Risk Factors for Speech-Language Pathologies in Children

Risk factors are understood to encompass “aspects of individual behavior or lifestyle, environmental exposure, hereditary or congenital characteristics that are associated with a health related condition”. These are conditions that increase the chances of the child presenting speech-language disorders and that can be avoided, controlled, or treated. Risk is defined as the chance of a child exposed to certain factors (environmental or biological) to acquire or develop speech-language disorders. The objectives of the present study were: to identify the risk factors for speech-language disorders in children up to five years of age and to verify the relationship between risk factors and speech-language diagnostic hypotheses. The aspects of being male gender, prematurity, shyness, being an only child or youngest child, presenting deleterious oral habits, having a family history of speech-language disorders, and use of licit or illicit drugs during pregnancy seem to be the factors that should draw the attention of the health professionals in child development. Therefore, the monitoring of children who have these risk factors should be performed in order to promote the necessary stimulation and the construction of healthy environments

The hard X-ray view of bright infrared galaxies

Aims. The synthesis of the cosmic X-ray background (CXB) requires a large population of Compton-thick active galactic nuclei that have not been detected so far. We probe whether bright infrared galaxies could harbor a population of Compton-thick nuclei and if they could contribute significantly. Methods. We analyzed 112 Msec of INTEGRAL observations obtained on 613 galaxies from the IRAS Revised Bright Galaxy Sample. We derived the average hard X-ray (18-80 keV) emission of Seyfert and various non Seyfert galaxy subsamples to estimate their relative contribution to the locally emitted CXB. Results. The Seyfert 1 & 2 are detected at hard X-rays. None of the other galaxy subsamples were detected. ULIRGs are at least 5 times under-luminous at hard X-rays when compared to Seyferts. The upper limit obtained for the average non Seyfert galaxies is as low as 7E-13 erg/s cm2. On average, these galaxies do not contain active nuclei brighter than 10E41 erg/s at hard X-rays. The total hard X-ray flux detected from the sample is 4.9E-9 erg/s cm2 (about 1% of the CXB), and 64% of this originates in absorbed active nuclei. Local non-Seyfert galaxies contribute for less than 7% and do not harbor the Compton-thick nuclei assumed to synthesize the locally emitted CXB.Comment: 6 pages, accepted for publication in Astronomy & Astropohysic

Suzaku and SWIFT-BAT observations of a newly discovered Compton-thick AGN

Obscured AGN are fundamental to understand the history of Super Massive Black Hole growth and their influence on galaxy formation. However, the Compton-thick AGN (NH>1e24 cm^-2) population is basically unconstrained, with less than few dozen confirmed Compton-thick AGN found and studied so far. A way to select heavily obscured AGN is to compare the X-ray emission below 10 keV (which is strongly depressed) with the emission from other bands less affected by the absorption, i.e. the IR band. To this end, we have cross-correlated the 2XMM catalogue with the IRAS Point Source catalogue and, by using the X-ray to infrared flux ratio and X-ray colors, we selected a well defined sample of Compton-thick AGN candidates at z<0.1. The aim of this work is to confirm the nature and to study one of these local Compton-thick AGN candidates, the nearby (z=0.029) Seyfert 2 galaxy IRAS 04507+0358, by constraining the amount of intrinsic absorption (NH) and thus the intrinsic luminosity. To this end we obtained deep (100 ks) Suzaku observations (AO4 call) and performed a joint fit with SWIFT-BAT data. We analyzed XMM-Newton, Suzaku and SWIFT-BAT data and we present here the results of this broad-band (0.4-100 keV) spectral analysis. We found that the broad-band X-ray emission of IRAS 04507+0358 requires a large amount of absorption (larger than 1e24 cm^-2) to be well reproduced, thus confirming the Compton-thick nature of this source. In particular, the most probable scenario is that of a mildly (NH (1.3-1.5)x1e24 cm^-2, L(2-10 keV) (5-7)x1e43 erg s^-1) Compton-thick AGN.Comment: Accepted for publication in A&A; 8 pages, 7 figure

