267 research outputs found
Search for proton decay in the Frejus experiment
The status of the Frejus experiment and the preliminary results obtained in the search for nucleon decay are discussed. A modular, fine grain tracking calorimeter was installed in the Frejus laboratory in the period extending from October 1983 to May 1985. The 3300 cubic meter underground laboratory, located in the center of the Frejus tunnel in the Alps, is covered in the vertical direction by 1600 m of rocks (4400 m w.e.). The average number of atmospheric muons in the lab is 4.2 square meters per day. The 912 ton detector is made of 114 modules, each one including eight flash chamber and one Geiger vertical planes of (6 x 6) square meters dimensions. The flash chamber (and Geiger) planes are alternatively crossed to provide a 90 deg. stereo reconstruction. No candidate for the nucleon decay into charged lepton is found in the first sample of events
Combination, Modulation and Interplay of Modern Radiotherapy with the Tumor Microenvironment and Targeted Therapies in Pancreatic Cancer: Which Candidates to Boost Radiotherapy?
Pancreatic ductal adenocarcinoma cancer (PDAC) is a highly diverse disease with low tumor immunogenicity. PDAC is also one of the deadliest solid tumor and will remain a common cause of cancer death in the future. Treatment options are limited, and tumors frequently develop resistance to current treatment modalities. Since PDAC patients do not respond well to immune checkpoint inhibitors (ICIs), novel methods for overcoming resistance are being explored. Compared to other solid tumors, the PDAC's tumor microenvironment (TME) is unique and complex and prevents systemic agents from effectively penetrating and killing tumor cells. Radiotherapy (RT) has the potential to modulate the TME (e.g., by exposing tumor-specific antigens, recruiting, and infiltrating immune cells) and, therefore, enhance the effectiveness of targeted systemic therapies. Interestingly, combining ICI with RT and/or chemotherapy has yielded promising preclinical results which were not successful when translated into clinical trials. In this context, current standards of care need to be challenged and transformed with modern treatment techniques and novel therapeutic combinations. One way to reconcile these findings is to abandon the concept that the TME is a well-compartmented population with spatial, temporal, physical, and chemical elements acting independently. This review will focus on the most interesting advancements of RT and describe the main components of the TME and their known modulation after RT in PDAC. Furthermore, we will provide a summary of current clinical data for combinations of RT/targeted therapy (tRT) and give an overview of the most promising future directions
Study of 2 beta-decay of Mo-100 and Se-82 using the NEMO3 detector
After analysis of 5797 h of data from the detector NEMO3, new limits on neutrinoless double beta decay of Mo-100 (T-1/2 > 3.1 x 10(23) y, 90% CL) and Se-82 (T-1/2 > 1.4 x 10(23) y, 90% CL) have been obtained. The corresponding limits on the effective majorana neutrino mass are: 1.4 x 10(22) y (90% CL) for Mo-100 and T-1/2 > 1.2 x 10(22) y (90% CL) for Se-82. Corresponding bounds on the Majoron-neutrino coupling constant are < (0.5-0.9) x 10(- 4) and <(0.7-1.6) x 10(- 4). Two-neutrino 2beta-decay half-lives have been measured with a high accuracy, (T1/2Mo)-Mo-100 = [7.68 +/- 0.02(stat) +/- 0.54(syst)] x 10(18) y and (T1/2Se)-Se-82 = [10.3 +/- 0.3(stat) +/- 0.7(syst)] x 10(19) y. (C) 2004 MAIK "Nauka/Interperiodica"
Measurement of double beta decay of ¹⁰⁰Mo to excited states in the NEMO 3 experiment
The double beta decay of ¹⁰⁰Mo to the 0_{1}^{+} and 2_{1}^{+} excited states of ¹⁰⁰Ru is studied using the NEMO 3 data. After the analysis of 8024 h of data the half-life for the two-neutrino double beta decay of ¹⁰⁰Mo to the excited 0_{1}^{+} state is measured to be T_{1/2}^{2v} = [5.7_{-0.9}^{+1.3} (stat.) ± 0.8 (syst.)] x 10²⁰ y. The signal-to-background ratio is equal to 3. Information about energy and angular distributions of emitted electrons is also obtained. No evidence for neutrinoless double beta decay to the excited 0_{1}^{+} state has been found. The corresponding half-life limit is T_{1/2}^{0v} (0⁺→0_{1}^{+}) > 8.9 x 10²² y (at 90% C.L.). The search for the double beta decay to the 2_{1}^{+} excited state has allowed the determination of limits on the half-life for the two neutrino mode T_{1/2}^{0v} (0⁺→2_{1}^{+}) > 1.1 x 10²¹ y (at 90% C.L.) and for the neutrinoless mode T_{1/2}^{0v} (0⁺→2_{1}^{+}) > 1.6 x 10²³ y (at 90% C.L.)
