The banal as heritage of Costa del Sol. Torremolinos (1959‑1979)

Considerar patrimonialmente la cultura del ocio en la Costa del Sol supone reconocer como ‘otro’ patrimonio los productos culturales generados por el turismo de ‘sol y playa’ en la Costa del Sol en los años 60 y 70, tratando como caso paradigmático de estudio la localidad malagueña de Torremolinos. Desde una concepción patrimonial alejada de parámetros tradicionales, reconocemos a esta localidad por objetos, lugares, edificios, espacios, ambientes y escenarios considerados banales, pero que proponemos como nuevos ‘monumentos’. De esta manera hacemos posible una lectura de la ciudad a través de distintos archivos de producciones humanas –artísticas, cinematográficas, arquitectónicas, literarias, etc. -; una especie de análisis estratigráfico que nos permite recomponer una identidad patrimonial incomprendida en su momento, a través de las diferentes capas de producciones culturales de estas dos décadas de intensa actividad turísticaConsider as heritage the culture of leisure in Costa del Sol supposes to recognize as ‘another’ heritage the cultural products generated by ‘sun and beach’ tourism on the Costa del Sol in the 60s and 70s, studying as a paradigmatic case the town of Torremolinos (Málaga). From a heritage concept away from traditional parameters, we recognize it through objects, places, buildings, spaces, environments and banal scenes, which propose as new ‘monuments’. In this way we make possible a reading of the city across different human productions -artistic, cinematographic, architectural, literary, etc. -; a kind of stratigraphic analysis that allows us to re -compose an ununderstood patrimonial identity, through of the different layers of cultural productions of these two decades of intense touristic activit

Cooperativas vecinales. Una aproximación a la gestión colaborativa en rehabilitación y conservación de barriadas

The economic and administrative model of cooperative housing -established for the creation of housing developments with advantageous conditions for their futureowners- has been adopted as a successful model in numerous countries. However, most of cooperative promotions are extinguished once the goal of obtaining housinghas been achieved, so that the potential of the collaborative model is not extended in time beyond this milestone.The cohousing experiences mean an important step in the concept of cooperative activity, extending it to the functioning of the groups that inhabit them. Thus, theinhabitants of a cohousing community may provide benefits such as obtaining services with advantageous prices and conditions, and the provision of recreational areas withlow acquisition and maintenance costs. In other words, the cohousing model attempts to transfer the collaborative aspects of the cooperative model onto the neighbors’activity, introducing a lifestyle able to exploit the potential of group versus individual.There are many historical references of these ideas, from the proposals of utopian socialism (Fourier, Godin) to well-known Le Corbusier’s Unités d'Habitation, butperhaps the novelty of contemporary experiences of cohousing is the fact that these are initiatives bottom-up, where the starting point is the community. Therefore, one ofthe determining factors for the success of cohousing is the existence of strong social cohesion of the collective and a sense of belonging to the group. This causes oftentend to think that cohousing is linked to certain ideological sectors, but the reality is that this is a model that transcends these topics and has proven to be a very suitablealternative for certain social groups..El modelo económico y administrativo de la cooperativa de viviendas, desarrollado para la promoción de viviendas con condiciones ventajosas para sus propietarios, haconstituido un modelo de éxito en numerosas experiencias, un sistema capaz de eludir algunos problemas típicos de la promoción convencional. Sin embargo, la mayor partede las cooperativas de promoción se extinguen una vez conseguido el objetivo de la obtención de las viviendas, por lo que el potencial del modelo colaborativo no seprolonga más allá de este hito.Frente a esto, los modelos residenciales basados en el llamado co-housing (covivienda) suponen un paso más en el concepto de cooperativa, extendiendo suactividad al funcionamiento de los colectivos que los habitan. Así, los habitantes de una comunidad co-housing podrán disponer de beneficios como la obtención deservicios con precios y condiciones ventajosas, o la disposición de espacios de esparcimiento o actividad con bajos costes de adquisición y mantenimiento. En otraspalabras, el modelo de co-housing intenta trasladar los aspectos colaborativos del modelo cooperativo al entorno y a la actividad de una comunidad de vecinos,implantando un modo de vida capaz de aprovechar el potencial del grupo frente al individuo.Existen multitud de referentes históricos de estas ideas, desde las propuestas del socialismo utópico (Fourier, Godin) a las conocidas Unités d’habitation de LeCorbusier. Lo novedoso de las iniciativas contemporáneas de co-housing es su carácter bottom-up: modelos en los que el punto de partida es la comunidad, y desdeella surge la necesidad y la idea de la vida colaborativa. Por tanto, uno de los factores determinantes para el éxito de un co-housing es una fuerte cohesión social de grupo yun sentimiento de pertenencia al colectivo. Esto hace pensar, a menudo, que el cohousing está vinculado a determinados sectores ideológicos; en realidad, se trata deun modelo que trasciende esos tópicos y se ha mostrado como una alternativa muy apropiada para determinados grupos sociales.El proyecto I+D+i Cooperativas vecinales. Modelo de gestión colaborativa en rehabilitación y conservación de barriadas intenta, entre otros objetivos, indagar en lasposibilidades del cooperativismo y el co-housing como medio para la recuperación, rehabilitación y conservación de edificios y entornos urbanos

