditions. Multimorbidity is associated with poor quality of life and high treatment burden. Palliative care identification tools have been developed for use in primary care to seek out patients who could benefit from a palliative approach to their care. There has been little evaluative research on such tools; patient perspectives on the process of identifying their palliative care needs is a significant gap. The aim of this research is to provide new understanding into patient perspectives of the experience of having their palliative care needs identified, and the impact on their healthcare.
Methods and analysis: This qualitative study will employ semistructured interviews to elicit the views of participants. We will purposively sample 10â12 adults with advanced serious illness who have been identified by their primary care team as having palliative care needs, and/or are receiving care from specialist palliative care services. A family member or carer may be included in an interview at the participantâs request. A descriptive, thematic analysis will be carried out using the data analysis software NVivo.
Ethics and dissemination: Ethical approval has been granted by the North of Scotland Research Ethics Committee. Study findings will be disseminated in peer-reviewed journals and through conference presentations. Other activities include the development of patient-centred outcomes for clinical practice and policy in relation to the use of palliative care identification tools.
Trial registration number: National Institute for Health Research (NIHR) Clinical Studies Portfolio, UK Clinical Research Network (UKCRN) Study number 51296
Suppressing CMB Quadrupole with a Bounce from Contracting Phase to Inflation
Recent released WMAP data show a low value of quadrupole in the CMB
temperature fluctuations, which confirms the early observations by COBE. In
this paper, a scenario, in which a contracting phase is followed by an
inflationary phase, is constructed. We calculate the perturbation spectrum and
show that this scenario can provide a reasonable explanation for lower CMB
anisotropies on large angular scales.Comment: 5 pages, 3 figure
Inflation, cold dark matter, and the central density problem
A problem with high central densities in dark halos has arisen in the context
of LCDM cosmologies with scale-invariant initial power spectra. Although n=1 is
often justified by appealing to the inflation scenario, inflationary models
with mild deviations from scale-invariance are not uncommon and models with
significant running of the spectral index are plausible. Even mild deviations
from scale-invariance can be important because halo collapse times and
densities depend on the relative amount of small-scale power. We choose several
popular models of inflation and work out the ramifications for galaxy central
densities. For each model, we calculate its COBE-normalized power spectrum and
deduce the implied halo densities using a semi-analytic method calibrated
against N-body simulations. We compare our predictions to a sample of dark
matter-dominated galaxies using a non-parametric measure of the density. While
standard n=1, LCDM halos are overdense by a factor of 6, several of our example
inflation+CDM models predict halo densities well within the range preferred by
observations. We also show how the presence of massive (0.5 eV) neutrinos may
help to alleviate the central density problem even with n=1. We conclude that
galaxy central densities may not be as problematic for the CDM paradigm as is
sometimes assumed: rather than telling us something about the nature of the
dark matter, galaxy rotation curves may be telling us something about inflation
and/or neutrinos. An important test of this idea will be an eventual consensus
on the value of sigma_8, the rms overdensity on the scale 8 h^-1 Mpc. Our
successful models have values of sigma_8 approximately 0.75, which is within
the range of recent determinations. Finally, models with n>1 (or sigma_8 > 1)
are highly disfavored.Comment: 13 pages, 6 figures. Minor changes made to reflect referee's
Comments, error in Eq. (18) corrected, references updated and corrected,
conclusions unchanged. Version accepted for publication in Phys. Rev. D,
scheduled for 15 August 200
Weak Lensing and CMB: Parameter forecasts including a running spectral index
We use statistical inference theory to explore the constraints from future
galaxy weak lensing (cosmic shear) surveys combined with the current CMB
constraints on cosmological parameters, focusing particularly on the running of
the spectral index of the primordial scalar power spectrum, . Recent
papers have drawn attention to the possibility of measuring by
combining the CMB with galaxy clustering and/or the Lyman- forest. Weak
lensing combined with the CMB provides an alternative probe of the primordial
power spectrum. We run a series of simulations with variable runnings and
compare them to semi-analytic non-linear mappings to test their validity for
our calculations. We find that a ``Reference'' cosmic shear survey with
and galaxies per steradian can reduce the
uncertainty on and by roughly a factor of 2 relative to the
CMB alone. We investigate the effect of shear calibration biases on lensing by
including the calibration factor as a parameter, and show that for our
Reference Survey, the precision of cosmological parameter determination is only
slightly degraded even if the amplitude calibration is uncertain by as much as
5%. We conclude that in the near future weak lensing surveys can supplement the
CMB observations to constrain the primordial power spectrum.Comment: 12 pages, 10 figures, revtex4. Final form to appear in Phys Rev
Primordial power spectrum from WMAP
The observed angular power spectrum of the cosmic microwave background
temperature anisotropy, , is a convolution of a cosmological radiative
transport kernel with an assumed primordial power spectrum of inhomogeneities.
