33 research outputs found
Phenomenology of the Lense-Thirring effect in the Solar System
Recent years have seen increasing efforts to directly measure some aspects of
the general relativistic gravitomagnetic interaction in several astronomical
scenarios in the solar system. After briefly overviewing the concept of
gravitomagnetism from a theoretical point of view, we review the performed or
proposed attempts to detect the Lense-Thirring effect affecting the orbital
motions of natural and artificial bodies in the gravitational fields of the
Sun, Earth, Mars and Jupiter. In particular, we will focus on the evaluation of
the impact of several sources of systematic uncertainties of dynamical origin
to realistically elucidate the present and future perspectives in directly
measuring such an elusive relativistic effect.Comment: LaTex, 51 pages, 14 figures, 22 tables. Invited review, to appear in
Astrophysics and Space Science (ApSS). Some uncited references in the text
now correctly quoted. One reference added. A footnote adde
An Assessment of the Systematic Uncertainty in Present and Future Tests of the Lense-Thirring Effect with Satellite Laser Ranging
We deal with the attempts to measure the Lense-Thirring effect with the
Satellite Laser Ranging (SLR) technique applied to the existing LAGEOS and
LAGEOS II terrestrial satellites and to the recently approved LARES
spacecraft.The first issue addressed here is: are the so far published
evaluations of the systematic uncertainty induced by the bad knowledge of the
even zonal harmonic coefficients J_L of the multipolar expansion of the Earth's
geopotential reliable and realistic?
Our answer is negative. Indeed, if the differences Delta J_L among the even
zonals estimated in different Earth's gravity field global solutions from the
dedicated GRACE mission are assumed for the uncertainties delta J_L instead of
using their covariance sigmas sigma_JL, it turns out that the systematic
uncertainty \delta\mu in the Lense-Thirring test with the nodes Omega of LAGEOS
and LAGEOS II may be up to 3 to 4 times larger than in the evaluations so far
published () based on the use of the sigmas of one model at a time
separately. The second issue consists of the possibility of using a different
approach in extracting the relativistic signature of interest from the
LAGEOS-type data. The third issue is the possibility of reaching a realistic
total accuracy of 1% with LAGEOS, LAGEOS II and LARES, which should be launched
in November 2009 with a VEGA rocket. While LAGEOS and LAGEOS II fly at
altitudes of about 6000 km, LARES will be likely placed at an altitude of 1450
km. Thus, it will be sensitive to much more even zonals than LAGEOS and LAGEOS
II. Their corrupting impact has been evaluated with the standard Kaula's
approach up to degree L=60 by using Delta J_L and sigma_JL; it turns out that
it may be as large as some tens percent.Comment: LaTex, 19 pages, 1 figure, 12 tables. Invited and refereed
contribution to The ISSI Workshop, 6-10 October 2008, on The Nature of
Gravity Confronting Theory and Experiment in Space To appear in Space Science
Review
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Associations of autozygosity with a broad range of human phenotypes
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding