Surjectivity of the asymptotic Borel map in Carleman-Roumieu ultraholomorphic classes defined by regular sequences

We study the surjectivity of, and the existence of right inverses for, the asymptotic Borel map in Carleman?Roumieu ultraholomorphic classes defined by regular sequences in the sense of E. M. Dyn?kin. We extend previous results by J. Schmets and M. Valdivia, by V. Thilliez, and by the authors, and show the prominent role played by an index, associated with the sequence, that was introduced by V. Thilliez. The techniques involve regular variation, integral transforms and characterization results of A. Debrouwere in a half-plane, stemming from his study of the surjectivity of the moment mapping in general Gelfand?Shilov spaces.The first two authors are partially supported by the Spanish Ministry of Economy, Industry and Competitiveness under the project MTM2016-77642-C2-1-P, and by the Spanish Ministry of Science and Innovation under the project PID2019-105621GB-I00. The third author is supported by FWF-Projects P32905- N and P33417-

La comisaría algodonera del Estado en Sevilla : recuperación virtual

La Real Orden de 10 de Noviembre de 1923 dictó las normas para la constitución y funcionamiento de la Comisaría Algodonera del Estado en la ciudad de Sevilla, acordándose la adquisición de los terrenos donde había de construirse la factoría de desmotación y de la maquinaria necesaria para su funcionamiento. El proyecto inicial de este complejo industrial en estilo neomudéjar es obra de Lorenzo Ortiz Iríbar conformando un conjunto de pabellones cuyos usos eran fábrica textil, almacenes y oficinas, pero es José Espiau y Muñoz el que se encarga de su construcción respetando el diseño de Iríbar. Posteriormente, en 1935, también se le encarga su ampliación, en un estilo racionalista en la composición general pero con elementos decorativos neomudéjares como rasgos de identidad del conjunto. Tras el cese de su actividad industrial, el complejo entra en un periodo de abandono y paulatina ruina hasta que en 1989 se propone su rehabilitación para albergar a la Consejería de Agricultura y Pesca de la Junta de Andalucía, encargándose de este proyecto el estudio de arquitectura de González Cordón, recuperando algunas de sus viejas naves, demoliendo otras y añadiendo un nuevo edificio de oficinas. Si bien su pasado industrial ya quedó prácticamente en el olvido, la mezcla de estilos regionalista, racionalista y contemporáneo, fruto de las distintas fases históricas por las que ha pasado, así como su valor patrimonial, hacen que el conjunto sea único y digno de estudio y conservación. Con este trabajo se pretende recordar la importancia que este complejo industrial supuso para la ciudad de Sevilla y su entorno más cercano, rescatando del olvido su composición original y su pasado industrial mediante la recuperación virtual con herramientas asistidas por ordenador de sus edificios originales para, al menos virtualmente, poder seguir contemplando su alto valor patrimonial

¿Cómo actúan y porqué se usan los inodilatadores simpaticomiméticos e inhibidores de la fosfodiesterasa en la insuficiencia cardiaca?: I