The XMM deep survey in the CDF-S II. a 9-20 keV selection of heavily obscured active galaxies at z>1.7

We present results on a search of heavily obscured active galaxies z>1.7 using the rest-frame 9-20 keV excess for X-ray sources detected in the deep XMM-CDFS survey. Out of 176 sources selected with the conservative detection criteria (>8 sigma) in the first source catalogue of Ranalli et al., 46 objects lie in the redshift range of interest with the median redshift z~2.5. Their typical rest-frame 10-20 keV luminosity is 1e+44 erg/s, as observed. Among optically faint objects that lack spectroscopic redshift, four were found to be strongly absorbed X-ray sources, and the enhanced Fe K emission or absorption features in their X-ray spectra were used to obtain X-ray spectroscopic redshifts. Using the X-ray colour-colour diagram based on the rest-frame 3-5 keV, 5-9 keV, and 9-20 keV bands, seven objects were selected for their 9-20 keV excess and were found to be strongly absorbed X-ray sources with column density of nH > 0.6e+24 cm-2, including two possible Compton thick sources. While they are emitting at quasar luminosity, ~3/4 of the sample objects are found to be absorbed by nH > 1e+22 cm-2. A comparison with local AGN at the matched luminosity suggests an increasing trend of the absorbed source fraction for high-luminosity AGN towards high redshifts.Comment: 9 pages, 7 figures. Accepted for publication in A&

The HELLAS2XMM survey. VII. The hard X-ray luminosity function of AGN up to z=4: more absorbed AGN at low luminosities and high redshifts

We have determined the cosmological evolution of the density of AGN and of their Nh distribution as a function of the un-absorbed 2-10 keV luminosity up to redshift 4. We used the HELLAS2XMM sample combined with other published catalogs, yielding a total of 508 AGN. Our best fit is obtained with a luminosity-dependent density evolution (LDDE) model where low luminosity (Lx~10^43 erg s^-1) AGN peak at z~0.7, while high luminosity AGN (Lx>10^45 erg s^-1) peak at z~2.0. A pure luminosity evolution model (PLE) can instead be rejected. There is evidence that the fraction of absorbed (Nh>10^22 cm^-2) AGN decreases with the intrinsic X-ray luminosity, and increases with the redshift. Our best fit solution provides a good fit to the observed counts, the cosmic X-ray background, and to the observed fraction of absorbed AGN as a function of the flux in the 10^-15<S(2-10)<10^-10 erg s^-1 cm^-2 range. We find that the absorbed, high luminosity (Lx>10^44 erg s^-1) AGN have a density of 267 deg^-2 at fluxes S(2-10)>10^-15 erg s^-1 cm^-2. Using these results, we estimate a density of supermassive black holes in the local Universe of 3.2 (h^2_70) x 10^5 M_sol Mpc^-3, which is consistent with the recent measurements of the black hole mass function in the local galaxies.Comment: 16 pages, 20 figures. Scheduled on ApJ, Vol. 635, 2005 December 2

The INTEGRAL/IBIS AGN catalogue I: X-ray absorption properties versus optical classification

In this work we present the most comprehensive INTEGRAL AGN sample which lists 272 objects. Here we mainly use this sample to study the absorption properties of active galaxies, to probe new AGN classes and to test the AGN unification scheme. We find that half (48%) of the sample is absorbed while the fraction of Compton thick AGN is small (~7%). In line with our previous analysis, we have however shown that when the bias towards heavily absorbed objects which are lost if weak and at large distance is removed, as it is possible in the local Universe, the above fractions increase to become 80% and 17%. We also find that absorption is a function of source luminosity, which implies some evolution in the obscuration properties of AGN. Few peculiar classes, so far poorly studied in the hard X-ray band, have been detected and studied for the first time such as 5 XBONG, 5 type 2 QSOs and 11 LINERs. In terms of optical classification, our sample contains 57% of type 1 and 43% of type 2 AGN; this subdivision is similar to that found in X-rays if unabsorbed versus absorbed objects are considered, suggesting that the match between optical and X-ray classification is overall good. Only a small percentage of sources (12%) does not fulfill the expectation of the unified theory as we find 22 type 1 AGN which are absorbed and 10 type 2 AGN which are unabsorbed. Studying in depth these outliers we found that most of the absorbed type 1 AGN have X-ray spectra characterized by either complex or warm/ionized absorption more likely due to ionized gas located in an accretion disk wind or in the biconical structure associated to the central nucleus, therefore unrelated to the toroidal structure. Among 10 type 2 AGN which resulted to be unabsorbed, at most 3-4% is still eligible to be classified as a "true" type 2 AGN.Comment: 21 pages, 6 figures, 5 tables. Accepted for publication on MNRAS. arXiv admin note: text overlap with arXiv:0709.2077 by other author

