The Blazar Sequence: Validity and Predictions

The "blazar sequence" posits that the most powerful BL Lacertae objects and flat-spectrum radio quasars should have relatively small synchrotron peak frequencies, nu_peak, and that the least powerful such objects should have the highest nu_peak values. This would have strong implications for our understanding of jet formation and physics and the possible detection of powerful, moderately high-redshift TeV blazars. I review the validity of the blazar sequence by using the results of very recent surveys and compare its detailed predictions against observational data. I find that the blazar sequence in its simplest form is ruled out. However, powerful flat-spectrum radio quasars appear not to reach the nu_peak typical of BL Lacs. This could indeed be related to some sort of sequence, although it cannot be excluded that it is instead due to a selection effect.Comment: 9 pages, 4 figures, invited talk at the Workshop "The Multi-messenger approach to high energy gamma-ray sources", Barcelona, Spain, July 4-7, 2006, to appear in the proceeding

VLA Observations of a New Population of Blazars

We present the first deep VLA radio images of flat-spectrum radio quasars (FSRQ) with multiwavelength emission properties similar to those of BL Lacs with synchrotron X-rays. Our observations of twenty-five of these sources show that their radio morphologies are similar to those of other radio quasars. However, their range of extended powers is more similar to that of BL Lacertae objects (BL Lacs) and extends down to the low values typical of FR I radio galaxies. Five out of our nine lobe-dominated sources have extended radio powers in the range typical of both FR I and FR II radio galaxies, but their extended radio structure is clearly FR II-like. Therefore, we have not yet found a large population of radio quasars hosted by FR Is. Two thirds of our sources have a core-dominated radio morpholgy and thus X-rays likely dominated by the jet. We find that their ratios of radio core to total X-ray luminosity are low and in the regime indicative of synchrotron X-rays. This result shows that also blazars with strong emission lines can produce jets of high-energy synchrotron emission and undermines at least in part the ``blazar sequence'' scenario which advocates that particle Compton cooling by an external radiation field governs the frequency of the synchrotron emission peak.Comment: 26 pages, 33 figures. Accepted for publication in Ap

Multi-wavelength observations of the obscuring wind in the radio-quiet quasar MR 2251-178

Obscuring winds driven away from active supermassive black holes are rarely seen due to their transient nature. They have been observed with multi-wavelength observations in a few Seyfert 1 galaxies and one broad absorption line radio-quiet quasar so far. An X-ray obscuration event in MR 2251-178 was caught in late 2020, which triggered multi-wavelength (NIR to X-ray) observations targeting this radio-quiet quasar. In the X-ray band, the obscurer leads to a flux drop in the soft X-ray band from late 2020 to early 2021. X-ray obscuration events might have a quasi-period of two decades considering earlier events in 1980 and 1996. In the UV band, a forest of weak blueshifted absorption features emerged in the blue wing of Ly$\alpha$ $\lambda1216$ in late 2020. Our XMM-Newton, NuSTAR, and HST/COS observations are obtained simultaneously, hence, the transient X-ray obscuration event is expected to account for the UV outflow, although they are not necessarily caused by the same part of the wind. Both blueshifted and redshifted absorption features were found for He {\sc i} $\lambda10830$, but no previous NIR spectra are available for comparison. The X-ray observational features of MR 2251-178 shared similarities with some other type 1 AGNs with obscuring wind. However, observational features in the UV to NIR bands are distinctly different from those seen in other AGN with obscuring winds. A general understanding of the observational variety and the nature of obscuring wind is still lacking.Comment: ApJ accepte

Detailed Structure of the X-ray Jet in 4C 19.44 (=PKS1354+195)

We investigate the variations of the magnetic field, Doppler factor, and relativistic particle density along the jet of a quasar at z=0.72. We chose 4C 19.44 for this study because of its length and straight morphology. The 18 arcsec length of the jet provides many independent resolution elements in the Chandra X-ray image. The straightness suggests that geometry factors, although uncertain, are almost constant along the jet. We assume the X-ray emission is from inverse Compton scattering of the cosmic microwave background. With the aid of assumptions about jet alignment, equipartition between magnetic-field and relativistic-particle energy, and filling factors, we find that the jet is in bulk relativistic motion with a Doppler factor about 6 at an angle no more than 10 degrees to the line of sight over deprojected distances about 150--600 kpc from the quasar, and with a magnetic field approximately 10 micro Gauss.Comment: To appear in "Black Holes: from Stars to Galaxies" Proceedings IAU Symp. No. 238, eds. V. Karas & G. Matt, 2 pages, 1 figure, needs iaus.cl

A dust-parallax distance of 19 megaparsecs to the supermassive black hole in NGC 4151

