9,808 research outputs found
Le défigement linguistique comme recours stylistique, et les écueils traductologiques induits de l’espagnol vers le français
The man\u27s gaze transcends reality to so often cosmetic purposes. Referring to literature, here we will only tackle the part of the narrative creation which are the metaphorical interpretation and its derivatives to linger over this other type of diversion realized by the language de-fossilization in its phraseology and lexical applications, leading to many puns.
The translator must accommodate to this sign of discursive freedom of authors, establishing semantic and semiotic relations of collusion between the source language and the target language. This is what we will develop on the basis of about ten illustrations from Hispanic literature. For each case, we will emphasize the intuitive logic of the original find, to propose its transfer in French, pointing that through a translatological "intuitivo-cognitive" posture, the translator can develop his very own creativity, a true wager of literary faithfulness
Halo properties and secular evolution in barred galaxies
The halo plays a crucial role in the evolution of barred galaxies. Its
near-resonant material absorbs angular momentum emitted from some of the disc
particles and helps the bar become stronger. As a result, a bar (oval) forms in
the inner parts of the halo of strongly barred disc galaxies. It is thinner in
the inner parts (but still considerably fatter than the disc bar) and tends to
spherical at larger radii. Its length increases with time, while always staying
shorter than the disc bar. It is roughly aligned with the disc bar, which it
trails only slightly, and it turns with roughly the same pattern speed. The
bi-symmetric component of the halo density continues well outside the halo bar,
where it clearly trails behind the disc bar. The length and strength of the
disc and halo bars correlate; the former being always much stronger than the
latter. If the halo is composed of weakly interacting massive particles, then
the formation of the halo bar, by redistributing the matter in the halo and
changing its shape, could influence the expected annihilation signal. This is
indeed found to be the case if the halo has a core, but not if it has a steep
cusp. The formation and evolution of the bar strongly affect the halo orbits. A
fraction of them becomes near-resonant, similar to the disc near-resonant
orbits at the same resonance, while another fraction becomes chaotic. Finally,
a massive and responsive halo makes it harder for a central mass concentration
to destroy the disc bar.Comment: 6 pages, 3 figures, to appear in "Island Universes - Structure and
Evolution of Disk Galaxies" ed. R. S. de Jon
OxyCAP UK: Oxyfuel Combustion - academic Programme for the UK
The OxyCAP-UK (Oxyfuel Combustion - Academic Programme for the UK) programme was a £2 M collaboration involving researchers from seven UK universities, supported by E.On and the Engineering and Physical Sciences Research Council. The programme, which ran from November 2009 to July 2014, has successfully completed a broad range of activities related to development of oxyfuel power plants. This paper provides an overview of key findings arising from the programme. It covers development of UK research pilot test facilities for oxyfuel applications; 2-D and 3-D flame imaging systems for monitoring, analysis and diagnostics; fuel characterisation of biomass and coal for oxyfuel combustion applications; ash transformation/deposition in oxyfuel combustion systems; materials and corrosion in oxyfuel combustion systems; and development of advanced simulation based on CFD modelling
Zein-based nanospheres and nanocapsules for the encapsulation and oral delivery of quercetin
In this study, the ability of zein nanospheres (NS) and zein nanocapsules containing wheat germ oil (NC) to
enhance the bioavailability and efficacy of quercetin was evaluated. Both types of nanocarriers had similar
physico-chemical properties, including size (between 230 and 250 nm), spherical shape, negative zeta potential,
and surface hydrophobicity. However, NS displayed a higher ability than NC to interact with the intestinal
epithelium, as evidenced by an oral biodistribution study in rats. Moreover, both types of nanocarriers offered
similar loading efficiencies and release profiles in simulated fluids. In C. elegans, the encapsulation of quercetin in
nanospheres (Q-NS) was found to be two twice more effective than the free form of quercetin in reducing lipid
accumulation. For nanocapsules, the presence of wheat germ oil significantly increased the storage of lipids in
C. elegans; although the incorporation of quercetin (Q-NC) significantly counteracted the presence of the oil.
Finally, nanoparticles improved the oral absorption of quercetin in Wistar rats, offering a relative oral
bioavailability of 26% and 57% for Q-NS and Q-NC, respectively, compared to a 5% for the control formulation.
