50 research outputs found
Early diastolic filling dynamics in diastolic dysfunction
- Author
- B Villari
- CG Brilla
- Failure European Study Group on Diastolic H
- Faisal Almane
- Gerard J King
- JE Otterstad
- Jerome B Foley
- JM Bland
- K Fukuda
- K Isaaz
- K Shan
- L Galiuto
- L Rodriguez
- LK Waldman
- MB Buchalter
- MG Garcia
- Michael J Walsh
- MJ Garcia
- MJ Garcia
- MS Firstenberg
- N Ohte
- Peter A Crean
- R Erbel
- SF Nagueh
- SF Nagueh
- SF Nagueh
- WN McDicken
- YJ Kim
- Publication venue
- BioMed Central
- Publication date
- 01/01/2003
- Field of study
BACKGROUND: The aim of the study was to determine the relationship between the rate of peak early mitral inflow velocity and the peak early diastolic mitral annular tissue velocities in normal controls and to compare them with subjects with diastolic dysfunction. METHODS: The relationship between early passive diastolic transmitral flow and peak early mitral annular velocity in the normal and in diastolic dysfunction was studied. Two groups comprising 22 normal controls and 25 patients with diastolic dysfunction were studied. RESULTS: Compared with the normal group, those with diastolic dysfunction had a lower E/A ratio (0.7 ± 0.2 vs. 1.9 ± 0.5, p < 0.001), a higher time-velocity integral of the atrial component (11.7 ± 3.2 cm vs. 5.5 ± 2.1 cm, p < 0.0001), a longer isovolumic relaxation time 73 ± 12 ms vs. 94 ± 6 ms, p < 0.01 and a lower rate of acceleration of blood across the mitral valve (549.2 ± 151.9 cm/sec(2 )vs. 871 ± 128.1 cm/sec(2), p < 0.001). They also had a lower mitral annular relaxation velocity (Ea) (6.08 ± 1.6 cm/sec vs 12.8 ± 0.67 cm/sec, p < 0.001), which was positively correlated to the acceleration of early diastolic filling (R = 0.66), p < 0.05. CONCLUSIONS: This investigation provides information on the acceleration of early diastolic filling and its relationship to mitral annular peak tissue velocity (Ea) recorded by Doppler tissue imaging. It supports not only the premise that recoil is an important mechanism for rapid early diastolic filling but also the existence of an early diastolic mechanism in normal
Spatial Pattern of Standing Timber Value across the Brazilian Amazon
- Author
- A Verissimo
- A Verissimo
- AH Gentry
- B Mertens
- C Uhl
- CA Quesada
- CDC Prates-Clark
- CJA Bradshaw
- D Nepstad
- D Nepstad
- DC Nepstad
- EF Moran
- EY Arima
- EY Arima
- F Merry
- F Montagnini
- GB Bonan
- GP Asner
- GP Asner
- H ter Steege
- H ter Steege
- J Chave
- J Southworth
- JA Foley
- Jerome Chave
- JJ Gerwing
- JM Melillo
- KR Kirby
- MM Caldas
- NL Stephenson
- OL Phillips
- PM Fearnside
- PM Fearnside
- PR Giraudoux
- R Dirzo
- RA Betts
- Robert M. Ewers
- Sadia E. Ahmed
- SG Perz
- SS Saatchi
- SW Stone
- TP Evans
- TR Baker
- TR Baker
- WF Laurance
- WF Laurance
- Y Malhi
- Y Malhi
- Y Malhi
- Y Malhi
- Y Malhi
- Y Malhi
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The Amazon is a globally important system, providing a host of ecosystem services from climate regulation to food sources. It is also home to a quarter of all global diversity. Large swathes of forest are removed each year, and many models have attempted to predict the spatial patterns of this forest loss. The spatial patterns of deforestation are determined largely by the patterns of roads that open access to frontier areas and expansion of the road network in the Amazon is largely determined by profit seeking logging activities. Here we present predictions for the spatial distribution of standing value of timber across the Amazon. We show that the patterns of timber value reflect large-scale ecological gradients, determining the spatial distribution of functional traits of trees which are, in turn, correlated with timber values. We expect that understanding the spatial patterns of timber value across the Amazon will aid predictions of logging movements and thus predictions of potential future road developments. These predictions in turn will be of great use in estimating the spatial patterns of deforestation in this globally important biome
Regional Management Units for Marine Turtles: A Novel Framework for Prioritizing Conservation and Research across Multiple Scales
- Author
- A Formia
- AB Bolten
- AB Meylan
- AD Foote
- AL Bass
- AL Bass
- Alan B. Bolten
- Alejandro Fallabrino
- Alexandre Girard
- Alice Costa
- Andrew D. DiMatteo
- B. C. Choudhury
- BA Block
- BJ Godley
- BJ Godley
- BL Taylor
- Blair Witherington
- BM Bolker
- BP Wallace
- Brendan J. Hurley
- Brian J. Hutchinson
- Brian W. Bowen
- Bryan P. Wallace
- BW Bowen
- BW Bowen
- BW Bowen
- BW Bowen
- BW Bowen
- C Carreras
- C Carreras
- C Monzon-Arguello
- C Moritz
- CJ Limpus
- CJ Limpus
- CJ Limpus
- Diego Amorocho
- Elena M. Finkbeiner
- F. Alberto Abreu-Grobois
- FA Abreu-Grobois
- GL Shillinger
- J Dryden
- J Frazier
- JA Musick
- JA Seminoff
- Jeanne A. Mortimer
- Jeffrey A. Seminoff
- Jerome Bourjea
- JM Blumenthal
- John A. Musick
- K Bjorndal
- KA Bjorndal
- KA Bjorndal
- Karen A. Bjorndal
- KEM Dethmers
- KK Martien
- LB Crowder
- M Hamann
- Marc Girondot
- Maria Angela Marcovaldi
- Mark Hamann
- Matthew H. Godfrey
- MC Boyle
- Milagros López-Mendilaharsu
- Milani Y. Chaloupka
- MJ Witt
- MM Foley
- MV Ashley
- N Mrosovsky
- Nicolas J. Pilcher
- NN FitzSimmons
- NN FitzSimmons
- P Yorio
- Paolo Casale
- Peter H. Dutton
- PH Dutton
- PN Halpin
- PN Lahanas
- PN Lahanas
- Raquel Briseño Dueñas
- RM Suryan
- Roderic B. Mast
- Ronel Nel
- RS Waples
- RS Waples
- SA Karl
- Sebastian Troëng
- SJ Jorgensen
- Steven J. Bograd
- TA Conant
- W Dow
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: Resolving threats to widely distributed marine megafauna requires definition of the geographic distributions of both the threats as well as the population unit(s) of interest. In turn, because individual threats can operate on varying spatial scales, their impacts can affect different segments of a population of the same species. Therefore, integration of multiple tools and techniques - including site-based monitoring, genetic analyses, mark-recapture studies and telemetry - can facilitate robust definitions of population segments at multiple biological and spatial scales to address different management and research challenges. Methodology/Principal Findings: To address these issues for marine turtles, we collated all available studies on marine turtle biogeography, including nesting sites, population abundances and trends, population genetics, and satellite telemetry. We georeferenced this information to generate separate layers for nesting sites, genetic stocks, and core distributions of population segments of all marine turtle species. We then spatially integrated this information from fine-to coarse-spatial scales to develop nested envelope models, or Regional Management Units (RMUs), for marine turtles globally. Conclusions/Significance: The RMU framework is a solution to the challenge of how to organize marine turtles into units of protection above the level of nesting populations, but below the level of species, within regional entities that might be on independent evolutionary trajectories. Among many potential applications, RMUs provide a framework for identifying data gaps, assessing high diversity areas for multiple species and genetic stocks, and evaluating conservation status of marine turtles. Furthermore, RMUs allow for identification of geographic barriers to gene flow, and can provide valuable guidance to marine spatial planning initiatives that integrate spatial distributions of protected species and human activities. In addition, the RMU framework - including maps and supporting metadata - will be an iterative, user-driven tool made publicly available in an online application for comments, improvements, download and analysis
