Working at a remove: continuous, collective, and configurative approaches to qualitative secondary analysis

In this paper, we define and operationalise three modes of research engagement using qualitative secondary analysis (QSA). We characterise these forms of engagement as continuous, collective and configurative. Continuous QSA involves modes of engagement that centre on asking new questions of existing datasets to (re)apprehend empirical evidence, and develop continuous (or contiguous) samples in ways that principally leverage epistemic distance. Collective QSA characteristically involves generating dialogue between members of different research teams to establish comparisons and linkages across studies, and formulate new analytic directions harnessing relational distance. Configurative QSA refers to how existing data are brought into conversation with broader sources of theory and evidence, typically in ways which exploit greater temporal distance. In relation to each mode of engagement we discuss how processes of both (re)contextualisation and (re)connection offer opportunities for new analytical engagement through different combinations and degrees of proximity to, and distance from, the formative contexts of data production

Cosmology of Axions and Moduli: A Dynamical Systems Approach

This paper is concerned with string cosmology and the dynamics of multiple scalar fields in potentials that can become negative, and their features as (Early) Dark Energy models. Our point of departure is the "String Axiverse", a scenario that motivates the existence of cosmologically light axion fields as a generic consequence of string theory. We couple such an axion to its corresponding modulus. We give a detailed presentation of the rich cosmology of such a model, ranging from the setting of initial conditions on the fields during inflation, to the asymptotic future. We present some simplifying assumptions based on the fixing of the axion decay constant $f_a$, and on the effective field theory when the modulus trajectory is adiabatic, and find the conditions under which these assumptions break down. As a by-product of our analysis, we find that relaxing the assumption of fixed $f_a$ leads to the appearance of a new meta-stable de-Sitter region for the modulus without the need for uplifting by an additional constant. A dynamical systems analysis reveals the existence of many fixed point attractors, repellers and saddle points, which we analyse in detail. We also provide geometric interpretations of the phase space. The fixed points can be used to bound the couplings in the model. A systematic scan of certain regions of parameter space reveals that the future evolution of the universe in this model can be rich, containing multiple epochs of accelerated expansion.Comment: 27 pages, 12 figures, comments welcome, v2 minor correction

Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease topical collection on autoimmunity

Recent investigations have expanded our knowledge of the regulatory bone marrow (BM) niche, which is critical in maintaining and directing hematopoietic stem cell (HSC) self-renewal and differentiation. Osteoblasts, mesenchymal stem cells (MSCs), and CXCL12-abundant reticular (CAR) cells are niche components in close association with HSCs and have been more clearly defined in immune cell function and homeostasis. Importantly, cellular inhabitants of the BM niche signal through G protein-coupled surface receptors (GPCRs) for various appropriate immune functions. In this article, recent literature on BM niche inhabitants (HSCs, osteoblasts, MSCs, CAR cells) and their GPCR mechanistic interactions are reviewed for better understanding of the BM cells involved in immune development, immunologic disease, and current immune reconstitution therapies

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase

SummaryHER4/ErbB4 is a ubiquitously expressed member of the EGF/ErbB family of receptor tyrosine kinases that is essential for normal development of the heart, nervous system, and mammary gland. We report here crystal structures of the ErbB4 kinase domain in active and lapatinib-inhibited forms. Active ErbB4 kinase adopts an asymmetric dimer conformation essentially identical to that observed to be important for activation of the EGF receptor/ErbB1 kinase. Mutagenesis studies of intact ErbB4 in Ba/F3 cells confirm the importance of this asymmetric dimer for activation of intact ErbB4. Lapatinib binds to an inactive form of the ErbB4 kinase in a mode equivalent to its interaction with the EGF receptor. All ErbB4 residues contacted by lapatinib are conserved in the EGF receptor and HER2/ErbB2, which lapatinib also targets. These results demonstrate that key elements of kinase activation and inhibition are conserved among ErbB family members

Nova light curves from the Solar Mass Ejection Imager (SMEI) - II. The extended catalogue

We present the results from observing nine Galactic novae in eruption with the Solar Mass Ejection Imager (SMEI) between 2004 and 2009. While many of these novae reached peak magnitudes that were either at or approaching the detection limits of SMEI, we were still able to produce light curves that in many cases contained more data at and around the initial rise, peak, and decline than those found in other variable star catalogs. For each nova, we obtained a peak time, maximum magnitude, and for several an estimate of the decline time (t2). Interestingly, although of lower quality than those found in Hounsell et al. (2010a), two of the light curves may indicate the presence of a pre-maximum halt. In addition the high cadence of the SMEI instrument has allowed the detection of low amplitude variations in at least one of the nova light curves

The Prostate Care Questionnaire for Carers (PCQ-C): reliability, validity and acceptability

