Quality Improvement of Substance Misuse Screening of Older Adults in Primary Care Using Evidence-based Training

Background The largest increase in preventable overdose deaths from 1999-2017 occurred among adults 50 and older, yet substance misuse among older adults is often not screened for or recognized in primary care settings. This oversight has been attributed to many factors, including age-related biases, unrecognized psychosocial and physiological differences, stigmatization, and a rapidly growing geriatric population. Objectives A quality improvement program using evidence-based educational training was implemented in a primary care setting with the intention to expand care knowledge and ultimately improve screening practices of older adults, especially those suffering from substance misuse. Design This quality improvement (QI) project used a pre-test and post-test to evaluate the effectiveness of an evidence-based educational intervention designed by the DNP student. Subjects Participants were recruited from a large community health center in West Virginia and invited to an educational session. Results A statistical significant improvement in post-test scores (p Conclusion The evidence-based training program used for this QI project is an effective, feasible, and cost efficient training tool to improve knowledge of the care of older adults in a primary care setting

TeV Scale Leptoquarks as a Signature of Standard--like Superstring Models

We show that there can be TeV scale scalar and fermionic leptoquarks with very weak Yukawa couplings in a generic standard--like superstring model. Leptoquark--(down--like) quark mixing though present, is not large enough to violate the unitarity bounds on the CKM matrix. The constraints on leptoquark masses and couplings from FCNCs are easily satisfied whereas those from baryon number violation may cause problems. The leptoquarks of the model are compared to the ones in $E_6$ Calabi--Yau and flipped $SU(5) \times U(1)$ models.Comment: 14 pages, uses phyzzx.tex, WIS-93/114/DEC-PH. (Section 2 is shortened, comparison to the flipped SU(5)XU(1) models added in Section 5 and six references added.

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite-specific thiol, by glutathione. Here we show that TcGPXI activity can also be linked to trypanothione reduction by an alternative pathway involving the thioredoxin-like protein tryparedoxin. The presence of this new pathway was first detected using dialyzed soluble fractions of parasite extract. Tryparedoxin was identified as the intermediate molecule following purification, sequence analysis, antibody studies, and reconstitution of the redox cycle in vitro. The system can be readily saturated by trypanothione, the rate-limiting step being the interaction of trypanothione with the tryparedoxin. Both tryparedoxin and TcGPXI operate by a ping-pong mechanism. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides. TcGPXI contains a carboxyl-terminal tripeptide (ARI) that could act as a targeting signal for the glycosome, a kinetoplastid-specific organelle. Using immunofluorescence, tagged fluorescent proteins, and biochemical fractionation, we have demonstrated that TcGPXI is localized to both the glycosome and the cytosol. The ability of TcGPXI to use alternative electron donors may reflect their availability at the corresponding subcellular sites

Electric Dipole Moment Constraints on Phases in the Constrained MSSM

We consider constraints on \cp-violating phases in the Constrained Minimal Supersymmetric Standard Model. We find that by combining cosmological limits on gaugino masses with experimental bounds on the neutron and electron electric dipole moments, we can constrain the phase of the Higgs mixing mass $\mu$ to be $|\theta_\mu| < \pi/10$, independent of choices of the other mass parameters in the model. The other \cp-violating phase $\theta_A$ is essentially unconstrained.Comment: 10 pages in LaTeX + 3 postscript figures, uses epsf.st

Crafting Partnerships: Exploring Student-Led Feminist Strategies for Community Literacy Projects

Relationships have served as a cornerstone to feminist research in community-based research and service learning sites, as feminist scholars have argued for co-constructing knowledges in these sites, while being attentive to the reciprocal nature of these relationships within any context of and for learning (Bayer, Grossman, & Dubois, 2015; Parks & Goldblatt, 2000; Novek, 1999). These relationships are especially crucial when feminists attempt to create real and sustained partnerships through mentoring in their community-based literacy site (DuBois & Karcher, 2005). We stress the value of cultivating sustained relationships, as oftentimes discourses surrounding service learning exhibit a level of engagement that is not sustained and/or does not adequately expose the workings of power and privilege in a systematic way (Deans, 2002). In light of our feminist motivations, we need to continuously create spaces to foreground the value of experience and take seriously the process of cultivating relationships with students in ways that are both ethical and accountable.https://nsuworks.nova.edu/shss_facbooks/1122/thumbnail.jp

