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Zebrafish Globin Switching Occurs in Two Developmental Stages and Is Controlled by the LCR

Author: de Jong Jill L.O.
DiBiase Anthony
Ganis Jared Jason
Hsia Nelson
Jia Zhiying
Lambert Janelle S.
Sabo Peter J.
Sandstrom Richard
Stamatoyannopoulos John A.
Trompouki Eirini
Weaver Molly
Zhou Yi
Zon Leonard Ira
Publication venue: 'Elsevier BV'
Publication date: 28/07/2014
Field of study

Globin gene switching is a complex, highly regulated process allowing expression of distinct globin genes at specific developmental stages. Here, for the first time, we have characterized all of the zebrafish globins based on the completed genomic sequence. Two distinct chromosomal loci, termed major (chromosome 3) and minor (chromosome 12), harbor the globin genes containing α/β pairs in a 5′–3′ to 3′–5′ orientation. Both these loci share synteny with the mammalian α-globin locus. Zebrafish globin expression was assayed during development and demonstrated two globin switches, similar to human development. A conserved regulatory element, the locus control region (LCR), was revealed by analyzing DNase I hypersensitive sites, H3K4 trimethylation marks and GATA1 binding sites. Surprisingly, the position of these sites with relation to the globin genes is evolutionarily conserved, despite a lack of overall sequence conservation. Motifs within the zebrafish LCR include CACCC, GATA, and NFE2 sites, suggesting functional interactions with known transcription factors but not the same LCR architecture. Functional homology to the mammalian α-LCR MCS-R2 region was confirmed by robust and specific reporter expression in erythrocytes of transgenic zebrafish. Our studies provide a comprehensive characterization of the zebrafish globin loci and clarify the regulation of globin switching.Stem Cell and Regenerative Biolog

