4,827 research outputs found
Some Correlation Functions of Minimal Superconformal Models Coupled to Supergravity
We compute general three-point functions of minimal superconformal models
coupled to supergravity in the Neveu-Schwarz sector for spherical topology thus
extending to the superconformal case the results of Goulian and Li and of
Dotsenko.Comment: 15 page
On the complete classification of the unitary N=2 minimal superconformal field theories
Aiming at a complete classification of unitary N=2 minimal models (where the
assumption of space-time supersymmetry has been dropped), it is shown that each
modular invariant candidate of a partition function for such a theory is indeed
the partition function of a minimal model. A family of models constructed via
orbifoldings of either the diagonal model or of the space-time supersymmetric
exceptional models demonstrates that there exists a unitary N=2 minimal model
for every one of the allowed partition functions in the list obtained from
Gannon's work.
Kreuzer and Schellekens' conjecture that all simple current invariants can be
obtained as orbifolds of the diagonal model, even when the extra assumption of
higher-genus modular invariance is dropped, is confirmed in the case of the
unitary N=2 minimal models by simple counting arguments.Comment: 53 pages; Latex; minor changes in v2: intro expanded, references
added, typos corrected, footnote added on p31; renumbering of sections; main
theorem reformulated for clarity, but contents unchanged. Minor revisions in
v3: typos corrected, footnotes 5, 6 added, lemma 1 and section 3.3.2
rewritten for greater generality, section 3.3 review removed. To appear in
Comm. Math. Phy
Fuzzy Supernova Templates I: Classification
Modern supernova (SN) surveys are now uncovering stellar explosions at rates
that far surpass what the world's spectroscopic resources can handle. In order
to make full use of these SN datasets, it is necessary to use analysis methods
that depend only on the survey photometry. This paper presents two methods for
utilizing a set of SN light curve templates to classify SN objects. In the
first case we present an updated version of the Bayesian Adaptive Template
Matching program (BATM). To address some shortcomings of that strictly Bayesian
approach, we introduce a method for Supernova Ontology with Fuzzy Templates
(SOFT), which utilizes Fuzzy Set Theory for the definition and combination of
SN light curve models. For well-sampled light curves with a modest signal to
noise ratio (S/N>10), the SOFT method can correctly separate thermonuclear
(Type Ia) SNe from core collapse SNe with 98% accuracy. In addition, the SOFT
method has the potential to classify supernovae into sub-types, providing
photometric identification of very rare or peculiar explosions. The accuracy
and precision of the SOFT method is verified using Monte Carlo simulations as
well as real SN light curves from the Sloan Digital Sky Survey and the
SuperNova Legacy Survey. In a subsequent paper the SOFT method is extended to
address the problem of parameter estimation, providing estimates of redshift,
distance, and host galaxy extinction without any spectroscopy.Comment: 26 pages, 12 figures. Accepted to Ap
Spin chains with dynamical lattice supersymmetry
Spin chains with exact supersymmetry on finite one-dimensional lattices are
considered. The supercharges are nilpotent operators on the lattice of
dynamical nature: they change the number of sites. A local criterion for the
nilpotency on periodic lattices is formulated. Any of its solutions leads to a
supersymmetric spin chain. It is shown that a class of special solutions at
arbitrary spin gives the lattice equivalents of the N=(2,2) superconformal
minimal models. The case of spin one is investigated in detail: in particular,
it is shown that the Fateev-Zamolodchikov chain and its off-critical extension
admits a lattice supersymmetry for all its coupling constants. Its
supersymmetry singlets are thoroughly analysed, and a relation between their
components and the weighted enumeration of alternating sign matrices is
conjectured.Comment: Revised version, 52 pages, 2 figure
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
Epilepsy is a major health burden, calling for new mechanistic insights and therapies. CRISPR-mediated gene editing shows promise to cure genetic pathologies, although hitherto it has mostly been applied ex vivo. Its translational potential for treating non-genetic pathologies is still unexplored. Furthermore, neurological diseases represent an important challenge for the application of CRISPR, because of the need in many cases to manipulate gene function of neurons in situ. A variant of CRISPR, CRISPRa, offers the possibility to modulate the expression of endogenous genes by directly targeting their promoters. We asked if this strategy can effectively treat acquired focal epilepsy, focusing on ion channels because their manipulation is known be effective in changing network hyperactivity and hypersynchronziation. We