33 research outputs found
Nano-friction in cavity quantum electrodynamics
The dynamics of cold trapped ions in a high-finesse resonator results from
the interplay between the long-range Coulomb repulsion and the cavity-induced
interactions. The latter are due to multiple scatterings of laser photons
inside the cavity and become relevant when the laser pump is sufficiently
strong to overcome photon decay. We study the stationary states of ions coupled
with a mode of a standing-wave cavity as a function of the cavity and laser
parameters, when the typical length scales of the two self-organizing
processes, Coulomb crystallization and photon-mediated interactions, are
incommensurate. The dynamics are frustrated and in specific limiting cases can
be cast in terms of the Frenkel-Kontorova model, which reproduces features of
friction in one dimension. We numerically recover the sliding and pinned
phases. For strong cavity nonlinearities, they are in general separated by
bistable regions where superlubric and stick-slip dynamics coexist. The cavity,
moreover, acts as a thermal reservoir and can cool the chain vibrations to
temperatures controlled by the cavity parameters and by the ions phase. These
features are imprinted in the radiation emitted by the cavity, which is readily
measurable in state-of-art setups of cavity quantum electrodynamics.Comment: 9 pages, 7 figure
Análisis financiero y su incidencia en la toma de decisiones en la Empresa Servicom Lorenzo EIRL Nuevo Chimbote – 2022
El presente trabajo de investigación tuvo como propósito, Determinar la incidencia
del análisis financiero en la toma de decisiones en la empresa Servicom Lorenzo
EIRL, del Distrito de Nuevo Chimbote durante el periodo 2022.
Todo esto correspondió a un estudio cuantitativo, de diseño no experimental,
aplicativo, descriptivo-propositivo, correlacional y de corte transversal. La población
estuvo constituida por los trabajadores de la empresa Servicom Lorenzo EIRL y se
tomó como muestra a sus estados financieros del periodo 2022.
Asimismo, se utilizó como técnica, el análisis documental y la entrevista con el fin
de recoger datos para argumentar evidencias y dichos objetivos específicos con el
fin de contrastar la hipótesis planteada en el problema y como instrumento el
reporte de resultados económicos y financieros y la guía de entrevista los mismo
que serán validados por tal razón.
Se concluyó que la empresa tiene un índice estructural estable, acerca a lo
económico-financiero, ya que está tomando buenas decisiones al momento de
querer invertir o financiar algo y todo eso se refleja en el buen manejo de sus
recursos propios que está generando, por otra parte la empresa cuenta con una
liquidez y rentabilidad segura que le permite cumplir con sus obligaciones en el
corto y largo plazo e invirtiendo para que siga desarrollando sus actividades, todo
esto es gracias a la toma de decisiones que está tomando el gerente de la
empresa
Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat
Background: Combined congenic breeding and
microarray gene expression profiling previously identified
glutathione S-transferase m-type 1 (Gstm1) as a positional
and functional candidate gene for blood pressure (BP)
regulation in the stroke-prone spontaneously hypertensive
(SHRSP) rat. Renal Gstm1 expression in SHRSP rats is
significantly reduced when compared with normotensive
Wistar Kyoto (WKY) rats. As Gstm1 plays an important
role in the secondary defence against oxidative stress,
significantly lower expression levels may be functionally
relevant in the development of hypertension. The aim of
this study was to investigate the role of Gstm1 in BP
regulation and oxidative stress by transgenic
overexpression of the Gstm1 gene.
Method: Two independent Gstm1 transgenic SHRSP lines
were generated by microinjecting SHRSP embryos with a
linear construct controlled by the EF-1a promoter encoding
WKY Gstm1 cDNA [SHRSP-Tg(Gstm1)1WKY and SHRSPTg(Gstm1)2WKY].
