263 research outputs found
The low-frequency response in the surface superconducting state of ZrB single crystal}
The large nonlinear response of a single crystal ZrB to an ac field
(frequency 40 - 2500 Hz) for has been observed. Direct
measurements of the ac wave form and the exact numerical solution of the
Ginzburg-Landau equations, as well as phenomenological relaxation equation,
permit the study of the surface superconducting states dynamics. It is shown,
that the low frequency response is defined by transitions between the
metastable superconducting states under the action of an ac field. The
relaxation rate which determines such transitions dynamics, is found.Comment: 7 pages, 11 figure
Multi-particle decoherence free subspaces in extended systems
We develop a method to determine spatial configurations to realize decoherence-free subspaces for spatially extended multi-particle systems. We have assumed normal reservoir behavior including translational invariance of the reservoir and preparation in stationary states or mixture thereof and weak Markovian system-reservoir coupling that requires energy transfer. One important outcome of our method is a proof that there does not exist a multi-particle decoherence-free subspace in such systems except in the limit that the spatial extent of the system becomes infinitesimal
Geodetic Brane Gravity
Within the framework of geodetic brane gravity, the Universe is described as
a 4-dimensional extended object evolving geodetically in a higher dimensional
flat background. In this paper, by introducing a new pair of canonical fields
{lambda, P_{lambda}}, we derive the quadratic Hamiltonian for such a brane
Universe; the inclusion of matter then resembles minimal coupling. Second class
constraints enter the game, invoking the Dirac bracket formalism. The algebra
of the first class constraints is calculated, and the BRST generator of the
brane Universe turns out to be rank-1. At the quantum level, the road is open
for canonical and/or functional integral quantization. The main advantages of
geodetic brane gravity are: (i) It introduces an intrinsic, geometrically
originated, 'dark matter' component, (ii) It offers, owing to the Lorentzian
bulk time coordinate, a novel solution to the 'problem of time', and (iii) It
enables calculation of meaningful probabilities within quantum cosmology
without any auxiliary scalar field. Intriguingly, the general relativity limit
is associated with lambda being a vanishing (degenerate) eigenvalue.Comment: 23 pages, 1 figure, minor change
Black Holes in Higher-Dimensional Gravity
These lectures review some of the recent progress in uncovering the phase
structure of black hole solutions in higher-dimensional vacuum Einstein
gravity. The two classes on which we focus are Kaluza-Klein black holes, i.e.
static solutions with an event horizon in asymptotically flat spaces with
compact directions, and stationary solutions with an event horizon in
asymptotically flat space. Highlights include the recently constructed
multi-black hole configurations on the cylinder and thin rotating black rings
in dimensions higher than five. The phase diagram that is emerging for each of
the two classes will be discussed, including an intriguing connection that
relates the phase structure of Kaluza-Klein black holes with that of
asymptotically flat rotating black holes.Comment: latex, 49 pages, 5 figures. Lectures to appear in the proceedings of
the Fourth Aegean Summer School, Mytiline, Lesvos, Greece, September 17-22,
200
Ultraslow spreading and volcanism at the eastern end of Gakkel Ridge, Arctic Ocean
Ultraslow spreading ridges are poorly understood plate boundaries consisting of magmatic and amagmatic segments that expose mostly mantle peridotite and only traces of basalt and gabbro. The slowest part of the global spreading system is represented by the eastern Gakkel Ridge in the Central Arctic Ocean, where crustal accretion is characterized by extreme focusing of melt to discrete magmatic centers. Close to its eastern tip lies the unusual 5,310 m deep Gakkel Rift Deep (GRD) with limited sediment infill, which is in strong contrast to the broader sediment-filled rift valleys to the east and west. Here, we report an 40Ar/39Ar age of 3.65±0.01 Ma for a pillow basalt from a seamount located on the rim the GRD confirming ultraslow spreading rates of ~7 mm/yr close to the Laptev Sea as suggested from aeromagnetic data. Its geochemistry points to an alkaline lava, attributed to partial melting of a source that underwent prior geochemical enrichment. We note that the GRD extracts compositionally similar melts as the sparsely magmatic zone further west but at much slower spreading velocities of only ~6-7 mm/yr, indicating the widespread occurrence of similarly fertile mantle in the High Arctic. This enriched source differs from sub-continental lithospheric mantle that influences magmatism along the Western Volcanic Zone (Goldstein et al. 2008) and is similar to metasomatized mantle - shown to influence melt genesis along the Eastern Volcanic Zone
