943 research outputs found
The evolutionary approach to history:sociocultural phylogenetics
There are three forms of modern Darwinian evolutionism in the social sciences and humanities: the gene-based biological, the social learning-based sociocultural, and geneâculture coevolution dealing with their interaction. This chapter focuses on cultural or sociocultural evolution. It begins with a discussion of the Darwinian-inspired evolutionary approach to history. It then outlines modern evolutionary phylogenetic methods borrowed from biology but now used extensively in the social sciences and humanities. The chapter provides examples of how language trees may be inferred; phylogenetic comparative methods that use language trees to answer questions about aspects of geographical, social, political, cultural, or economic organization; and phylogenetic investigations of material culture and traditions. It is concluded that culture does indeed âdescend with modification.â</p
Impact of Immigrant Entrepreneurs and Workers in Leisure and Hospitality Businesses: Massachusetts and New England
This report examines the role and impact of immigrant entrepreneurs and workers on Leisure and Hospitality businesses in New England, particularly Massachusetts. A significant portion of state economies in New England, especially in Massachusetts, relies heavily on the employment of the foreign-born. As the native workforce ages and population growth declines, businesses are becoming increasingly dependent upon the availability of the foreign-born. This development has facilitated an increasingly significant presence and role of immigrant entrepreneurs in Leisure and Hospitality businesses that is documented for the first time in this report
Virulence Gene Sequencing Highlights Similarities and Differences in Sequences in Listeria monocytogenes Serotype 1/2a and 4b Strains of Clinical and Food Origin From 3 Different Geographic Locations
peer-reviewedThe Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2018.01103/full#supplementary-materialThe prfA-virulence gene cluster (pVGC) is the main pathogenicity island in Listeria monocytogenes, comprising the prfA, plcA, hly, mpl, actA, and plcB genes. In this study, the pVGC of 36 L. monocytogenes isolates with respect to different serotypes (1/2a or 4b), geographical origin (Australia, Greece or Ireland) and isolation source (food-associated or clinical) was characterized. The most conserved genes were prfA and hly, with the lowest nucleotide diversity (Ï) among all genes (P < 0.05), and the lowest number of alleles, substitutions and non-synonymous substitutions for prfA. Conversely, the most diverse gene was actA, which presented the highest number of alleles (n = 20) and showed the highest nucleotide diversity. Grouping by serotype had a significantly lower Ï value (P < 0.0001) compared to isolation source or geographical origin, suggesting a distinct and well-defined unit compared to other groupings. Among all tested genes, only hly and mpl were those with lower nucleotide diversity in 1/2a serotype than 4b serotype, reflecting a high within-1/2a serotype divergence compared to 4b serotype. Geographical divergence was noted with respect to the hly gene, where serotype 4b Irish strains were distinct from Greek and Australian strains. Australian strains showed less diversity in plcB and mpl relative to Irish or Greek strains. Notable differences regarding sequence mutations were identified between food-associated and clinical isolates in prfA, actA, and plcB sequences. Overall, these results indicate that virulence genes follow different evolutionary pathways, which are affected by a strain's origin and serotype and may influence virulence and/or epidemiological dominance of certain subgroups.This study was supported by the 7th Framework
Programme projects PROMISE, contract number
265877
Recommended from our members
A Comparative Study of the ReCellÂź Device and Autologous Spit-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries.
Early excision and autografting are standard care for deeper burns. However, donor sites are a source of significant morbidity. To address this, the ReCellŸ Autologous Cell Harvesting Device (ReCell) was designed for use at the point-of-care to prepare a noncultured, autologous skin cell suspension (ASCS) capable of epidermal regeneration using minimal donor skin. A prospective study was conducted to evaluate the clinical performance of ReCell vs meshed split-thickness skin grafts (STSG, Control) for the treatment of deep partial-thickness burns. Effectiveness measures were assessed to 1 year for both ASCS and Control treatment sites and donor sites, including the incidence of healing, scarring, and pain. At 4 weeks, 98% of the ASCS-treated sites were healed compared with 100% of the Controls. Pain and assessments of scarring at the treatment sites were reported to be similar between groups. Significant differences were observed between ReCell and Control donor sites. The mean ReCell donor area was approximately 40 times smaller than that of the Control (P < .0001), and after 1 week, significantly more ReCell donor sites were healed than Controls (P = .04). Over the first 16 weeks, patients reported significantly less pain at the ReCell donor sites compared with Controls (P †.05 at each time point). Long-term patients reported higher satisfaction with ReCell donor site outcomes compared with the Controls. This study provides evidence that the treatment of deep partial-thickness burns with ASCS results in comparable healing, with significantly reduced donor site size and pain and improved appearance relative to STSG
The public health risk posed by Listeria monocytogenes in frozen fruit and vegetables including herbs, blanched during processing
