Communication Sciences and Disorders Graduate Students\u27 Strengths and Vulnerabilities Related to Resilience: A Survey of Graduate Programs

Burnout in health care professionals may pose a threat to the quality of care provided in any setting. The purpose of this project was to examine dimensions related to future resilience in CSD graduate students. METHODS: In this project, 146 master’s degree students from Communication Sciences and Disorders (CSD) programs in the Midwest completed an online survey regarding lifestyle stresses affecting resilience, and patterns in five areas correlated with resilience. RESULTS: Top lifestyle stresses affecting academics were general stress, maintaining mental health, and sleep difficulties. Notably, more than half of the participants reported feeling rested three or fewer days per week. Further, CSD students reported significantly higher incidence of general stress, mental health conditions, chronic health conditions, concern for a friend or family member’s struggles, and sleep difficulty than college age peers. Positive factors identified related to resilience in CSD students included presence of professional networks and mentoring, maintaining positivity, opportunities for reflecting on strengths and weaknesses, and having a sense meaning in life. Respondent areas of resilience vulnerability were reduced optimism on a daily basis, limited sense of life balance, and hesitancy to discuss life issues or accommodation needs with faculty. Implications are discussed regarding CSD graduate programs’ roles in fostering resilience. CONCLUSION: Professional programs can support and promote the development of personal and professional resilience in students training for healthcare professions. This survey project provides a starting point to describe patterns in CSD master’s programs within the Midwestern region of the US

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Diploma and degree : a unique collaborative approach to sonographer education

The development of the Mohawk College–McMaster University Medical Radiation Sciences (MRSc) diploma/degree program was in process for approximately 10 years. In the fall of 1999, a Mohawk-McMaster steering committee was charged with the task of developing a program model for a collaborative college-university undergraduate program in medical radiation sciences. The model provided a platform on which to base growth, particularly to allow for the addition of future undergraduate specializations in medical radiation sciences, such as radiation therapy, magnetic resonance imaging (MRI), and nuclear medicine

Esential cases on natural causation

Bibliografija išnašose ; Rodyklė: p. 619-627This volume of the „Digest of European Tort Law" is the first product of a most ambitious research project: a collection of court decisions from almost all European jurisdictions on the most fundamental aspects of tort law. These cases are not only accumulated, but also structured, analysed and commented both from a national as well as a comparative perspective. Historical aspects are also considered, as are future trends, as outlined by current projects on the harmonisation of European tort laws. This complex comparative study shall thereby not only offer guidance for researching cross-border cases, but also allow a discussion of such harmonisation projects on the basis of real-life case settings. This first volume covers one key aspect of tortious liability – natural causation. The conditio sine qua non rule is examined and tested throughout all jurisdictions, in particular with an eye on whether and to what extent courts are willing to deviate from the strict concept of this formulaMykolo Romerio universiteta

Essential cases on damage

Bibliogr. išnašoseThe increasing Europeanisation of the law of delict/torts has produced textbooks, casebooks, monographs, and also sets of model rules of a genuinely European character. A major gap still existing today relates to the experiences gathered in the national legal systems over the past decades. The present work attempts to fill this gap for one key element of tort law: the notion of damage. It thus does what the previous volume in the ‘Digest of European Tort Law’ series did for another key element, ie natural causation. Once again, the publication contains a selection of the most important cases decided in 26 states across Europe as well as by the European Court of Justice. For each case the facts and the relevant court decision are presented, and the decision is analysed within the wider context of the development of the respective legal system. In addition, the editors provide comparative analyses of the case law reported in this volume concerning all the specific problems raised under the heading of damage. The publication also looks into how key cases would be resolved under the European model rules drafted in the field of tort law; and it also highlights cases from earlier periods of legal history. The editors believe that the material gathered here may provide guidance for an organic convergence of the national legal systems in Europe. It constitutes the basis of an acquis commun that is infinitely richer (though also much more complex) than the rather bland and abstract concepts contained in national codifications, European legislation, and the modern model rulesMykolo Romerio universitetasPrivatinės teisės katedraVytauto Didžiojo universiteta