82 research outputs found
A new method to evaluate the completeness of case ascertainment by a cancer registry
- Author
- American Cancer Society
- Area Resource File (ARF)
- Barnali Das
- DN Midthune
- EL Lehmann
- Eric J. Feuer
- HL Howe
- HL Howe
- HL Howe
- J Swan
- JP Fulton
- Limin X. Clegg
- Linda W. Pickle
- LW Pickle
- LX Clegg
- PA Wingo
- SDJ Roffers
- TC Tucker
- TC Tucker
- United States Cancer Statistics Working Group
- United States Cancer Statistics Working Group
- United States Cancer Statistics Working Group
- Publication venue
- Springer Netherlands
- Publication date
- 01/01/2008
- Field of study
Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition
- Author
- A Alajati
- A Bonauer
- A Chamorro-Jorganes
- A Holmberg
- AE Guller
- AI Saeed
- C Doebele
- DC Pedroso
- DW Losordo
- DW Losordo
- EA Silva
- F Timmermans
- GD Yancopoulos
- GM Bishop
- GP Fadini
- H Bompais
- H Haider
- H Hutchings
- HP Gerber
- HY Hu
- J Maia
- KA O’Donnell
- KK Hirschi
- LJAC Hawinkels
- LW Clegg
- MR Riley
- MT Pickering
- N Ferrara
- N Singh
- NS Dawson
- R Catena
- R Menghini
- R Simon
- R Weissleder
- S Aday
- S Lee
- S Mattiussi
- SF Aldred
- SJ Lee
- SK Sanganalmath
- SM Anderson
- SM Anderson
- T Bruhl
- T Kirkegaard
- T Korff
- TE Robey
- TT Chen
- WW Franke
- YH Shen
- Z Raval
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Several cell-based therapies are under pre-clinical and clinical evaluation for the treatment of ischemic diseases. Poor survival and vascular engraftment rates of transplanted cells force them to work mainly via time-limited paracrine actions. Although several approaches, including the use of soluble vascular endothelial growth factor (sVEGF)-VEGF165, have been developed in the last 10 years to enhance cell survival, they showed limited efficacy. Here, we report a pro-survival approach based on VEGF-immobilized microparticles (VEGF-MPs). VEGF-MPs prolong VEGFR-2 and Akt phosphorylation in cord blood-derived late outgrowth endothelial progenitor cells (OEPCs). In vivo, OEPC aggregates containing VEGF-MPs show higher survival than those treated with sVEGF. Additionally, VEGF-MPs decrease miR-17 expression in OEPCs, thus increasing the expression of its target genes CDKN1A and ZNF652. The therapeutic effect of OEPCs is improved in vivo by inhibiting miR-17. Overall, our data show an experimental approach to improve therapeutic efficacy of proangiogenic cells for the treatment of ischemic diseases.Soluble vascular endothelial growth factor (VEGF) enhances vascular engraftment of transplanted cells but the efficacy is low. Here, the authors show that VEGF-immobilized microparticles prolong survival of endothelial progenitors in vitro and in vivo by downregulating miR17 and upregulating CDKN1A and ZNF652
Frailty still matters to health and survival in centenarians: the case of China
- Author
- A Clegg
- A Kulminski
- A Kulminski
- A Mitnitski
- A Oksuzyan
- AB Mitnitski
- AI Yashin
- AM Kulminski
- B Wang
- BJ Wilcox
- D Gu
- D Gu
- Danan Gu
- DB Hogan
- GE Bijwaard
- H Bergman
- I Janssen
- J Evert
- JE Morley
- JSK Kwan
- K Andersen-Ranberg
- K Bouillon
- K Rockwood
- K Rockwood
- K Rockwood
- K Rockwood
- LA Gavrilov
- LP Fried
- LW Poon
- MF Folstein
- N Duarte
- NT Duarte
- Qiushi Feng
- S Horiuchi
- S Karunananthan
- S Kim
- SE Hardy
- TI Missov
- United Nations Population Division
- WB Goggins
- Y Gondo
- Y Gondo
- Y Zeng
- Y Zeng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Drilling their own graves:How the European oil and gas supermajors avoid sustainability tensions through mythmaking
- Author
- A Ansar
- A Beelitz
- A Lindgreen
- A McWilliams
- A Strauss
- A Williams
- AD Brown
- AD Brown
- AD Brown
- AD Brown
- AG Scherer
- Aliette Lambert
- AT Hall
- B Beurden van
- B Beurden van
- B Beurden van
- B Beurden van
- B Czarniawska
- B Devall
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Dudley
- B Lovell
- B Townley
- BBF Wittneben
- C Argyris
- C Bottici
- C David
- C Hardy
- C Hardy
- C Margerie de
- C Sundaramurthy
- C Wright
- C Wright
- C Wright
- CA Byl Van der
- D Leonard-Barton
- D Levy
- D Levy
- D Levy
- D Levy
- DK Mumby
- DM Boje
- DM Boje
- DM Boje
- DM Boje
- E Cassirer
- E Vaara
- G Burrell
- G Fairhurst
- G Ferns
- G Palazzo
- GE Miller
- George Ferns
- H Mäkelä
- I Castelló
- I Filby
- I Palmer
- IE Berger
- International Oil Daily