Key signaling nodes in mammary gland development and cancer: β-catenin
- Author
- A Abdalkhani
- A Farooq
- A Imbert
- A Iwai
- A Prasad
- A Ryo
- A Tsukamoto
- AA Mailleux
- AC Medeiros
- AG Ridgeway
- AI Khramtsov
- AJ Karayiannakis
- AK Virmani
- AM Mhashilkar
- AM Thompson
- Angela Incassati
- Anupama Chandramouli
- AP Kowalczyk
- AR Moser
- B Gu
- B Howard
- B Lustig
- B Shi
- B Teissedre
- BP Zhou
- BY Liu
- BY Liu
- C Brisken
- C Brisken
- C Gaspar
- C Gillett
- C Lamberti
- C Lindvall
- C Lindvall
- C Nagi
- C van Genderen
- C Wissmann
- CC Liu
- CP Prasad
- CP Prasad
- CR Graveel
- D Sarrio
- D Schramek
- D Srinivasan
- D Xie
- DK Biswas
- DY Fu
- E Foubert
- E Sadot
- EA Musgrove
- EJ Gunther
- EJ Sawyer
- EL Huguet
- EY Chu
- F Ugolini
- G Berx
- GG Chung
- GM Wulf
- H Kirikoshi
- H Korkaya
- H Kouros-Mehr
- H McNeill
- H Suzuki
- H Wang
- H Zhao
- I Bieche
- I Van der Auwera
- J Foley
- J Hens
- J Liu
- J Rhee
- J Stingl
- J Teuliere
- J Veeck
- J Veeck
- J Veeck
- J Zhang
- JA Schroeder
- JA Schroeder
- JE Fata
- JI Herschkowitz
- JJ Wysolmerski
- JJ Wysolmerski
- JM Bradbury
- JM Veltmaat
- JM Veltmaat
- JR Hens
- JS Biscardi
- JS Michaelson
- JY Lee
- K Benhaj
- K Boras-Granic
- K Furuuchi
- K Kondo
- K Miyoshi
- K Roarty
- K Roarty
- K Shomori
- KJ Gauger
- KW Cho
- KY Ho
- L Ai
- L Xu
- LA Jerome-Majewska
- M Beleut
- M Dolled-Filhart
- M Gasco
- M Hiremath
- M Jonsson
- M Jonsson
- M Kashiwaba
- M Katoh
- M Kuraguchi
- M Patturajan
- M Pummila
- M Shackleton
- M Shulewitz
- M Yamamoto
- MA Forget
- MC Eblaghie
- ME Dunbar
- ME Rieger
- MG Ponzo
- MJ Hayes
- MM Koker
- MS Roh
- MT Maher
- MT Webster
- NM Badders
- O Boussadia
- O Watanabe
- P Bjorklund
- P Cowin
- PA Joshi
- Pamela Cowin
- PG Andrews
- PL Depowski
- PM Ismail
- PW Derksen
- PW Schlosshauer
- Q Yu
- R Nusse
- R van Amerongen
- Rachel Eelkema
- RC Gallagher
- RT Sormunen
- RW Cho
- S Aulmann
- S Chadi
- S Lejeune
- S Ozaki
- S Persad
- S Roura
- SB Tepera
- SC Abraham
- SC Wong
- SI Matsuzawa
- SJ Weber-Hall
- SY Lin
- T Milovanovic
- T Nagahata
- T Sorlie
- TA Buhler
- TA DiMeo
- TC Dale
- TD Bui
- TF Lane
- TG Davenport
- TM Rowlands
- TM Rowlands
- VH Cowling
- W Hsu
- WA Woodward
- X Wang
- Y Li
- Y Matsuda
- Y Mei
- YA Zeng
- YC Kim
- YC Kim
- YC Liou
- Z Jin
- ZQ Yang
- Publication venue
- BioMed Central
- Publication date
- Field of study
β-Catenin plays important roles in mammary development and tumorigenesis through its functions in cell adhesion, signal transduction and regulation of cell-context-specific gene expression. Studies in mice have highlighted the critical role of β-catenin signaling for stem cell biology at multiple stages of mammary development. Deregulated β-catenin signaling disturbs stem and progenitor cell dynamics and induces mammary tumors in mice. Recent data showing deregulated β-catenin signaling in metaplastic and basal-type tumors suggest a similar link to reactivated developmental pathways and human breast cancer. The present review will discuss β-catenin as a central transducer of numerous signaling pathways and its role in mammary development and breast cancer
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
- Carmichael Owen
- Carr Vaughan J
- Carrillo Maria
- Carroll Maria
- Carson Richard E
- Carter Raina
- Casaceli Cynthia
- Casalin Paola
- Caseras Xavier
- Caspell Chelsea
- Caspers Svenja
- Catafau Ana
- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
- Debette Stephanie
- Debette Stephanie
- Decarli Charles
- DeCarli Charles
- Deeley Cheryl
- Degenhardt Franziska
- Delanty Norman
- DeMarco Kathryn
- den Braber Anouk
- Dennis Michelle F
- Depondt Chantal
- Desrivieres Sylvane
- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
- Dooley Eoin
- Doraiswamy P Murali
- Drost Dick
- Duara Ranjan
- Dubow Jordan S
- Dunlop Becky
- Egebjerg Jan
- Ehrlich Stefan
- El Khouli Riham
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espay Alberto