A multi-country outbreak ofListeria monocytogenesST6 linked to blanched frozen vegetables (bfV)took place in the EU (2015â2018). Evidence of food-borne outbreaks shows thatL. monocytogenesisthe most relevant pathogen associated with bfV. The probability of illness per serving of uncooked bfV,for the elderly (65â74 years old) population, is up to 3,600 times greater than cooked bfV and verylikely lower than any of the evaluated ready-to-eat food categories. The main factors affectingcontamination and growth ofL. monocytogenesin bfV during processing are the hygiene of the rawmaterials and process water; the hygienic conditions of the food processing environment (FPE); andthe time/Temperature (t/T) combinations used for storage and processing (e.g. blanching, cooling).Relevant factors after processing are the intrinsic characteristics of the bfV, the t/T combinations usedfor thawing and storage and subsequent cooking conditions, unless eaten uncooked. Analysis of thepossible control options suggests that application of a complete HACCP plan is either not possible orwould not further enhance food safety. Instead, specific prerequisite programmes (PRP) andoperational PRP activities should be applied such as cleaning and disinfection of the FPE, water control,t/T control and product information and consumer awareness. The occurrence of low levels ofL. monocytogenesat the end of the production process (e.g.<10 CFU/g) would be compatible with thelimit of 100 CFU/g at the moment of consumption if any labelling recommendations are strictly followed(i.e. 24 h at 5°C). Under reasonably foreseeable conditions of use (i.e. 48 h at 12°C),L. monocytogeneslevels need to be considerably lower (not detected in 25 g). Routine monitoring programmes forL. monocytogenesshould be designed following a risk-based approach and regularly revised based ontrend analysis, being FPE monitoring a key activity in the frozen vegetable industry
Abundance stratification in Type Ia supernovae - III. The normal SN 2003du
The element abundance distributions in the ejecta of Type Ia supernova (SN)
is studied by modelling a time series of optical spectra of SN 2003du until ~1
year after the explosion. Since SN 2003du is a very normal Type Ia SN both
photometrically and spectroscopically, the abundance distribution derived for
it can be considered as representative of normal Type Ia SNe. We find that the
innermost layers are dominated by stable Fe-group elements, with a total mass
of ~ 0.2 Msun, which are synthesized through electron capture. Above the core
of stable elements there are thick 56Ni-rich layers. The total mass of 56Ni is
0.65 Msun. The Si- and S-rich layers are located above the 56Ni-rich layers.
The dominant element in the outermost layers (M_r > 1.1 Msun, v > 13000 km/s)
is O, with a small amount of Si. Little unburned C remains, with an upper limit
of 0.016 Msun. The element distributions in the ejecta are moderately mixed,
but not fully mixed as seen in three-dimensional deflagration models.Comment: 15 pages, 11 figures, Accepted for publication in MNRA
Film-Forming Amines for the Corrosion Protection of Carbon Steels in Nuclear Power Plant Secondary Circuit Conditions: An Impedance Study
Octadecylamine (ODA) has been the subject of numerous investigations for the corrosion protection of carbon steels in nuclear pressurized water reactors (PWR). In the present work, electrochemical impedance spectroscopy was used to study and to compare the ODA behavior after different treatment temperatures (from 80 °C to 275 °C) representative of the secondary circuit of the PWR. The ODA films were characterized at room temperature. The impedance data analysis allowed the ODA film parameters (thickness and permittivity) to be obtained. The ODA film thickness was independent of the treatment conditions and was about 20 nm. At 120 °C and 220 °C, the presence of magnetite, formed during the treatment in the autoclave, strongly improved the corrosion protection afforded by the ODA films. An instantaneous inhibitive efficiency of 99.9% was assessed. At 275 °C, thermal degradation of the ODA molecules was shown
Spatial distribution of cerebral white matter lesions predicts progression to mild cognitive impairment and dementia
CONTEXT White matter lesions (WML) increase the risk of dementia. The relevance of WML location is less clear. We sought to determine whether a particular WML profile, based on the density and location of lesions, could be associated with an increased risk of mild cognitive impairment (MCI) or dementia over the following 7 years. METHODS In 426 healthy subjects from a cohort of community-dwelling people aged 65 years and over (ESPRIT Project), standardized cognitive and neurological evaluations were repeated after 2, 4 and 7 years. Patterns of WML were computed with a supervised data mining approach (decision trees) using the regional WML volumes (frontal, parietal, temporal, and occipital regions) and the total WML volume estimated at baseline. Cox proportional hazard models were then constructed to study the association between WML patterns and risk of MCI/dementia. RESULTS Total WML volume and percentage of WML in the temporal region proved to be the best predictors of progression to MCI and dementia. Specifically, severe total WML load with a high proportion of lesions in the temporal region was significantly associated with the risk of developing MCI or dementia. CONCLUSIONS Above a certain threshold of damage, a pattern of WML clustering in the temporal region identifies individuals at increased risk of MCI or dementia. As this WML pattern is observed before the onset of clinical symptoms, it may facilitate the detection of patients at risk of MCI/dementia.The ESPRIT Project is financed by the regional government of Languedoc-Roussillon (http://www.laregion.fr), the Agence Nationale de la Recherche
(ANR: http://www.agence-nationale-recherche.fr) and an unconditional grant from Novartis (http://www.novartis.fr). This study is also supported by France
Alzheimer (http://www.francealzheimer.org/)
- âŠ