Sin resume

Estudio de la unión neuromuscular en el origen patogénico de la ELA

La esclerosis lateral amiotrófica (ELA) es una enfermedad neurodegenerativa progresiva que afecta rápidamente a las motoneuronas del cerebro y la médula espinal. Esta enfermedad, a día de hoy, no tiene cura. En alrededor del 90% de los casos el origen de la enfermedad es desconocido, pero en un 10% está causada por mutaciones genéticas de herencia mendeliana en más de 20 genes, entre los que destacan TARBDP, que codifica para TDP-43, y FUS. Recientes hallazgos han cuestionado el origen neurogénico de la enfermedad para situarlo en las células sostén de las motoneuronas dentro del sistema neuromuscular, como lo son las células de la glía y las células del músculo esquelético. Con el objetivo de tratar de esclarecer si el origen patogénico en la motoneurona es suficiente para causar enfermedad de ELA se ha llevado a cabo la generación y caracterización de dos modelos de Drosophila melanogaster que reproducen uno de los principales detonantes de la enfermedad, la pérdida de función del ortólogo de TDP-43 (Tbph) o FUS (Caz), en motoneurona mediante el silenciamiento condicionado de dichos genes en este tipo celular. Además, se ha comprobado la validez de estos modelos para ensayos de testado farmacológico usando un tratamiento con demostrada capacidad de proteger frente a los efectos de la disfunción de TDP-43 y FUS: la inhibición de FoxO. Los resultados muestran un déficit locomotor característico de la ELA en el modelo generado con el promotor de la proteína OK6, sin variaciones acordes en su longevidad. Dicho modelo fue tratado con un inhibidor selectivo de FoxO, AS1842856, el cual fue capaz de mitigar las anomalías locomotoras detectadas en las moscas con silenciamiento de Tbph. A falta de realizar estudios histopatológicos que demuestren neurodegeneración de motoneurona, se puede extraer de los presentes resultados que los modelos de inducción de pérdida de función de Tbph y Caz en motoneurona de Drosophila son capaces de provocar fenotipos compatibles con la ELA, y por tanto son legítimos para realizar tratamientos farmacológicos. Además, la inhibición de los factores de transcripción FoxO a nivel de motoneurona tiene efectos beneficiosos como tratamiento de la enfermedad.<br /

Influence of 12-week concurrent training on exosome cargo and its relationship with cardiometabolic health parameters in men with obesity

[EN] Exosome release varies depending on the physiological state of the cell, so they could play a fundamental role in obesity, the biggest pandemic in today's societies. The beneficial effects that physical activity has both on weight and cardiovascular parameters may be mediated by exosomes released in response to exercise. Thus, we aimed (I) to study the influence of a 12-week CT intervention on exosome cargo modifications in men with obesity and (II) to determine whether changes in exosomes after the intervention were related to changes in cardiometabolic health parameters in our cohorts. An experimental, controlled design was performed in twelve (nine with valid data) adult male obese patients (mean values: 41.6 years old, 97.6 kg and 32.4 kg/m2) who were randomly divided into a control group (n = 4) and a training group (n = 5), which completed 36 sessions of CT (concurrent training) for 12 weeks. Before and after the training period, cardiometabolic health parameters were evaluated and blood samples to measure exosomes and proteins were drawn. No changes were observed in the levels of any exosomal markers and proteins; however, associations of changes between CD81 and both fat mass and weight, Flot-1 and VO2max, HSP70 and both CRP and left ventricle diastolic diameter or CD14 and leptin were found (all p ≤ 0.05). Although the current CT was not able to clearly modify the exosome cargo, a certain medium to large clinical effect was manifested considering the nature of this study. Moreover, the associations found between the promoted changes in cardiometabolic parameters and exosome-carried proteins could indicate a relationship to be considered for future treatments in patients with obesity.SICurrent research activities of D.J.-P. are supported by a grant from the Spanish Ministry of Science and Innovation—MINECO (RYC-2014-16938) and the EXERNET Research Network on Exercise and Health in Special Populations (DEP2005-00046/ACTI). Technology Fund—FEDER funds (R&D&I Operating Program) was used by and for the benefit of companies (Technology Fund) INNTERCONECTA (BRISA Contract-University of Cádiz). The results of the study are presented clearly, honestly and without fabrication, falsification or inappropriate data manipulation.Biomedical Research Networking Center on Frailty and Healthy Aging (CIBERFES) and FEDER funds from the European Union (CB16/10/00477)