- Espay Kristy
- Espeseth Thomas
- Espiritu Ryan
- Faber Kelley
- Factor Stewart
- Fan Chun Chieh
- Fargher Kristin
- Farlow Martin R
- Fatica Parianne
- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
- Flor Herta
- Flor Herta
- Foley Sonya F
- Fontaine Deborah
- Fontoura Paulo
- Ford Judith M
- Fornage Myriam
- Fornage Myriam
- Foroud Tatiana
- Foroud Tatiana M
- Forstner Andreas J
- Foster Eric
- Foster Norm
- Fox Nick
- Francks Clyde
- Frank Richard
- Frank Samuel
- Franke Barbara
- Franklin Erin
- Franz Carol E
- Frasier Mark
- Frouin Vincent
- Fröhner Juliane
- Fukunaga Masaki
- Gaikwad Mrunalini
- Galasko Douglas
- Garavan Hugh
- Garijo Daniel
- Garrett Melanie E
- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
- Green Robert C
- Green Robert C
- Greig-Custo Maria T
- Griffith Randall
- Grimmer Yvonne
- Groenewold Nynke A
- Grossman Hillel
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
- Hariri Ahmad R
- Harlan Sherry
- Harless Kelly
- Harris Mat
- Harris Mathew A
- Harrison Marc B
- Hart David
- Hartman Catharina A
- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
- Heinz Andreas
- Heinz Andreas
- Heinzen Erin L
- Henskens Frans A
- Hergesheimer Lindsey
- Herms Stefan
- Hernando Raymundo
- Herring Scott
- Heslenfeld Dirk J
- Hetelle Joel
- Hewitt David L
- Heyn Chris Chinthaka
- Hibar Derrek P
- Hillegers Manon H J
- Himali Jayandra J
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J
- Hofer Edith
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U
- Hofman Albert
- Hogarth Penelope
- Hohmann Sarah
- Holleran Laurena
- Holmes Avram J
- Holsboer Florian
- Holtzman David
- Homuth Georg
- Hong L Elliot
- Honig Lawrence S
- Hoogman Martine
- Hopkins William D
- Hosein Chris
- Hosten Norbert
- Hottenga Jouke-Jan
- Hsiao John
- Hsiung Ging-Yuek Robin
- Hu Shu-Ching
- Hulshoff Pol Hilleke E
- Hunter Christine
- Hynes Mary L
- Häusler Alexander N
- Håberg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Arfan
- Ing Alex
- Initiative Alzheimer’s Disease Neuroimaging
- Initiative Parkinson’s Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
- James Angela
- James Olga
- James Raymond
- Jang MiHyun
- Jankovic Joseph
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E
- Jennings Danna
- Jernigan Terry L
- Jia Tianye
- Jia Tianye
- Jian Xueqiu
- Jiang Jiyang
- Jicha Greg
- Jimenez Gustavo
- Jockwitz Christiane
- Johnson Kathleen
- Johnson Keith A
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
- Jones David
- Jönsson Erik G
- Kahn René S
- Kanai Ryota
- Kantarci Kejal
- Karama Sherif
- Karama Sherif
- Karlawish Jason H
- Kasperaviciute Dalia
- Kass Joseph S
- Kataki Maria
- Kaufmann Tobias
- Kaye Jeffrey A
- Kelly Sinead
- Keltz Melanie
- Kennedy Martin A
- Kertesz Andrew
- Kerwin Diana
- Khachaturian Zaven
- Kieburtz Karl
- Kielb Stephanie
- Kikuchi Masataka
- Killiany Ronald
- Kim Sungeun
- Kimbrel Nathan A
- Kircher Tilo T J
- Kittur Smita
- Kiyasova Vera
- Klein Marieke
- Knapp Michael
- Knodt Annchen R
- Knol Maria J
- Knopman David
- Kochunov Peter
- Koeppe Robert A
- Koleva Hristina
- Kolskår Knut
- Koops Sanne
- Kopil Catherine
- Korecka Magdalena
- Kowalksi Nancy
- Kowall Neil
- Kremen Sarah
- Kremen William S
- Krug Axel
- Krämer Bernd
- Kuller Lew
- Kwok John B
- Kwok John B J
- Lah James J
- Lam Max
- Lamar Melissa
- Lamb Ashley
- Lancaster Thomas M
- Landau Susan
- Lane Barton
- Lasch Shirley
- Launer Lenore
- Le Hellard Stephanie
- Leach Christi
- Leary Laura
- Lee Athena
- Lee Phil H
- Lee T-Y
- Lee Virginia
- Lemaitre Hervé
- Lenahan Art
- Leonard Gabriel
- Lerner Alan
- Lethbridge Emma
- Lett Tristram A
- Leverenz James
- Levey Allan I
- Lewis Lindsay
- Lewis Lindsay B
- Li Shuo
- Liang Grace
- Lim Kelvin O
- Lin Honghuang
- Lin Michael
- Lind Betty
- Lind Penelope A
- Linder Carly
- Lipowski Kristine
- Loeffler Markus
- Logovinsky Veronika
- Logue Mark
- Longstreth W. T.
- Longstreth William T
- Lopes-Cendes Iscia
- Lopez Oscar L
- Lopez Oscar L
- Lord Joanne L
- Loughland Carmel M
- Love Marissa Natelson
- Lu Po H
- Luciano Michelle
- Luciano Michelle
- Luykx Jurjen J
- Lyons Michael J
- Macciardi Fabio
- Maillard Pauline
- Maingault Sophie
- Makino Kelly M
- Malferrari Giulia
- Malloy Paul
- Marek Kenneth
- Mari Zoltan
- Marquand Andre F
- Marshall Gad A
- Marson Daniel
- Martin Kim
- Martin Nicholas G
- Martinot Jean-Luc
- Martinot Jean-Luc
- Martinot Marie-Laure Paillère
- Mason Sara S
- Mathalon Daniel H
- Mather Karen A
- Mather Karen A
- Mathews Dana
- Mathias Samuel R
- Mathis Chet
- Mattay Venkata S
- Matthews Brandy R
- Matthews Sarah
- Mayoral Van Son Jaqueline
- Mazoyer Bernard
- Mazoyer Bernard
- McCoy Arita
- McDonald Colm
- McEwen Sarah C
- McMahon Katie L
- McMahon Mary Agnes B
- Medland Sarah E
- Melle Ingrid
- Melzer Tracy R
- Mendick Susan
- Mesulam M Marcel
- Mesulam Marek-Marsel
- Meyer Javier Villanueva
- Meyer-Lindenberg Andreas
- Michie Patricia T
- Milaneschi Yuri
- Millenet Sabina
- Miller Bruce L
- Miller Delwyn D
- Miller Sarah
- Minton Mark
- Mintun Mark A
- Mintz Akiva
- Mintzer Jacobo
- Miranda Ruben
- Mirza-Schreiber Nazanin
- Mishra Aniket
- Mitsis Effie
- Mollenhauer Brit
- Monahan Nancy
- Montine Tom
- Moreira Jose C V
- Morey Rajendra A
- Morris Derek W
- Morris John
- Morris John C
- Mosley Thomas H
- Mosley Thomas H
- Mota Nina Roth
- Mowry Bryan
- Mudge Benita
- Mueller Bryon A
- Muglia Pierandrea
- Mule Jennifer
- Muni Donna
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Najt Pablo
- Nakahara Soichiro
- Nam Ki Won
- Nauck Matthias
- Neale Michael C
- Nees Frauke
- Neu Scott
- Nho Kwangsik
- Nho Kwangsik
- Niessen Wiro J
- Norbash Alexander
- Nordvik Jan E
- Nyberg Lars
- Nöthen Markus M
- O'Leary Daniel S
- Oakley MaryAnn
- Oates Elizabeth
- Obisesan Thomas O
- Obradov Sanja
- Ogrocki Paula
- Ogunlana Olu
- Olde Loohuis Loes M
- Olichney John
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- Oyonumo Ntekim E
- Pacini Nathaniel
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- Panizzon Matthew S
- Pantelis Christos
- Papadopoulos Dimitri
- Parfitt Francine
- Pasternak Stephen
- Paul Steven
- Paus Tomas
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- Pavlosky William
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- Pearlson Godfrey D
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- Posthuma Danielle
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- Toga Arthur W
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- Trncic Nadira
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- Vanderswag Helen
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- Verhoef Ellen
- Vernooij Meike W
- Villena Teresa
- Villringer Arno
- Voyvodic James T
- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
- Walter Sarah
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- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
- Weinberger Daniel R
- Weiner Michael
- Weiner Michael W
- Weintraub Sandra
- Wen Wei
- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
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- Badri Hummy
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- Baker M.
- Baker Richard
- Bakis Michele
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- Banerjee Ruby
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- Bao Qiyu
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- Barbe Valérie
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- Barker Darren
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- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
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- Bituin Aleksandr
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- Comstock Robin
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- Conrad Ansgar
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- Dawoe Tenzin
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- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
- Groza Matthew
- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
- Guo Jane
- Guo Lili
- Gustafson Erik
- Guthrie Ian
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- Gyaltsen Kunsang
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- Görlich Yvonne
- Ha Chi
- Hafez Nabil
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- Hall Brett Lynn
- Hall Brittany
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- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
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- Hashimoto Wakako
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- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
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- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
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- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
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- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
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- Iwatate Mariko
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- Izumiyama Tomohiro
- Jacintho Mark
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- Jackson Terri
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- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
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- Jareborg Niclas
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- Jeffery Grant
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- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
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- Jimenez Alberto
- Jin Jian
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- Jones Myrna D.
- Jones Steven
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- Kegg Lisa
- Kelley Simon
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- Kettleborough Ross
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- Khan Umer F.
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- Khine Susu
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- Kohlberg Sara
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Lambart Christine
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- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
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- Lapidus Alla
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- Lewis Keith
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
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- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
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- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Maheshwari Manjula
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- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
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- Mardis Elaine R.
- Mareth David
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- Marinelli Lisa
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- Marquis-Homeyer Catherine
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- Marra Marco
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- Matthews Sterling D.
- Mauceli Evan
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- McLeod Michael P.
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- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
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- McWilliams Natalie
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- Meidi Patrick
- Meier Elke
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- Mejima Mio
- Meldrim James
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- Meng Shanshan
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- Mercado Christian
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- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
- Mesirov Jill P.
- Metzker Michael Lee
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- Miller Christie
- Miller Donald
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- Miner Sheri
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- Minja Emmanuel
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- Morgan Margaret B.