Overall, the study suggests that zein nanocarriers, particularly nanospheres, could be useful in improving the
bioavailability and efficacy of quercetin
Annihilation vs. Decay: Constraining dark matter properties from a gamma-ray detection
Most proposed dark matter candidates are stable and are produced thermally in
the early Universe. However, there is also the possibility of unstable (but
long-lived) dark matter, produced thermally or otherwise. We propose a strategy
to distinguish between dark matter annihilation and/or decay in the case that a
clear signal is detected in gamma-ray observations of Milky Way dwarf
spheroidal galaxies with gamma-ray experiments. The sole measurement of the
energy spectrum of an indirect signal would render the discrimination between
these cases impossible. We show that by examining the dependence of the
intensity and energy spectrum on the angular distribution of the emission, the
origin could be identified as decay, annihilation, or both. In addition, once
the type of signal is established, we show how these measurements could help to
extract information about the dark matter properties, including mass,
annihilation cross section, lifetime, dominant annihilation and decay channels,
and the presence of substructure. Although an application of the approach
presented here would likely be feasible with current experiments only for very
optimistic dark matter scenarios, the improved sensitivity of upcoming
experiments could enable this technique to be used to study a wider range of
dark matter models.Comment: 29 pp, 8 figs; replaced to match published version (minor changes and
some new references
Are peripheral biomarkers determinants of eating styles in childhood and adolescence obesity? A cross-sectional study
Disturbances in eating behaviors have been widely related to obesity. However, little is known about the role of obesity-related biomarkers in shaping habitual patterns of eating behaviors (i.e., eating styles) in childhood. The objective of the present study was to explore the relationships between several biomarkers crucially involved in obesity (ghrelin, insulin resistance, and leptin/adiponectin ratio) and eating styles in children and adolescents with obesity. Seventy participants aged between 8 and 16 (56.2% men) fulfilled the Spanish version of the Dutch Eating Behavior Questionnaire for Children to measure external, emotional, and restrained eating styles. In addition, concentrations of ghrelin, leptin, adiponectin, insulin, and glucose were obtained through a blood test. Hierarchical multiple regression analyses controlling for age and sex were computed for each eating style. Results indicated that individuals with higher ghrelin concentration levels showed lower scores in restrained eating (beta = -0.61, p < 0.001). The total model explained 32% of the variance of the restrained pattern. No other relationships between obesity-related biomarkers and eating behaviors were found. This study highlights that one of the obesity-risk factors, namely lower plasma ghrelin levels, is substantially involved in a well-known maladaptive eating style, restraint eating, in childhood obesity
Fractals vs. halos: Asymptotic scaling without fractal properties
Precise analyses of the statistical and scaling properties of galaxy
distribution are essential to elucidate the large-scale structure of the
universe. Given the ongoing debate on its statistical features, the development
of statistical tools permitting to discriminate accurately different spatial
patterns is highly desiderable. This is specially the case when non-fractal
distributions have power law two-point correlation functions, which are usually
signatures of fractal properties. Here we review some possible methods used in
the literature and introduce a new variable called "scaling gradient". This
tool and the conditional variance are shown to be effective in providing an
unambiguous way for such a distinction. Their application is expected to be of
outmost importance in the analysis of upcoming galaxy catalogues.Comment: 7 pages, 3 figure
Implications of the Fermi-LAT diffuse gamma-ray measurements on annihilating or decaying Dark Matter
We analyze the recently published Fermi-LAT diffuse gamma-ray measurements in
the context of leptonically annihilating or decaying dark matter (DM) with the
aim to explain simultaneously the isotropic diffuse gamma-ray and the PAMELA,
Fermi and HESS (PFH) anomalous data. Five different DM
annihilation/decay channels , , , , or (the latter
two via an intermediate light particle ) are generated with PYTHIA. We
calculate both the Galactic and extragalactic prompt and inverse Compton (IC)
contributions to the resulting gamma-ray spectra. To find the Galactic IC
spectra we use the interstellar radiation field model from the latest release
of GALPROP. For the extragalactic signal we show that the amplitude of the
prompt gamma-emission is very sensitive to the assumed model for the
extragalactic background light. For our Galaxy we use the Einasto, NFW and
Isothermal DM density profiles and include the effects of DM substructure
assuming a simple subhalo model. Our calculations show that for the
annihilating DM the extragalactic gamma-ray signal can dominate only if rather
extreme power-law concentration-mass relation is used, while more
realistic relations make the extragalactic component comparable or
subdominant to the Galactic signal. For the decaying DM the Galactic signal
always exceeds the extragalactic one. In the case of annihilating DM the PFH
favored parameters can be ruled out only if power-law relation is
assumed. For DM decaying into or the PFH favored DM parameters
are not in conflict with the Fermi gamma-ray data. We find that, due to the
(almost) featureless Galactic IC spectrum and the DM halo substructure,
annihilating DM may give a good simultaneous fit to the isotropic diffuse
gamma-ray and to the PFH data without being in clear conflict with the
other Fermi-LAT gamma-ray measurements.Comment: Accepted for publication in JCAP, added missing references, new Figs.