The active galaxy NGC 4151 has a crucial role as one of only two active galactic nuclei for which black hole mass measurements based on emission line reverberation mapping can be calibrated against other dynamical methods. Unfortunately, effective calibration requires an accurate distance to NGC 4151, which is currently not available. Recently reported distances range from 4 to 29 megaparsecs (Mpc). Strong peculiar motions make a redshift-based distance very uncertain, and the geometry of the galaxy and its nucleus prohibit accurate measurements using other techniques. Here we report a dust-parallax distance to NGC 4151 of $D_A = 19.0^{+2.4}_{-2.6}$ Mpc. The measurement is based on an adaptation of a geometric method proposed previously using the emission line regions of active galaxies. Since this region is too small for current imaging capabilities, we use instead the ratio of the physical-to-angular sizes of the more extended hot dust emission as determined from time-delays and infrared interferometry. This new distance leads to an approximately 1.4-fold increase in the dynamical black hole mass, implying a corresponding correction to emission line reverberation masses of black holes if they are calibrated against the two objects with additional dynamical masses.Comment: Authors' version of a letter published in Nature (27 November 2014); 8 pages, 5 figures, 1 tabl

The Deep X-Ray Radio Blazar Survey (DXRBS). III. Radio Number Counts, Evolutionary Properties, and Luminosity Function of Blazars

Our knowledge of the blazar surface densities and luminosity functions, which are fundamental parameters, relies still on samples at relatively high flux limits. As a result, our understanding of this rare class of active galactic nuclei is mostly based on relatively bright and intrinsically luminous sources. We present the radio number counts, evolutionary properties, and luminosity functions of the faintest blazar sample with basically complete (~ 95%) identifications. Based on the Deep X-ray Radio Blazar Survey (DXRBS), it includes 129 flat-spectrum radio quasars (FSRQ) and 24 BL Lacs down to a 5 GHz flux and power ~ 50 mJy and ~ 10^{24} W/Hz, respectively, an order of magnitude improvement as compared to previously published (radio-selected) blazar samples. DXRBS FSRQ are seen to evolve strongly, up to redshift ~ 1.5, above which high-power sources show a decline in their comoving space density. DXRBS BL Lacs, on the other hand, do not evolve. High-energy (HBL) and low-energy (LBL) peaked BL Lacs share the same lack of cosmological evolution, which is at variance with some previous results. The observed luminosity functions are in good agreement with the predictions of unified schemes, with FSRQ getting close to their expected minimum power. Despite the fact that the large majority of our blazars are FSRQ, BL Lacs are intrinsically ~ 50 times more numerous. Finally, the relative numbers of HBL and LBL in the radio and X-ray bands are different from those predicted by the so-called "blazar sequence" and support a scenario in which HBL represent a small minority (~ 10%) of all BL Lacs.Comment: 19 pages, 14 figures (1 color), accepted for publication in the Astrophysical Journa

The Spitzer High Redshift Radio Galaxy Survey

We present results from a comprehensive imaging survey of 70 radio galaxies at redshifts 1<z<5.2 using all three cameras onboard the Spitzer Space Telescope. The resulting spectral energy distributions unambiguously show a stellar population in 46 sources and hot dust emission associated with the active nucleus in 59. Using a new restframe S_3um/S_1.6um versus S_um/S_3um criterion, we identify 42 sources where the restframe 1.6um emission from the stellar population can be measured. For these radio galaxies, the median stellar mass is high, 2x10^11 M_sun, and remarkably constant within the range 13, there is tentative evidence for a factor of two decrease in stellar mass. This suggests that radio galaxies have assembled the bulk of their stellar mass by z~3, but confirmation by more detailed decomposition of stellar and AGN emission is needed. The restframe 500 MHz radio luminosities are only marginally correlated with stellar mass but are strongly correlated with the restframe 5um hot dust luminosity. This suggests that the radio galaxies have a large range of Eddington ratios. We also present new Very Large Array 4.86 and 8.46 GHz imaging of 14 radio galaxies and find that radio core dominance --- an indicator of jet orientation --- is strongly correlated with hot dust luminosity. While all of our targets were selected as narrow-lined, type 2 AGNs, this result can be understood in the context of orientation-dependent models if there is a continuous distribution of orientations from obscured type 2 to unobscured type 1 AGNs rather than a clear dichotomy. Finally, four radio galaxies have nearby (<6") companions whose mid-IR colors are suggestive of their being AGNs. This may indicate an association between radio galaxy activity and major mergers.Comment: 31 pages, 125 figures. Accepted for publication in the Astrophysical Journa

Simultaneous Planck, Swift, and Fermi observations of X-ray and gamma-ray selected blazars

