Measuring our universe from galaxy redshift surveys

Galaxy redshift surveys have achieved significant progress over the last couple of decades. Those surveys tell us in the most straightforward way what our local universe looks like. While the galaxy distribution traces the bright side of the universe, detailed quantitative analyses of the data have even revealed the dark side of the universe dominated by non-baryonic dark matter as well as more mysterious dark energy (or Einstein's cosmological constant). We describe several methodologies of using galaxy redshift surveys as cosmological probes, and then summarize the recent results from the existing surveys. Finally we present our views on the future of redshift surveys in the era of Precision Cosmology.Comment: 82 pages, 31 figures, invited review article published in Living Reviews in Relativity, http://www.livingreviews.org/lrr-2004-

Rainbow-trapping absorbers: Broadband, perfect and asymmetric sound absorption by subwavelength panels for transmission problems

[EN] Perfect, broadband and asymmetric sound absorption is theoretically, numerically and experimentally reported by using subwavelength thickness panels in a transmission problem. The panels are composed of a periodic array of varying crosssection waveguides, each of them being loaded by Helmholtz resonators (HRs) with graded dimensions. The low cut-off frequency of the absorption band is fixed by the resonance frequency of the deepest HR, that reduces drastically the transmission. The preceding HR is designed with a slightly higher resonance frequency with a geometry that allows the impedance matching to the surrounding medium. Therefore, reflection vanishes and the structure is critically coupled. This results in perfect sound absorption at a single frequency. We report perfect absorption at 300¿Hz for a structure whose thickness is 40 times smaller than the wavelength. Moreover, this process is repeated by adding HRs to the waveguide, each of them with a higher resonance frequency than the preceding one. Using this frequency cascade effect, we report quasi-perfect sound absorption over almost two frequency octaves ranging from 300 to 1000¿Hz for a panel composed of 9 resonators with a total thickness of 11¿cm, i.e., 10 times smaller than the wavelength at 300¿Hz.The authors acknowledge fnancial support from the Metaudible Project No. ANR-13-BS09-0003, cofunded by ANR and FRAE.Jimenez, N.; Romero García, V.; Pagneux, V.; Groby, J. (2017). Rainbow-trapping absorbers: Broadband, perfect and asymmetric sound absorption by subwavelength panels for transmission problems. Scientific Reports. 7(1). doi:10.1038/s41598-017-13706-4S1359571Zheludev, N. I. & Kivshar, Y. S. From metamaterials to metadevices. Nature materials 11, 917–924 (2012).Ding, Y., Liu, Z., Qiu, C. & Shi, J. Metamaterial with simultaneously negative bulk modulus and mass density. 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The association between socioeconomic status and traditional chinese medicine use among children in Taiwan

<p>Abstract</p> <p>Background</p> <p>Traditional Chinese medicine (TCM) utilization is common in Asian countries. Limited studies are available on the socioeconomic status (SES) associated with TCM use among the pediatric population. We report on the association between SES and TCM use among children and adolescents in Taiwan.</p> <p>Methods</p> <p>A National Health Interview Survey was conducted in Taiwan in 2001 that included 5,971 children and adolescents. We assessed the children's SES using the head of household's education, occupation and income. This information was used to calculate pediatric SES scores, which in turn were divided into quartiles. Children and adolescents who visited TCM in the past month were defined as TCM users.</p> <p>Results</p> <p>Compared to children in the second SES quartile, children in the fourth SES quartile had a higher average number of TCM visits (0.12 vs. 0.06 visits, p = 0.027) and higher TCM use prevalence (5.0% vs. 3.6%, p = 0.024) within the past month. The adjusted odds ratio (OR) for TCM use was higher for children in the fourth SES quartile than for those in the first SES quartile (OR 1.49; 95% confidence interval [CI] 1.02-2.17). The corresponding OR was 2.17 for girls (95% CI 1.24-3.78). The highest-SES girls (aged 10-18 years) were most likely to visit TCM practices (OR 2.47; 95% CI 1.25-4.90).</p> <p>Conclusions</p> <p>Children and adolescents with high SES were more likely to use TCM and especially girls aged 10-18 years. Our findings point to the high use of complementary and alternative medicine among children and adolescents.</p

Levodopa-Induced Dyskinesia Is Associated with Increased Thyrotropin Releasing Hormone in the Dorsal Striatum of Hemi-Parkinsonian Rats

Background Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to hyper-responsive dopamine receptor signaling in the sensorimotor striatum is thought to underlie this currently untreatable condition. Methodology/Principal Findings Quantitative real-time polymerase chain reaction (PCR) was employed to evaluate the molecular changes associated with L-DOPA-induced dyskinesias in Parkinson's disease. With this technique, we determined that thyrotropin releasing hormone (TRH) was greatly increased in the dopamine-depleted striatum of hemi-parkinsonian rats that developed abnormal movements in response to L-DOPA therapy, relative to the levels measured in the contralateral non-dopamine-depleted striatum, and in the striatum of non-dyskinetic control rats. ProTRH immunostaining suggested that TRH peptide levels were almost absent in the dopamine-depleted striatum of control rats that did not develop dyskinesias, but in the dyskinetic rats, proTRH immunostaining was dramatically up-regulated in the striatum, particularly in the sensorimotor striatum. This up-regulation of TRH peptide affected striatal medium spiny neurons of both the direct and indirect pathways, as well as neurons in striosomes. Conclusions/Significance TRH is not known to be a key striatal neuromodulator, but intrastriatal injection of TRH in experimental animals can induce abnormal movements, apparently through increasing dopamine release. Our finding of a dramatic and selective up-regulation of TRH expression in the sensorimotor striatum of dyskinetic rat models suggests a TRH-mediated regulatory mechanism that may underlie the pathologic neuroplasticity driving dopamine hyper-responsivity in Parkinson's disease.Morris K. Udall Center for Excellence in Parkinson’s Research at MGH/MITNational Institutes of Health (U.S.) (NIH NS38372)American Parkinson Disease Association, Inc.University of Alabama at BirminghamMassachusetts General HospitalNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (NIDDK/NIH grant R01 DK58148)National Institute of Neurological Disorders and Stroke (U.S.) (R01 NINDS/NIH grant NS045231)Stanley H. and Sheila G. Sydney FundMichael J. Fox Foundation for Parkinson's Researc

