Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus

Sirolimus, a potent inhibitor of B- and T-cell activation, is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus

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Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus

Sirolimus, a potent inhibitor of B- and T-cell activation. is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus

LoCuSS: The mid-infrared Butcher-Oemler effect

We study the mid-infrared (MIR) properties of galaxies in 30 massive galaxy clusters at 0.02<z<0.40, using panoramic Spitzer/MIPS 24micron and NIR data. This is the largest sample of clusters to date with MIR data covering not only the cluster cores, but extending into the infall regions. We revisit the Butcher-Oemler effect, measuring the fraction of massive infrared-luminous galaxies (K5x10^10L_sun) within r_200, finding a steady increase in the fraction with redshift from ~3% at z=0.02 to ~10% by z=0.30, and an rms cluster-to-cluster scatter about this trend of 0.03. The best-fit redshift evolution model is of the form f_SF ~ (1+z)^5.7, which is stronger redshift evolution than that of L*_IR in both clusters and the field. We find that, statistically, this excess is associated with galaxies found at large cluster-centric radii, implying that the MIR Butcher-Oemler effect can be explained by a combination of both the global decline in star-formation in the universe since z~1 and enhanced star formation in the infall regions of clusters at intermediate redshifts. This picture is supported by a simple infall model based on the Millennium Simulation semi-analytic galaxy catalogs, whereby star-formation in infalling galaxies is instantaneously quenched upon their first passage through the cluster, in that the observed radial trends of f_SF trace those inferred from the simulations. We also find that f_SF does not depend on simple indicators of the dynamical state of clusters, including the offset between the brightest cluster galaxy and the peak of the X-ray emission. This is consistent with the picture described above in that most new star-formation in clusters occurs in the infall regions, and is thus not sensitive to the details of cluster-cluster mergers in the core regions.Comment: 11 pages, 7 figures, accepted for publication in Ap

Analyzing Somatic DNA Repair in Arabidopsis Meiotic Mutants

Meiotic and somatic recombination share a common set of factors. Thus, the analysis of somatic DNA repair in meiotic mutant lines should be of special interest. Growth defects of mutant plants induced by specific genotoxins can thereby hint to DNA repair functions of the affected proteins. Here, we describe two kinds of approaches to characterize deficiencies in DNA repair in mutant lines of Arabidopsis thaliana, after genotoxin treatment

Ultrasonication effects on thermal and rheological properties of carbon nanotube suspensions

The preparation of nanofluids is very important to their thermophysical properties. Nanofluids with the same nanoparticles and base fluids can behave differently due to different nanofluid preparation methods. The agglomerate sizes in nanofluids can significantly impact the thermal conductivity and viscosity of nanofluids and lead to a different heat transfer performance. Ultrasonication is a common way to break up agglomerates and promote dispersion of nanoparticles into base fluids. However, research reports of sonication effects on nanofluid properties are limited in the open literature. In this work, sonication effects on thermal conductivity and viscosity of carbon nanotubes (0.5 wt%) in an ethylene glycol-based nanofluid are investigated. The corresponding effects on the agglomerate sizes and the carbon nanotube lengths are observed. It is found that with an increased sonication time/energy, the thermal conductivity of the nanofluids increases nonlinearly, with the maximum enhancement of 23% at sonication time of 1,355 min. However, the viscosity of nanofluids increases to the maximum at sonication time of 40 min, then decreases, finally approaching the viscosity of the pure base fluid at a sonication time of 1,355 min. It is also observed that the sonication process not only reduces the agglomerate sizes but also decreases the length of carbon nanotubes. Over the current experimental range, the reduction in agglomerate size is more significant than the reduction of the carbon nanotube length. Hence, the maximum thermal conductivity enhancement and minimum viscosity increase are obtained using a lengthy sonication, which may have implications on application

Transit Timing and Duration Variations for the Discovery and Characterization of Exoplanets

Transiting exoplanets in multi-planet systems have non-Keplerian orbits which can cause the times and durations of transits to vary. The theory and observations of transit timing variations (TTV) and transit duration variations (TDV) are reviewed. Since the last review, the Kepler spacecraft has detected several hundred perturbed planets. In a few cases, these data have been used to discover additional planets, similar to the historical discovery of Neptune in our own Solar System. However, the more impactful aspect of TTV and TDV studies has been characterization of planetary systems in which multiple planets transit. After addressing the equations of motion and parameter scalings, the main dynamical mechanisms for TTV and TDV are described, with citations to the observational literature for real examples. We describe parameter constraints, particularly the origin of the mass/eccentricity degeneracy and how it is overcome by the high-frequency component of the signal. On the observational side, derivation of timing precision and introduction to the timing diagram are given. Science results are reviewed, with an emphasis on mass measurements of transiting sub-Neptunes and super-Earths, from which bulk compositions may be inferred.Comment: Revised version. Invited review submitted to 'Handbook of Exoplanets,' Exoplanet Discovery Methods section, Springer Reference Works, Juan Antonio Belmonte and Hans Deeg, Eds. TeX and figures may be found at https://github.com/ericagol/TTV_revie

A critical review of the use of 3-D printing in the construction industry

3-D printing, which is an automated production process with layer-by-layer control, has been gaining rapid development in recent years. The technology has been adopted in the manufacturing industry for decades and has recently been introduced in the construction industry to print houses and villas. The technology can bring significant benefits to the construction industry in terms of increased customization, reduced construction time, reduced manpower, and construction cost. A few isolated products and projects have been preliminarily tested using the 3-D printing technology. However, it should be noted that such tests and developments on the use of 3-D printing in the construction industry are very fragmented at the time of the study. It is therefore necessary for the building and construction industry to understand the technology, its historical applications and challenges for better utilization in the future. A systematic review shows that 3-D printing technology, after years of evolution, can be used to print large-scale architectural models and buildings. However, the potential of the technology is limited by the lack of large-scale implementation, the development of building information modeling, the requirements of mass customization, and the life cycle cost of the printed projects. It is therefore expected that future studies should be conducted on these areas to consolidate the stability and expand the applicability of 3-D printing in the construction industry

Beta-Catenin Signaling Plays a Disparate Role in Different Phases of Fracture Repair: Implications for Therapy to Improve Bone Healing

In a study in mice Benjamin Alman and colleagues show that β-catenin functions differently in different stages of fracture repair; moreover, activation of β-catenin by lithium improves fracture healing when used in later phases of repair