Nano- to millimeter scale morphology of connected and isolated porosity in the permo-triassic khuff formation of Oman

Carbonate reservoirs form important exploration targets for the oil and gas industry in many parts of the world. This study aims to differentiate and quantify pore types and their relation to petrophysical properties in the Permo-Triassic Khuff Formation, a major carbonate reservoir in Oman. For that purpose, we have employed a number of laboratory techniques to test their applicability for the characterization of respective rock types. Consequently, a workflow has been established utilizing a combined analysis of petrographic and petrophysical methods which provide the best results for pore-system characterization. Micro-computed tomography (μCT) analysis allows a representative 3D assessment of total porosity, pore connectivity, and effective porosity of the ooid-shoal facies but it cannot resolve the full pore-size spectrum of the highly microporous mud-/wackestone facies. In order to resolve the smallest pores, combined mercury injection capillary pressure (MICP), nuclear magnetic resonance (NMR), and BIB (broad ion beam)-SEM analyses allow covering a large pore size range from millimeter to nanometer scale. Combining these techniques, three different rock types with clearly discernible pore networks can be defined. Moldic porosity in combination with intercrystalline porosity results in the highest effective porosities and permeabilities in shoal facies. In back-shoal facies, dolomitization leads to low total porosity but well-connected and heterogeneously distributed vuggy and intercrystalline pores which improves permeability. Micro- and nanopores are present in all analyzed samples but their contribution to effective porosity depends on the textural context. Our results confirm that each individual rock type requires the application of appropriate laboratory techniques. Additionally, we observe a strong correlation between the inverse formation resistivity factor and permeability suggesting that pore connectivity is the dominating factor for permeability but not pore size. In the future, this relationship should be further investigated as it could potentially be used to predict permeability from wireline resistivity measured in the flushed zone close to the borehole wall. © 2019 by the authors. Licensee MDPI, Basel, Switzerland

Nano- to Millimeter Scale Morphology of Connected and Isolated Porosity in the Permo-Triassic Khuff Formation of Oman

Carbonate reservoirs form important exploration targets for the oil and gas industry in many parts of the world. This study aims to differentiate and quantify pore types and their relation to petrophysical properties in the Permo-Triassic Khuff Formation, a major carbonate reservoir in Oman. For that purpose, we have employed a number of laboratory techniques to test their applicability for the characterization of respective rock types. Consequently, a workflow has been established utilizing a combined analysis of petrographic and petrophysical methods which provide the best results for pore-system characterization. Micro-computed tomography (μCT) analysis allows a representative 3D assessment of total porosity, pore connectivity, and effective porosity of the ooid-shoal facies but it cannot resolve the full pore-size spectrum of the highly microporous mud-/wackestone facies. In order to resolve the smallest pores, combined mercury injection capillary pressure (MICP), nuclear magnetic resonance (NMR), and BIB (broad ion beam)-SEM analyses allow covering a large pore size range from millimeter to nanometer scale. Combining these techniques, three different rock types with clearly discernible pore networks can be defined. Moldic porosity in combination with intercrystalline porosity results in the highest effective porosities and permeabilities in shoal facies. In back-shoal facies, dolomitization leads to low total porosity but well-connected and heterogeneously distributed vuggy and intercrystalline pores which improves permeability. Micro- and nanopores are present in all analyzed samples but their contribution to effective porosity depends on the textural context. Our results confirm that each individual rock type requires the application of appropriate laboratory techniques. Additionally, we observe a strong correlation between the inverse formation resistivity factor and permeability suggesting that pore connectivity is the dominating factor for permeability but not pore size. In the future, this relationship should be further investigated as it could potentially be used to predict permeability from wireline resistivity measured in the flushed zone close to the borehole wall

Ice-core evidence of the thickness and character of clear-facies basal ice:Glacier de Tsanfleuron, Switzerland