- J Amernic
- J Amernic
- J Amernic
- J Browne
- J Browne
- J Browne
- J Browne
- J Browne
- J Browne
- J Browne
- J Dryzek
- J Elkington
- J Gao
- J Jay
- J Lovelock
- J Meyer
- J Schad
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- J Veer van der
- JD Margolis
- JJ Klerk De
- JK Benson
- Kenneth Amaeshi
- KM Eisenhardt
- L Putnam
- L Putnam
- LK Treviño
- LT Christensen
- LW Pondy
- M Chelli
- M Ganzin
- M Halderen van
- M Hulme
- M Humphreys
- M Peeters
- MC McGee
- ME Boyce
- ML Bowles
- MW Lewis
- N Beech
- N Fairclough
- N Klein
- N Phillips
- N Slawinski
- NM Brennan
- O Oliver
- OF Williams
- P Dey
- P Jarzabkowski
- P Jarzabkowski
- P Pouyanné
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Voser
- P Watts
- R Barthes
- R Craig
- R Durand
- R Garud
- R Hooghiemstra
- R Kinley
- R Quest
- R Suddaby
- R Vince
- S Böhm
- S Clegg
- S Clegg
- S Clegg
- S Du
- S Poole
- S Pulver
- S Tengblad
- SC Bhattacharyya
- T Farmer
- T Hahn
- T Hahn
- T Hahn
- T Hayward
- T Hayward
- T Hayward
- T Hayward
- T Hayward
- T Hayward
- T Hayward
- T Hayward
- T Reay
- TC Dandridge
- TM Devinney
- TN Gladwin
- U Gehmann
- U Idemudia
- V Leeuwen
- W Smith
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2017
- Field of study
This study explores how paradoxical tensions between economic growth and environmental protection are avoided through organizational mythmaking. By examining the European oil and gas supermajors’ ‘‘CEOspeak’’ about climate change, we show how mythmaking facilitates the disregarding, diverting, and/or displacing of sustainability tensions. In doing so, our findings further illustrate how certain defensive responses are employed: (1) regression, or retreating to the comforts of past familiarities, (2) fantasy, or escaping the harsh reality that fossil fuels and climate change are indeed irreconcilable, and (3) projecting, or shifting blame to external actors for failing to address climate change. By highlighting the discursive effects of enacting these responses, we illustrate how the European oil and gas supermajors self-determine their inability to substantively address the complexities of climate change. We thus argue that defensive responses are not merely a form of mismanagement as the paradox and corporate sustainability literature commonly suggests, but a strategic resource that poses serious ethical concerns given the imminent danger of issues such as climate change
Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function
- Author
- A Kamikawa
- A Maccio
- AM Rowzee
- AV Capuco
- B Cousin
- BA Howard
- BE Elliott
- BK Levay-Young
- BW Booth
- C Brisken
- C Couldrey
- C Ling
- CA Carrington
- CJ Watson
- CM Alexander
- CW Welsch
- CW Welsch
- DA Proia
- DL Kleinberg
- DT Ramsay
- E Pujol
- E Vandeweyer
- EJ Ehrhart
- ER Hugo
- FR Miller
- G Cheng
- G Mayer
- GE Kilroy
- GK Bandyopadhyay
- GK Bandyopadhyay
- GR Cunha
- HA Tucker
- HZ Zhang
- IN Soemarwoto
- JB Hansen
- JC Bartley
- JC Beck
- JD Chow
- JD Rink
- JE Celis
- JF Levine
- JF Trott
- JJ Elias
- JN Lilla
- JR Hens
- JS Russell
- JV Soriano
- K Hoshino
- K Hoshino
- K Sejrsen
- LG Sheffield
- LJ Faulkin Jr
- LN Bell
- Lucila Aimo
- LW Nelson
- M Freemark
- M Lejour
- M Matsumoto
- M Matsumoto
- M Matsumoto
- M Peaker
- M Peaker
- M Rebuffe-Scrive
- M Zinger
- MC Neville
- MJ Meyer
- MJ Meyer
- MJ Meyer
- MJ Miyamoto-Tiaven
- MM Richert
- MN Dieudonne
- N Rahimi
- OT Anastassiades
- P Wang
- PB Blair
- PD Walden
- R Anbazhagan
- R Anbazhagan
- RA Clegg
- RA Knazek
- RC Hovey
- RC Hovey
- RC Hovey
- RC Hovey
- RC Hovey
- RC Hovey
- RC Hovey
- RJ Santen
- RO Scow
- Russell C. Hovey
- S Bianchi
- S Cinti
- S Cinti
- S Ellis
- S Landskroner-Eiger
- S Perrier
- S Viengchareun
- SD Berry
- SL Sigurdson
- SO Mueller
- SP Oliver
- SR Master
- SR Thorn
- T Anzai
- T Bani-Sacchi
- T Sakakura
- TD Russell
- V Gouon-Evans
- W Tang
- Y Feuermann
- Y Lin
- YG Illouz
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
