Smart Cities: Towards a New Citizenship Regime? A Discourse Analysis of the British Smart City Standard

Growing practice interest in smart cities has led to calls for a less technology-oriented and more citizen-centric approach. In response, this articles investigates the citizenship mode promulgated by the smart city standard of the British Standards Institution. The analysis uses the concept of citizenship regime and a mixture of quantitative and qualitative methods to discern key discursive frames defining the smart city and the particular citizenship dimensions brought into play. The results confirm an explicit citizenship rationale guiding the smart city (standard), although this displays some substantive shortcomings and contradictions. The article concludes with recommendations for both further theory and practice development

The evolution of low mass, close binary systems with a neutron star component: a detailed grid

In close binary systems composed of a normal, donor star and an accreting neutron star, the amount of material received by the accreting component is, so far, a real intrigue. In the literature there are available models that link the accretion disk surrounding the neutron star with the amount of material it receives, but there is no model linking the amount of matter lost by the donor star to that falling onto the neutron star. In this paper we explore the evolutionary response of these close binary systems when we vary the amount of material accreted by the neutron star. We consider a parameter \beta, which represents the fraction of material lost by the normal star that can be accreted by the neutron star. \beta is considered as constant throughout evolution. We have computed the evolution of a set of models considering initial donor star masses (in solar units) between 0.5 and 3.50, initial orbital periods (in days) between 0.175 and 12, initial masses of neutron stars (in solar units) of 0.80, 1.00, 1.20 and 1.40 and several values of beta. We assumed solar abundances. These systems evolve to ultracompact or to open binary systems, many of which form low mass helium white dwarfs. We present a grid of calculations and analyze how these results are affected upon changes in the value of \beta. We find a weak dependence of the final donor star mass with respect to \beta. In most cases this is also true for the final orbital period. The most sensitive quantity is the final mass of the accreting neutron star. As we do not know the initial mass and rotation rate of the neutron star of any system, we find that performing evolutionary studies is not helpful for determining \beta.Comment: 18 pages, 6 figures, 6 tables. Accepted for publication in MNRA

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability.

To identify genetic causes of intellectual disability (ID), we screened a cohort of 986 individuals with moderate to severe ID for variants in 565 known or candidate ID-associated genes using targeted next-generation sequencing. Likely pathogenic rare variants were found in ∼11% of the cases (113 variants in 107/986 individuals: ∼8% of the individuals had a likely pathogenic loss-of-function [LoF] variant, whereas ∼3% had a known pathogenic missense variant). Variants in SETD5, ATRX, CUL4B, MECP2, and ARID1B were the most common causes of ID. This study assessed the value of sequencing a cohort of probands to provide a molecular diagnosis of ID, without the availability of DNA from both parents for de novo sequence analysis. This modeling is clinically relevant as 28% of all UK families with dependent children are single parent households. In conclusion, to diagnose patients with ID in the absence of parental DNA, we recommend investigation of all LoF variants in known genes that cause ID and assessment of a limited list of proven pathogenic missense variants in these genes. This will provide 11% additional diagnostic yield beyond the 10%-15% yield from array CGH alone.Action Medical Research (SP4640); the Birth Defect Foundation (RG45448); the Cambridge National Institute for Health Research Biomedical Research Centre (RG64219); the NIHR Rare Diseases BioResource (RBAG163); Wellcome Trust award WT091310; The Cell lines and DNA bank of Rett Syndrome, X-linked mental retardation and other genetic diseases (member of the Telethon Network of Genetic Biobanks (project no. GTB12001); the Genetic Origins of Congenital Heart Disease Study (GO-CHD)- funded by British Heart Foundation (BHF)This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/humu.2290

Governing effective and legitimate smart grid developments

Smart grids which use Information and Communication Technologies to augment energy network management have been developed in several locations including London and Stockholm. Common rationales for smart grids include: de-carbonising energy supply, maintaining security of supply and promoting affordability. However, beyond these general abstractions, smart grids seem to exhibit considerable diversity in terms of their characteristics and rationales for development. Thus, while the term smart grid may imply abstract notions of what smart grids are and might do, they are developed in response to local contingencies and diverse. In this paper we therefore explore the governance processes through which smart grids are constructed. The paper suggests that standardising smart grids through definitions and best practices that fix both problems and solutions should be avoided. Rather governance processes should be promoted in which local contingencies can be articulated and more legitimate smart grids developed in response to these

Caffeine Reduces 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in Human Trophoblast Cells through the Adenosine A2B Receptor

Maternal caffeine consumption is associated with reduced fetal growth, but the underlying molecular mechanisms are unknown. Since there is evidence that decreased placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is linked to fetal growth restriction, we hypothesized that caffeine may inhibit fetal growth partly through down regulating placental 11β-HSD2. As a first step in examining this hypothesis, we studied the effects of caffeine on placental 11β-HSD2 activity and expression using our established primary human trophoblast cells as an in vitro model system. Given that maternal serum concentrations of paraxanthine (the primary metabolite of caffeine) were greater in women who gave birth to small-for-gestational age infants than to appropriately grown infants, we also studied the effects of paraxanthine. Our main findings were: (1) both caffeine and paraxanthine decreased placental 11β-HSD2 activity, protein and mRNA in a concentration-dependent manner; (2) this inhibitory effect was mediated by the adenosine A2B receptor, since siRNA-mediated knockdown of this receptor prevented caffeine- and paraxanthine-induced inhibition of placental 11β-HSD2; and (3) forskolin (an activator of adenyl cyclase and a known stimulator of 11β-HSD2) abrogated the inhibitory effects of both caffeine and paraxanthine, which provides evidence for a functional link between exposure to caffeine and paraxanthine, decreased intracellular levels of cAMP and reduced placental 11β-HSD2. Taken together, these findings reveal that placental 11β-HSD2 is a novel molecular target through which caffeine may adversely affect fetal growth. They also uncover a previously unappreciated role for the adenosine A2B receptor signaling in regulating placental 11β-HSD2, and consequently fetal development

Measurement of neutron star parameters: a review of methods for low-mass X-ray binaries

Measurement of at least three independent parameters, for example, mass, radius and spin frequency, of a neutron star is probably the only way to understand the nature of its supranuclear core matter. Such a measurement is extremely difficult because of various systematic uncertainties. The lack of knowledge of several system parameter values gives rise to such systematics. Low-mass X-ray binaries, which contain neutron stars, provide a number of methods to constrain the stellar parameters. Joint application of these methods has a great potential to significantly reduce the systematic uncertainties, and hence to measure three independent neutron star parameters accurately. Here we review the methods based on (1) thermonuclear X-ray bursts; (2) accretion-powered millisecond-period pulsations; (3) kilohertz quasi-periodic oscillations; (4) broad relativistic iron lines; (5) quiescent emissions; and (6) binary orbital motions.Comment: 30 pages, 20 figures, 1 table, An Invited and Refereed Review, will be published in "Advances in Space Research