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- Moyzis Robert K.
- Mu Feng
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- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
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- Munk Christie A.
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- Murayama Yuji
- Murnane Clare
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- Murphy Michael
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- Nagamine Kentaro
- Nagao Syunsuke
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- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
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- Nazareth Lynne V.
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- Nelson Deborah A.
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- Nguyen Natalie M.
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- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
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- Okui Michiyo
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- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
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- Olson Maynard V.
- Omotosho Bamidele
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- Parry-Brown Ginny
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- Pasternak Shiran
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- Paul Heidie A.
- Paul Shelia
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- Payton Brett A.
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- Pearman Charlene
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- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
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- Polman Jos
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- Porter Keith
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- Prathalingham Radhika
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- Qiang Boqin
- Qiao Zhenyong
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- Radionenko Maxim
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- Richardson Susan
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- Ridler Kerry
- Riethman Harold
- Riethoven Lyn
- Rigby Rachel
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- Rise Cecil
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- Rong Li
- Rong Li
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- Salazar Angelica
- Salter Natalie
- Samain Sylvie
- Sana Moazzam Mohammad
- Sanders Brent
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- Santibanez Jireh
- Santoyo-Lopez Javier
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- Schmidt Esther
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- Schnabl Matthew
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- Schupbach Rebecca
- Schuster Michael
- Schön Oliver
- Scott Carol
- Scott Damian
- Scott Deborah
- Scott Duncan
- Scott Graham
- Scott Ian
- Scott Kelsi
- Scott Paul
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- Searle Paul
- Searle Stephen
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- Severin Jessica
- Seymour Burt
- Shah Neha
- Shakespeare Joe
- Shams Saima
- Shao Chunyan
- Shao Yufen
- Shapiro Harris
- Shardelow Jason
- Sharp Greg
- Sharpe Ted
- Shaw Teresa
- Shaw-Smith Charles
- She Xinwei
- Shearing Jennifer
- Shen Fengye
- Shen Hua
- Shen Meishan
- Shen Yan
- Shen Yan
- Shen Yan
- Sheng Haihui
- Sheppard Karen
- Sheridan Andrew
- Sheridan Elizabeth
- Sherpa Ngawang
- Shi Guibin
- Shi Hongfang
- Shibuya Kazunori
- Shiino Noriko
- Shimizu Atsushi
- Shimizu Hidetsugu
- Shimizu Nobuyoshi
- Shimizu Yoshiko
- Shin Maria
- Shindoh Nobuaki
- Shintani Ai
- Shiohama Aiko
- Shoji Minami
- Shotland Yoram
- Shought Timothy
- Shownkeen Ratna
- Shreve Jeff
- Siddiqui Roman
- Siepel Adam C.
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- Silk Richard
- Sims Matthew
- Sims Matthew
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- Sims Sarah
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- Sinha Prashant
- Sisson Ida
- Sivadasan Shanthi
- Sivadasan Shanthi
- Skowronski Evan
- Skuce Carl
- Skuce Carl
- Slater Nathaniel
- Slezak Tom
- Smedley Damian
- Smink Luc
- Smink Luc
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- Smith Doug
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- Smith James
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- Smith Joel
- Smith Karen
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- Smith Lorraine
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- Smith Stephanie
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- Smith Troy
- Sneath Hannah
- Sneath Hannah
- Sodergren Erica
- Soderlund Cari
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- Soderlund Cari
- Solovyev Victor
- Solovyez Victor
- Sonaike Titilola
- Song Liping
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- Song Shuping
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- Stallings Raymond I.
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- Standring Lisa
- Stange-Thomann Nicole
- Stavropoulos Sharon
- Steffen David
- Stege Justin T.
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- Stephens Yvonne
- Stephens-Bolds Shaela
- Stetson Kevin
- Stevko Victor
- Steward Charles
- Stewart Aengus
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- Still Ian
- Stock Mo
- Stone Casey
- Stone Evan
- Stone Sabrina
- Stoppard Lisa
- Storey Philip
- Storey Roy
- Stowe Sarah
- Strachan Carol
- Strachan Greg
- Strasser Jonathan
- Stribling Claire
- Strong Cynthia
- Stubbs Lisa
- Stubbs Matthew
- Stultz Janet
- Sturdy John
- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
- Sun Jiandong
- Sun Jiu Qin
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- Sun Tao
- Sun Wei
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- Sun Yu
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- Svatek Amanda F.