The mammary gland is unique in its requirement to develop in close association with a depot of adipose tissue that is commonly referred to as the mammary fat pad. As discussed throughout this issue, the mammary fat pad represents a complex stromal microenvironment that includes a variety of cell types. In this article we focus on adipocytes as local regulators of epithelial cell growth and their function during lactation. Several important considerations arise from such a discussion. There is a clear and close interrelationship between different stromal tissue types within the mammary fat pad and its adipocytes. Furthermore, these relationships are both stage- and species-dependent, although many questions remain unanswered regarding their roles in these different states. Several lines of evidence also suggest that adipocytes within the mammary fat pad may function differently from those in other fat depots. Finally, past and future technologies present a variety of opportunities to model these complexities in order to more precisely delineate the many potential functions of adipocytes within the mammary glands. A thorough understanding of the role for this cell type in the mammary glands could present numerous opportunities to modify both breast cancer risk and lactation performance
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
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- Espinoza F
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- Kordorwu HEK
- Korkolis D
- Kosai NR
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- Kose E
- Koskenvuo L
- Kostov E
- Kotb AHE-B
- Kotecha D
- Koto MZ
- Kotobi H
- Koumpa F
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- Lawani I
- Lawther R
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- Lecompte J-F
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- Mohamed M
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- Mohamed O
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- Mohammad A
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- Montrimaite M
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- Samaraweera DI
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
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- Soldevila-Verdeguer C
- Soley R
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- Soliman AR
- Soliman N
- Soliman NA
- Soliman S
- Soliman Y
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
A review of the biology of calcium phosphate sequestration with special reference to milk
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- A George
- A Gericke
- A Heiss
- AL Boskey
- B Christensen
- C Holt
- C Holt
- C Holt
- C Holt
- C Holt
- C Holt
- Carl Holt
- D Gebauer
- D Gebauer
- EM Little
- F Nudelman
- F Nudelman
- G Rice
- J Wald
- J Wald
- JCD White
- JL Meyer
- K Kawasaki
- K Kawasaki
- L Wang
- LW Fisher
- M Mazzali
- MJ Olszta
- MJ Olszta
- MR Christoffersen
- O Mekmene
- O Mekmene
- P Grøn
- PA Price
- RA Clegg
- RE Wuthier
- RLJ Lyster
- Samuel Lenton
- Susana C. M. Teixeira
- SV Dorozhkin
- T Aoki
- Tommy Nylander
- W Jahnen-Dechent
- W Jahnen-Dechent
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Chen Cy
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- de Leó
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- Dell A
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- Elkorashy Am
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- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
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- Farrugia A
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- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
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- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
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- La Brocca A
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- Labib P
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- Latif A
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- Laugzemys E
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- Laurie K
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- Law Jh
- Lawal A
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- Lawani I
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- Leal A
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- Lee C
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- Macfarlane A
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- Marks E
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- Mohamed F
- Mohamed I
- Mohamed M
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- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Monteleone M
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- Montes I
