Serre weight conjectures for pp-adic unitary groups of rank 2

We prove a version of the weight part of Serre's conjecture for mod $p$ Galois representations attached to automorphic forms on rank 2 unitary groups which are non-split at $p$. More precisely, let $F/F^+$ denote a CM extension of a totally real field such that every place of $F^+$ above $p$ is unramified and inert in $F$, and let $\overline{r}: \textrm{Gal}(\overline{F^+}/F^+) \longrightarrow {}^C\mathbf{U}_2(\overline{\mathbb{F}}_p)$ be a Galois parameter valued in the $C$-group of a rank 2 unitary group attached to $F/F^+$. We assume that $\overline{r}$ is semisimple and sufficiently generic at all places above $p$. Using base change techniques and (a strengthened version of) the Taylor-Wiles-Kisin conditions, we prove that the set of Serre weights in which $\overline{r}$ is modular agrees with the set of Serre weights predicted by Gee-Herzig-Savitt

Lifetimes of doubly K -shell ionized states

The present work provides a reliable interpretation of the Khα₁/Khα₂ intensity ratios and an explanation of the lifetime values for K-shell hollow atoms based on an advanced theoretical analysis (using extensive multiconfiguration Dirac–Fock calculations with the inclusion of the transverse Breit interaction and quantum electrodynamics corrections). It was found that, as a result of closing the Khα₁ de-excitation channel in the pure LS coupling scheme, the Khα₁/Khα₂ intensity ratio changes with the atomic number from small values (for the LS coupling limit at low Z) to about 1.5– 1.6 (for the j–j coupling limit at high Z). However, closing the Khα₁ de-excitation channel (due to the domination of the pure LS coupling for the low-Z atoms) does not enlarge the lifetimes of hollow atoms

High-resolution tungsten spectroscopy relevant to the diagnostic of high-temperature tokamak plasmas

The x-ray transitions in Cu- and Ni-like tungsten ions in the 5.19–5.26 A wavelength range that are relevant ˚ as a high-temperature tokamak diagnostic, in particular for JET in the ITER-like wall configuration, have been studied. Tungsten spectra were measured at the upgraded Shanghai- Electron Beam Ion Trap operated with electron-beam energies from 3.16 to 4.55 keV. High-resolution measurements were performed by means of a flat Si 111 crystal spectrometer equipped by a CCD camera. The experimental wavelengths were determined with an accuracy of 0.3–0.4 mA. The wavelength of the ground-state transition in Cu-like tungsten from the ˚ 3p53d104s4d [(3/2,(1/2,5/2)2]1/2 level was measured. All measured wavelengths were compared with those measured from JET ITER-like wall plasmas and with other experiments and various theoretical predictions including COWAN, RELAC, multiconfigurational Dirac-Fock (MCDF), and FAC calculations. To obtain a higher accuracy from theoretical predictions, the MCDF calculations were extended by taking into account correlation effects (configuration-interaction approach). It was found that such an extension brings the calculations closer to the experimental values in comparison with other calculations.National Magnetic Confinement Fusion Program of China 2015GB117000National Natural Science Foundation of China 11374061EURATOM 63305

Чутливість рецепторів клітин ендометрію до естрогенів та прогестерону у корів хворих на субклінічний ендометрит

Pathological processes that strongly affect the uterine endometrium lead to infertility and abortion. The most common of these pathologies are clinical and subclinical endometritis. Subclinical endometritis is characterized by endometrial inflammation in the absence of clinical signs of endometritis. In this study, we used uterine samples obtained from Ukrainian black-and-white dairy cows aged 4 to 7 years to compare the histology of the uterine endometrium and changes in estrogen-α (ER-α), estrogen-β (ER-β) and progesterone (PgR) nuclear receptor sensitivity in cows with subclinical endometritis. Cows were separated based on cytological examination of the endometrium into a healthy group, or those presenting with subclinical endometritis. From these groups endometrial and epithelial tissue samples were obtained using biopsy forceps and an endoscope then analyzed using immunohistochemistry. Our results demonstrate that the sensitivity of ER-α and ER-β is lower while PgR sensitivity is elevated in cows with subclinical endometritis compared to the healthy control group. Additionally, we observed markedly altered histological changes characterized by enlargement of uterine glands, epithelial desquamation, and infiltration of leukocytes. These results suggest that there are significant changes in the endometrium linked to the sensitivity of nuclear steroid hormone receptors that may also play an immunoregulatory role in cows with subclinical endometriosis. While the interaction of steroid hormones and immunoregulation in the uterus remains to be elucidated, it may provide key insights into the uterine immune response.В основі патологічних процесів, що проходять у матці приводять до неплідності та абортів, важливу роль відіграє ендометрій. Найбільш поширеними патологіями, що проходять у матці є клінічний та субклінічний ендометрит. Субклінічний ендометрит характеризується запальним процесом у ендометрії без клінічних ознак. Метою нашої роботи було проаналізувати гістологічні зміни та зміни чутливості ендометрію матки до естроген-α (ER-α), естроген-β (ER-β) та прогестерону (PgR), що відбуваються у матці здорових корів та у корів за субклінічного ендометриту. Дослідження проводилось на двох групах корів української чорно-рябої молочної породи віком від 4 до 7 років. На основі цитологічного дослідження ендометрію, корови були поділені на дві групи. Контрольну групу (К), що включала клінічно здорових корів, та дослідну (Д), що включала корів хворих на субклінічний ендометрит. Надалі проводили забір зразків за допомогою біопсійних щипців та ендоскопу. Наші результати дають змогу більш глибоко зрозуміти процеси, що відбуваються у ендометрії корів хворих на субклінічний ендометрит. Активність рецепторів ядер ER-α, ER-β та PgR спостерігали у епітелії ендометрію, епітелії маткових залоз та стромі ендометрію. Активність рецепторів ядер ER-α та ER-β була нижчою у корів з субклінічним ендометритом, ніж у корів контрольної групи. Активність рецепторів ядер PgR була вищою у корів хворих на субклінічний ендометрит, ніж у корів контрольної групи. На основі отриманих даних встановлено, що ендометрій хворих на субклінінчий ендометрит зазнає значних змін, що характеризується появою лейкоцитів, розширенням маткових залоз та ділянками десквамації епітелію. Зміни відбуваються на основі чутливості ядер ендометрію до рецепторів ER-α, ER-β та PgR. Чутливість ендометрію до гормонів є важливою у локальному захисті матки. В перспективі подальших досліджень слід вивчити експресію стероїдних гормонів та цитокінів у корів хворих на субклінічний ендометрит

