25 research outputs found

    Minimally invasive Ivor Lewis esophagectomy

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    The need for structured thoracic robotic training: the perspective of an American Association for Thoracic Surgery surgical robotic fellow

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    Since the initial experiences with robotic platforms in thoracic surgery (1), the number of procedures performed with this technique have continued to increase (2). Not only have newer trainees demonstrated interest in the field, but former open and VATS surgeons have also become aware of the advantages that the robotic platform provides (1,3). However, although some authors have implemented robotic thoracic surgery safely (4,5) others still consider it inefficient, citing the increased operative time (related to the learning curve), the initial instrument cost, and the lack of appropriate directed training (3)

    The genetic architecture of the human cerebral cortex

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    The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

    The need for structured thoracic robotic training: the perspective of an American Association for Thoracic Surgery surgical robotic fellow

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    Since the initial experiences with robotic platforms in thoracic surgery (1), the number of procedures performed with this technique have continued to increase (2). Not only have newer trainees demonstrated interest in the field, but former open and VATS surgeons have also become aware of the advantages that the robotic platform provides (1,3). However, although some authors have implemented robotic thoracic surgery safely (4,5) others still consider it inefficient, citing the increased operative time (related to the learning curve), the initial instrument cost, and the lack of appropriate directed training (3)

    Case report of tracheobronchial squamous cell carcinoma treated with radiation therapy and concurrent chemotherapy

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    Tracheobronchial tumors include primary malignant tumors, secondary malignant tumors, and benign tumors. Primary malignant tumors of the trachea are rare, representing only 0.1% to 0.4% of all malignant disease. Squamous cell carcinoma (SCC) and adenoid cystic carcinoma are the most common histological subtypes, making up approximately two-thirds of primary tracheal neoplasms.1 Such tumors have typically been treated with surgical resection and adjuvant radiation therapy (RT; Table 1). Medically inoperable tumors are usually treated with definitive RT, but because of the rarity of these tumors, there are no randomized trials to determine the optimal treatment regimen. A radiation dose of ∼60 Gy has been most commonly reported for external beam RT, with higher doses having significant toxicity of the tracheal and esophageal tissue using historical techniques. In contrast to definitive RT, the use of definitive RT with concurrent chemotherapy for tracheal SCC has been sparingly described in the literature. In this report, we describe our experience with 2 patients at our institution who received definitive RT using modern techniques with concurrent chemotherapy for tracheobronchial SCC
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