<p>Abstract</p> <p>Background</p> <p>Patient experience is commonly monitored in evaluating and improving health care, but the experience of carers (partners/relatives/friends) is rarely monitored even though the role of carers can often be substantial. For carers to fulfil their role it is necessary to address their needs. This paper describes an evaluation of the reliability, validity and acceptability of the PCQ-C, a newly developed instrument designed to measure the experiences of carers of men with prostate cancer.</p> <p>Methods</p> <p>The reliability, acceptability and validity of the PCQ-C were tested through a postal survey and interviews with carers. The PCQ-C was posted to 1087 prostate cancer patients and patients were asked to pass the questionnaire on to their carer. Non-responders received one reminder. To assess test-retest reliability, 210 carers who had responded to the questionnaire were resent it a second time three weeks later. A subsample of nine carers from patients attending one hospital took part in qualitative interviews to assess validity and acceptability of the PCQ-C. Acceptability to service providers was evaluated based on four hospitals' experiences of running a survey using the PCQ-C.</p> <p>Results</p> <p>Questionnaires were returned by 514 carers (47.3%), and the majority of questions showed less than 10% missing data. Across the sections of the questionnaire internal consistency was high (Cronbach's alpha ranging from 0.80 to 0.89), and test-retest stability showed moderate to high stability (intraclass correlation coefficients ranging from 0.52 to 0.83). Interviews of carers indicated that the PCQ-C was valid and acceptable. Feedback from hospitals indicated that they found the questionnaire useful, and highlighted important considerations for its future use as part of quality improvement initiatives.</p> <p>Conclusions</p> <p>The PCQ-C has been found to be acceptable to carers and service providers having been used successfully in hospitals in England. It is ready for use to measure the aspects of care that need to be addressed to improve the quality of prostate cancer care, and for research.</p

Solar-like oscillations in low-luminosity red giants: first results from Kepler

We have measured solar-like oscillations in red giants using time-series photometry from the first 34 days of science operations of the Kepler Mission. The light curves, obtained with 30-minute sampling, reveal clear oscillations in a large sample of G and K giants, extending in luminosity from the red clump down to the bottom of the giant branch. We confirm a strong correlation between the large separation of the oscillations (Delta nu) and the frequency of maximum power (nu_max). We focus on a sample of 50 low-luminosity stars (nu_max > 100 muHz, L <~ 30 L_sun) having high signal-to-noise ratios and showing the unambiguous signature of solar-like oscillations. These are H-shell-burning stars, whose oscillations should be valuable for testing models of stellar evolution and for constraining the star-formation rate in the local disk. We use a new technique to compare stars on a single echelle diagram by scaling their frequencies and find well-defined ridges corresponding to radial and non-radial oscillations, including clear evidence for modes with angular degree l=3. Measuring the small separation between l=0 and l=2 allows us to plot the so-called C-D diagram of delta nu_02 versus Delta nu. The small separation delta nu_01 of l=1 from the midpoint of adjacent l=0 modes is negative, contrary to the Sun and solar-type stars. The ridge for l=1 is notably broadened, which we attribute to mixed modes, confirming theoretical predictions for low-luminosity giants. Overall, the results demonstrate the tremendous potential of Kepler data for asteroseismology of red giants.Comment: accepted by ApJ Letters, to appear in special Kepler issue. Updated reference

Amplitudes and lifetimes of solar-like oscillations observed by CoRoT* Red-giant versus main-sequence stars

Context. The advent of space-borne missions such as CoRoT or Kepler providing photometric data has brought new possibilities for asteroseismology across the H-R diagram. Solar-like oscillations are now observed in many stars, including red giants and main- sequence stars. Aims. Based on several hundred identified pulsating red giants, we aim to characterize their oscillation amplitudes and widths. These observables are compared with those of main-sequence stars in order to test trends and scaling laws for these parameters for both main-sequence stars and red giants. Methods. An automated fitting procedure is used to analyze several hundred Fourier spectra. For each star, a modeled spectrum is fitted to the observed oscillation spectrum, and mode parameters are derived. Results. Amplitudes and widths of red-giant solar-like oscillations are estimated for several hundred modes of oscillation. Amplitudes are relatively high (several hundred ppm) and widths relatively small (very few tenths of a {\mu}Hz). Conclusions. Widths measured in main-sequence stars show a different variation with the effective temperature than red giants. A single scaling law is derived for mode amplitudes of both red giants and main-sequence stars versus their luminosity to mass ratio. However, our results suggest that two regimes may also be compatible with the observations.Comment: Accepted in A&A on 2011 February 8th, now includes corrections (results now more precise on \Gamma and A_max in Section 4.3 and 4.4, fig. 7 corrected consequently

The ATLAS SCT grounding and shielding concept and implementation

This paper presents a complete description of Virgo, the French-Italian gravitational wave detector. The detector, built at Cascina, near Pisa (Italy), is a very large Michelson interferometer, with 3 km-long arms. In this paper, following a presentation of the physics requirements, leading to the specifications for the construction of the detector, a detailed description of all its different elements is given. These include civil engineering infrastructures, a huge ultra-high vacuum (UHV) chamber (about 6000 cubic metres), all of the optical components, including high quality mirrors and their seismic isolating suspensions, all of the electronics required to control the interferometer and for signal detection. The expected performances of these different elements are given, leading to an overall sensitivity curve as a function of the incoming gravitational wave frequency. This description represents the detector as built and used in the first data-taking runs. Improvements in different parts have been and continue to be performed, leading to better sensitivities. These will be detailed in a forthcoming paper