Revising working models across time: Relationship situations that enhance attachment security

We propose the Attachment Security Enhancement Model (ASEM) to suggest how romantic relationships can promote chronic attachment security. One part of the ASEM examines partner responses that protect relationships from the erosive effects of immediate insecurity, but such responses may not necessarily address underlying insecurities in a person’s mental models. Therefore, a second part of the ASEM examines relationship situations that foster more secure mental models. Both parts may work in tandem. We posit that attachment anxiety should decline most in situations that foster greater personal confidence and more secure mental models of the self. In contrast, attachment avoidance should decline most in situations that involve positive dependence and foster more secure models of close others. The ASEM integrates research and theory, suggests novel directions for future research, and has practical implications, all of which center on the idea that adult attachment orientations are an emergent property of close relationships

Teens in trouble: cigarette use and risky behaviors among private, high school students in La Paz, Bolivia Adolescentes en problemas: consumo de cigarrillos y conductas de riesgo en estudiantes de escuelas privadas de enseñanza media superior de La Paz, Bolivia

OBJECTIVE: To describe the prevalence of cigarette smoking and to identify risky behaviors associated with smoking among adolescents attending high schools in a district of La Paz, Bolivia. METHODS: The Youth Risk Behavior Survey was administered to a sample of 394 males and 182 females, from 13-18 years of age, at six, randomly-selected schools in District II of La Paz. Frequencies, chi-square tests, and logistic regression were employed to identify factors associated with cigarette use during the 30 days prior to the survey. RESULTS: Approximately 40% of the sample (39.4% of males and 33.7% of females) had smoked cigarettes in the 30 days prior to interview. For both males and females, consumption of alcohol was the single greatest risk factor associated with cigarette use. The males and females who reported consuming at least one alcoholic beverage on three or more occasions in the previous 30 days were 22.3 and 58.5 times (95% CIs: 6.7, 74.1 and 6.8, 502.6, respectively) more likely to smoke tobacco than those who reported no alcohol consumption. Additional risk factors included having participated in a physical fight, having carried a weapon, having had sexual intercourse, and having used illicit drugs during the previous 30 days. CONCLUSIONS: Because teenagers who smoke are also likely to engage in a variety of other risky behaviors, parents, school administrators, and health educators may wish to use smoking to identify at-risk individuals. Among Bolivian teenagers, interventions should focus on preventing cigarette use and associated risk behaviors.OBJETIVO: Describir la prevalencia del consumo de cigarrillos e identificar las conductas de riesgo asociadas con el hábito de fumar en adolescentes de enseñanza media superior de un distrito de La Paz, Bolivia. MÉTODOS: Se aplicó la Encuesta sobre Conductas de Riesgo en los Jóvenes a una muestra de 394 varones y 182 mujeres de 13-18 años de edad de seis escuelas del Distrito II de La Paz seleccionadas al azar. Se identificaron los factores asociados con el consumo de cigarrillos durante los 30 días previos a la encuesta, mediante el análisis de frecuencias, la prueba de la ji al cuadrado y la regresión logística. RESULTADOS: Aproximadamente 40% de la muestra (39,4% de los varones y 33,7% de las mujeres) había fumado cigarrillos en los 30 días previos a la encuesta. Tanto para ellos como para ellas, el consumo de alcohol fue el mayor factor de riesgo asociado con el consumo de cigarrillos. Los varones y las mujeres que informaron haber consumido al menos una bebida alcohólica en tres ocasiones o más durante los 30 días previos presentaron 22,3 y 58,5 veces (IC95%: 6,7 a 74,1 y 6,8 a 502,6, respectivamente) mayor probabilidad de fumar que los que informaron no haber consumido alcohol. Otros factores de riesgo adicionales fueron haber participado en una pelea física, haber portado un arma, haber tenido relaciones sexuales y haber tomado alguna droga ilícita durante los 30 días anteriores. CONCLUSIONES: Debido a que los adolescentes que fuman tienden también a incurrir en otras conductas de riesgo, los padres, los responsables escolares y los educadores sanitarios podrían utilizar el hábito de fumar para identificar a los adolescentes en riesgo. Las intervenciones dirigidas a adolescentes bolivianos deben enfocarse en la prevención del consumo de cigarrillos y de las conductas de riesgo asociadas

All Anxiety is not Created Equal: Correlates of Parent/Youth Agreement Vary Across Subtypes of Anxiety

Research has examined patterns and correlates of parent/youth informant discrepancies in the reporting of youth anxiety. However, little work has examined whether it is better to conceptualize patterns and correlates of informant disagreement across anxiety broadly, or more useful to consider disagreement on specific symptom clusters. Using data from the Child Adolescent/Anxiety Multimodal Study (CAMS; N = 488; Walkup et al., 2008), the current study applied the most recent recommended analytic strategies to study informant discrepancies and examined differences in the magnitude and patterns of disagreement for: (a) broadband anxiety symptoms, versus (b) symptoms of specific anxiety diagnoses (or anxiety subtypes; e.g., separation, social anxiety). Correlates of informant discrepancies were also examined. Results indicated that there was variability in agreement across anxiety subtypes, with parent/youth agreement higher on separation anxiety and school refusal symptoms relative to other domains. Parental psychopathology was associated with disagreement on broadband anxiety symptoms, such that parental psychopathology was highest when parents reported higher symptoms than their children; however, this finding was largely driven by a relationship between parental psychopathology and disagreement on separation anxiety symptoms. Age was associated with disagreement on total and separation anxiety symptoms. Gender was not associated with disagreement. Clinical implications are discussed

A comparative analysis of KMT2D missense variants in Kabuki syndrome, cancers and the general population

Determining the clinical significance of germline and somatic KMT2D missense variants (MVs) in Kabuki syndrome (KS) and cancers can be challenging. We analysed 1920 distinct KMT2D MVs that included 1535 germline MVs in controls (Control-MVs), 584 somatic MVs in cancers (Cancer-MVs) and 201 MV in individuals with KS (KS-MVs). The proportion of MVs likely to affect splicing was significantly higher for Cancer-MVs and KS-MVs than in Control-MVs (p = 0.000018). Our analysis identified significant clustering of Cancer-MVs and KS-MVs in the PHD#3 and #4, RING#4 and SET domains. Areas of enrichment restricted to just Cancer-MVs (FYR-C and between amino acids 3043–3248) or KS-MVs (coiled-coil#5, FYR-N and between amino acids 4995–5090) were also found. Cancer-MVs and KS-MVs tended to affect more conserved residues (lower BLOSUM scores, p < 0.001 and p = 0.007). KS-MVs are more likely to increase the energy for protein folding (higher ELASPIC ∆∆G scores, p = 0.03). Cancer-MVs are more likely to disrupt protein interactions (higher StructMAn scores, p = 0.019). We reclassify several presumed pathogenic MVs as benign or as variants of uncertain significance. We raise the possibility of as yet unrecognised ‘non-KS’ phenotype(s) associated with some germline pathogenic KMT2D MVs. Overall, this work provides insights into the disease mechanism of KMT2D variants and can be extended to other genes, mutations in which also cause developmental syndromes and cancer