84 research outputs found
Satisfaction with Care among Residents and Families in a Long-Term and Complex Continuing Care Organization
This article looks at one organization’s implementation of a satisfaction survey for all of its residents. It also explores how satisfaction ratings vary between complex continuing care (CCC) and long-term care (LTC) residents between residents with and without dementia.
Satisfaction with care at St. Joseph’s Health Centre (SJHC) Guelph was measured during the fall and winter of 2004/2005. A total of 107 residents and patients from both LTC and CCC were interviewed and 141 family members returned mailed surveys. Overall quality of care was rated highly by both residents and families. There were no statistically significant differences comparing LTC and CCC residents and only one comparing those with and without dementia. Within the area of medical care, 57.7% of residents with dementia compared to 78.0% of residents without dementia agreed they received therapy when needed (p=.03).
This information has been very valuable to SJHC staff and administrators as they strive to improve their quality of care. The project also highlights the important work that can be achieved through collaborations between researchers and health care providers
18: Local Control in Young Women with Early-Stage Breast Cancer Treated with Hypofractionated whole Breast Radiotherapy
A Crisis in the Farming Community: A Pathway to Acceptable, Accessible and Available Mental Health Care in Rural Minnesota
Minnesota relies on farmers to put food on our tables and to help drive our economy. The chronic stressors associated with an unstable farm economy is taking its toll on farm families all across Minnesota. Chronic stress can contribute to marital tensions, domestic violence, work disruption, depression, anxiety, and suicide. Minnesota has only 1 mental health counselor dedicated to doing outreach and crisis counseling to farm families. Many mental health professionals lack competency in working in rural communities, including understanding farm related stressors. Minnesota is doing some things right, like the Minnesota Farm and Rural Help Line. But, it needs to do more to strategically invest in effective and innovative approaches that improve acceptability, accessibility, and availability of mental health services and supports to farm families across Minnesota
Introducing the importance and difficulties of a three-step approach to improve nonadherence to antihypertensive drugs:A case series
Nonadherence to antihypertensive drugs is an important reason for not reaching blood pressure goals. A possible method to improve nonadherence involves three essential steps: identification of nonadherent patients (step 1), determination of underlying causes (step 2) and a personalized solution (step 3). We present three unique cases to show the importance and difficulties of this three-step approach. Patients participated in a randomized controlled trial to improve nonadherence to antihypertensive drugs (RHYME-RCT, Dutch Trial Register NL6736). Drug level measurements were used to identify nonadherence to antihypertensive drugs and communication on drug levels was supported by a tailored feedback tool in these patients. These cases showed that a three-step approach of identifying nonadherence and determination of the underlying cause, can lead to a personalized solution to improve therapy even when nonadherence was excluded. Open communication with patients remains an essential part when improving nonadherence
In-Datacenter Performance Analysis of a Tensor Processing Unit
Many architects believe that major improvements in cost-energy-performance
must now come from domain-specific hardware. This paper evaluates a custom
ASIC---called a Tensor Processing Unit (TPU)---deployed in datacenters since
2015 that accelerates the inference phase of neural networks (NN). The heart of
the TPU is a 65,536 8-bit MAC matrix multiply unit that offers a peak
throughput of 92 TeraOps/second (TOPS) and a large (28 MiB) software-managed
on-chip memory. The TPU's deterministic execution model is a better match to
the 99th-percentile response-time requirement of our NN applications than are
the time-varying optimizations of CPUs and GPUs (caches, out-of-order
execution, multithreading, multiprocessing, prefetching, ...) that help average
throughput more than guaranteed latency. The lack of such features helps
explain why, despite having myriad MACs and a big memory, the TPU is relatively
small and low power. We compare the TPU to a server-class Intel Haswell CPU and
an Nvidia K80 GPU, which are contemporaries deployed in the same datacenters.
Our workload, written in the high-level TensorFlow framework, uses production
NN applications (MLPs, CNNs, and LSTMs) that represent 95% of our datacenters'
NN inference demand. Despite low utilization for some applications, the TPU is
on average about 15X - 30X faster than its contemporary GPU or CPU, with
TOPS/Watt about 30X - 80X higher. Moreover, using the GPU's GDDR5 memory in the
TPU would triple achieved TOPS and raise TOPS/Watt to nearly 70X the GPU and
200X the CPU.Comment: 17 pages, 11 figures, 8 tables. To appear at the 44th International
Symposium on Computer Architecture (ISCA), Toronto, Canada, June 24-28, 201
Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape
The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
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