Measurements, Models, Systems and Design

531 s.

Forest genetic resources strategy for Europe

202

Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus -- the "D-shuttle" project --

Twelve high schools in Japan (of which six are in Fukushima Prefecture), four in France, eight in Poland and two in Belarus cooperated in the measurement and comparison of individual external doses in 2014. In total 216 high-school students and teachers participated in the study. Each participant wore an electronic personal dosimeter "D-shuttle" for two weeks, and kept a journal of his/her whereabouts and activities. The distributions of annual external doses estimated for each region overlap with each other, demonstrating that the personal external individual doses in locations where residence is currently allowed in Fukushima Prefecture and in Belarus are well within the range of estimated annual doses due to the background radiation level of other regions/countries

The ESSnuSB design study: overview and future prospects

ESSnuSB is a design study for an experiment to measure the CP violation in the leptonic sector at the second neutrino oscillation maximum using a neutrino beam driven by the uniquely powerful ESS linear accelerator. The reduced impact of systematic errors on sensitivity at the second maximum allows for a very precise measurement of the CP violating parameter. This review describes the fundamental advantages of measurement at the 2nd maximum, the necessary upgrades to the ESS linac in order to produce a neutrino beam, the near and far detector complexes, the expected physics reach of the proposed ESSnuSB experiment, concluding with the near future developments aimed at the project realization.Comment: 19 pages, 11 figures; Corrected minor error in alphabetical ordering of the authors: the author list is now fully alphabetical w.r.t. author surnames as was intended. Corrected an incorrect affiliation for two authors per their reques

The Different Function of Single Phosphorylation Sites of Drosophila melanogaster Lamin Dm and Lamin C

Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis. In our study we used Drosophila lamin Dm (B-type) to examine the function of particular phosphorylation sites using pseudophosphorylated mutants mimicking single phosphorylation at experimentally confirmed in vivo phosphosites (S25E, S45E, T435E, S595E). We also analyzed lamin C (A-type) and its mutant S37E representing the N-terminal cdc2 (mitotic) site as well as lamin Dm R64H mutant as a control, non-polymerizing lamin. In the polymerization assay we could observe different effects of N-terminal cdc2 site pseudophosphorylation on A- and B-type lamins: lamin Dm S45E mutant was insoluble, in contrast to lamin C S37E. Lamin Dm T435E (C-terminal cdc2 site) and R64H were soluble in vitro. We also confirmed that none of the single phosphorylation site modifications affected the chromatin binding of lamin Dm, in contrast to the lamin C N-terminal cdc2 site. In vivo, all lamin Dm mutants were incorporated efficiently into the nuclear lamina in transfected Drosophila S2 and HeLa cells, although significant amounts of S45E and T435E were also located in cytoplasm. When farnesylation incompetent mutants were expressed in HeLa cells, lamin Dm T435E was cytoplasmic and showed higher mobility in FRAP assay

The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults

Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing a variety of chronic diarrheal diseases. In addition to current pharmacological therapies, there is growing interest in alternative products such as mucoprotectants, which form a mucoadhesive film over the epithelium to reduce and protect against the development of altered intestinal permeability, dysbiosis, and mucosal micro-inflammation. This manuscript focuses on chronic diarrhea in adults, and we will review recent evidence on the ability of these natural compounds to improve symptoms associated with chronic diarrhea and to exert protective effects for the intestinal barrier