Dynamical structure factor of a fermionic supersolid on an optical lattice

Interfacing unbiased quantum Monte Carlo simulations with state-of-art analytic continuation techniques, we obtain exact numerical results for dynamical density and spin correlations in the attractive Hubbard model, describing a spin-balanced two-dimensional cold Fermi gas on an optical lattice. We focus on half-filling, where on average one fermion occupies each lattice site, and the system displays an intriguing supersolid phase: a superfluid with a checkerboard density modulation. The coexistence of $U(1)$ broken symmetry and the density modulations makes this regime very challenging and interesting for the calculation of dynamical properties. We compare our unbiased results with state-of-the-art Generalized Random Phase Approximation calculations: both approaches agree on a well-defined low-energy Nambu-Goldstone collective mode in the density correlations, while the higher energy structures appear to differ significantly. We also observe an interesting high-energy spin mode. We argue that our results provide a robust benchmark for Generalized Random Phase Approximation techniques, which are widely considered to be the method of choice for dynamical correlations in Fermi gases. Also, our calculations yield new physical insight in the high-energy behavior of the dynamical structure factor of the attractive Hubbard model, which is a well known prototype lattice model for superconductors and is a fertile field to target the observation of collective modes in strongly correlated systems.Comment: 12 pages, 6 figures, post-print versio

Gestión del talento humano en el compromiso organizacional de los colaboradores de una empresa de mantenimiento, Lima - 2022

El trabajo de investigación propuesto lleva como título: Gestión del talento humano en el compromiso organizacional de los colaboradores de una empresa de mantenimiento, Lima-2022. Tuvo como propósito determinar la influencia entre las variables gestión del talento humano en el compromiso organizacional. Para sustentar la tesis de investigación se apeló a las bases teóricas de Chiavenato (2020) sobre la definición de la variable gestión del talento humano, además se mencionó a Meyer & Allen (1991) citando a Hurtado (2017) para definir a la variable compromiso organizacional. La metodología es de tipo básica, el diseño es no experimental, no se manipularon las variables de estudio siendo de corte transversal – correlacional causal. La población fue formada por 70 colaboradores que pertenecen a la empresa estudiada. El método aplicado fue hipotético deductivo, para la prueba de hipótesis se empelo la prueba de Chi-cuadrada. Como resultado obtenido fue que gestión del talento humano influye de forma baja al compromiso organizacional, en cuanto al logaritmo de verosimilitud es 16.774; siendo reforzado por p = 0,04 < 0.05

El juego en el aprendizaje significativo de los niños de la I.E.I. N°086 Divino Niño Jesús- Huacho, durante el año escolar 2019

El objetivo de este estudio es, determinar la influencia que ejerce el juego en el aprendizaje significativo de los niños de la I.E.E. No 086 Divino niño Jesús-Huacho, durante el año escolar 2019. Para este fin la pregunta de investigación es la siguiente: ¿De qué manera influye el juego en el aprendizaje significativo de los niños de la I.E.E. No 086 Divino niño Jesús-Huacho, durante el año escolar 2019? Al estudiar la lista de verificación del juego en el aprendizaje significativo, la misma que fue aplicada por el equipo de apoyo de los investigadores también adoptó el mismo método. En este caso, la lista de verificación consta de 21 ítems en una tabla de doble entrada y se evalúan 3 opciones en el nivel del estudiante. En un total de 150 estudiantes, la herramienta de recolección de datos se aplicó a 60 sujetos de muestra. Se analizan los siguientes aspectos: desarrollo psicomotor, desarrollo intelectual, desarrollo sociabilidad y desarrollo afectivo-emocional de la variable juego; y las dimensiones lo que se tiene que hacer y aprender, expectativas referentes al contexto del aprendizaje, expectativas respecto a los métodos de enseñanza y expectativas de valor respecto del profesor de la variable aprendizaje significativo. Teniendo esto en cuenta, se recomienda que los docentes no dejen de aprender, y busquen siempre mejores y mejores estrategias de enseñanza para llegar a los niños, para que los educandos obtengan los mejores resultados de aprendizaje