Boost-based MPPT for the MTM PCDU of the Bepicolombo mission

BepiColombo is an ESA mission to Mercury to be launched in 2013. A better knowledge of the origin and evolution of the planet, of its structure and vestigial atmosphere, of its magnetosphere, and of the origin of its magnetic field are the main objectives for the program. The journey to Mercury will last for approximately 6 years, and will be based on the gravity of the Earth, Venus and Mercury, and on the use of Solar Electric Propulsion. For the last, the use of the MPPT concept is essential for the mission. A mission power demand of up to 14kW is foreseen in the cruise phase for the Mercury Transfer Module (MTM) PCDU, being the power subsystem based on a 100V bus. Under this scenario, the use of a classical step-down regulator for the implementation of the MPPT power cell would require to keep the worst case minimum solar array voltage over the bus for any mission operating condition. Then, the maximum solar array voltage would become as high as to overpass the insulating capability of the isolation layer between the solar array cells and the substrate, under the high temperature environment experienced by the spacecraft near Mercury. As a result, the development of a step-up MPPT Array Power Regulator (APR) becomes a critical issue for the mission feasibility. Moreover, due to the hard environment that the solar array will be exposed to, the segregation of the solar array power is a very desirable feature. Furthermore, apart from the two classical operating modes of the APR – conductance or MPPT, depending on the spacecraft user loads demand and the available solar array power – the APR will have to operate in S3R mode for solar array voltages over the bus, with a fully autonomous transition between the three operating modes. This paper covers all the aspects related with the design of the APR MPPT concept and its implementation: APR power cell topology, control scheme, control strategy, protections. The implications on the design of the MTM PCDU MEA will be also addressed. Finally, they will be presented the results of the test carried out over an 1/10 scaled-down engineering model of the BepiColombo PCU - including 3 APRs - in front of the real operating conditions foreseen for the MTM PCDU, including all the relevant issues related to the behaviour of the Electric Propulsion load like beam-out events and load transients

Highlights from the 1st Latin American meeting on metronomic chemotherapy and drug repositioning in oncology, 27–28 May, 2016, Rosario, Argentina

Following previous metronomic meetings in Marseille (2011), Milano (2014), and Mumbai (2016), the first Latin American metronomic meeting was held in the School of Medical Sciences, National University of Rosario, Rosario, Argentina on 27 and 28 of May, 2016. For the first time, clinicians and researchers with experience in the field of metronomics, coming from different countries in Latin America, had the opportunity of presenting and discussing their work. The talks were organised in three main sessions related to experience in the pre-clinical, and clinical (paediatric and adult) areas. The different presentations demonstrated that the fields of metronomic chemotherapy and repurposing drugs in oncology, known as metronomics, constitute a branch of cancer therapy in permanent evolution, which have strong groups working in LatinAmerica, both in the preclinical and the clinical settings including large, adequately designed randomised studies. It was shown that metronomics offers treatments, which, whether they are combined or not with the standard therapeutic approaches, are not only effective but also minimally toxic, with the consequent improvement of the patient’s quality of life, and inexpensive, a feature very important in low resource clinical settings. The potential use of metronomic chemotherapy was proposed as a cost/effective treatment in low-/middle-income countries, for adjuvant therapy in selected tumours. The fundamental role of the governmental agencies and non-governmental alliances, as the Metronomic Global Health Initiative, in supporting this research with public interest was underlined

