1,033 research outputs found
The role of Schizosaccharomyces pombe SUMO ligases in genome stability
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins
Cluster Monte Carlo study of multi-component fluids of the Stillinger-Helfand and Widom-Rowlinson type
Phase transitions of fluid mixtures of the type introduced by Stillinger and
Helfand are studied using a continuum version of the invaded cluster algorithm.
Particles of the same species do not interact, but particles of different types
interact with each other via a repulsive potential. Examples of interactions
include the Gaussian molecule potential and a repulsive step potential.
Accurate values of the critical density, fugacity and magnetic exponent are
found in two and three dimensions for the two-species model. The effect of
varying the number of species and of introducing quenched impurities is also
investigated. In all the cases studied, mixtures of -species are found to
have properties similar to -state Potts models.Comment: 25 pages, 5 figure
Uric acid: an old actor for a new role
The role of uric acid as an independent risk factor for cardiovascular events is still debated. In fact, other confounding factors such as glucose intolerance, obesity, dyslipidaemia, hypertension, use of diuretics and insulin resistance may play a role in determining the increased vascular risk associated to elevated uric acid concentrations. These factors (including high uric acid) have been mentioned in one or more definitions of the metabolic syndrome. Recently, much attention has been paid to the metabolic syndrome due to its possible role as a risk factor for the development of type 2 diabetes and cardiovascular disease. The worldwide increase in the prevalence of obesity and diabetes is a reason not only for the increasing prevalence of the metabolic syndrome but also of hyperuricaemia.
A better understanding of the role of uric acid in health and in disease states may help physicians to improve their performance in preventing and treating cardiovascular disease
Multivariate Small Area Estimation of Multidimensional Latent Economic Well-being Indicators
© 2019 The Authors. International Statistical Review © 2019 International Statistical Institute Factor analysis models are used in data dimensionality reduction problems where the variability among observed variables can be described through a smaller number of unobserved latent variables. This approach is often used to estimate the multidimensionality of well-being. We employ factor analysis models and use multivariate empirical best linear unbiased predictor (EBLUP) under a unit-level small area estimation approach to predict a vector of means of factor scores representing well-being for small areas. We compare this approach with the standard approach whereby we use small area estimation (univariate and multivariate) to estimate a dashboard of EBLUPs of the means of the original variables and then averaged. Our simulation study shows that the use of factor scores provides estimates with lower variability than weighted and simple averages of standardised multivariate EBLUPs and univariate EBLUPs. Moreover, we find that when the correlation in the observed data is taken into account before small area estimates are computed, multivariate modelling does not provide large improvements in the precision of the estimates over the univariate modelling. We close with an application using the European Union Statistics on Income and Living Conditions data
Facilitating children's self-concept: A rationale and evaluative study
This study reports on the design and effectiveness of the Exploring Self-Concept program for primary school children using self-concept as the outcome measure. The program aims to provide a procedure that incorporates organisation, elaboration, thinking, and problem-solving strategies and links these to children's multidimensional self-concept. The results of this research support the notion that teachers and guidance counsellors need to establish a nonthreatening framework that allows them to discuss with children a range of relevant issues related to peer pressure, parent relations, self-image, body image, gender bias, media pressure, values and life goals, in a systematic, objective and cooperative manner. Within the paper, notions associated with self-concept maturation, 'crystallisation' of self-concept beliefs, cognitive differentiation and self-concept segmentation are reviewed
True and intentionally fabricated memories
The aim of the experiment reported here was to investigate the processes underlying the construction of truthful and deliberately fabricated memories. Properties of memories created to be intentionally false - fabricated memories - were compared to properties of memories believed to be true - true memories. Participants recalled and then wrote or spoke true memories and fabricated memories of everyday events. It was found that true memories were reliably more vivid than fabricated memories and were nearly always recalled from a first person perspective. In contrast, fabricated differed from true memories in that they were judged to be reliably older, were more frequently recalled from a third person perspective, and linguistic analysis revealed that they required more cognitive effort to generate. No notable differences were found across modality of reporting. Finally, it was found that, intentionally fabricated memories were created by recalling and then ‘editing’ true memories. Overall, these findings show that true and fabricated memories systematically differ, despite the fact that both are based on true memories
Phi meson production in Au+Au and p+p collisions at sqrt (s)=200 GeV
We report the STAR measurement of Phi meson production in Au+Au and p+p
collisions at sqrt (s)=200 GeV. Using the event mixing technique, the Phi
spectra and yields are obtained at mid-rapidity for five centrality bins in
Au+Au collisions and for non-singly-diffractive p+p collisions. It is found
that the Phi transverse momentum distributions from Au+Au collisions are better
fitted with a single-exponential while the p+p spectrum is better described by
a double-exponential distribution. The measured nuclear modification factors
indicate that Phi production in central Au+Au collisions is suppressed relative
to peripheral collisions when scaled by the number of binary collisions. The
systematics of versus centrality and the constant Phi/K- ratio versus beam
species, centrality, and collision energy rule out kaon coalescence as the
dominant mechanism for Phi production.Comment: 6 pages, 3 figures, submitted to Phys. Rev. Let
Azimuthal anisotropy at RHIC: the first and fourth harmonics
We report the first observations of the first harmonic (directed flow, v_1),
and the fourth harmonic (v_4), in the azimuthal distribution of particles with
respect to the reaction plane in Au+Au collisions at the Relativistic Heavy Ion
Collider (RHIC). Both measurements were done taking advantage of the large
elliptic flow (v_2) generated at RHIC. From the correlation of v_2 with v_1 it
is determined that v_2 is positive, or {\it in-plane}. The integrated v_4 is
about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8)
harmonics upper limits on the magnitudes are reported.Comment: 6 pages with 3 figures, as accepted for Phys. Rev. Letters The data
tables are at
http://www.star.bnl.gov/central/publications/pubDetail.php?id=3
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
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