The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Property and Contract Rights in Autocracies and Democracies

We present and test empirically a new theory of property and contract rights. Any incentive an autocrat has to respect such rights comes from his interest in future tax collections and national income and increases with his planning horizon. We find a compelling empirical relationship between property and contract rights and an autocrat's time in power. In lasting -- but not in new -- democracies, the same rule of law and individual rights that ensure continued free elections entail extensive property and contract rights. We show that the age of a democratic system is strongly correlated with property and contract rights

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

It\u27s Time to Create a Bay Area Regional Government

The San Francisco Bay Area and its six million people face an increasing number of urban problems that cannot be solved by its present form of government. Traffic congestion, ineffective public transportation, pollution, growing mounds of garbage, lack of affordable housing, decreasing open space, and dwindling water supplies are just some of the problems facing Bay Area residents. All of these problems are regional in nature and cannot be solved by individual cities or counties. Yet, the Bay Area has no governing body with the power to address the region\u27s collective problems. Instead, the Bay Area continues to try to solve these problems locally, through its nine county governments, ninety-eight municipal governments, and a number of large special districts. This Note argues that a limited form of regional government must be created to address the Bay Area\u27s regional problems. It examines the Bay Area\u27s past efforts to create a regional government and how these efforts have failed, largely for political reasons. The author then examines the various types of regional governments that exist, including those in Miami, Toronto, and Minneapolis-St. Paul, all of which have been largely successful. The author proposes that the state legislature create a federation type of regional government for the Bay Area, modeled after Metropolitan Toronto, and examines how the new government would survive a legal challenge under California\u27s home rule doctrine

Investigating the unification of LOFAR-detected powerful AGN in the Boötes field

Low radio frequency surveys are important for testing unified models of radio-loud quasars and radio galaxies. Intrinsically similar sources that are randomly oriented on the sky will have different projected linear sizes. Measuring the projected linear sizes of these sources provides an indication of their orientation. Steep-spectrum isotropic radio emission allows for orientation-free sample selection at low radio frequencies. We use a new radio survey of the Bo\"otes field at 150 MHz made with the Low Frequency Array (LOFAR) to select a sample of radio sources. We identify 44 radio galaxies and 16 quasars with powers $P>10^{25.5}$ W Hz$^{-1}$ at 150 MHz using cross-matched multi-wavelength information from the AGN and Galaxy Evolution Survey (AGES), which provides spectroscopic redshifts. We find that LOFAR-detected radio sources with steep spectra have projected linear sizes that are on average 4.4$\pm$1.4 larger than those with flat spectra. The projected linear sizes of radio galaxies are on average 3.1$\pm$1.0 larger than those of quasars (2.0$\pm$0.3 after correcting for redshift evolution). Combining these results with three previous surveys, we find that the projected linear sizes of radio galaxies and quasars depend on redshift but not on power. The projected linear size ratio does not correlate with either parameter. The LOFAR data is consistent within the uncertainties with theoretical predictions of the correlation between the quasar fraction and linear size ratio, based on an orientation-based unification scheme.Comment: 14 pages, accepted for publication in MNRA