Desarrollo de un Modelo 3D para un Sistema Infotainment

At present, we are witnessing the constant advance in the development of technologies for the automotive industry. Every day, there are significant advances and improvements to provide greater comfort to passengers. One of the vehicle technologies that are especially under development is designing specific user interfaces for infotainment systems and different types of interaction, for example, the implementation of 3D user interfaces to provide feedback to the user. These interfaces can be created from technologies available on the market, both free and private software for designing 3D models, and the development of Human Machine Interfaces used in the automotive industry. This article describes the process followed to develop a functional interface from technologies for 3D modeling and interface design. This interface provides visual feedback to the user that allows understanding of what is happening in the vehicle.En la actualidad somos testigos del constante avance en el desarrollo de tecnologías para la industria automotriz donde cada día hay avances y mejoras significativas para brindar mayor comodidad a los pasajeros. Una de las tecnologías del vehículo que está especialmente en desarrollo es el diseño de interfaces de usuario específicas para sistemas infotainment y diferentes tipos de interacción, por ejemplo, la implementación de interfaces de usuario 3D para proporcionar retroalimentación al usuario. Estas interfaces se pueden crear a partir de tecnologías disponibles en el mercado, tanto de software libre como privado para el diseño de modelos 3D y para el desarrollo de Interfaces Humano Máquina utilizados en la industria automotriz. Este artículo describe el proceso que se llevó a cabo para el desarrollo de una interfaz funcional a partir de tecnologías para el modelado 3D y diseño de interfaces. Dicha interfaz proporciona una retroalimentación visual al usuario que permite comprender lo que sucede en el vehículo

A comparison of Covid-19 early detection between convolutional neural networks and radiologists

[EN] Background The role of chest radiography in COVID-19 disease has changed since the beginning of the pandemic from a diagnostic tool when microbiological resources were scarce to a different one focused on detecting and monitoring COVID-19 lung involvement. Using chest radiographs, early detection of the disease is still helpful in resource-poor environments. However, the sensitivity of a chest radiograph for diagnosing COVID-19 is modest, even for expert radiologists. In this paper, the performance of a deep learning algorithm on the first clinical encounter is evaluated and compared with a group of radiologists with different years of experience. Methods The algorithm uses an ensemble of four deep convolutional networks, Ensemble4Covid, trained to detect COVID-19 on frontal chest radiographs. The algorithm was tested using images from the first clinical encounter of positive and negative cases. Its performance was compared with five radiologists on a smaller test subset of patients. The algorithm's performance was also validated using the public dataset COVIDx. Results Compared to the consensus of five radiologists, the Ensemble4Covid model achieved an AUC of 0.85, whereas the radiologists achieved an AUC of 0.71. Compared with other state-of-the-art models, the performance of a single model of our ensemble achieved nonsignificant differences in the public dataset COVIDx. Conclusion The results show that the use of images from the first clinical encounter significantly drops the detection performance of COVID-19. The performance of our Ensemble4Covid under these challenging conditions is considerably higher compared to a consensus of five radiologists. Artificial intelligence can be used for the fast diagnosis of COVID-19.Project Chest screening for patients with COVID 19 (COV2000750 Special COVID19 resolution) funded by Instituto de Salud Carlos III. Project DIRAC (INNVA1/2020/42) funded by the Agencia Valenciana de la Innovacion, Generalitat Valenciana.Albiol Colomer, A.; Albiol, F.; Paredes Palacios, R.; Plasencia-Martínez, JM.; Blanco Barrio, A.; García Santos, JM.; Tortajada, S.... (2022). A comparison of Covid-19 early detection between convolutional neural networks and radiologists. Insights into Imaging. 13(1):1-12. https://doi.org/10.1186/s13244-022-01250-311213

Aspectos clínicos de la angustia

Disposición para la angustia: Los accesos emocionales, entre ellos la angustia, tienen su asiento, según Fenichel, en factores biológicos y filogenéticos. Entendemos por el enunciado anterior la existencia de estructuras glandulares y nerviosas, de funcionamientos anclados sobre reacciones neuro-hormonales y bioquímicas, y de predisposiciones congénitamente adquiridas. Sobre lo anatómico y funcional nada podemos decir aquí; ese campo corresponde a la neurofisiología