9 \& 10, 35 page
The Tobacco mosaic virus movement protein associates with but does not integrate into biological membranes
Plant positive-strand RNA viruses require association with plant cell endomembranes for viral translation and replication, as
well as for intra- and intercellular movement of the viral progeny. The membrane association and RNA binding of the Tobacco
mosaic virus (TMV) movement protein (MP) are vital for orchestrating the macromolecular network required for virus movement.
A previously proposed topological model suggests that TMV MP is an integral membrane protein with two putative -helical
transmembrane (TM) segments. Here we tested this model using an experimental system that measured the efficiency with
which natural polypeptide segments were inserted into the ER membrane under conditions approximating the in vivo situation,
as well as in planta. Our results demonstrated that the two hydrophobic regions (HRs) of TMV MP do not span biological membranes.
We further found that mutations to alter the hydrophobicity of the first HR modified membrane association and precluded
virus movement. We propose a topological model in which the TMV MP HRs intimately associate with the cellular membranes,
allowing maximum exposure of the hydrophilic domains of the MP to the cytoplasmic cellular components.This work was supported by grants BFU2009-08401 and BFU2012-39482 (to I. M.) and BIO2011-25018 (to V. P.) from the Spanish MINECO. A. P. is the recipient of a JAE predoc position (CSIC).Peiró Morell, A.; Martínez-Gil, L.; Tamborero, S.; Pallás Benet, V.; Sanchez Navarro, JA.; Mingarro, I. (2014). The Tobacco mosaic virus movement protein associates with but does not integrate into biological membranes. Journal of Virology. 88(5):3016-3026. https://doi.org/10.1128/JVI.03648-13S3016302688
Sonidegib as a Locally Advanced Basal Cell Carcinoma Therapy in Real-life Clinical Setting: A National Multicentre Study
Background: Basal cell carcinoma (BCC) is the most prevalent cancer. A minority of BCCs have an aggressive behaviour (laBCC) and may require hedgehog pathway inhibitors such as sonidegib as its treatment. Objective: To describe the use of sonidegib in a large number of patients and provide more data on its real-life efficacy and safety profile.Methods: We conducted a retrospective and multicentric study that included patients treated with sonidegib. Epidemiological, effectiveness and safety data were collected.Results: A total of 82 patients with a mean age of 73.9 years were included. Ten patients had Gorlin syndrome. Median treatment duration was 6 months. Median follow-up duration was 34.2 months. Globally, 81.7% of the patients showed clinical improvement (52.4% partial response and 29.3% complete response), 12.2% clinical stability and 6.1% disease progression. There was no statistically significant difference in clinical improvement between the 24 h and 48 h sonidegib posology. After 6 months of treatment, 48.8% of the patients discontinued sonidegib. Prior vismodegib treatment and recurrent primary BCC were associated with a poorer response to sonidegib. At 6 months of treatment, 68.3% of the patients experienced at least one adverse effect. Conclusion: Sonidegib shows good effectiveness and acceptable safety profile in usual clinical practice.& COPY; 2023 AEDV. Published by Elsevier Espan & SIM;a, S.L.U.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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