We present simultaneous Planck, Swift, Fermi, and ground-based data for 105 blazars belonging to three samples with flux limits in the soft X-ray, hard X-ray, and gamma-ray bands. Our unique data set has allowed us to demonstrate that the selection method strongly influences the results, producing biases that cannot be ignored. Almost all the BL Lac objects have been detected by Fermi-LAT, whereas ~40% of the flat-spectrum radio quasars (FSRQs) in the radio, soft X-ray, and hard X-ray selected samples are still below the gamma-ray detection limit even after integrating 27 months of Fermi-LAT data. The radio to sub-mm spectral slope of blazars is quite flat up to ~70GHz, above which it steepens to ~-0.65. BL Lacs have significantly flatter spectra than FSRQs at higher frequencies. The distribution of the rest-frame synchrotron peak frequency (\nupS) in the SED of FSRQs is the same in all the blazar samples with =10^13.1 Hz, while the mean inverse-Compton peak frequency, , ranges from 10^21 to 10^22 Hz. The distributions of \nupS and of \nupIC of BL Lacs are much broader and are shifted to higher energies than those of FSRQs and strongly depend on the selection method. The Compton dominance of blazars ranges from ~0.2 to ~100, with only FSRQs reaching values >3. Its distribution is broad and depends strongly on the selection method, with gamma-ray selected blazars peaking at ~7 or more, and radio-selected blazars at values ~1, thus implying that the assumption that the blazar power is dominated by high-energy emission is a selection effect. Simple SSC models cannot explain the SEDs of most of the gamma-ray detected blazars in all samples. The SED of the blazars that were not detected by Fermi-LAT may instead be consistent with SSC emission. Our data challenge the correlation between bolometric luminosity and \nupS predicted by the blazar sequence.Comment: Version accepted by A&A. Joint Planck, Swift, and Fermi collaborations pape

Heparan sulfate and heparin interactions with proteins.

Heparan sulfate (HS) polysaccharides are ubiquitous components of the cell surface and extracellular matrix of all multicellular animals, whereas heparin is present within mast cells and can be viewed as a more sulfated, tissuespecific, HS variant. HS and heparin regulate biological processes through interactions with a large repertoire of proteins. Owing to these interactions and diverse effects observed during in vitro, ex vivo and in vivo experiments, manifold biological/pharmacological activities have been attributed to them. The properties that have been thought to bestow protein binding and biological activity upon HS and heparin vary from high levels of sequence specificity to a dependence on charge. In contrast to these opposing opinions, we will argue that the evidence supports both a level of redundancy and a degree of selectivity in the structure–activity relationship. The relationship between this apparent redundancy, the multi-dentate nature of heparin and HS polysaccharide chains, their involvement in protein networks and the multiple binding sites on proteins, each possessing different properties, will also be considered. Finally, the role of cations in modulating HS/heparin activity will be reviewed and some of the implications for structure–activity relationships and regulation will be discussed

The clinical and molecular spectrum of galactosemia in patients from the Cape Town region of South Africa

BACKGROUND: The objective of this study was to document the clinical, laboratory and genetic features of galactosemia in patients from the Cape Town metropolitan region. METHODS: Diagnoses were based on thin layer chromatography for galactosuria/galactosemia and assays of erythrocyte galactose-1-phosphate uridyltransferase (GALT) and galactokinase activities. Patients were screened for the common S135L and Q188R transferase gene mutations, using PCR-based assays. Screening for the S135L mutation in black newborns was used to estimate the carrier rate for galactosemia in black South Africans. RESULTS: A positive diagnosis of galactosemia was made in 17 patients between the years 1980 to 2001. All had very low or absent galactose-1-phosphate uridyltransferase (GALT) activity, and normal galactokinase levels. The mean age at diagnosis was 5.1 months (range 4 days to 6.5 months). A review of 9 patients showed that hepatomegaly (9/9), and splenomegaly, failure to thrive, developmental delay, bilateral cataracts (6/9) were the most frequent features at diagnosis. Six had conjugated hyperbilirubinemia. Four experienced invasive E. coli infection before diagnosis. Ten patients were submitted to DNA analysis. All 4 black patients and 2 of mixed extraction were homozygous for the S135L allele, while all 3 white patients were homozygous for the Q188R allele. The remaining patient of mixed extraction was heterozygous for the Q188R allele. The estimated carrier frequency of the S135L mutation in 725 healthy black newborns was 1/60. CONCLUSIONS: In the absence of newborn screening the delay in diagnosis is most often unacceptably long. Also, carrier frequency data predict a galactosemia incidence of approximately 1/14 400 for black newborns in the Cape Metropole, which is much higher than the current detection rate. It is thus likely that many patients go undetected