Constraints on fluid flow processes in the Hellenic Accretionary Complex (eastern Mediterranean Sea) from numerical modeling

The dynamics of accretionary convergent margins are severely influenced by intense deformation and fluid expulsion. To quantify the fluid pressure and fluid flow velocities in the Hellenic subduction system, we set up 2-D hydrogeological numerical models following two seismic reflection lines across the Mediterranean Ridge. These profiles bracket the along-strike variation in wedge geometry: moderate compression and a >4 km thick underthrust sequence in the west versus enhanced compression and <1 km of downgoing sediment in the center. Input parameters were obtained from preexisting geophysical data, drill cores, and new geotechnical laboratory experiments. A permeability-porosity relationship was determined by a sensitivity analysis, indicating that porosity and intrinsic permeability are small. This hampers the expulsion of fluids and leads to the build up of fluid overpressure in the deeper portion of the wedge and in the underthrust sediment. The loci of maximum fluid pressure are mainly controlled by the compactional fluid source, which generally decreases toward the backstop. However, pore pressure is still high at the decollement level at distances <100 km from the deformation front, either by the incorporation of low permeability evaporites or additional compaction of the wedge sediments in the two profiles. In the west, however, formation of a wide accretionary complex is facilitated by high pore pressure zones. When compared to other large accretionary complexes such as Nankai or Barbados, our results not only show broad similarities but also that near-lithostatic pore pressures may be easier to maintain in the Hellenic Arc because of accentuated collision, some underthrust evaporates, and a thicker underthrust sequence

Some sharp inequalities for integral operators with homogeneous kernel

One goal of this paper is to show that a big number of inequalities for functions in L-p(R+), p >= 1, proved from time to time in journal publications are particular cases of some known general results for integral operators with homogeneous kernels including, in particular, the statements on sharp constants. Some new results are also included, e.g. the similar general equivalence result is proved and applied for 0 < p < 1. Some useful new variants of these results are pointed out and a number of known and new Hardy-Hilbert type inequalities are derived. Moreover, a new Polya-Knopp (geometric mean) inequality is derived and applied. The constants in all inequalities in this paper are sharp

The Devastating 2022 M6.2 Afghanistan Earthquake: Challenges, Processes, and Implications

On June 21st, a Mw6.2 earthquake struck the Afghan-Pakistan-border-region, situated within the India-Asia collision. Thousand thirty-nine deaths were reported, making the earthquake the deadliest of 2022. We investigate the event\u27s rupture processes by combining seismological and geodetic observations, aiming to understand what made it that fatal. Our Interferometric Synthetic Aperture Radar-constrained slip-model and regional moment-tensor inversion, confirmed through field observations, reveal a sinistral rupture with maximum slip of 1.8 m at 5 km depth on a N20°E striking, sub-vertical fault. We suggest that not only external factors (event-time, building stock) but fault-specific factors made the event excessively destructive. Surface rupture was favored by the rock foliation, coinciding with the fault strike. The distribution of Peak-Ground-Velocity was governed by the sub-vertical fault. Maximum slip was large compared to other events globally and might have resulted in peak-frequencies coinciding with resonance-frequencies of the local buildings and demonstrates the devastating impact of moderate-size earthquakes

White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke-results from the PROSCIS-B study

Background: White matter hyperintensities (WMH) are the result of cerebral small vessel disease and may increase the risk of cognitive impairment (CI), recurrent stroke, and depression. We aimed to explore the association between selected cerebrovascular risk factors (CVRF) and WMH load as well as the effect of increased WMH burden on recurrent vascular events, CI, and depression in first-ever ischemic stroke patients.Methods: 431 from the PROSpective Cohort with Incident Stroke (PROSCIS) were included; Age-Related White Matter Changes (ARWMC) score was used to assess WMH burden on FLAIR. The presence of CVRF (defined via blood pressure, body-mass-index, and serological markers of kidney dysfunction, diabetes mellitus, and hyperlipoproteinemia) was categorized into normal, borderline, and pathological profiles based on commonly used clinical definitions. The primary outcomes included recurrent vascular events (combined endpoint of recurrent stroke, myocardial infarction and/or death), CI 3 years post-stroke, and depression 1-year post-stroke.Results: There was no clear association between CVRF profiles and WMH burden. High WMH lesion load (ARWMC score ≥ 10) was found to be associated with CI (adjusted OR 1.05 [95% CI 1.00-1.11]; p Conclusion: Higher WMH burden was associated with a significant decline in cognition 3 years post-stroke in this cohort of first-ever stroke patients