Harvard University - DASH

Search for particles with unexpected mass and charge in Z decays

Author: Abbaneo D.
Adlung S.
Ajaltouni Ziad,
Alemany R.
Amendolia S R.
Antonelli A.
Ariztizabal F.
Ashman J G.
Assmann R W.
Aubert J.J.
Babbage W.
Badaud F.
Badier J.
Bagliesi G.
Baldini R.
Barbiero E.
Bardadin-Otwinowska M.
Batignani G.
Bauer C.
Bauerdick L A T.
Belk A T.
Bellantoni L.
Bencheikh A.M.
Benchouk C.
Bencivenni G.
Betteridge A P.
Beuselinck R.
Binnie D M.
Bloch-Devaux B.
Blondel A.
Blucher E.
Blum W.
Boehrer A.
Bologna G.
Bonissent A.
Bonneaud G.
Bonvicini G.
Booth C N.
Bosisio L.
Bossi F.
Botterill D R.
Bottigli U.
Boucrot J.
Boudreau J.
Bowdery C K.
Bozzi C.
Bradaschia C.
Brandl B.
Brandt S.
Braun O.
Brient J C.
Brodbeck T J.
Brown D.
Buskulic D.
Buttar C.
Callot O.
Cameron W.
Campana P.
Candlin D J.
Capon G.
Carney R E.
Carpinelli M.
Carr J.
Carter J M.
Cartwright S L.
Casper D.
Cattaneo M.
Cattaneo P W.
Cerutti F.
Chen W.,
Chiarella V.
Cinabro D.
Ciocci M A.
Clifft R W.
Colas P.
Colling D J.
Colrain P.
Comas P.
Combley F.
Conway J S.
Corden M.
Cordier A.
Cowan G.
Cowen D F.
Coyle P.
Creanza D.
Crespo J M.
D'Ettorre Piazzoli B.
Davier M.
De Palma M.
Decamp D.
Dehning B.
Delfino M.
Dell'Orso R.
Della Marina R.
Dietl H.
Dornan P J.
Drevermann H.
Drinkard J.
Duarte H.
Duflot L.
Dugeay S.
Dydak F.
Edgecock T R.
Edwards M.
Efthymiopoulos I.
El-Fellous R.
Etienne F.
Falvard Alain
Farilla A.
Fearnley T.
Felici G.
Feng Z.
Ferguson D P S.
Fernandez E.
Fernandez-Bosman M.
Ferrante I.
Fidecaro F.
Finch A J.
Fisher S M.
Foa L.
Focardi E.
Forti F.
Forty R W.
Foster F.
Fouque G.
Frank M.
Gaitan V.
Ganis G.
Gao Y S.
Garrido L.
Gay C.
Gay Pascal
Georgiopoulos C.
Geweniger C.
Giannini G.
Giassi A.
Giorgi M A.
Gobbo B.
Goy C.
Grahl J.
Green M G.
Greene A M.
Grivaz J F.
Grupen C.
Guicheney C.
Hagelberg R.
Halley A W.
Hanke P.
Hansen J D.
Hansen J R.
Hansen P H.
Harton J L.
Harvey J.
Hassard J F.
Hatfield F.
Haywood S.
Henrard Pierre
Hepp V.
Heusse P.
Hilgart J.
Hu H.
Huang D.
Huang X.
Hughes G.
Iaselli G.
Ikeda M.
Jackson D.
Jacobsen R.
Jaffe D E.
Janot P.
Jared R C.
Johnson R P.
Jones T J.
Jost B.
Jousset J.
Keemer N R.
Kim D W.
Kleinknecht K.
Kluge E E.
Kneringer E.
Knobloch J.
Kozanecki W.
Kuhn D.
Kyriakis A.
Lancon E.
Lannutti J.
Lauber J.
Laurelli P.
Le Diberder F.
LeClaire B W.
Lees J P.
Lefrancois J.
Lehraus I.
Lemaire M C.
Levinthal D.
Lieske N M.
Ligabue F.
Lin Jiali
Lishka C.
Litke A M.
Locci E.
Lohse T.
Lou J.
Luetjens G.
Lusiani A.
Lutters G.
Lutz A M.
Lutz G.
Lynch J G.
Maggi G.
Maggi M.
Maitland W.
Mannelli E B.
Manner W.
Mannocchi G.
March P V.
Marrocchesi P S.
Martinez M.
Mato P.
Mattison T.
Maumary Y.
Medcalf T.
Meinhard H.
Mermikides M.
Messineo A.
Michel B.
Minard M N.
Minten A.
Miotto A.
Miquel R.
Mir L M.
Mollerud R.
Moneta L.
Monnier E.
Montret Jean-Claude
Morton W T.
Moser H G.
Mours B.
Murtas F.
Murtas G P.
Nash J.
Natali S.
Nilsson B S.
Norton P R.
Nuttall M.
Nuzzo S.
Orteu S.
Pacheco A.
Padilla C.
Palazzi P.
Palla F.
Pallin D.
Pan Y B.
Papalexiou S.
Parrini G.
Parsons M I.
Pascual A.
Passalacqua L.
Patel A D.
Pater J R.
Payne D G.
Payre P.
Pepe-Altarelli M.
Perez P.
Perlas J A.
Perret Pascal
Perrier F.
Phillips M J.
Picchi P.
Pietrzyk B.
Proriol Joseph
Prulhiere F.
Pusztaszeri J F.
Putzer A.
Qian Z.
Qiao C.
Quattromini M.
Quazi I S.
Raab J.
Ragusa F.
Raine C.
Rander J.
Ranieri A.
Ranjard F.
Raso G.
Redlinger G.
Reeves P.
Renardy J F.
Renk B.
Rensch B.
Richter R H.
Rivera F.
Rizzo G.
Rolandi L.
Romano F.
Roos L.
Rosowsky A.
Rothberg J.
Rotscheidt H.
Rouge A.
Roussarie A.
Rousseau D.
Ruan T.
Rudolph G.
Ruggieri F.
Rumpf M.
Saadi Y.
Saich M.
Salmon D P.
Sander H G.
Sanguinetti G.
Sawyer L.
Scarr J M.
Schaefer U.
Schlatter D.
Schmelling M.
Schmidt H.
Schmitt M.
Schroeder J.
Schuller J P.
Schune M H.
Schwarz A S.
Schwemling P.
Schwindling J.
Sedgbeer J K.
Sefkow F.
Selvaggi G.
Settles R.
Seywerd H.
Sharma V.
Shi Z H.
Si Mohand D.
Silvestris L.
Simopoulou E.
Sloan T.
Smith K.
Smith M G.
Snow S W.
Spagnolo P.
Stahl A.
Steeg F.
Steinberger J.
Stiegler U.
Stierlin U.
Stimpfl G.
Strong J A.
Takashima M.
Talby M.
Tanaka R.
Taylor G.
Tejessy W.
Tempesta P.
Ten Have I.
Tenchini R.
Thomas J.
Thompson A S.
Thompson J C.
Thompson L F.
Tittel K.
Tomalin I R.
Tonelli G.
Triggiani G.
Turnbull R M.
Vallage B.
Vannini C.
Vayaki A.
Veillet J J.
Veitch E.
Venturi A.
Verderi M.
Verdini P G.
Videau H.
Videau I.
Wachsmuth H.
Walsh A M.
Walsh J.
Walther S M.
Wang T.
Wanke R.
Wasserbaech S.
Wear J.
Weber F V.
West L R.
Whelan E P.
Whitney M H.
Wiedenmann W.
Wildish T.
Witzeling W.
Wolf B.
Wolf G.
Wotschack J.
Wright A G.
Wu Sau Lan.
Wu X.
Wunsch M.
Xie Y.
Xu D.
Xu R.
Zachariadou K.
Zhang J.
Zhang Zhiqing
Zhao W.
Zito G.
Zobernig G.
Publication venue: 'Elsevier BV'
Publication date: 01/01/1993
Field of study