Possible background reductions in double beta decay experiments
The background induced by radioactive impurities of and
in the source of the double beta experiment NEMO-3 has been
investigated. New methods of data analysis which decrease the background from
the above mentioned contamination are identified. The techniques can also be
applied to other double beta decay experiments capable of measuring
independently the energies of the two electrons.Comment: 15 pages, 13 figures, accepted in the Nuclear Instruments and Methods
Study of 2b-decay of Mo-100 and Se-82 using the NEMO3 detector
After analysis of 5797 h of data from the detector NEMO3, new limits on
neutrinoless double beta decay of Mo-100 (T_{1/2} > 3.1 10^{23} y, 90% CL) and
Se-82 (T_{1/2} > 1.4 10^{23} y, 90% CL) have been obtained. The corresponding
limits on the effective majorana neutrino mass are: m < (0.8-1.2) eV and m <
(1.5-3.1) eV, respectively. Also the limits on double-beta decay with Majoron
emission are: T_{1/2} > 1.4 10^{22} y (90% CL) for Mo-100 and T_{1/2}> 1.2
10^{22} y (90%CL) for Se-82. Corresponding bounds on the Majoron-neutrino
coupling constant are g < (0.5-0.9) 10^{-4} and < (0.7-1.6) 10^{-4}.
Two-neutrino 2b-decay half-lives have been measured with a high accuracy,
T_{1/2} Mo-100 = [7.68 +- 0.02(stat) +- 0.54(syst) ] 10^{18} y and T_{1/2}
Se-82 = [10.3 +- 0.3(stat) +- 0.7(syst) ] 10^{19} y.Comment: 5 pages, 4 figure
Probing New Physics Models of Neutrinoless Double Beta Decay with SuperNEMO
The possibility to probe new physics scenarios of light Majorana neutrino
exchange and right-handed currents at the planned next generation neutrinoless
double beta decay experiment SuperNEMO is discussed. Its ability to study
different isotopes and track the outgoing electrons provides the means to
discriminate different underlying mechanisms for the neutrinoless double beta
decay by measuring the decay half-life and the electron angular and energy
distributions.Comment: 17 pages, 14 figures, to be published in E.P.J.
Technical design and performance of the NEMO3 detector
The development of the NEMO3 detector, which is now running in the Frejus
Underground Laboratory (L.S.M. Laboratoire Souterrain de Modane), was begun
more than ten years ago. The NEMO3 detector uses a tracking-calorimeter
technique in order to investigate double beta decay processes for several
isotopes. The technical description of the detector is followed by the
presentation of its performance.Comment: Preprint submitted to Nucl. Instrum. Methods A Corresponding author:
Corinne Augier ([email protected]
Limits on different Majoron decay modes of Mo and Se for neutrinoless double beta decays in the NEMO-3 experiment
The NEMO-3 tracking detector is located in the Fr\'ejus Underground
Laboratory. It was designed to study double beta decay in a number of different
isotopes. Presented here are the experimental half-life limits on the double
beta decay process for the isotopes Mo and Se for different
Majoron emission modes and limits on the effective neutrino-Majoron coupling
constants. In particular, new limits on "ordinary" Majoron (spectral index 1)
decay of Mo ( y) and Se ( y) have been obtained. Corresponding bounds on the
Majoron-neutrino coupling constant are
and .Comment: 23 pages includind 4 figures, to be published in Nuclear Physics
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