Theory of mind impairment in patients with behavioural variant fronto-temporal dementia (bv-FTD) increases caregiver burden

Background: Theory of mind (ToM), the capacity to infer the intention, beliefs and emotional states of others, is frequently impaired in behavioural variant fronto-temporal dementia patients (bv-FTDp); however, its impact on caregiver burden is unexplored. Setting: National Institute of Neurological Disorders and Stroke, National Institutes of Health. Subjects: bv-FTDp (n = 28), a subgroup of their caregivers (n = 20) and healthy controls (n = 32). Methods: we applied a faux-pas (FP) task as a ToM measure in bv-FTDp and healthy controls and the Zarit Burden Interview as a measure of burden in patients' caregivers. Patients underwent structural MRI; we used voxel-based morphometry to examine relationships between regional atrophy and ToM impairment and caregiver burden. Results: FP task performance was impaired in bv-FTDp and negatively associated with caregiver burden. Atrophy was found in areas involved in ToM. Caregiver burden increased with greater atrophy in left lateral premotor cortex, a region associated in animal models with the presence of mirror neurons, possibly involved in empathy. Conclusion: ToM impairment in bv-FTDp is associated with increased caregiver burde

Core Competencies in Civic Engagement

A review and synthesis of key competencies contained in national-level reports on Civic Engagement, academic programs engaged in community-based models of teaching, learning and research, including a review of the literature and almost 30 academic civic engagement programs around the country

The Forum: Fall 2007

Fall 2007 journal of the Honors Program at the University of North Dakota. The issue includes stories, poems, essays and art by undergraduate students.https://commons.und.edu/und-books/1040/thumbnail.jp

Detection of Ongoing Mass Loss from HD 63433c, a Young Mini-Neptune

We detect Lyα absorption from the escaping atmosphere of HD 63433c, a R = 2.67R⊕, P = 20.5 day mini-Neptune orbiting a young (440 Myr) solar analog in the Ursa Major Moving Group. Using Hubble Space Telescope (HST)/Space Telescope Imaging Spectrograph, we measure a transit depth of 11.1 ± 1.5% in the blue wing and 8 ± 3% in the red. This signal is unlikely to be due to stellar variability, but should be confirmed by an upcoming second transit observation with HST. We do not detect Lyα absorption from the inner planet, a smaller R = 2.15R⊕ mini-Neptune on a 7.1 day orbit. We use Keck/NIRSPEC to place an upper limit of 0.5% on helium absorption for both planets. We measure the host star\u27s X-ray spectrum and mid-ultraviolet flux with XMM-Newton, and model the outflow from both planets using a 3D hydrodynamic code. This model provides a reasonable match to the light curve in the blue wing of the Lyα line and the helium nondetection for planet c, although it does not explain the tentative red wing absorption or reproduce the excess absorption spectrum in detail. Its predictions of strong Lyα and helium absorption from b are ruled out by the observations. This model predicts a much shorter mass-loss timescale for planet b, suggesting that b and c are fundamentally different: while the latter still retains its hydrogen/helium envelope, the former has likely lost its primordial atmosphere

Detection of ongoing mass loss from HD 63433c, a young mini-Neptune

L.D.S. and D.E. acknowledge that this project received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (project Four Aces grant agreement No. 724427), and it has been carried out in the frame of the National Centre for Competence in Research PlanetS supported by the Swiss National Science Foundation (SNSF). T.G.W. acknowledges support from STFC consolidated grant No. ST/R000824/1. S.H. acknowledges CNES funding through the grant 837319. S.H. acknowledges CNES funding through the grant 837319. G.W.H. acknowledges long-term support of the APT program from NASA, NSF, Tennessee State University, and the State of Tennessee through its Centers of Excellence Program.We detect Lyα absorption from the escaping atmosphere of HD 63433c, a R = 2.67R⊕, P = 20.5 day mini-Neptune orbiting a young (440 Myr) solar analog in the Ursa Major Moving Group. Using Hubble Space Telescope (HST)/Space Telescope Imaging Spectrograph, we measure a transit depth of 11.1 ± 1.5% in the blue wing and 8 ± 3% in the red. This signal is unlikely to be due to stellar variability, but should be confirmed by an upcoming second transit observation with HST. We do not detect Lyα absorption from the inner planet, a smaller R = 2.15R⊕ mini-Neptune on a 7.1 day orbit. We use Keck/NIRSPEC to place an upper limit of 0.5% on helium absorption for both planets. We measure the host star’s X-ray spectrum and mid-ultraviolet flux with XMM-Newton, and model the outflow from both planets using a 3D hydrodynamic code. This model provides a reasonable match to the light curve in the blue wing of the Lyα line and the helium nondetection for planet c, although it does not explain the tentative red wing absorption or reproduce the excess absorption spectrum in detail. Its predictions of strong Lyα and helium absorption from b are ruled out by the observations. This model predicts a much shorter mass-loss timescale for planet b, suggesting that b and c are fundamentally different: while the latter still retains its hydrogen/helium envelope, the former has likely lost its primordial atmosphere.Publisher PDFPeer reviewe

Trait Rumination Influences Neural Correlates of the Anticipation but Not the Consumption Phase of Reward Processing

Cumulative evidence suggests that trait rumination can be defined as an abstract information processing mode, which leads people to constantly anticipate the likely impact of present events on future events and experiences. A previous study with remitted depressed patients suggested that enhanced rumination tendencies distort brain mechanisms of anticipatory processes associated with reward and loss cues. In the present study, we explored the impact of trait rumination on neural activity during reward and loss anticipation among never-depressed people. We analyzed the data of 37 healthy controls, who performed the monetary incentive delay (MID) task which was designed for the simultaneous measurement of the anticipation (motivational) and consumption (hedonic) phase of reward processing, during functional magnetic resonance imaging (fMRI). Our results show that rumination-after controlling for age, gender, and current mood-significantly influenced neural responses to reward (win) cues compared to loss cues. Blood-oxygenation-level-dependent (BOLD) activity in the left inferior frontal gyrus (IFG) triangularis, left anterior insula, and left rolandic operculum was positively related to Ruminative Response Scale (RRS) scores. We did not detect any significant rumination-related activations associated with win-neutral or loss-neutral cues and with reward or loss consumption. Our results highlight the influence of trait rumination on reward anticipation in a non-depressed sample. They also suggest that for never-depressed ruminators rewarding cues are more salient than loss cues. BOLD response during reward consumption did not relate to rumination, suggesting that rumination mainly relates to processing of the motivational (wanting) aspect of reward rather than the hedonic (liking) aspect, at least in the absence of pathological mood

A chemical survey of exoplanets with ARIEL

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN