Internet e-ethics in confrontation with an activists' agenda: Yahoo! on trial

A prolonged confrontation between Yahoo! Inc. and French anti-racism activists who ask for the removal of Nazi items from auction sites as well as restricted access to neo-Nazis sites is analyzed. We present the case and its development up to the decision of Yahoo! Inc. to remove the items from yahoo.com following a French court’s verdict against the firm. Using a business ethics approach, we distinguish the legal, technical, philosophical and managerial issues involved in the case and their management by Yahoo! We conclude on the difficulty of governing relations with society from corporate and legal affairs departments at the headquarters level, and on the clash of two visions over the regulation of social freedom.E-business, e-ethics, auctions, legal compliance, internet regulation, freedom of expression, media crisis

Patient-reported outcomes measures and patient preferences for minimally invasive glaucoma surgical devices.

BackgroundMany therapeutic options are available to glaucoma patients. One recent therapeutic option is minimally invasive glaucoma surgical (MIGS) devices. It is unclear how patients view different treatments and which patient-reported outcomes would be most relevant in patients with mild to moderate glaucoma. We developed a questionnaire for patients eligible for MIGS devices and a patient preference study to examine the value patients place on certain outcomes associated with glaucoma and its therapies.ObjectivesTo summarize the progress to date.MethodsQuestionnaire development: We drafted the questionnaire items based on input from one physician and four patient focus groups, and a review of the literature. We tested item clarity with six cognitive interviews. These items were further refined. Patient preference study: We identified important benefit and risk outcomes qualitatively using semi-structured, one-on-one interviews with patients who were eligible for MIGS devices. We then prioritized these outcomes quantitatively using best-worst scaling methods.ResultsQuestionnaire testing: Three concepts were deemed relevant for the questionnaire: functional limitations, symptoms, and psychosocial factors. We will evaluate the reliability and validity of the 52-item draft questionnaire in an upcoming field test. Patient preference study: We identified 13 outcomes that participants perceived as important. Outcomes with the largest relative importance weights were "adequate IOP control" and "drive a car during the day."ConclusionsPatients have the potential to steer clinical research towards outcomes that are important to them. Incorporating patients' perspectives into the MIGS device development and evaluation process may expedite innovation and availability of these devices

Low-Temperature Series for the Correlation Length in d=3d=3 Ising Model

We extend low-temperature series for the second moment of the correlation function in $d=3$ simple-cubic Ising model from $u^{15}$ to $u^{26}$ using finite-lattice method, and combining with the series for the susceptibility we obtain the low-temperature series for the second-moment correlation length to $u^{23}$. An analysis of the obtained series by inhomogeneous differential approximants gives critical exponents $2\nu^{\prime} + \gamma^{\prime} \approx 2.55$ and $2\nu^{\prime} \approx 1.27$.Comment: 13 pages + 5 uuencoded epsf figures in Latex, OPCT-94-

Extension to order β23\beta^{23} of the high-temperature expansions for the spin-1/2 Ising model on the simple-cubic and the body-centered-cubic lattices

Using a renormalized linked-cluster-expansion method, we have extended to order $\beta^{23}$ the high-temperature series for the susceptibility $\chi$ and the second-moment correlation length $\xi$ of the spin-1/2 Ising models on the sc and the bcc lattices. A study of these expansions yields updated direct estimates of universal parameters, such as exponents and amplitude ratios, which characterize the critical behavior of $\chi$ and $\xi$. Our best estimates for the inverse critical temperatures are $\beta^{sc}_c=0.221654(1)$ and $\beta^{bcc}_c=0.1573725(6)$. For the susceptibility exponent we get $\gamma=1.2375(6)$ and for the correlation length exponent we get $\nu=0.6302(4)$. The ratio of the critical amplitudes of $\chi$ above and below the critical temperature is estimated to be $C_+/C_-=4.762(8)$. The analogous ratio for $\xi$ is estimated to be $f_+/f_-=1.963(8)$. For the correction-to-scaling amplitude ratio we obtain $a^+_{\xi}/a^+_{\chi}=0.87(6)$.Comment: Misprints corrected, 8 pages, latex, no figure

Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep

The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms of approximately 33 and 26 kDa, corresponding to the biglycosylated and unglycosylated isoforms of brain PrPC. Neither the mean concentration nor the electrophoretic profile of CSF PrP differed between healthy and scrapieaffected sheep, whereas a slightly increased resistance of CSF PrP to mild proteolysis by proteinase K was evident in the CSF of scrapie-affected sheep. No difference in susceptibility to proteolysis was observed between the two ARR and VRQ genetic variants of the purified prokaryote recombinant PrP. It was concluded that the physicochemical properties of PrPC in the CSF could be altered during scrapie and that these changes might reflect the physiopathological process of prion disease

ISM Properties in Low-Metallicity Environments II. The Dust Spectral Energy Distribution of NGC 1569

We present new 450 and 850 microns SCUBA data of the dwarf galaxy NGC 1569. We construct the mid-infrared to millimeter SED of NGC 1569, using ISOCAM, ISOPHOT, IRAS, KAO, SCUBA and MAMBO data, and model the SED in order to explore the nature of the dust in low metallicity environments. The detailed modeling is performed in a self-consistent way, synthesizing the global ISRF of the galaxy using an evolutionary synthesis model with further constraints provided by the observed MIR ionic lines and a photoionisation model. Our results show that the dust properties are different in this low metallicity galaxy compared to other more metal rich galaxies. The results indicate a paucity of PAHs probably due to the destructive effects of the ISRF penetrating a clumpy environment and a size-segregation of grains where the emission is dominated by small grains of size ~3 nm, consistent with the idea of shocks having a dramatic effect on the dust properties in NGC 1569. A significant millimetre excess is present in the dust SED which can be explained by the presence of ubiquitous very cold dust (T = 5-7 K). This dust component accounts for 40 to 70 % of the total dust mass in the galaxy (1.6 - 3.4 10^5 Msol) and could be distributed in small clumps (size a few pc) throughout the galaxy. We find a gas-to-dust mass ratio of 740 - 1600, larger than that of the Galaxy and a dust-to-metals ratio of 1/4 to 1/7. We generate an extinction curve for NGC 1569, consistent with the modeled dust size distribution. This extinction curve has relatively steep FUV rise and smaller 2175 Angstroms bump, resembling the observed extinction curve of some regions in the Large Magellanic Cloud.Comment: 20 pages, 20 figures, accepted by A&

Electronic excited state of protonated aromatic molecules: protonated Fluorene

The photo-fragmentation spectrum of protonated fluorene has been recorded in the visible spectral region, largely red shifted as compared to the first excited state absorption of neutral fluorene. The spectrum shows two different vibrational progressions, separated by 0.19 eV that are assigned to the absorption of two isomers. As in protonated linear PAHs, comparison with ab-initio calculations indicates that the red shift is due to the charge transfer character of the excited state

The Physical Properties of the Red Supergiant WOH G64: The Largest Star Known?

WOH G64 is an unusual red supergiant (RSG) in the Large Magellanic Cloud (LMC), with a number of properties that set it apart from the rest of the LMC RSG population, including a thick circumstellar dust torus, an unusually late spectral type, maser activity, and nebular emission lines. Its reported physical properties are also extreme, including the largest radius for any star known and an effective temperature that is much cooler than other RSGs in the LMC, both of which are at variance with stellar evolutionary theory. We fit moderate-resolution optical spectrophotometry of WOH G64 with the MARCS stellar atmosphere models, determining an effective temperature of 3400 +/- 25 K. We obtain a similar result from the star's broadband V - K colors. With this effective temperature, and taking into account the flux contribution from the aysmmetric circumstellar dust envelope, we calculate log(L/L_sun) = 5.45 +/- 0.05 for WOH G64, quite similar to the luminosity reported by Ohnaka and collaborators based on their radiative transfer modeling of the star's dust torus. We determine a radius of R/R_sun = 1540, bringing the size of WOH G64 and its position on the H-R diagram into agreement with the largest known Galactic RSGs, although it is still extreme for the LMC. In addition, we use the Ca II triplet absorption feature to determine a radial velocity of 294 +/- 2 km/s for the star; this is the same radial velocity as the rotating gas in the LMC's disk, which confirms its membership in the LMC and precludes it from being an unusual Galactic halo giant. Finally, we describe the star's unusual nebula emission spectrum; the gas is nitrogen-rich and shock-heated, and displays a radial velocity that is significantly more positive than the star itself by 50 km/s.Comment: 25 pages, 5 figures; accepted for publication in The Astronomical Journa