HAL-IN2P3

Hal - Université Grenoble Alpes

HAL AMU

HAL Clermont Université

HAL Université de Savoie

HAL-Polytechnique

Update of electroweak parameters from Z decays

Author: Abbaneo D.
Adlung S.
Ajaltouni Ziad,
Alemany R.
Antonelli A.
Ariztizabal F.
Ashman J G.
Assmann R W.
Aubert J.J.
Babbage W.
Badaud F.
Badier J.
Bagliesi G.
Baldini R.
Barbiero E.
Bardadin-Otwinowska M.
Batignani G.
Bauer C.
Bauerdick L A T.
Belk A T.
Bellantoni L.
Bencheikh A.M.
Benchouk C.
Bencivenni G.
Betteridge A P.
Beuselinck R.
Binnie D M.
Bloch-Devaux B.
Blondel A.
Blucher E.
Blum W.
Boehrer A.
Bologna G.
Bonissent A.
Bonneaud G.
Bonvicini G.
Booth C N.
Bosisio L.
Bossi F.
Botterill D R.
Bottigli U.
Boucrot J.
Boudreau J.
Bowdery C K.
Bozzi C.
Brandl B.
Brandt S.
Braun O.
Brient J C.
Brodbeck T J.
Brown D.
Buskulic D.
Buttar C.
Calderini G.
Callot O.
Cameron W.
Campana P.
Candlin D J.
Capon G.
Carney R E.
Carpinelli M.
Carr J.
Carter J M.
Cartwright S L.
Casper D.
Cattaneo M.
Cattaneo P W.
Cerutti F.
Chai Y.
Chen W.,
Chiarella V.
Cinabro D.
Ciocci M A.
Clifft R W.
Colas P.
Colling D J.
Colrain P.
Comas P.
Combley F.
Conway J S.
Corden M.
Cordier A.
Cowan G.
Cowen D F.
Coyle P.
Creanza D.
Crespo J M.
D'Ettorre Piazzoli B.
Davier M.
De Palma M.
Decamp D.
Dehning B.
Delfino M.
Dell'Orso R.
Della Marina R.
Dietl H.
Dornan P J.
Drevermann H.
Drinkard J.
Duarte H.
Duflot L.
Dugeay S.
Dydak F.
Edgecock T R.
Edwards M.
Efthymiopoulos I.
El-Fellous R.
Etienne F.
Falvard Alain
Farilla A.
Fearnley T.
Felici G.
Feng Z.
Ferguson D P S.
Fernandez E.
Fernandez-Bosman M.
Ferrante I.
Fidecaro F.
Finch A J.
Fisher S M.
Foa L.
Focardi E.
Forti F.
Forty R W.
Foster F.
Fouque G.
Frank M.
Gaitan V.
Ganis G.
Gao Y S.
Garrido L.
Gay C.
Gay Pascal
Georgiopoulos C.
Geweniger C.
Giannini G.
Giassi A.
Giorgi M A.
Girtler P.
Gobbo B.
Goy C.
Grahl J.
Green M G.
Greene A M.
Gregorio A.
Grivaz J F.
Grupen C.
Guicheney C.
Hagelberg R.
Halley A W.
Hanke P.
Hansen J D.
Hansen J R.
Hansen P H.
Harton J L.
Harvey J.
Hassard J F.
Hatfield F.
Haywood S.
Henrard Pierre
Hepp V.
Heusse P.
Hilgart J.
Hu H.
Huang D.
Huang X.
Hughes G.
Iaselli G.
Ikeda M.
Jackson D.
Jacobsen R.
Jaffe D E.
Janot P.
Jared R C.
Johnson R P.
Jones T J.
Jost B.
Jousset J.
Keemer N R.
Kim D W.
Kleinknecht K.
Kluge E E.
Kneringer E.
Knobloch J.
Kozanecki W.
Kuhn D.
Kyriakis A.
Lancon E.
Lannutti J.
Lauber J.
Laurelli P.
Le Diberder F.
LeClaire B W.
Lees J P.
Lefrancois J.
Lehraus I.
Lemaire M C.
Levinthal D.
Lieske N M.
Ligabue F.
Lin Jiali
Lishka C.
Litke A M.
Locci E.
Lohse T.
Luetjens G.
Lusiani A.
Lutters G.
Lutz A M.
Lutz G.
Lynch J G.
Maggi G.
Maggi M.
Maitland W.
Mannelli E B.