Ambient Intelligence Systems for Personalized Sport Training

Several research programs are tackling the use of Wireless Sensor Networks (WSN) at specific fields, such as e-Health, e-Inclusion or e-Sport. This is the case of the project “Ambient Intelligence Systems Support for Athletes with Specific Profiles”, which intends to assist athletes in their training. In this paper, the main developments and outcomes from this project are described. The architecture of the system comprises a WSN deployed in the training area which provides communication with athletes’ mobile equipments, performs location tasks, and harvests environmental data (wind speed, temperature, etc.). Athletes are equipped with a monitoring unit which obtains data from their training (pulse, speed, etc.). Besides, a decision engine combines these real-time data together with static information about the training field, and from the athlete, to direct athletes’ training to fulfill some specific goal. A prototype is presented in this work for a cross country running scenario, where the objective is to maintain the heart rate (HR) of the runner in a target range. For each track, the environmental conditions (temperature of the next track), the current athlete condition (HR), and the intrinsic difficulty of the track (slopes) influence the performance of the athlete. The decision engine, implemented by means of (m; s)-splines interpolation, estimates the future HR and selects the best track in each fork of the circuit. This method achieves a success ratio in the order of 80%. Indeed, results demonstrate that if environmental information is not take into account to derive training orders, the success ratio is reduced notably.Ministerio de Educación y Ciencia; DEP2006-56158-C03-01/02/03Ministerio de Educación y Ciencia; TEC2007-67966 -01/02/TCM CON-PARTE-1/2Ministerio de Industria, Turismo y Comercio ; TSI-020301-2008-16 ELISAMinisterio de Industria, Turismo y Comercio ; TSI-020301-2008-2 PIRAmID

Tracking microbial diversity and hygienic-sanitary status during processing of farmed rainbow trout (Oncorhynchus mykiss)

Aquaculture is becoming a strategic sector for many national economies to supply the increasing demand for fish from consumers. Fish culture conditions and processing operations can lead to an increase in microbial contamination of farmed fish that may shorten the shelf-life of fish products and byproducts, and ready-to-eat fishery products. The objective of this study was to evaluate the hygienic-sanitary status of water, environment, and processing of fresh-farmed rainbow trout (Oncorhynchus mykiss) fillets produced in a local fish farm in Andalusia, Spain. To achieve this, a longitudinal study was carried out by collecting environmental (air and food-contact surfaces), water from fish ponds, and rainbow trout samples. Thereby, seven sampling visits were performed between February 2021 and July 2022, where foodborne pathogens and spoilage microorganisms, together with physicochemical parameters, were analysed in the collected samples. Further, microbial identification of microbiota was achieved through a culture-dependent technique using blast analysis of 16S RNA gene sequencing. The results showed that Listeria monocytogenes and Salmonella were not detected in the analysed samples. Regarding the hygienic-sanitary status of the fish farm, the slaughtering bath, the eviscerating machine and the outlet water from fish ponds presented the highest counts of coliforms, Enterobacteriaceae, and Aerobic Mesophilic Bacteria. Staphylococcus aureus and sulphite-reducing Clostridium were identified in the conveyor belts, fish flesh, and viscera. The 16S RNA identification confirmed the presence of viable spoilage bacteria such as Citrobacter gillenii, Macrococcus caseolyticus, Hafnia paralvei, Lactococcus lactis, Lactococcus cremoris, Klebsiella, Escherichia coli, Morganella morganii, and Shewanella. Three of these genera (Citrobacter, Hafnia, and Pseudomonas) were present in all types of samples analysed. The results evidenced potential transmission of microbial contamination from contaminated packaging belts and boxes, evisceration and filleting machines to flesh and viscera samples, thus the establishment of control measures should be implemented in fish farm facilities to extend the shelf-life of farmed fishery products

The Influence of Therapeutic Exercise on Survival and the Quality of Life in Survivorship of Women with Ovarian Cancer

