79 research outputs found
Impact of endometrial carcinoma histotype on the prognostic value of the TCGA molecular subgroups
Background: The Cancer Genome Atlas (TCGA) identified four prognostic subgroups of endometrial carcinoma: copy-number-low/p53-wild-type (p53wt), POLE-mutated/ultramutated (POLEmt), microsatellite-instability/hypermutated (MSI), and copy-number-high/p53-mutated (p53mt). However, it is still unclear if they may be integrated with the current histopathological prognostic factors, such as histotype. Objective: To assess the impact of histotype on the prognostic value of the TCGA molecular subgroups of endometrial carcinoma. Methods: A systematic review and meta-analysis was performed by searching 7 electronic databases from their inception to April 2019 for studies assessing prognosis in all TCGA subgroups of endometrial carcinoma. Pooled hazard ratio (HR) for overall survival (OS) was calculated in two different groups (âall-histotypesâ and âendometrioidâ), using p53wt subgroup as reference standard; HR for non-endometrioid histotypes was calculated indirectly. Disease-specific survival and progression-free survival were assessed as additional analyses. Results: Six studies with 2818 patients were included. In the p53mt subgroup, pooled HRs for OS were 4.322 (all-histotypes), 2.505 (endometrioid), and 4.937 (non-endometrioid). In the MSI subgroup, pooled HRs were 1.965 (all-histotypes), 1.287 (endometrioid), and 6.361 (non-endometrioid). In the POLEmt subgroup, pooled HRs were 0.763 (all-histotypes), 0.481 (endometrioid), and 2.634 (non-endometrioid). Results of additional analyses were consistent for all subgroups except for non-endometrioid POLEmt carcinomas. Conclusion: Histotype of endometrial carcinoma shows a crucial prognostic value independently of the TCGA molecular subgroup, with non-endometrioid carcinomas having a worse prognosis in each TCGA subgroup. Histotype should be integrated with molecular characterization for the risk stratification of patients in the future
Milk from cows fed a diet with a high forage:concentrate ratio improves inflammatory state, oxidative stress, and mitochondrial function in rats.
Excessive energy intake may evoke complex biochemical processes characterized by inflammation, oxidative stress, and impairment of mitochondrial function that represent the main factors underlying noncommunicable diseases. Because cow milk is widely used for human nutrition and in food industry processing, the nutritional quality of milk is of special interest with respect to human health. In our study, we analyzed milk produced by dairy cows fed a diet characterized by a high forage:concentrate ratio (high forage milk, HFM). In view of the low n-6:n-3 ratio and high content of conjugated linoleic acid of HFM, we studied the effects of this milk on lipid metabolism, inflammation, mitochondrial function, and oxidative stress in a rat model. To this end, we supplemented for 4 wk the diet of male Wistar rats with HFM and with an isocaloric amount (82 kJ, 22 mL/d) of milk obtained from cows fed a diet with low forage:concentrate ratio, and analyzed the metabolic parameters of the animals. Our results indicate that HFM may positively affect lipid metabolism, leptin:adiponectin ratio, inflammation, mitochondrial function, and oxidative stress, providing the first evidence of the beneficial effects of HFM on rat metabolism
Continuos clinical remission with biologics in Ulcerative Colitis: the A.U.R.O.R.A. comparative study
Comparative trials among biological drugs for the treatment of ulcerative colitis (UC) provided conflicting results. After patent expire of infliximab originator, adalimumab, infliximab biosimilar, golimumab and vedolizumab have been approved in Italy.We compared the efficacy of these four biologics in UC according to the concept of continuous clinical remission (CCR)
Corrosion behaviour of porous Ti intended for biomedical applications
Porous Ti implants are being developed inorder to reduce the biomechanical mismatch between theimplant and the bone, as well as increasing the osseointegrationby improving the bone in-growth. Most of the focusin the literature has been on the structural, biological andmechanical characterization of porous Ti whereas there islimited information on the electrochemical characterization.Therefore, the present work aims to study the corrosionbehaviour of porous Ti having 30 and 50 % ofnominal porosity, produced by powder metallurgy routeusing the space holder technique. The percentage, size anddistribution of the pores were determined by image analysis.Electrochemical tests consisting of potentiodynamicpolarization and electrochemical impedance spectroscopywere performed in 9 g/L NaCl solution at body temperature.Electrochemical studies revealed that samples presenteda less stable oxide film at increased porosity, morespecifically, the complex geometry and the interconnectivityof the pores resulted in formation of less protectiveoxide film in the pores.This study was supported by FCT with the
reference project UID/EEA/04436/2013, by FEDER funds through
the COMPETE 2020 â Programa Operacional Competitividade e
InternacionalizacžaËo (POCI) with the reference project POCI-01-0145-
FEDER-006941, Programa de AccžoËes UniversitaÂŽrias Integradas LusoFrancesasâ
(PAUILF TC-12_14), and The Calouste Gulbenkian
Foundation through ââPrograma de Mobilidade AcadeÂŽmica para Professoresââ.
The authors would also like to acknowledge Prof. Ana
Senos (University of Aveiro) and Prof. JoseÂŽ Carlos Teixeira
(University of Minho) for the provision of the characterization
facilities.info:eu-repo/semantics/publishedVersio
Effectiveness and safety of vedolizumab in a matched cohort of elderly and nonelderly patients with inflammatory bowel disease: the IG-IBD LIVE study
Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness
Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. Weevaluated whether PSVs inBRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 30 region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. Significance: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.Peer reviewe
Etude par thermogravimétrie et par calorimétrie différentielle de la réduction et réoxydation des molybdates de bismuth (2:1, 2:3)
Il a été poursuivi par thermogravimétrie et par calorimétrie différentielle (DSC) une étude des réactions de réduction et de réoxydation de deux échantillons de molybdates de bismuth, le Bi2O3 ΠMoO3 et le Bi2O3 Π3MoO3.Ces mesures nous ont permis de mettre en évidence différentes énergies d'activation au fur et à mesure que la réaction avec l'hydrogÚne se produit.Au moins trois sites de réoxydation ont été ainsi détectés par DSC. De ces thermogrammes on peut aussi obtenir le dosage du bismuth métallique produit pendant la réduction
Energies of different surface rehydration processes on 'eta', 'theta' and 'alpha' aluminas
Management di paziente gravida affetta da morbo di Gaucher: Nostra esperienza
We present a case of a 25-year-old lady pregnant at 37th week affected by Gaucher disease. About her clinical history, the patient reports normochromic normocitic anaemia, thrombocytopenia, hypertension and proteinuria. Gaucher disease is a rare autosomal recessive metabolic disorder caused by lack of a lysosomal enzyme (beta-glucosidase) which cause a heavy swelling of spleen and liver, bone damage (osteoporosis, spontaneous fractures), growth deficit in children, anaemia, bleeding tendency and neurological damages in some forms. The present study describe the management of the patient related to severe complicances derived by basic disease and demonstrate that there is no contraindication to pregnancy in women with Gaucher disease
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