The crust in the pamir: Insights from receiver functions

The Cenozoic convergence between India and Asia has created Earth's thickest crust in the Pamir‐Tibet Plateau by extreme crustal shortening. Here we study the crustal structure of the Pamir and western Tian Shan, the adjacent margins of the Tajik, Tarim, and Ferghana Basins, and the Hindu Kush, using data collected by temporary seismic experiments. We derive, compare, and combine independent observations from P and S receiver functions. The obtained Moho depth varies from ~40 km below the basins to a double‐normal thickness of 65–75 km underneath the Pamir and Hindu Kush. A Moho doublet—with the deeper interface down to a depth of ~90 km—coincides with the arc of intermediate‐depth seismicity underneath the Pamir, where Asian continental lower crust delaminates and rolls back. The crust beneath most of the Central and South Pamir has a low Vp/Vs ratio (<1.70), suggesting a dominantly felsic composition, probably a result of delamination/foundering of the mafic rocks of the lower crust. Beneath the Cenozoic gneiss domes of the Central and South Pamir, which represent extensional core complexes, the Vp/Vs ratios are moderate to high (~1.75), consistent with the previously observed, midcrustal low‐velocity zones, implying the presence of crustal partial melts. Even higher crustal average Vp/Vs ratios up to 1.90 are found in the sedimentary basins and along the Main Pamir Thrust. The ratios along the latter—the active thrust front of the Pamir—may reflect fluid accumulations within a strongly fractured fault system

Highly variable friction and slip observed at Antarctic ice stream bed

The slip of glaciers over the underlying bed is the dominant mechanism governing the migration of ice from land into the oceans, with accelerating slip contributing to sea-level rise. Yet glacier slip remains poorly understood, and observational constraints are sparse. Here we use passive seismic observations to measure both frictional shear stress and slip at the bed of the Rutford Ice Stream in Antarctica using 100,000 repetitive stick-slip icequakes. We find that basal shear stresses and slip rates vary from 10$^4$ to 10$^7$ Pa and 0.2 to 1.5 m per day, respectively. Friction and slip vary temporally over the order of hours, and spatially over 10s of metres, due to corresponding variations in effective normal stress and ice–bed interface material. Our findings suggest that the bed is substantially more complex than currently assumed in ice stream models and that basal effective normal stresses may be significantly higher than previously thought. Our observations can provide constraints on the basal boundary conditions for ice-dynamics models. This is critical for constraining the primary contribution of ice mass loss in Antarctica and hence for reducing uncertainty in sea-level rise projections

Toeplitz operators with radial symbols on weighted holomorphic Orlicz space

Peer reviewe

Evolution of Blood-Brain Barrier Permeability in Subacute Ischemic Stroke and Associations With Serum Biomarkers and Functional Outcome

Background and Purpose: In the setting of acute ischemic stroke, increased blood-brain barrier permeability (BBBP) as a sign of injury is believed to be associated with increased risk of poor outcome. Pre-clinical studies show that selected serum biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), matrix metallopeptidases (MMP), and vascular endothelial growth factors (VEGFs) may play a role in BBBP post-stroke. In the subacute phase of stroke, increased BBBP may also be caused by regenerative mechanisms such as vascular remodeling and therefore may improve functional recovery. Our aim was to investigate the evolution of BBBP in ischemic stroke using contrast-enhanced (CE) magnetic resonance imaging (MRI) and to analyze potential associations with blood-derived biomarkers as well as functional recovery in subacute ischemic stroke patients. Methods: This is an exploratory analysis of subacute ischemic stroke patients enrolled in the BAPTISe study nested within the randomized controlled PHYS-STROKE trial (interventions: 4 weeks of aerobic fitness training vs. relaxation). Patients with at least one CE-MRI before (v1) or after (v2) the intervention were eligible for this analysis. The prevalence of increased BBBP was visually assessed on T1-weighted MR-images based on extent of contrast-agent enhancement within the ischemic lesion. The intensity of increased BBBP was assessed semi-quantitatively by normalizing the mean voxel intensity within the region of interest (ROI) to the contralateral hemisphere ("normalized CE-ROI"). Selected serum biomarkers (high-sensitive CRP, IL-6, TNF-alpha, MMP-9, and VEGF) at v1 (before intervention) were analyzed as continuous and dichotomized variables defined by laboratory cut-off levels. Functional outcome was assessed at 6 months after stroke using the modified Rankin Scale (mRS). Results: Ninety-three patients with a median baseline NIHSS of 9 [IQR 6-12] were included into the analysis. The median time to v1 MRI was 30 days [IQR 18-37], and the median lesion volume on v1 MRI was 4 ml [IQR 1.2-23.4]. Seventy patients (80%) had increased BBBP visible on v1 MRI. After the trial intervention, increased BBBP was still detectable in 52 patients (74%) on v2 MRI. The median time to v2 MRI was 56 days [IQR 46-67]. The presence of increased BBBP on v1 MRI was associated with larger lesion volumes and more severe strokes. Aerobic fitness training did not influence the increase of BBBP evaluated at v2. In linear mixed models, the time from stroke onset to MRI was inversely associated with normalized CE-ROI (coefficient -0.002, Standard Error 0.007, p < 0.01). Selected serum biomarkers were not associated with the presence or evolution of increased BBBP. Multivariable regression analysis did not identify the occurrence or evolution of increased BBBP as an independent predictor of favorable functional outcome post-stroke. Conclusion: In patients with moderate-to-severe subacute stroke, three out of four patients demonstrated increased BBB permeability, which decreased over time. The presence of increased BBBP was associated with larger lesion volumes and more severe strokes. We could not detect an association between selected serum biomarkers of inflammation and an increased BBBP in this cohort. No clear association with favorable functional outcome was observed