Results: Transgenic rats exhibit significantly reduced BP and
pulse pressure when compared with SHRSP [systolic: SHRSP
205.2 3.7 mmHg vs. SHRSP-Tg(Gstm1)1WKY
175.5 1.6 mmHg and SHRSP-Tg(Gstm1)2WKY
172 3.2 mmHg, P< 0.001; pulse pressure: SHRSP
58.4 0.73 mmHg vs. SHRSP-Tg(Gstm1)1WKY
52.7 0.19 mmHg and SHRSP-Tg(Gstm1)2WKY
40.75 0.53 mmHg, P< 0.001]. Total renal and aortic
Gstm1 expression in transgenic animals was significantly
increased compared with SHRSP [renal relative quantification
(RQ): SHRSP-Tg(Gstm1)1WKY 1.95 vs. SHRSP 1.0, P< 0.01;
aorta RQ: SHRSP-Tg(Gstm1)1WKY 2.8 vs. SHRSP 1.0,
P< 0.05]. Renal lipid peroxidation (malondialdehyde: protein)
and oxidized : reduced glutathione ratio levels were
significantly reduced in both transgenic lines when compared
with SHRSP [malondialdehyde: SHRSP 0.04 0.009mmol/l
vs. SHRSP-Tg(Gstm1)1WKY 0.024 0.002mmol/l and SHRSPTg(Gstm1)2WKY
0.021 0.002mmol/l; (oxidized : reduced
glutathione ratio): SHRSP 5.19 2.26mmol/l vs. SHRSPTg(Gstm1)1WKY
0.17 0.111mmol/l and SHRSPTg(Gstm1)2WKY
0.471 0.223mmol/l]. Transgenic SHRSP
rats containing the WKY Gstm1 gene demonstrate
significantly lower BP, reduced oxidative stress and improved
levels of renal Gstm1 expression.
Conclusion: These data support the hypothesis that
reduced renal Gstm1 plays a role in the development of
hypertension
Rosuvastatin Can Block Pro-Inflammatory Actions of Transgenic Human C-Reactive Protein Without Reducing its Circulating Levels
n/
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
Papillary thyroid cancer (PTC) among individuals exposed to radioactive iodine in their childhood or adolescence is a major internationally recognized health consequence of the Chernobyl accident. To identify genetic determinants affecting individual susceptibility to radiation-related PTC, we conducted a genome-wide association study employing Belarusian patients with PTC aged 0-18 years at the time of accident and age-matched Belarusian control subjects. Two series of genome scans were performed using independent sample sets, and association with radiation-related PTC was evaluated. Meta-analysis by the Mantel-Haenszel method combining the two studies identified four SNPs at chromosome 9q22.33 showing significant associations with the disease (Mantel-Haenszel P: mhp = 1.7 x 10(-9) to 4.9 x 10(-9)). The association was further reinforced by a validation analysis using one of these SNP markers, rs965513, with a new set of samples (overall mhp = 4.8 x 10(-12), OR = 1.65, 95% CI: 1.43-1.91). Rs965513 is located 57-kb upstream to FOXE1, a thyroid-specific transcription factor with pivotal roles in thyroid morphogenesis and was recently reported as the strongest genetic risk marker of sporadic PTC in European populations. Of interest, no association was obtained between radiation-related PTC and rs944289 (mhp = 0.17) at 14p13.3 which showed the second strongest association with sporadic PTC in Europeans. These results show that the complex pathway underlying the pathogenesis may be partly shared by the two etiological forms of PTC, but their genetic components do not completely overlap each other, suggesting the presence of other unknown etiology-specific genetic determinants in radiation-related PTC
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Modeling and Imaging of Multiscale Geological Media: Exploding Reflection Revisited
Computation of Common Middle Point seismic sections and their subsequent time migration and diffraction imaging provides very important knowledge about the internal structure of 3D heterogeneous geological media and are key elements for successive geological interpretation. Full-scale numerical simulation, that computes all single shot seismograms, provides a full understanding of how the features of the image reflect the properties of the subsurface prototype. Unfortunately, this kind of simulations of 3D seismic surveys for realistic geological media needs huge computer resources, especially for simulation of seismic waves’ propagation through multiscale media like cavernous fractured reservoirs. Really, we need to combine smooth overburden with microstructure of reservoirs, which forces us to use locally refined grids. However, to resolve realistic statements with huge multi-shot/multi-offset acquisitions it is still not enough to provide reasonable needs of computing resources. Therefore, we propose to model 3D Common Middle Point seismic cubes directly, rather than shot-by-shot simulation with subsequent stacking. To do that we modify the well-known "exploding reflectors principle" for 3D heterogeneous multiscale media by use of the finite-difference technique on the base of grids locally refined in time and space. We develop scalable parallel software, which needs reasonable computational costs to simulate realistic models and acquisition. Numerical results for simulation of Common Middle Points sections and their time migration are presented and discussed