XMM-Newton observations of Seyfert galaxies from the Palomar spectroscopic survey: the X-ray absorption distribution

We present XMM-Newton spectral analysis of all 38 Seyfert galaxies from the Palomar spectroscopic sample of galaxies. These are found at distances of up to 67 Mpc and cover the absorbed 2-10 keV luminosity range ~10^38-10^43 ergs/s. Our aim is to determine the distribution of the X-ray absorption in the local Universe. Three of these are Compton-thick with column densities just above 10^24 cm^-2 and high equivalent width FeKa lines (>700 eV). Five more sources have low values of the X-ray to [OIII] flux ratio suggesting that they could be associated with obscured nuclei. Their individual spectra show neither high absorbing columns nor flat spectral indices. However, their stacked spectrum reveals an absorbing column density of N_H~10^23 cm^-2. Therefore the fraction of absorbed sources (>10^22 cm^-2 could be as high as 55+/-12%. A number of Seyfert-2 appear to host unabsorbed nuclei. These are associated with low-luminosity sources Lx < 3x10^41 ergs/s. Their stacked spectrum again shows no absorption while inspection of the \chandra images, where available, shows that contamination from nearby sources does not affect the {\it XMM-Newton} spectra in most cases. Nevertheless, such low luminosity sources are not contributing significantly to the X-ray background flux. When we consider only the brighter, $>10^{41}$ \lunits, 21 sources, we find that the fraction of absorbed nuclei rises to $75\pm19$ % while that of Compton-thick sources to 15-20%. The fraction of Compton-thick AGN is lower than that predicted by the X-ray background synthesis model in the same luminosity and redshift range.}Comment: 17 pages, to appear in A&

Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome

Somatostatin (SS) and dopamine (DA) receptors are widely expressed in neuroendocrine tumours that cause Cushing's Syndrome (CS). Increasing knowledge of specific subtype expression within these tumours and the ability to target these receptor subtypes with high-affinity compounds, has driven the search for new SS- or DA-based medical therapies for the various forms of CS. In Cushing's disease, corticotroph adenomas mainly express dopamine receptor subtype 2 (D2) and somatostatin receptor subtype 5 (sst5), whereas sst2is expressed at lower levels. Activation of these receptors can inhibit ACTH-release in primary cultured corticotroph adenomas and compounds that target either sst5(pasireotide, or SOM230) or D2(cabergoline) have shown significant efficacy in subsets of patients in recent clinical studies. Combination therapy, either by administration of both types of compounds separately or by treatment with novel somatostatin-dopamine chimeric molecules (e.g. BIM-23A760), appears to be a promising approach in this respect. In selected cases of Ectopic ACTH-producing Syndrome (EAS), the sst2-preferring compound octreotide is able to reduce cortisol levels effectively. A recent study showed that D2receptors are also significantly expressed in the majority of EAS and that cabergoline may decrease cortisol levels in subsets of these patients. In both normal adrenal tissue as well as in adrenal adenomas and carcinomas that cause CS, sst and DA receptor expression has been demonstrated. Although selected cases of adrenal CS may benefit from sst or DA-targeted treatment, its total contribution to the treatment of these patients is likely to be low as surgery is effective in most cases