A conference on liquidity in frictional markets

This Policy Discussion Paper summarizes the papers that were presented at the Liquidity in Frictional Markets conference in November 2008. The papers, which looked at markets for assets as diverse as houses, bank loans, and electronic funds transfer, all explored that amorphous concept called “liquidity” and how its presence—or absence—affects the economy.Liquidity (Economics) ; Monetary policy ; Payment systems

Uplift of Quaternary shorelines in Eastern Patagonia : Darwin revisited

International audienceDuring his journey on the Beagle, Darwin observed the uniformity in the elevation of coastal Eastern Patagonia along more than 2000 km. More than one century later, the sequences of Quaternary shorelines of eastern Patagonia have been described and their deposits dated but not yet interpreted in terms of geodynamics. Consequently, we i) mapped the repartition of the Quaternary coastal sequences in Argentinean Patagonia, ii) secured accurate altitudes of shoreline angles associated with erosional morphologies (i.e. marine terraces and notches), iii) took into account previous chrono-stratigraphical interpretations in order to calculate mean uplift rates since ~440 ka (MIS 11) and proposed age ranges for the higher and older features (up to ~180 m), and iv) focused on the Last Interglacial Maximum terrace (MIS 5e) as the best constrained marine terrace (in terms of age and altitude) in order to use it as a tectonic benchmark to quantify uplift rates along the entire passive margin of Eastern South America. Our results show that the eastern Patagonia uplift is constant through time and twice the uplift of the rest of the South American margin. We suggest that the enhanced uplift along the eastern Patagonian coast that interested Darwin during his journey around South America on the Beagle could originate from the subduction of the Chile ridge and the associated dynamic uplift

'Magic coins' and 'magic squares': the discovery of astrological sigils in the Oldenburg Letters

Enclosed in a 1673 letter to Henry Oldenburg were two drawings of a series of astrological sigils, coins and amulets from the collection of Strasbourg mathematician Julius Reichelt (1637–1719). As portrayals of particular medieval and early modern sigils are relatively rare, this paper will analyse the role of these medals in medieval and early modern medicine, the logic behind their perceived efficacy, and their significance in early modern astrological and cabalistic practice. I shall also demonstrate their change in status in the late seventeenth century from potent magical healing amulets tied to the mysteries of the heavens to objects kept in a cabinet for curiosos. The evolving perception of the purpose of sigils mirrored changing early modern beliefs in the occult influences of the heavens upon the body and the natural world, as well as the growing interests among virtuosi in collecting, numismatics and antiquities

Critical analysis of Big Data Challenges and analytical methods

Big Data (BD), with their potential to ascertain valued insights for enhanced decision-making process, have recently attracted substantial interest from both academics and practitioners. Big Data Analytics (BDA) is increasingly becoming a trending practice that many organizations are adopting with the purpose of constructing valuable information from BD. The analytics process, including the deployment and use of BDA tools, is seen by organizations as a tool to improve operational efficiency though it has strategic potential, drive new revenue streams and gain competitive advantages over business rivals. However, there are different types of analytic applications to consider. Therefore, prior to hasty use and buying costly BD tools, there is a need for organizations to first understand the BDA landscape. Given the significant nature of the BD and BDA, this paper presents a state-of-the-art review that presents a holistic view of the BD challenges and BDA methods theorized/proposed/employed by organizations to help others understand this landscape with the objective of making robust investment decisions. In doing so, systematically analysing and synthesizing the extant research published on BD and BDA area. More specifically, the authors seek to answer the following two principal questions: Q1 – What are the different types of BD challenges theorized/proposed/confronted by organizations? and Q2 – What are the different types of BDA methods theorized/proposed/employed to overcome BD challenges?. This systematic literature review (SLR) is carried out through observing and understanding the past trends and extant patterns/themes in the BDA research area, evaluating contributions, summarizing knowledge, thereby identifying limitations, implications and potential further research avenues to support the academic community in exploring research themes/patterns. Thus, to trace the implementation of BD strategies, a profiling method is employed to analyze articles (published in English-speaking peer-reviewed journals between 1996 and 2015) extracted from the Scopus database. The analysis presented in this paper has identified relevant BD research studies that have contributed both conceptually and empirically to the expansion and accrual of intellectual wealth to the BDA in technology and organizational resource management discipline

Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival TrkA and pro-death p75NTR membrane receptors of neurotrophin nerve growth factor (NGF), acting as a neurotrophic factor: (1) the anti-apoptotic effects of DHEA were reversed by siRNA against TrkA or by a specific TrkA inhibitor; (2) [3H]-DHEA binding assays showed that it bound to membranes isolated from HEK293 cells transfected with the cDNAs of TrkA and p75NTR receptors (KD: 7.4±1.75 nM and 5.6±0.55 nM, respectively); (3) immobilized DHEA pulled down recombinant and naturally expressed TrkA and p75NTR receptors; (4) DHEA induced TrkA phosphorylation and NGF receptor-mediated signaling; Shc, Akt, and ERK1/2 kinases down-stream to TrkA receptors and TRAF6, RIP2, and RhoGDI interactors of p75NTR receptors; and (5) DHEA rescued from apoptosis TrkA receptor positive sensory neurons of dorsal root ganglia in NGF null embryos and compensated NGF in rescuing from apoptosis NGF receptor positive sympathetic neurons of embryonic superior cervical ganglia. Phylogenetic findings on the evolution of neurotrophins, their receptors, and CYP17, the enzyme responsible for DHEA biosynthesis, combined with our data support the hypothesis that DHEA served as a phylogenetically ancient neurotrophic factor

Genomic insights into the 2016-2017 cholera epidemic in Yemen.

Yemen is currently experiencing, to our knowledge, the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported1. Here we investigate the phylogenetic relationships, pathogenesis and determinants of antimicrobial resistance by sequencing the genomes of Vibrio cholerae isolates from the epidemic in Yemen and recent isolates from neighbouring regions. These 116 genomic sequences were placed within the phylogenetic context of a global collection of 1,087 isolates of the seventh pandemic V. cholerae serogroups O1 and O139 biotype El Tor2-4. We show that the isolates from Yemen that were collected during the two epidemiological waves of the epidemic1-the first between 28 September 2016 and 23 April 2017 (25,839 suspected cases) and the second beginning on 24 April 2017 (more than 1 million suspected cases)-are V. cholerae serotype Ogawa isolates from a single sublineage of the seventh pandemic V. cholerae O1 El Tor (7PET) lineage. Using genomic approaches, we link the epidemic in Yemen to global radiations of pandemic V. cholerae and show that this sublineage originated from South Asia and that it caused outbreaks in East Africa before appearing in Yemen. Furthermore, we show that the isolates from Yemen are susceptible to several antibiotics that are commonly used to treat cholera and to polymyxin B, resistance to which is used as a marker of the El Tor biotype

Nord-Sud : la médecine parisienne dans son contexte européen. À propos de La Médecine médiévale dans le cadre parisien de Danielle Jacquart

Ziegler Joseph, Weill-Parot Nicolas. Nord-Sud : la médecine parisienne dans son contexte européen. À propos de La Médecine médiévale dans le cadre parisien de Danielle Jacquart. In: Médiévales, n°43, 2002. Le bain : espaces et pratiques, sous la direction de Didier Boisseuil . pp. 147-162

Modelling approaches in sedimentology: Introduction to the thematic issue

(IF 1.54; Q2)International audienceAs an introduction to this thematic issue on “Modelling approaches in sedimentology”, this paper gives an overview of the workshop held in Paris on 7 November 2013 during the 14th Congress of the French Association of Sedimentologists. A synthesis of the workshop in terms of concepts, spatial and temporal scales, constraining data, and scientific challenges is first presented, then a discussion on the possibility of coupling different models, the industrial needs, and the new potential domains of research is exposed

CATS – A process-based model for turbulent turbidite systems at the reservoir scale

AbstractThe Cellular Automata for Turbidite systems (CATS) model is intended to simulate the fine architecture and facies distribution of turbidite reservoirs with a multi-event and process-based approach. The main processes of low-density turbulent turbidity flow are modeled: downslope sediment-laden flow, entrainment of ambient water, erosion and deposition of several distinct lithologies. This numerical model, derived from (Salles, 2006; Salles et al., 2007), proposes a new approach based on the Rouse concentration profile to consider the flow capacity to carry the sediment load in suspension. In CATS, the flow distribution on a given topography is modeled with local rules between neighboring cells (cellular automata) based on potential and kinetic energy balance and diffusion concepts. Input parameters are the initial flow parameters and a 3D topography at depositional time. An overview of CATS capabilities in different contexts is presented and discussed