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- Montrimaite M
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- Moodley Y
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- Mostafa M
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- Mshelbwala P
- Msiska N
- Msosa V
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- Mukuzunga C
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- Napolitano L
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- Naranjo Aristizã
- Narayanan R
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- Negida A
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- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
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- Nevieraite V
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Notarnicola M
- Nouh T
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- Novak A
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- Nsengimana Vjp
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- Ntirenganya F
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- Nwinee V
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- Syibrah Kz
- Sykes M
- Szczap A
- Szeto Ccl
- Szeto Kj
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha Ems
- Tahboub H
- Taher Aa
- Taher M
- Taher Mm
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan Cl
- Tan Cy
- Tan Jj
- Tan Jk
- Tan Ksk
- Tan Rck
- Tan Yk
- Tan Yw
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani Si
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata Md
- Tatagiba Ls
- Tawfik Ba
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah Mm
- Tembo T
- Temoche E
- Tennakoon A
- Teo Sy
- Ter Ez
- Tessera G
- Teufelberger G
- Tew Yy
- Tew Yy
- Tewari S
- Th&apos
- Thabet W
- Thalgaspitiya Spb
- Tham Jc
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Ticona Wa
- Tierney G
- Tilston Tw
- Timothy Ok
- Ting Jrs
- To K
- To K
- Todd O
- Toeema Ag
- Tolba H
- Tolg C
- Tolonen M
- Tolotra Tec
- Tori Sa
- Torrance Hd
- Torrance Hd
- Torres Cpg
- Torres Sg
- Toto Ö
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola Sk
- Tugnoli G
- Tugnoli G
- Tun Ak
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze Rge
- Tze Rge
- Tzikos G
- Uš
- Ubhi Hk
- Ubiali P
- Ugalde P
- Ukwenya Y
- Uluş
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
- Urbonas T
- Urniež
- Urniezius Z
- Urquizu Mc
- Usaityte A
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldañ
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Vega Gmm
- Vega Gmm
- Velá
- Velá
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Alc
- Verjee A
- Vermaas M
- Veronese E
- Viš
- Vianna P
- Vicario E
- Vico Td
- Vida Lc
- Vida Lc
- Vilč
- Villa R
- Villalobos S
- Villegas Mi
- Vimalachandran D
- Vincent J
- Violi P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Vth Le
- Wael N
- Wagener M
- Wakefield R
- Walę
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward Ae
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick Am
- Waterman A
- Watson Nf
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein Ms
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini Ta
- Widmer Lw
- Wijayarathna Ls
- Wild Jrl
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson Ms
- Wilson Msj
- Wimalge Pmsn
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold Tb
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong Cs
- Wong Cy
- Wong F
- Wong Hy
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright Nj
- Xerri T
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- Yahaya Mt
- Yakubu M
- Yallop L
- Yam Sy
- Yang J
- Yap S
- Yaseen T
- Yaseen Tm
- Yau Jd
- Yavuz Ma
- Ye J
- Yeang Lj
- Yee J
- Yeo Ls
- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
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- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
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- Zilinskas J
- Zilinskas J
- Zilinskas J
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Expression of neurofilament L-promoter GFP reporter constructs in immortalized Schwann cell/neuron coculture
- Publication venue
- Publication date
- 01/01/1999
- Field of study
Control of expression from the neurofilament NF-468 promoter in clonally-derived schwann cells in contact with axons
- Publication venue
- Publication date
- 01/01/1998
- Field of study
- …