applied a doxycycline-inducible CRISPRa technology to increase the expression of the potassium channel gene Kcna1 (encoding Kv1.1) in mouse hippocampal excitatory neurons. CRISPRa-mediated Kv1.1 upregulation led to a substantial decrease in neuronal excitability. Continuous video-EEG telemetry showed that AAV9-mediated delivery of CRISPRa, upon doxycycline administration, decreased spontaneous generalized tonic-clonic seizures in a model of temporal lobe epilepsy, and rescued cognitive impairment and transcriptomic alterations associated with chronic epilepsy. The focal treatment minimizes concerns about off-target effects in other organs and brain areas. This study provides the proof-of-principle for a translational CRISPR-based approach to treat neurological diseases characterized by abnormal circuit excitability
Critical Role of AKT in Myeloma-induced Osteoclast Formation and Osteolysis
Abnormal osteoclast formation and osteolysis are the hallmarks of multiple myeloma (MM) bone disease, yet the underlying molecular mechanisms are incompletely understood. Here, we show that the AKT pathway was up-regulated in primary bone marrow monocytes (BMM) from patients with MM, which resulted in sustained high expression of the receptor activator of NF-ÎşB (RANK) in osteoclast precursors. The up-regulation of RANK expression and osteoclast formation in the MM BMM cultures was blocked by AKT inhibition. Conditioned media from MM cell cultures activated AKT and increased RANK expression and osteoclast formation in BMM cultures. Inhibiting AKT in cultured MM cells decreased their growth and ability to promote osteoclast formation. Of clinical significance, systemic administration of the AKT inhibitor LY294002 blocked the formation of tumor tissues in the bone marrow cavity and essentially abolished the MM-induced osteoclast formation and osteolysis in SCID mice. The level of activating transcription factor 4 (ATF4) protein was up-regulated in the BMM cultures from multiple myeloma patients. Adenoviral overexpression of ATF4 activated RANK expression in osteoclast precursors. These results demonstrate a new role of AKT in the MM promotion of osteoclast formation and bone osteolysis through, at least in part, the ATF4-dependent up-regulation of RANK expression in osteoclast precursors
Immunoassays Based on Penicillium marneffei Mp1p Derived from Pichia pastoris Expression System for Diagnosis of Penicilliosis
BACKGROUND: Penicillium marneffei is a dimorphic fungus endemic in Southeast Asia. It can cause fatal penicilliosis in humans, particularly in HIV-infected people. Diagnosis of this infection is difficult because its clinical manifestations are not distinctive. Specialized laboratory tests are necessary to establish a definitive diagnosis for successful management. We have demonstrated previously that a cell wall mannoprotein Mp1p, abundant in P. marneffei, is a potential biomarker for diagnosis of P. marneffei infections. In the present study, we describe immunoassays based on Mp1p derived from the yeast Pichia pastoris expression system. METHODOLOGY/PRINCIPAL FINDINGS: We generated monoclonal antibodies (MAbs) and rabbit polyclonal antibodies (PAbs) against Mp1p expressed in P. pastoris. Subsequently, we developed two Mp1p antigen capture ELISAs which employed MAbs for both the capture and detecting antibodies (MAb-MAb pair) or PAbs and MAbs as the capture and detecting antibodies (PAbs-MAb pair) respectively. The two Mp1p antigen ELISAs detected Mp1p specifically in cultures of P. marneffei yeast phase at 37-40 degrees C and had no cross-reaction with other tested pathogenic fungi. The sensitivities and specificities of the two antigen assays were found to be 55% (11/20) and 99.6% (538/540) for MAb-MAb Mp1p ELISA, and 75% (15/20) and 99.4% (537/540) for PAbs-MAb Mp1p ELISA performed using 20 sera with culture-confirmed penicilliosis, and 540 control sera from 15 other mycosis patients and 525 healthy donors. Meanwhile, we also developed an anti-Mp1p IgG antibody ELISA with an evaluated sensitivity of 30% (6/20) and a specificity of 98.5% (532/540) using the same sera. Furthermore, combining the results of Mp1p antigen and antibody detection improved the sensitivity of diagnosis to 100% (20/20). CONCLUSIONS/SIGNIFICANCE: Simultaneous detection of antigen and antibody using the immunoassays based on Mp1p derived from P. pastoris greatly improves detection sensitivity. The procedures should be useful for the routine diagnosis of penicilliosis.published_or_final_versio
Pinhole-free perovskite films for efficient solar modules
We report on a perovskite solar module with an aperture area of 4 cm2 and geometrical fill factor of 91%. The module exhibits an aperture area power conversion efficiency (PCE) of 13.6% from a current–voltage scan and 12.6% after 5 min of maximum power point tracking. High PCE originates in pinhole-free perovskite films made with a precursor combination of Pb(CH3CO2)2·3H2O, PbCl2, and CH3NH3I
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