Long-Range Autocorrelations of CpG Islands in the Human Genome

In this paper, we use a statistical estimator developed in astrophysics to study the distribution and organization of features of the human genome. Using the human reference sequence we quantify the global distribution of CpG islands (CGI) in each chromosome and demonstrate that the organization of the CGI across a chromosome is non-random, exhibits surprisingly long range correlations (10 Mb) and varies significantly among chromosomes. These correlations of CGI summarize functional properties of the genome that are not captured when considering variation in any particular separate (and local) feature. The demonstration of the proposed methods to quantify the organization of CGI in the human genome forms the basis of future studies. The most illuminating of these will assess the potential impact on phenotypic variation of inter-individual variation in the organization of the functional features of the genome within and among chromosomes, and among individuals for particular chromosomes

Fano resonance engineering in mirror-symmetry-broken THz metamaterials

We introduce a comprehensive approach to the design of mirror-symmetry broken terahertz (THz) metamaterials and present both the simulation and experimental results which show the desired asymmetric Fano resonances and electromagnetic induced transparency (EIT)-like windows. With a full wave simulation, we find these asymmetry-induced resonance modes possess extremely high quality factors and they broaden with increase of the structure asymmetry. This phenomenon arises from the destructive interference of a super-radiative bright mode and a sub-radiative dark mode which can’t be excited directly. Surface current and electric field distributions are analyzed to explain the emergence of these Fano resonances. An intuitive mechanical coupled oscillator model is derived to explain the unique line-shape of such Fano resonances. Moreover, large resonant frequency tuning (50 GHz) of Fano resonance has been demonstrated by temperature induced phase change in liquid crystals. We believe that the Fano resonance in THz metamaterials may serve as a strong building block for passive or active THz elements with potential applications for future detection and sensing systems and devices.The authors would like to thank the UK Engineering and Physical Sciences Research Council (EPSRC) for the support through the Platform Grant for Liquid Crystal Photonics (EP/F00897X/1). Xuefeng Li would like to acknowledge the support from Cambridge Trust.This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Springer

EGG: hatching a mock Universe from empirical prescriptions⋆

This paper introduces EGG, the Empirical Galaxy Generator, a tool designed within the ASTRODEEP collaboration to generate mock galaxy catalogs for deep fields with realistic fluxes and simple morphologies. The simulation procedure is based exclusively on empirical prescriptions -- rather than first principles -- to provide the most accurate match with observations at 0<z<7. In particular, we consider that galaxies can be either quiescent or star-forming, and use their stellar mass (M*) and redshift (z) as the fundamental properties from which all the other observables can be statistically derived. Drawing z and M* from the observed galaxy stellar mass functions, we associate a star formation rate (SFR) to each galaxy from the tight SFR-M* main sequence, while dust attenuation, optical colors and morphologies (including bulge-to-total ratios, sizes and aspect ratios) are obtained from empirical relations that we establish from the high quality Hubble and Herschel observations available in the CANDELS fields. Random scatter is introduced in each step to reproduce the observed distributions of each parameter. Based on these observables, a panchromatic spectral energy distribution (SED) is selected for each galaxy and synthetic photometry is produced by integrating the redshifted SED in common broad-band filters. Finally, the mock galaxies are placed on the sky at random positions with a fixed angular two-point correlation function to implement basic clustering. The resulting flux catalogs reproduce accurately the observed number counts in all broad bands from the ultraviolet up to the sub-millimeter, and can be directly fed to image simulators such as Skymaker. The images can then be used to test source extraction softwares and image-based techniques such as stacking. EGG is open-source, and is made available to the community together with a set of pre-generated catalogs and images.Comment: 24 pages, 18 figures, accepted for publication in A&

Stereotactic dose computation and plan optimization using the convolution theorem. I. Dose computation

With Leksell Gamma Knife stereotactic radiosurgery, the dose distribution delivered by a specific helmet can be assumed to remain as a fixed-dose distribution when the shot is moved to different locations within the predefined dose calculation matrix. The convolution theorem may be implemented to take advantage of this fact for fast dose computation and plan construction. Using this technique, the shot spatial arrangement is formulated as a convolution kernel, which is theoretically a three-dimensional multi-delta function. The dose distribution is computed by the convolution of this single-shot dose distribution with the shot convolution kernel. To determine the shot arrangement, an ideal dose distribution is generated based upon the target structure. Deconvolution is then applied to find the convolution kernel which best fits the proposed ideal dose distribution. The primary task of this presentation is to focus on and describe in detail the dose computation using the convolution theorem