Повышение уровня готовности преподавателей к педагогическому проектированию

In the situation of pedagogical theory focus on a new personality-oriented and competence paradigm of education and upbringing, it becomes necessary to develop design activities of all subjects of educational process in a preschool educational institution. The relevance of the study is due to insufficient development of pedagogical design processes in a preschool educational institution. Therefore, the purpose of the article is to improve pedagogical design process in a preschool educational institution to increase the level of teachers' readiness for pedagogical activity.Pedagogical design in preschool educational institutions is very important due to the following socio-economic, psychological and pedagogical requirements: the development of market relations; development of design taking into account innovative processes in education; need for social protection of a person, preparing him for life in future. The authors developed a model of pedagogical design that ensures unity of administrative, pedagogical, educational activities of the subjects of educational process, thereby improving the level of management activities organization, personal and professional development of teachers and pupils. The treated results will contribute to further improvement of pedagogical design.En la situación de la teoría pedagógica centrada en un nuevo paradigma de educación y educación orientado a la personalidad y competencia, se hace necesario desarrollar actividades de diseño de todas las materias del proceso educativo en una institución educativa preescolar. La relevancia del estudio se debe al desarrollo insuficiente de los procesos de diseño pedagógico en una institución educativa preescolar. Por lo tanto, el propósito del artículo es mejorar el proceso de diseño pedagógico en una institución educativa preescolar para aumentar el nivel de preparación de los docentes para la actividad pedagógica. El diseño pedagógico en las instituciones educativas preescolares es muy importante debido a los siguientes aspectos socioeconómicos, psicológicos y pedagógicos. requisitos: el desarrollo de las relaciones de mercado; desarrollo de diseño teniendo en cuenta procesos innovadores en educación; necesidad de protección social de una persona, preparándolo para la vida en el futuro. Los autores desarrollaron un modelo de diseño pedagógico que garantiza la unidad de las actividades administrativas, pedagógicas y educativas de los sujetos del proceso educativo, mejorando así el nivel de organización de las actividades de gestión, el desarrollo personal y profesional de los docentes y alumnos. Los resultados tratados contribuirán a una mayor mejora del diseño pedagógico.В ситуации, когда педагогическая теория ориентируется на новую личностно-ориентированную и компетентностную парадигму обучения и воспитания, возникает необходимость в разработке проектных мероприятий всех субъектов образовательного процесса в дошкольном образовательном учреждении. Актуальность исследования обусловлена недостаточной разработкой процессов педагогического проектирования в дошкольном образовательном учреждении. Поэтому целью статьи является совершенствование процесса педагогического проектирования в дошкольном образовательном учреждении с целью повышения уровня готовности педагогов к педагогической деятельности. Педагогическое проектирование в дошкольных образовательных учреждениях очень важен в связи со следующими социально-экономическими, психолого-педагогическими требованиями: развитие рыночных отношений; разработка дизайна с учетом инновационных процессов в образовании; необходимость социальной защиты человека, подготовка его к жизни в будущем. Авторами разработана модель педагогического проектирования, обеспечивающая единство управленческой, педагогической, образовательной деятельности субъектов образовательного процесса, тем самым повышается уровень организации управленческой деятельности, личностного и профессионального развития учителей и учеников. Выявленные результаты будут способствовать дальнейшему совершенствованию педагогического проектирования

Detection of tick-borne pathogens in wild birds and their ticks in Western Siberia and high level of their mismatch

Abstract: The Tomsk region located in the south of Western Siberia is one of the most high-risk areas for tick-borne diseases due to elevated incidence of tick-borne encephalitis and Lyme disease in humans. Wild birds may be considered as one of the reservoirs for tick-borne pathogens and hosts for infected ticks. A high mobility of wild birds leads to unpredictable possibilities for the dissemination of tick-borne pathogens into new geographical regions. The primary goal of this study was to evaluate the prevalence of tick-borne pathogens in wild birds and ticks that feed on them as well as to determine the role of different species of birds in maintaining the tickborne infectious foci. We analysed the samples of 443 wild birds (60 species) and 378 ticks belonging to the genus Ixodes Latraille, 1795 collected from the wild birds, for detecting occurrence of eight tick-borne pathogens, the namely tick-borne encephalitis virus (TBEV), West Nile virus (WNV), and species of Borrelia, Rickettsia, Ehrlichia, Anaplasma, Bartonella and Babesia Starcovici, 1893, using RT-PCR/or PCR and enzyme immunoassay. One or more tick-borne infection markers were detected in 43 species of birds. All markers were detected in samples collected from fieldfare Turdus pilaris Linnaeus, Blyth’s reed warbler Acrocephalus dumetorum Blyth, common redstart Phoenicurus phoenicurus (Linnaeus), and common chaffinch Fringilla coelebs Linnaeus. Although all pathogens have been identified in birds and ticks, we found that in the majority of cases (75.5%), there were mismatches of pathogens in birds and ticks collected from them. Wild birds and their ticks may play an extremely important role in the dissemination of tick-borne pathogens into different geographical regions