Five ice cores have been retrieved from a transect close to the terminus of Glacier de Tsanfleuron, Switzerland. The cores extend from the ice surface to the glacier bed, and are 3.5-44.8 m long. Stratigraphic logging based on bubble size and density reveals the presence of a highly metamorphosed basal ice layer, about 10 m thick, from which all traces of bubble-rich ice have been removed. This bubble-poor ice, which corresponds closely with clear-facies ice observed in cavities beneath numerous temperate-based glaciers, contrasts with the overlying bubble-rich or bubble-foliated englacial ice and the underlying debris-rich and bubble-free dispersed-facies basal ice. Down-core patterns in major-ion composition, stable-isotope composition and total gas content and composition are generally consistent with formation of clear-facies ice by deformation-related metamorphism of bubbly, englacial ice. In addition, isotopic data suggest that storage of downward-percolating meltwaters occurs close to the upper surface of the clear-facies ice layer, perhaps reflecting a local variation in ice permeability across the transition from englacial to clear-facies ice. Enrichment in crustally derived ionic species is noted in the lowermost decimetres of the debris-free, clear-facies ice that immediately overlies debris-rich dispersed-facies basal ice. This ionic enrichment in debris-free ice is interpreted in terms of active inter-granular meltwater flow within some decimetres of the glacier bed.info:eu-repo/semantics/publishe

Sexual violence in older adults : a Belgian prevalence study

Background: Sexual violence (SV) is an important public health problem which may cause long-lasting health problems. SV in older adults remains neglected in research, policies and practices. Valid SV prevalence estimates and associated risk factors in older adults are currently unavailable. Objective: To measure lifetime and past 12-months sexual victimisation in older adults living in Belgium, its correlates, assailant characteristics and the way that victims framed their SV experiences. Design: Cross-sectional general population study. Setting: Community-dwelling, assisted living and nursing homes. Participants: 513 people of 70 years and older living in Belgium. Methods: SV was measured using behaviourally specific questions based on a broad definition of SV. Participants were selected via a cluster random probability sampling with a random route finding approach. Information on sexual victimisation, correlates, assailant characteristics and framing was collected via structured face-to-face interviews. Results: Lifetime SV prevalence was 44% (55% F, 29% M). Past 12-months prevalence was 8% (9% F, 8% M). Female sex and a higher number of sexual partners were associated with lifetime SV (p <.05), non-heterosexual sexual orientation with past 12-months SV (p <.05). Correlates generally linked to elder abuse and neglect were not linked with SV. ‘Someone unknown’ was identified as most common assailant. Conclusions: SV appears to be common in older adults in Belgium. Both correlates and assailant characteristics seem to differ from previous studies on elder abuse and neglect. Recognising older adults as a risk group for sexual victimisation in research, policies and practices is of the utmost importance

'Too grey to be true?' Sexual violence in older adults : a critical interpretive synthesis of evidence

Sexual violence (SV) is an important public health issue with a major impact on victims and their peers, offspring and community. However, SV in older adults is under-researched. This paper aims to establish the prevalence and nature of SV in older adults in Europe, link this with existing policies and health care workers’ response to sexual health needs in older age, and critically revise the currently used frameworks in public health research. To fill this gap in the literature, we applied a Critical Interpretative Synthesis (CIS) approach. The CIS approach uses techniques from grounded theory and processes from systematic review. It allows to critically interpret key findings from both academic as well as grey literature, engendering theory refining. In the first phase of purposive sampling, we conducted a systematic review of academic sources and included 14 references. The cut-off age used to define old age varied between 60 and 70 years old among the included studies. Subsequently we added another 14 references in the second phase of theoretical sampling. We ultimately included 16 peer-reviewed articles and 12 documents from the grey literature. The CIS results demonstrate that knowledge of SV in older adults is still limited. The current research suggests that SV in older adults rarely occurs, however, prevalence rates are likely to be underestimated because of methodological shortcomings. The complexity of SV in older adults is not acknowledged in ongoing research due to the conflation of SV with other types of violence. Information on specific risk factors and about assailants committing SV in old age is absent. Policy documents dealing with sexual and reproductive health, rights and ageing make no mention of SV in older adults. In clinical practice, the sexual health needs of older adults often remain unmet. In conclusion, our findings suggest that older adults are forgotten in prevention and response to SV. Greater awareness about this topic could contribute to a revision of current policies and health care practices, leading to more tailored care for older victims of SV

Challenges in conducting sexual health and violence research in older adults beyond the General Data Protection Regulation : a Belgian case study