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- Swainson Chris
- Swann Mark
- Swarbreck David
- Swearengen-Shahid Sharhonda
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- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
- Tahara Takashi
- Takahashi Keiko
- Takano Nobuhiro
- Takaoka Tori
- Takayanagi Atsushi
- Takenaka Tracy
- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
- Tamirisa Aparna
- Tan Olivia
- Tan Steven
- Tan Xinyu
- Tan Xinyu
- Tang Hongli
- Tang Xiangjun
- Tansey Jennifer
- Tao Ran
- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
- Taylor Kate
- Taylor Ruth
- Taylor Sam
- Taylor Susan
- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
- Valles Yvonne
- Van Brunt Andrew
- Van Dilla Marvin
- Van Helmond Zoe
- Van Luchene Ryan
- Vardanian Zachary
- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
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- Williams Andy
- Williams Bill
- Williams Gabrielle A.
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- Williamson Helen
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- Wilson Steve
- Wilson Wendy
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- Window Philip
- Winster Jenny
- Winzar Claire
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- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
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- Wong Gane K-S
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- Wood Joe
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- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA‐Epilepsy study
- Author
- Alvim Marina K. M.
- Arienzo Donatello
- Aventurato Ítalo K.
- Ballerini Alice
- Baltazar Gabriel F.
- Bargalló Núria
- Bender Benjamin
- Brioschi Ricardo
- Bürkle Eva
- Caligiuri Maria Eugenia
- Cendes Fernando
- de Tisi Jane
- Duncan John S.
- Engel Jerome P.
- Foley Sonya
- Fortunato Francesco
- Gambardella Antonio
- Giacomini Thea
- Guerrini Renzo
- Hall Gerard
- Hamandi Khalid
- Harding Ian H.
- Ives‐Deliperi Victoria
- João Rafael B.
- Keller Simon S.
- Kerestes Rebecca
- Kleiser Benedict
- Labate Angelo
- Lenge Matteo
- Marotta Cassandra
- Martin Pascal
- Mascalchi Mario
- McDonald Carrie R.
- Meletti Stefano
- O'Brien Terence J.
- Owens‐Walton Conor
- Parodi Costanza B.
- Pascual‐Diaz Saül
- Perry Andrew
- Powell David
- Rao Jun
- Rebsamen Michael
- Reiter Johannes
- Riva Antonella
- Rummel Christian
- Rüber Theodor
- Scheffler Freda
- Severino Mariasavina
- Silva Lucas S.
- Sisodiya Sanjay M.
- Staba Richard J.
- Stein Dan J.
- Striano Pasquale
- Taylor Peter N.
- Thomopoulos Sophia I.
- Thompson Paul M.
- Tortora Domenico
- Vaudano Anna Elisabetta
- Vivash Lucy
- Weber Bernd
- Wiest Roland
- Winston Gavin P.
- Yasuda Clarissa L.
- Zheng Hong
- Publication venue
- Wiley
- Publication date
- 01/01/2024
- Field of study
Objective: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross‐sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA‐Epilepsy working group. Methods: A state‐of‐the‐art deep learning‐based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions. Linear mixed models compared total and regional cerebellar volume in (1) all epilepsies, (2) temporal lobe epilepsy with hippocampal sclerosis (TLE‐HS), (3) nonlesional temporal lobe epilepsy, (4) genetic generalized epilepsy, and (5) extratemporal focal epilepsy (ETLE). Relationships were examined for cerebellar volume versus age at seizure onset, duration of epilepsy, phenytoin treatment, and cerebral cortical thickness. Results: Across all epilepsies, reduced total cerebellar volume was observed (d = .42). Maximum volume loss was observed in the corpus medullare (dmax = .49) and posterior lobe gray matter regions, including bilateral lobules VIIB (dmax = .47), crus I/II (dmax = .39), VIIIA (dmax = .45), and VIIIB (dmax = .40). Earlier age at seizure onset ( η ρ max 2 ηρmax2 = .05) and longer epilepsy duration ( η ρ max 2 ηρmax2 = .06) correlated with reduced volume in these regions. Findings were most pronounced in TLE‐HS and ETLE, with distinct neuroanatomical profiles observed in the posterior lobe. Phenytoin treatment was associated with reduced posterior lobe volume. Cerebellum volume correlated with cerebral cortical thinning more strongly in the epilepsy cohort than in controls. Significance: We provide robust evidence of deep cerebellar and posterior lobe subregional gray matter volume loss in patients with chronic epilepsy. Volume loss was maximal for posterior subregions implicated in nonmotor functions, relative to motor regions of both the anterior and posterior lobe. Associations between cerebral and cerebellar changes, and variability of neuroanatomical profiles across epilepsy syndromes argue for more precise incorporation of cerebellar subregional damage into neurobiological models of epilepsy