The Forest Observation System, building a global reference dataset for remote sensing of forest biomass

International audienceForest biomass is an essential indicator for monitoring the Earth's ecosystems and climate. It is a critical input to greenhouse gas accounting, estimation of carbon losses and forest degradation, assessment of renewable energy potential, and for developing climate change mitigation policies such as REDD+, among others. Wall-to-wall mapping of aboveground biomass (aGB) is now possible with satellite remote sensing (RS). However, RS methods require extant, up-to-date, reliable, representative and comparable in situ data for calibration and validation. Here, we present the Forest Observation System (FOS) initiative, an international cooperation to establish and maintain a global in situ forest biomass database. aGB and canopy height estimates with their associated uncertainties are derived at a 0.25 ha scale from field measurements made in permanent research plots across the world's forests. all plot estimates are geolocated and have a size that allows for direct comparison with many RS measurements. The FOS offers the potential to improve the accuracy of RS-based biomass products while developing new synergies between the RS and ground-based ecosystem research communities

Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway

A (series) range of potential dimorpholinoquinazoline-based inhibitors of the PI3K/Akt/mTOR cascade was synthesized. Several compounds exhibited cytotoxicity towards a panel of cancer cell lines in the low and sub-micromolar range. Compound 7c with the highest activity and moderate selectivity towards MCF7 cells which express the mutant type of PI3K was also tested for the ability to inhibit PI3K-(signaling pathway) downstream effectors and associated proteins. Compound 7c inhibited the phosphorylation of Akt, mTOR, and S6K at 125–250 nM. It also triggered PARP1 cleavage, ROS production, and cell death via several mechanisms. Inhibition of PI3Kα was observed at a concentration of 7b 50 µM and of 7c 500 µM and higher, that can indicate minority PI3Kα as a target among other kinases in the titled cascade for 7c. In vivo studies demonstrated an inhibition of tumor growth in the colorectal tumor model. According to the docking studies, the replacement of the triazine core in gedatolisib (8) by a quinazoline fragment, and incorporation of a (hetero)aromatic unit connected with the carbamide group via a flexible spacer, can result in more selective inhibition of the PI3Kα isoform

The Forest Observation System, building a global reference dataset for remote sensing of forest biomass

Forest biomass is an essential indicator for monitoring the Earth's ecosystems and climate. It is a critical input to greenhouse gas accounting, estimation of carbon losses and forest degradation, assessment of renewable energy potential, and for developing climate change mitigation policies such as REDD+, among others. Wall-to-wall mapping of aboveground biomass (AGB) is now possible with satellite remote sensing (RS). However, RS methods require extant, up-to-date, reliable, representative and comparable in situ data for calibration and validation. Here, we present the Forest Observation System (FOS) initiative, an international cooperation to establish and maintain a global in situ forest biomass database. AGB and canopy height estimates with their associated uncertainties are derived at a 0.25 ha scale from field measurements made in permanent research plots across the world's forests. All plot estimates are geolocated and have a size that allows for direct comparison with many RS measurements. The FOS offers the potential to improve the accuracy of RS- based biomass products while developing new synergies between the RS and ground-based ecosystem research communities.</p

Transverse momentum and pseudorapidity distributions of charged hadrons in pp collisions at (s)\sqrt(s) = 0.9 and 2.36 TeV

Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at sqrt(s) = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(charged)/d(eta) for |eta| < 0.5, are 3.48 +/- 0.02 (stat.) +/- 0.13 (syst.) and 4.47 +/- 0.04 (stat.) +/- 0.16 (syst.), respectively. The results at 0.9 TeV are in agreement with previous measurements and confirm the expectation of near equal hadron production in p-pbar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date