Exquisite measurements of over a wide range of multipoles from the
Wilkinson Microwave Anisotropy Probe (WMAP) has opened up the possibility to
deconvolve the primordial power spectrum for a given set of cosmological
parameters (base model). We implement an improved (error sensitive)
Richardson-Lucy deconvolution algorithm on the measured angular power spectrum
from WMAP assuming a concordance cosmological model. The most prominent feature
of the recovered is a sharp, infra-red cut off on the horizon scale. The
resultant spectrum using the recovered spectrum has a likelihood far
better than a scale invariant, or, `best fit' scale free spectra
( {\it w.r.t.} Harrison Zeldovich, and, {\it w.r.t.} power law with ). The recovered has a
localized excess just below the cut-off which leads to great improvement of
likelihood over the simple monotonic forms of model infra-red cut-off spectra
considered in the post WMAP literature. The recovered , in particular,
the form of infra-red cut-off is robust to small changes in the cosmological
parameters. We show that remarkably similar form of infra-red cutoff is known
to arise in very reasonable extensions and refinements of the predictions from
simple inflationary scenarios. Our method can be extended to other cosmological
observations such as the measured matter power spectrum and, in particular, the
much awaited polarization spectrum from WMAP.Comment: 20 pages, 12 figures, uses Revtex4, Matches version accepted to Phys.
Rev. D. More extensive discussion of the method in the appendix, references
added and typos correcte
Effects of temperature at constant air dew point on leaf carboxylation efficiency and CO 2 compensation point of different leaf types
The effect of temperature on photosynthesis at constant water-vapor pressure in the air was investigated using two sclerophyll species, Arbutus unedo and Quercus suber , and one mesophytic species, Spinacia oleracea . Photosynthesis and transpiration were measured over a range of temperatures, 20â39° C. The external concentration of CO 2 was varied from 340 ÎŒbar to near CO 2 compensation. The initial slope (carboxylation efficiency, CE) of the photosynthetic response to intercellular CO 2 concentration, the CO 2 compensation point (Î), and the extrapolated rate of CO 2 released into CO 2 -free air ( R i ) were calculated. At an external CO 2 concentration of 320â340 ÎŒbar CO 2 , photosynthesis decreased with temperature in all species. The effect of temperature on Î was similar in all species. While CE in S. oleracea changed little with temperature, CE decreased by 50% in Q. suber as temperature increased from 25 to 34° C. Arbutus unedo also exhibited a decrease in CE at higher temperatures but not as marked as Q. suber . The absolut value of R i increased with temperature in S. oleracea , while changing little or decreasing in the sclerophylls. Variations in Î and R i of the sclerophyll species are not consistent with greater increase of respiration with temperature in the light in these species compared with S. oleracea .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47470/1/425_2004_Article_BF00397389.pd
Performance of novel VUV-sensitive Silicon Photo-Multipliers for nEXO
Liquid xenon time projection chambers are promising detectors to search for
neutrinoless double beta decay (0), due to their response
uniformity, monolithic sensitive volume, scalability to large target masses,
and suitability for extremely low background operations. The nEXO collaboration
has designed a tonne-scale time projection chamber that aims to search for
0 of \ce{^{136}Xe} with projected half-life sensitivity of
~yr. To reach this sensitivity, the design goal for nEXO is
1\% energy resolution at the decay -value (~keV).
Reaching this resolution requires the efficient collection of both the
ionization and scintillation produced in the detector. The nEXO design employs
Silicon Photo-Multipliers (SiPMs) to detect the vacuum ultra-violet, 175 nm
scintillation light of liquid xenon. This paper reports on the characterization
of the newest vacuum ultra-violet sensitive Fondazione Bruno Kessler VUVHD3
SiPMs specifically designed for nEXO, as well as new measurements on new test
samples of previously characterised Hamamatsu VUV4 Multi Pixel Photon Counters
(MPPCs). Various SiPM and MPPC parameters, such as dark noise, gain, direct
crosstalk, correlated avalanches and photon detection efficiency were measured
as a function of the applied over voltage and wavelength at liquid xenon
temperature (163~K). The results from this study are used to provide updated
estimates of the achievable energy resolution at the decay -value for the
nEXO design
Planck early results III : First assessment of the Low Frequency Instrument in-flight performance
Peer reviewe
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