Barreiras no rastreamento do câncer de mama e o papel da enfermagem: revisão integrativa
- Author
- Anderson BO
- Anderson BO
- Aro AR
- Berry DA
- Budakoglu II
- CaleffiM
- Carter AC
- Chiarelli AM
- Chiarelli AM
- Crombie K
- Dalessandri KM
- Edmundo Carvalho Mauad
- Foley EC
- Fonseca ATL
- Gebrim LH
- George SA
- Godinho ER
- Godinho ER
- Grindel CG
- Holloway S
- Holowaty PH
- Jemal A
- Jerome-D'Emilia B
- Kelaher M
- Lagerlund M
- Lagerlund M
- Lauver DR
- Lee BL
- Lee BL
- Lee CH
- Liao MN
- Liu CY
- Lourenço TS
- Margolis KL
- Margolis KL
- Marinho LAB
- Mauad EC
- Mauad EC
- Ortega-Altamirano D
- Parkin DM
- Perry N
- Pisani P
- Remennick L
- René Aloisio da Costa Vieira
- Rimer BK
- Secginli S
- Shapiro S
- Sharp DJ
- Smith RA
- Soyer MT
- Sutton S
- Taran FA
- Thuler LC
- Tânia Silveira Lourenço
- Vieira RAC
- Vieira RAC
- Ward E
- Womeodu RJ
- Xavier NL
- Zapponi ALB
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
- Andrews L
- Andrews R
- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
- Archer A
- Armitage J
- Armstrong L
- Armstrong M
- Arnesson K
- Arnold M
- Arora P
- Arp H
- Asbill B
- Ashbrook-raby C
- Ashton L
- Assarsson E
- Audet K
- Augenbraun C
- Aung HNIN THANDA
- Auscher S
- Ausner J
- Aviles R
- Awasty V
- Axelsson U
- Ayers S
- Ayub H
- Babar G
- Babington G
- Backlund M
- Badal B
- Baggiore C
- Baghiana S
- Bai H
- Bai J
- Baigent C
- Baillargeon G
- Bakbak A
- Baker S
- Baldin Mg
- Baldini E
- Baldwin E
- Ballantyne C
- Baltic A
- Banerjee S
- Bang Hansen M
- Banks K
- Bansilal S
- Barkley-daughtry S
- Barnes D
- Barnes E
- Barnett S
- Baroni Claudio
- Barry S
- Barter P
- Bartolomei Mecatti B
- Barton I
- Barton J
- Baré C
- Bashton D
- Basler M
- Bastani L
- Basvi P
- Batchlett K
- Bateman S
- Battistelli E
- Baty J
- Bauersachs J
- Bauman A
- Bavendiek U
- Baxter A
- Bayly G
- Bays H
- Beasley T
- Beck P
- Beck S
- Becker P
- Beebe S
- Been M
- Begg R
- Behm K
- Beilker J
- Beißner S
- Bekfani T
- Belanger B
- Belew K
- Bellaby J
- Bellamy C
- Bellini S
- Beneat Am
- Benedetto K
- Benoni S
- Bentivenga L
- Benton R
- Berg Schmidt E
- Berg-johansen J
- Berge C
- Bergengen L
- Bergmark B
- Bergmark C
- Bergsten P
- Bergström Ml
- Bergström O
- Bergvall L
- Bernardinangeli M
- Bernstein R
- Berry C
- Berry M
- Bertoli D
- Bertram W
- Bescak D
- Bescak K
- Betzl G
- Bhargava A
- Bhargava R
- Bhatia
- Bian B
- Bian H
- Bian X
- Bianchini Filippo
- Bibi A
- Bies J
- Bigelow A
- Biggers J
- Bilazarian S
- Billings C
- Binley E
- Biondi A
- Bird C
- Birner C
- Bisceglia T
- Bittar N
- Bittel B
- Bitzer V
- Biundo V
- Bjerge Kaspersen B
- Bjergo J
- Bjorkas A
- Björkman-larnefeldt M
- Bjørhovde V
- Black L
- Blackwood S
- Blake J
- Blankenberg S
- Blaustein R
- Blechert Å
- Bloksgaard Nilesen S
- Blower G
- Board J
- Boccalandro F
- Boccati S
- Boelmans K
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- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
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- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
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- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
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- Bentley Joe
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- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
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- Bhaumik Shubhagata
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- Bini Sophie
- Birnholtz Ofek
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- Blackburn Kent
- Blagg L. A.
- Blair C. D.
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- Bobba F.
- Bode Nina
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
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- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
- Bonino A.
- Bonnand Romain
- Booker P.
- Borchers A.
- Boschi Valerio
- Bose S.
- Bossilkov V.
- Boudart Vincent
- Boudon A.
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- BRANCHESI Marica
- Brandt J.
- Braun I.
- Breschi Matteo
- Briant Tristan
- Brillet A.
- Brinkmann M.
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- Buscicchio Riccardo
- Buskulic D.
- Bustillo J. Calderón
- Buy Christelle
- Byer R. L.
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- Cabras Giuseppe
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- Cadonati Laura
- Cagnoli Gianpietro
- Cahillane Craig
- Callister T. A.
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- Camp J. B.
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- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini Claudio
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
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- Chakraborty Pratik
- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
- Char Prasanta
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study