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition
Demonstration of Fuel Hot-Spot Pressure in Excess of 50 Gbar for Direct-Drive, Layered Deuterium-Tritium Implosions on OMEGA
A record fuel hot-spot pressure P[subscript hs] = 56±7 Gbar was inferred from x-ray and nuclear diagnostics for direct-drive inertial confinement fusion cryogenic, layered deuterium–tritium implosions on the 60-beam, 30-kJ, 351-nm OMEGA Laser System. When hydrodynamically scaled to the energy of the National Ignition Facility, these implosions achieved a Lawson parameter ∼60% of the value required for ignition [A. Bose et al., Phys. Rev. E 93, LM15119ER (2016)], similar to indirect-drive implosions [R. Betti et al., Phys. Rev. Lett. 114, 255003 (2015)], and nearly half of the direct-drive ignition-threshold pressure. Relative to symmetric, one-dimensional simulations, the inferred hot-spot pressure is approximately 40% lower. Three-dimensional simulations suggest that low-mode distortion of the hot spot seeded by laser-drive nonuniformity and target-positioning error reduces target performance.United States. Department of Energy (DE-NA0001944
Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population
DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas
Background: Few studies have attempted to characterise genomic changes occurring in hereditary epithelial ovarian carcinomas
(EOCs) and inconsistent results have been obtained. Given the relevance of DNA copy number alterations in ovarian oncogenesis
and growing clinical implications of the BRCA-gene status, we aimed to characterise the genomic profiles of hereditary and
sporadic ovarian tumours.
Methods: High-resolution array Comparative Genomic Hybridisation profiling of 53 familial (21 BRCA1, 6 BRCA2 and 26 non-
BRCA1/2) and 15 sporadic tumours in combination with supervised and unsupervised analysis was used to define common and/or
specific copy number features.
Results: Unsupervised hierarchical clustering did not stratify tumours according to their familial or sporadic condition or to their
BRCA1/2 mutation status. Common recurrent changes, spanning genes potentially fundamental for ovarian carcinogenesis,
regardless of BRCA mutations, and several candidate subtype-specific events were defined. Despite similarities, greater
contribution of losses was revealed to be a hallmark of BRCA1 and BRCA2 tumours.
Conclusion: Somatic alterations occurring in the development of familial EOCs do not differ substantially from the ones occurring
in sporadic carcinomas. However, some specific features like extensive genomic loss observed in BRCA1/2 tumours may be of
clinical relevance helping to identify BRCA-related patients likely to respond to PARP inhibitorsThis study was funded by the Fondo de Investigacio´n
Sanitaria (FIS), Instituto de Salud Carlos III (grants CP07/00113
and PS09/01094
Genetic Determinants of Serum Testosterone Concentrations in Men
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as <300 ng/dl. Two single-nucleotide polymorphisms at the sex hormone-binding globulin (SHBG) locus (17p13-p12) were identified as independently associated with serum testosterone concentration (rs12150660, p = 1.2×10−41 and rs6258, p = 2.3×10−22). Subjects with ≥3 risk alleles of these variants had 6.5-fold higher risk of having low serum testosterone than subjects with no risk allele. The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p = 5.6×10−16). The rs6258 polymorphism in exon 4 of SHBG affected SHBG's affinity for binding testosterone and the measured free testosterone fraction (p<0.01). Genetic variants in the SHBG locus and on the X chromosome are associated with a substantial variation in testosterone concentrations and increased risk of low testosterone. rs6258 is the first reported SHBG polymorphism, which affects testosterone binding to SHBG and the free testosterone fraction and could therefore influence the calculation of free testosterone using law-of-mass-action equation
- …