Influence of the IL17A locus in giant cell arteritis susceptibility

Objective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. Methods: We carried out a large meta-analysis including a total of 1266 biopsy-proven GCA patients and 3779 healthy controls from four European populations (Spain, Italy, Germany and Norway). Five IL17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were selected by tagging and genotyped using TaqMan assays. Allelic combination and dependency tests were also performed. Results: In the pooled analysis, two of the five analysed polymorphisms showed evidence of association with GCA (rs2275913: PMH=1.85E−03, OR=1.17 (1.06-1.29); rs7747909: PMH=8.49E-03, OR=1.15 (1.04-1.27)). A clear trend of association was also found for the rs4711998 variant (PMH=0.059, OR=1.11 (1.00-1.23)). An independent effect of rs2275913 and rs4711998 was evident by conditional regression analysis. In addition, the haplotype harbouring the risk alleles better explained the observed association than the polymorphisms independently (likelihood p value <10−05). Conclusions: Polymorphisms within the IL17A locus show a novel association with GCA. This finding supports the relevant role of the Th17 cells in this vasculitis pathophysiology

The impact from survey depth and resolution on the morphological classification of galaxies

We consistently analyse for the first time the impact of survey depth and spatial resolution on the most used morphological parameters for classifying galaxies through non-parametric methods: Abraham and Conselice-Bershady concentration indices, Gini, M20moment of light, asymmetry, and smoothness. Three different non-local data sets are used, Advanced Large Homogeneous Area Medium Band Redshift Astronomical (ALHAMBRA) and Subaru/XMMNewton Deep Survey (SXDS, examples of deep ground-based surveys), and Cosmos Evolution Survey (COSMOS, deep space-based survey). We used a sample of 3000 local, visually classified galaxies, measuring their morphological parameters at their real redshifts (z ~ 0). Then we simulated them to match the redshift and magnitude distributions of galaxies in the non-local surveys. The comparisons of the two sets allow us to put constraints on the use of each parameter for morphological classification and evaluate the effectiveness of the commonly used morphological diagnostic diagrams. All analysed parameters suffer from biases related to spatial resolution and depth, the impact of the former being much stronger. When including asymmetry and smoothness in classification diagrams, the noise effects must be taken into account carefully, especially for ground-based surveys. M20 is significantly affected, changing both the shape and range of its distribution at all brightness levels. We suggest that diagnostic diagrams based on 2-3 parameters should be avoided when classifying galaxies in ground-based surveys, independently of their brightness; for COSMOS they should be avoided for galaxies fainter than F814 = 23.0. These results can be applied directly to surveys similar to ALHAMBRA, SXDS and COSMOS, and also can serve as an upper/lower limit for shallower/deeper ones.Ministerio de Economía y Competitividad AYA2010-15169, AYA2013-42227-P, AYA2013-4318

Human Immunodeficiency Virus/Hepatits C Virus Coinfection in Spain: Elimination Is Feasible, but the Burden of Residual Cirrhosis Will Be Significant

Background: We assessed the prevalence of antibodies against hepatitis C virus (HCV-Abs) and active HCV infection in patients infected with human immunodeficiency virus (HIV) in Spain in 2016 and compared the results with those of similar studies performed in 2002, 2009, and 2015. Methods: The study was performed in 43 centers during October-November 2016. The sample was estimated for an accuracy of 2% and selected by proportional allocation and simple random sampling. During 2016, criteria for therapy based on direct-acting antiviral agents (DAA) were at least significant liver fibrosis, severe extrahepatic manifestations of HCV, and high risk of HCV transmissibility. Results: The reference population and the sample size were 38904 and 1588 patients, respectively. The prevalence of HCV-Abs in 2002, 2009, 2015, and 2016 was 60.8%, 50.2%, 37.7%, and 34.6%, respectively (P trend <.001, from 2002 to 2015). The prevalence of active HCV in 2002, 2009, 2015, and 2016 was 54.0%, 34.0%, 22.1%, and 11.7%, respectively (P trend <.001). The anti-HCV treatment uptake in 2002, 2009, 2015, and 2016 was 23.0%, 48.0%, 59.3%, and 74.7%, respectively (P trend <.001). In 2016, HCV-related cirrhosis was present in 7.6% of all HIV-infected individuals, 15.0% of patients with active HCV, and 31.5% of patients who cleared HCV after anti-HCV therapy. Conclusions: Our findings suggest that with universal access to DAA-based therapy and continued efforts in prevention and screening, it will be possible to eliminate active HCV among HIV-infected individuals in Spain in the short term. However, the burden of HCV-related cirrhosis will continue to be significant among HIV-infected individuals.This work was funded by grant Ref. no. GLD14-00279 from the GILEAD Fellowship Programme (Spain) and by the Spanish AIDS Research Network (RD16/0025/0017, RD16/0025/0018) that is included in the Spanish I+D+I Plan and is co-financed by ISCIII-Subdirección General de Evaluacion and European Funding for Regional Development (FEDER).S