Background: Ovarian cancer is the most difficult of all gynaecological cancers to treat, mainly due to its late diagnosis. Although exercise interventions have been reported to be safe and beneficial for ovarian cancer, treatment does not include it and is usually a combination of chemotherapy and surgery. It is increasingly common to include exercise as a tool to increase survival in the cancer population. The aim of this study was to determine the influence of therapeutic exercise on survival and the quality of life in survivorship in women with ovarian cancer. Methods: Literature review of clinical trials, reviews and pilot studies compiled in three databases collected in PubMed, PEDro and Scopus. Results: Of the 44 articles found, 10 were selected. Improvements in survival, quality of life and comorbidities associated with ovarian cancer were found with exercise interventions as a treatment tool. Conclusions: Through the application of therapeutic exercise, improvements in survival and quality of life were observed, as well as in the general symptomatology of ovarian cancer. No adverse effects have been found with its use, but future studies with larger sample sizes with more detailed and individualised interventions combined with conventional treatment are needed

Predicción de la convección en los modelos HARMONIE-AROME y ECMWF

Ponencia presentada en: VI Simposio Nacional de Predicción, celebrado en los servicios centrales de AEMET, en Madrid, del 17 al 19 de septiembre de 2018.La convección es uno de los fenómenos meteorológicos más difíciles de predecir. Los modelos numéricos no hidrostáticos que se integran a escalas convectivas o convection-permitting han supuesto una mejora significativa en la simulación de la convección comparados con los modelos de escala sinóptica, que necesitan parametrizar la convección profunda. Se estudia el comportamiento de los modelos HARMONIE-AROME y del IFS del Centro Europeo de Predicción a Medio Plazo (ECMWF) utilizando métodos objetivos como la verificación puntual y la verificación espacial, así como métodos subjetivos. Se ve que los modelos convection-permitting como HARMONIE-AROME reproducen mucho mejor el ciclo diurno de la precipitación que los modelos que parametrizan la convección profunda como el del Centro Europeo. En promedio, el ciclo 40 obtiene mejores resultados que el ciclo 38 tanto con la verificación puntual como con la verificación espacial. El ciclo 38 tiende a producir más actividad convectiva y también a producir más falsas alarmas. Otro resultado interesante es que la resolución efectiva de HARMONIE para la precipitación parece estar en torno a los 50 k

Early intravenous nitroglycerin use in prehospital setting and in the emergency department to treat patients with acute heart failure: Insights from the EAHFE Spanish registry

Background and objective: Although recommended for the treatment of acute heart failure (AHF), the use of intravenous (IV) nitroglycerin (NTG) is supported by scarce and contradicting evidence. In the current analysis, we have assessed the impact of IV NTG administration by EMS or in emergency department (ED) on outcomes of AHF patients. Methods: We analyze AHF patients included by 45 hospitals that were delivered to ED by EMS. Patients were grouped according to whether treatment with IV NTG was started by EMS before ED admission (preED-NTG), during the ED stay (ED-NTG) or were untreated with IV NTG (no-NTG, control group). In-hospital, 30-day and 365-day all-cause mortality, prolonged hospitalization (>7 days) and 90-day post-discharge combined adverse events (ED revisit, hospitalization or death) were compared in EMS-NTG and ED-NTG respect to control group. Results: We included 8424 patients: preED-NTG = 292 (3.5%), ED-NTG = 1159 (13.8%) and no-NTG = 6973 (82.7%). preED-NTG group had the most severely decompensated cases of AHF (p < 0.001) but it had lower inhospital (OR = 0.724, 95%CI = 0.459-1.114), 30-day (HR = 0.818, 0.576-1.163) and 365-day mortality (HR = 0.692, 0.551-0.869) and 90-day post-discharge events (HR = 0.795, 0.643-0.984) than control group. ED-NTG group had mortalities similar to control group (in-hospital: OR = 1.164, 0.936-1.448; 30-day: HR = 0.980, 0.819-1.174; 365-day: HR = 0.929, 0.830-1.039) but significantly decreased 90-day post-discharge events (HR = 0.870, 0.780-0.970). Prolonged hospitalization rate did not differ among groups. Five different analyses confirmed these findings