60 research outputs found

    Memorandum for Captain Perry from H.E. Keisker on Japanese Menace on Terminal Island

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    https://digital.sandiego.edu/hirabayashi_petitions/1015/thumbnail.jp

    Die Fledermaus

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    The 2013 performance of Die Fledermaus by the USU Opera Theatre. Colin Baldy was the guest director.https://digitalcommons.usu.edu/music_programs/1185/thumbnail.jp

    Never in Your Wildest Dreams

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    A compilation of Opera\u27s Fairytales and Fantasies, presented by the Department of Music featuring the USU Opera Theatre.https://digitalcommons.usu.edu/music_programs/1177/thumbnail.jp

    Kognitive Eingangsvoraussetzungen, Studienwahlmotive und Studienerfolg Studierender mit dem Berufsziel "Lehrperson" und anderer Studiengänge

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    Im Hinblick auf die Entwicklung von Handlungskompetenz werden bei Studierenden mit Berufsziel «Lehrperson» kognitive und nicht kognitive Eingangsvoraussetzungen zunehmend beachtet. Der Einfluss auf den Studienerfolg ist jedoch empirisch noch nicht hinreichend geklärt. Der vorliegende Beitrag untersucht anhand von Längsschnittdaten für zwei Deutschschweizer Gruppen von 74 Studierenden der Lehrpersonenbildung und 463 Studierenden anderer Studiengänge die Effekte von kognitiven Voraussetzungen und Studienwahlmotiven auf Bachelorabschlussnoten. Den Pfad- und Strukturgleichungsmodellen zufolge unterscheidet sich in den beiden Gruppen die Bedeutsamkeit einzelner Prädiktoren für den jeweiligen Studienerfolg

    Joyful and Triumphant: Celebrating the Holidays in Concert

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    Joyful and Triumphant is Utah State University\u27s winter 2012 concert, celebrating the holidays. The performance took place in the Kent Concert Hall.https://digitalcommons.usu.edu/music_programs/1175/thumbnail.jp

    Cerebellar gray and white matter volume and their relation with age and manual motor performance in healthy older adults

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    ObjectivesFunctional neuroimaging and voxel‐based morphometry studies have confirmed the important role of the cerebellum in motor behavior. However, little is known about the relationship between cerebellar gray (GMv) and white matter (WMv) volume and manual motor performance in aging individuals. This study aims to quantify the relationship between cerebellar tissue volume and manual motor performance.Experimental designTo gain more insight into cerebellar function and how it relates to the role of the primary motor cortex (M1), we related cerebellar GMv, WMv, and M1v to manual motor performance in 217 healthy older individuals. Left and right cerebellar GMv and WMv, and M1v were obtained using FreeSurfer. The following motor measures were obtained: grip force, tapping speed, bimanual visuomotor coordination, and manual dexterity.Principal observationsSignificant positive relationships were observed between cerebellar GMv and WMv and grip strength, right cerebellar WMv and right‐hand tapping speed, right cerebellar WMv and dexterity, M1v and grip strength, and right M1v and left‐hand dexterity, though effect sizes were small.ConclusionsOur results show that cerebellar GMv and WMv are differently associated with manual motor performance. These associations partly overlap with the brain‐behavior associations between M1 and manual motor performance. Not all observed associations were lateralized (i.e., ipsilateral cerebellar and contralateral M1v associations with motor performance), which could point to age‐related neural dedifferentiation. The current study provides new insights in the role of the cerebellum in manual motor performance. In consideration of the small effect sizes replication studies are needed to validate these results. Hum Brain Mapp 36:2352–2363, 2015. © 2015 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111082/1/hbm22775.pd

    IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4+ T-cells

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    Direct interaction between T-cells exerts a major influence on tissue immunity and inflammation across multiple body sites including the human gut, which is highly enriched in ‘unconventional’ lymphocytes such as γδ T-cells. We previously reported that microbial activation of human Vγ9/Vδ2+ γδ T-cells in the presence of the mucosal damage-associated cytokine IL-15 confers the ability to promote epithelial barrier defence, specifically via induction of IL-22 expression in conventional CD4+ T-cells. In the current report, we assessed whether other cytokines enriched in the gut milieu also functionally influence microbe-responsive Vγ9/Vδ2 T-cells. When cultured in the presence of IL-21, Vγ9/Vδ2 T-cells acquired the ability to induce expression of the immunoregulatory cytokine IL-10 in both naïve and memory CD4+ T-cells, at levels surpassing those induced by monocytes or monocyte-derived DCs. These findings identify an unexpected influence of IL-21 on Vγ9/Vδ2 T-cell modulation of CD4+ T-cell responses. Further analyses suggested a possible role for CD30L and/or CD40L reverse signalling in mediating IL-10 induction by IL-21 conditioned Vγ9/Vδ2 T-cells. Our findings indicate that the local microenvironment exerts a profound influence on Vγ9/Vδ2 T-cell responses to microbial challenge, leading to induction of distinct functional profiles among CD4+ T-cells that may influence inflammatory events at mucosal surfaces. Targeting these novel pathways may offer therapeutic benefit in disorders such as inflammatory bowel disease

    Observing Virtual Arms that You Imagine Are Yours Increases the Galvanic Skin Response to an Unexpected Threat

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    Multi-modal visuo-tactile stimulation of the type performed in the rubber hand illusion can induce the brain to temporarily incorporate external objects into the body image. In this study we show that audio-visual stimulation combined with mental imagery more rapidly elicits an elevated physiological response (skin conductance) after an unexpected threat to a virtual limb, compared to audio-visual stimulation alone. Two groups of subjects seated in front of a monitor watched a first-person perspective view of slow movements of two virtual arms intercepting virtual balls rolling towards the viewer. One group was instructed to simply observe the movements of the two virtual arms, while the other group was instructed to observe the virtual arms and imagine that the arms were their own. After 84 seconds the right virtual arm was unexpectedly “stabbed” by a knife and began “bleeding”. This aversive stimulus caused both groups to show a significant increase in skin conductance. In addition, the observation-with-imagery group showed a significantly higher skin conductance (p<0.05) than the observation-only group over a 2-second period shortly after the aversive stimulus onset. No corresponding change was found in subjects' heart rates. Our results suggest that simple visual input combined with mental imagery may induce the brain to measurably temporarily incorporate external objects into its body image

    The cognitive neuroscience of prehension: recent developments

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    Prehension, the capacity to reach and grasp, is the key behavior that allows humans to change their environment. It continues to serve as a remarkable experimental test case for probing the cognitive architecture of goal-oriented action. This review focuses on recent experimental evidence that enhances or modifies how we might conceptualize the neural substrates of prehension. Emphasis is placed on studies that consider how precision grasps are selected and transformed into motor commands. Then, the mechanisms that extract action relevant information from vision and touch are considered. These include consideration of how parallel perceptual networks within parietal cortex, along with the ventral stream, are connected and share information to achieve common motor goals. On-line control of grasping action is discussed within a state estimation framework. The review ends with a consideration about how prehension fits within larger action repertoires that solve more complex goals and the possible cortical architectures needed to organize these actions
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