Using pi_2(1670) -> b_1(1235) pi to Constrain Hadronic Models

We show that current analyses of experimental data indicate that the strong decay mode pi_2 -> b_1 pi is anomalously small. Non-relativistic quark models with spin-1 quark pair creation, such as ^3P_0, ^3S_1 and ^3D_1 models, as well as instanton and lowest order one-boson (in this case pi) emission models, can accommodate the analyses of experimental data, because of a quark-spin selection rule. Models and effects that violate this selection rule, such as higher order one-boson emission models, as well as mixing with other Fock states, may be constrained by the small pi_2 -> b_1 pi decay. This can provide a viability check on newly proposed decay mechanisms. We show that for mesons made up of a heavy quark and anti-quark, the selection rule is exact to all orders of Quantum Chromodynamics (QCD) perturbation theory.Comment: 11 pages, LaTeX, 3 encapsulated Postscript figures, small change

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase family, play a key role as gluconeogenic suppressors downstream of LKB1 in the liver. The selective SIK inhibitor HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes, an effect that is abolished when an HG-9-91-01-insensitive mutant SIK is introduced or LKB1 is ablated. Although SIK2 was proposed as a key regulator of insulin-mediated suppression of gluconeogenesis, we provide genetic evidence that liver-specific ablation of SIK2 alone has no effect on gluconeogenesis and insulin does not modulate SIK2 phosphorylation or activity. Collectively, we demonstrate that the LKB1-SIK pathway functions as a key gluconeogenic gatekeeper in the liver

The Point-Agape survey: 4 high signal-to-noise ratio microlensing candidates detected towards M31

We have carried out a survey of the Andromeda galaxy for unresolved microlensing (pixel lensing). We present a subset of four short timescale, high signal-to-noise microlensing candidates found by imposing severe selection criteria: the source flux variation exceeds the flux of an R=21 magnitude star and the full width at half maximum timescale is less than 25 days. Remarkably, in three out of four cases, we have been able to measure or strongly constrain the Einstein crossing time of the event. One event, which lies projected on the M31 bulge, is almost certainly due to a stellar lens in the bulge of M31. The other three candidates can be explained either by stars in M31 and M32 or by MACHOs

Systems-thinking approach to identify and assess feasibility of potential interventions to reduce antibiotic use in tilapia farming in Egypt

Antibiotics are used in aquaculture to maintain the health and welfare of stocks; however, the emergence and selection of antibiotic resistance in bacteria poses threats to humans, animals and the environment. Mitigation of antibiotic resistance relies on understanding the flow of antibiotics, residues, resistant bacteria and resistance genes through interconnecting systems, so that potential solutions can be identified and issues around their implementation evaluated. Participatory systems-thinking can capture the deep complexity of a system while integrating stakeholder perspectives. In this present study, such an approach was applied to Nile tilapia (Oreochromis niloticus) production in the Nile Delta of Egypt, where disease events caused by antibiotic-resistant pathogens have been reported. A system map was co-produced with aquaculture stakeholders at a workshop in May 2018 and used to identify hotspots of antibiotic use, exposure and fate and to describe approaches that would promote fish health and thus reduce antibiotic use. Antibiotics are introduced into the aquaculture system via direct application for example in medicated feed, but residues may also be introduced into the system through agricultural drainage water, which is the primary source of water for most fish farms in Egypt. A follow-up survey of stakeholders assessed the perceived feasibility, advantages and disadvantages of potential interventions. Interventions that respondents felt could be implemented in the short-term to reduce antibiotic usage effectively included: more frequent water exchanges, regular monitoring of culture water quality parameters, improved storage conditions for feed, use of probiotics and greater access to farmer and service providers training programmes. Other potential interventions included greater access to suitable and rapid diagnostics, high quality feeds, improved biosecurity measures and genetically-improved fish, but these solutions were expected to be achieved as long-term goals, with cost being of one of the noted barriers to implementation. Identifying feasible and sustainable interventions that can be taken to reduce antibiotic use, and understanding implementation barriers, are important for addressing antibiotic resistance and ensuring the continued efficacy of antibiotics. This is vital to ensuring the productivity of the tilapia sector in Egypt. The approach taken in the present study provides a means to identify points in the system where the effectiveness of interventions can be evaluated and thus it may be applied to other food production systems to combat the problem of antibiotic resistance

A Candidate M31/M32 Intergalactic Microlensing Event

We report the discovery of a microlensing candidate projected 2'54" from the center of M32, on the side closest to M31. The blue color (R-I= 0.00 +/- 0.14) of the source argues strongly that it lies in the disk of M31, while the proximity of the line of sight to M32 implies that this galaxy is the most likely host of the lens. If this interpretation is correct, it would confirm previous arguments that M32 lies in front of M31. We estimate that of order one such event or less should be present in the POINT-AGAPE data base. If more events are discovered in this direction in a dedicated experiment, they could be used to measure the mass function of M32 up to an unknown scale factor. By combining microlensing observations of a binary-lens event with a measurement of the M31-M32 relative proper motion using the astrometric satellites SIM or GAIA, it will be possible to measure the physical separation of M31 and M32, the last of the six phase-space coordinates needed to assign M32 an orbit.Comment: Submitted to ApJ Letters. 13 pages, 2 figure

A Short Timescale Candidate Microlensing Event in the POINT-AGAPE Pixel Lensing Survey of M31

We report the discovery of a short-duration microlensing candidate in the northern field of the POINT-AGAPE pixel lensing survey towards M31. The full-width half-maximum timescale is very short, just 1.8 days. Almost certainly, the source star has been identified on Hubble Space Telescope archival images, allowing us to infer an Einstein crossing time of 10.4 days, a maximum magnification of about 18, and a lens-source proper motion greater than 0.3 microarcsec/day. The event lies projected at 8' from the center of M31, which is beyond the bulk of the stellar lens population. The lens is likely to reside in one of three locations. It may be a star in the M31 disk, or a massive compact halo object (Macho) in either M31 or the Milky Way. The most probable mass is 0.06 solar masses for an M31 Macho, 0.02 solar masses for a Milky Way Macho and 0.2 solar masses for an M31 stellar lens. Whilst the stellar interpretation is plausible, the Macho interpretation is the most probable for halo fractions above 20%.Comment: 20 pages, 4 figures, submitted to The Astrophysical Journal (Letters

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

Realistic simulations of gravitational lensing by galaxy clusters: extracting arc parameters from mock DUNE images

We present a newly developed code that allows simulations of optical observations of galaxy fields with a variety of instruments. The code incorporates gravitational lensing effects and is targetted at simulating lensing by galaxy clusters. Our goal is to create the tools required for comparing theoretical expectations with observations to obtain a better understanding of how observational noise affects lensing applications such as mass estimates, studies on the internal properties of galaxy clusters and arc statistics. Starting from a set of input parameters, characterizing both the instruments and the observational conditions, the simulator provides a virtual observation of a patch of the sky. It includes several sources of noise such as photon-noise, sky background, seeing, and instrumental noise. Ray-tracing through simulated mass distributions accounts for gravitational lensing. Source morphologies are realistically simulated based on shapelet decompositions of galaxy images retrieved from the GOODS-ACS archive. According to their morphological class, spectral-energy-distributions are assigned to the source galaxies in order to reproduce observations of each galaxy in arbitrary photometric bands. We illustrate our techniques showing virtual observations of a galaxy-cluster core as it would be observed with the space telescope DUNE, which was recently proposed to ESA within its "Cosmic vision" programme. (Abridged)Comment: 17 pages, 15 figures submitted to A&