XMG : Un Compilateur de Méta-Grammaires Extensible

National audienceDans cet article, nous présentons un outil permettant de produire automatiquement des ressources linguistiques, en l'occurence des grammaires. Cet outil se caractérise par son extensibilité, tant du point de vue des formalismes grammaticaux supportés (grammaires d'arbres adjoints et grammaires d'interaction à l'heure actuelle), que de son architecture modulaire, qui facilite l'intégration de nouveaux modules ayant pour but de vérifier la validité des structures produites. En outre, cet outil offre un support adapté au développement de grammaires à portée sémantique

A constraint driven metagrammar

International audienceWe present an operational framework allowing to express a large scale Tree Adjoining Grammar (TAG) by using higher level operational constraints on tree descriptions. These constraints first meant to guarantee the well formedness of the grammatical units may also be viewed as a way to put model theoretic syntax at work through an efficient offline grammatical compilation process. Our strategy preserves TAG formal properties, hence ensures a reasonable processing efficiency

Use of geochemical signatures, including rare earth elements, in mosses and lichens to assess spatial integration and the influence of forest environment

In order to assess the influence of local environment and spatial integration of Trace Metals (TM) by biomonitors, Al, As, Cd, Cr, Cs, Cu, Fe, Mn, Ni, Pb, Sb, Sn, V and Zn and some rare earth element (REE) concentrations have been measured in lichens and mosses collected in three French forest sites located in three distinct mountainous areas, as well as in the local soil and bedrock, and in both bulk deposition (BD) and throughfall (TF). Similar enrichment factors (EF) were calculated using lichens and mosses and local bedrock for most elements, except for Cs, Mn, Ni, Pb, and Cu which were significantly (KW, p < 0.05) more enriched in mosses. Similar REE ratios were measured in soils, bedrock, lichens and mosses at each study sites, indicating a regional integration of atmospheric deposition by both biomonitors. Both TM signature and REE composition of mosses revealed that this biomonitor is highly influenced by throughfall composition, and reflect atmospheric deposition interaction with the forest canopy. This explained the higher enrichment measured in mosses for elements which concentration in deposition were influenced by the canopy, either due to leaching (Mn), direct uptake (Ni), or dry deposition dissolution (Pb, Cu, Cs)

Caractérisation des environnements écologiques et socio-économiques de la production piscicole continentale à Madagascar

L’environnement de la production piscicole continentale à Madagascar est caractérisé par un écosystème aquatique très diversifié, une faune piscicole endémique pauvre et à faible productivité. L’exploitation par la pêche de la ressource disponible n’arrive pas à satisfaire la demande en poissons de la région des Hautes Terres et plus particulièrement du marché d’Antananarivo, le principal centre de consommation. Une revue des différentes actions menées visant à améliorer la production des eaux intérieures ainsi que leurs impacts respectifs sont répertoriés et analysés. Des suggestions sont émises pour une meilleure valorisation et préservation de la ressource piscicole.Ecological and socio-economic environment of inland fish production in Madagascar. The environment of inland fish production in Madagascar is characterized by a diversified ecosystem and a poor endemic piscicultural fauna with low productivity. Exploitation of available resource does not satisfy the market demand of Antananarivo, the principal centre of consumption. A review of the various carried out actions to improve the production of inland water and their impact respective are addressed and analyzed. Suggestions are emitted for a better resource valorization

XMG : eXtensible MetaGrammar

International audienceIn this article, we introduce eXtensible MetaGrammar (xmg), a framework for specifying tree-based grammars such as Feature-Based Lexicalised Tree-Adjoining Grammars (FB-LTAG) and Interaction Grammars (IG). We argue that xmg displays three features which facilitate both grammar writing and a fast prototyping of tree-based grammars. Firstly, \xmg\ is fully declarative. For instance, it permits a declarative treatment of diathesis that markedly departs from the procedural lexical rules often used to specify tree-based grammars. Secondly, the \xmg\ language has a high notational expressivity in that it supports multiple linguistic dimensions, inheritance and a sophisticated treatment of identifiers. Thirdly, xmg is extensible in that its computational architecture facilitates the extension to other linguistic formalisms. We explain how this architecture naturally supports the design of three linguistic formalisms namely, FB-LTAG, IG, and Multi-Component Tree-Adjoining Grammar (MC-TAG). We further show how it permits a straightforward integration of additional mechanisms such as linguistic and formal principles. To further illustrate the declarativity, notational expressivity and extensibility of \xmg , we describe the methodology used to specify an FB-LTAG for French augmented with a unification-based compositional semantics. This illustrates both how xmg facilitates the modelling of the tree fragment hierarchies required to specify tree-based grammars and of a syntax/semantics interface between semantic representations and syntactic trees. Finally, we briefly report on several grammars for French, English and German that were implemented using \xmg\ and compare \xmg\ to other existing grammar specification frameworks for tree-based grammars

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

International audienceAGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)