Background: Because of a growing older population, the sexual health (SH) of older adults, including sexual violence (SV), is becoming an increasingly important public health concern. Yet, reliable SV prevalence rates and risk factors are lacking, due to methodological shortcomings in current studies. SV research involves challenges regarding safety and disclosure, especially in older adults. In this paper we reflect on the methods used in a SH&V study in older adults balancing between GDPR imposed privacy rules and ethical and safety guidelines. Methods: To ensure the acceptability of the questionnaire, it was tested in a two-phase pilot study. To maximize SV disclosure, the questionnaire built up gradually towards the more sensitive SV modules. Interviewers were trained to approach participants in a non-judgemental manner. Due to GDPR, our data collection method was changed from a random sampling via the National Register to a cluster random probability sampling with a random route finding approach. Results: Older adults were willing to discuss SH&V during a face-to-face interview with trained interviewers. Following strict safety guidelines, no major incidents were reported. The cluster random probability sampling with random route finding approach provided an adequate sampling frame, but was inefficient and time-consuming. Conclusion: Doing research on SH&V in older adults is feasible, but requires a substantial investment of time and the challenges involved may incur greater costs. Research institutions, donors, and policy makers should convene to investigate how problems related to GDPR can be solved, especially regarding research on sensitive topics and hard to reach populations

In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility

There is an increased interest in secondary plant metabolites, such as polyphenols and carotenoids, due to their proposed health benefits. Much attention has focused on their bioavailability, a prerequisite for further physiological functions. As human studies are time consuming, costly, and restricted by ethical concerns, in vitro models for investigating the effects of digestion on these compounds have been developed and employed to predict their release from the food matrix, bioaccessibility, and assess changes in their profiles prior to absorption. Most typically, models simulate digestion in the oral cavity, the stomach, the small intestine, and, occasionally, the large intestine. A plethora of models have been reported, the choice mostly driven by the type of phytochemical studied, whether the purpose is screening or studying under close physiological conditions, and the availability of the model systems. Unfortunately, the diversity of model conditions has hampered the ability to compare results across different studies. For example, there is substantial variability in the time of digestion, concentrations of salts, enzymes, and bile acids used, pH, the inclusion of various digestion stages; and whether chosen conditions are static (with fixed concentrations of enzymes, bile salts, digesta, and so on) or dynamic (varying concentrations of these constituents). This review presents an overview of models that have been employed to study the digestion of both lipophilic and hydrophilic phytochemicals, comparing digestive conditions in vitro and in vivo and, finally, suggests a set of parameters for static models that resemble physiological conditions

Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries

Background: Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs. Aims: We studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs. Methods: We report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs). Results: Until August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey). Of these 63, 32 (51%) met the VITT criteria, compared to 103 of 165 (62%) from HICs. Only 5 of the 32 (16%) CVST-VITT cases from MICs had definite VITT, mostly because anti-platelet factor 4 antibodies were often not tested. The median age was 26 (interquartile range [IQR] 20–37) versus 47 (IQR 32–58) years, and the proportion of women was 25 of 32 (78%) versus 77 of 103 (75%) in MICs versus HICs, respectively. Patients from MICs were diagnosed later than patients from HICs (1/32 [3%] vs. 65/103 [63%] diagnosed before May 2021). Clinical manifestations, including intracranial hemorrhage, were largely similar as was intravenous immunoglobulin use. In-hospital mortality was lower in MICs (7/31 [23%, 95% confidence interval (CI) 11–40]) than in HICs (44/102 [43%, 95% CI 34–53], p = 0.039). Conclusions: The number of CVST-VITT cases reported from LMICs was small despite the widespread use of adenoviral vaccines. Clinical manifestations and treatment of CVST-VITT cases were largely similar in MICs and HICs, while mortality was lower in patients from MICs.</p

Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19

Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.</p

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Funder: Kennedy Trust Rheumatology Research Prize StudentshipFunder: DFG Cluster of Excellence “Precision Medicine in Chronic In-flammation” (PMI; ID: EXC2167)Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: “Ideas” Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 715772Funder: NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27, and NWO Gravitation grant ExposomeNLFunder: Li Ka Shing Foundation (Li Ka Shing Foundation Limited); doi: https://doi.org/10.13039/100007421Abstract: Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain–gut interactions underlying IBS