Manner W.
Mannocchi G.
March P V.
Marrocchesi P S.
Martinez M.
Mato P.
Mattison T.
Maumary Y.
Medcalf T.
Meinhard H.
Mermikides M.
Messineo A.
Michel B.
Minard M N.
Minten A.
Miotto A.
Miquel R.
Mir L M.
Mollerud R.
Moneta L.
Monnier E.
Montret Jean-Claude
Morton W T.
Moser H G.
Mours B.
Murtas F.
Murtas G P.
Nash J.
Natali S.
Nicod D.
Nilsson B S.
Norton P R.
Nuttall M.
Nuzzo S.
Orteu S.
Pacheco A.
Padilla C.
Palazzi P.
Palla F.
Pallin D.
Pan Y B.
Papalexiou S.
Parrini G.
Parsons M I.
Pascual A.
Passalacqua L.
Patel A D.
Pater J R.
Patton S J.
Payne D G.
Payre P.
Pepe-Altarelli M.
Perez P.
Perlas J A.
Perret Pascal
Perrier F.
Phillips M J.
Picchi P.
Pietrzyk B.
Proriol Joseph
Prulhiere F.
Pusztaszeri J F.
Putzer A.
Quattromini M.
Quazi I S.
Raab J.
Ragusa F.
Raine C.
Rander J.
Ranieri A.
Ranjard F.
Raso G.
Redlinger G.
Reeves P.
Renardy J F.
Renk B.
Rensch B.
Richter R H.
Rivera F.
Rizzo G.
Rolandi L.
Romano F.
Roos L.
Rosowsky A.
Rothberg J.
Rotscheidt H.
Rouge A.
Roussarie A.
Rousseau D.
Ruan T.
Rudolph G.
Ruggieri F.
Rumpf M.
Saadi F.
Saadi Y.
Saich M.
Salmon D P.
Sander H G.
Sanguinetti G.
Sawyer L.
Scarr J M.
Schaefer U.
Schlatter D.
Schmelling M.
Schmidt H.
Schmitt M.
Schroeder J.
Schuller J P.
Schune M H.
Schwarz A S.
Schwemling P.
Schwindling J.
Sedgbeer J K.
Sefkow F.
Selvaggi G.
Settles R.
Seywerd H.
Sharma V.
Shi Z H.
Si Mohand D.
Silvestris L.
Simopoulou E.
Sloan T.
Smith K.
Smith M G.
Smolik L.
Snow S W.
Spagnolo P.
Stahl A.
Steeg F.
Steinberger J.
Stiegler U.
Stierlin U.
Strong J A.
Talby M.
Tanaka R.
Taylor G.
Tejessy W.
Tempesta P.
Ten Have I.
Tenchini R.
Thompson A S.
Thompson J C.
Thompson L F.
Tittel K.
Tomalin I R.
Tonelli G.
Triggiani G.
Turnbull R M.
Vallage B.
Vannini C.
Vayaki A.
Veillet J J.
Veitch E.
Venturi A.
Verderi M.
Verdini P G.
Videau H.
Videau I.
Wachsmuth H.
Walsh A M.
Walsh J.
Walther S M.
Wang T.
Wanke R.
Wasserbaech S.
Wear J.
Weber F V.
West L R.
Whelan E P.
Wiedenmann W.
Wildish T.
Witzeling W.
Wolf B.
Wolf G.
Wotschack J.
Wright A G.
Wu Sau Lan.
Wu X.
Wunsch M.
Xie Y.
Xu D.
Xu R.
Zachariadou K.
Zhang J.
Zhang L.
Zhang Zhiqing
Zhao W.
Zheng M.
Zito G.
Zobernig G.
Publication venue: Springer Verlag
Publication date: 01/01/1993
Field of study

HAL-IN2P3

Hal - Université Grenoble Alpes

HAL AMU

HAL Clermont Université

HAL Université de Savoie

HAL-Polytechnique

Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR

Author: de Jong Jill L.O.
DiBiase Anthony
Ganis Jared J.
Hsia Nelson
Jia Zhiying
Lambert Janelle S.
Sabo Peter J.
Sandstrom Richard
Stamatoyannopoulos John A.
Trompouki Eirini
Weaver Molly
Zhou Yi
Zon Leonard I.
Publication venue: Elsevier Inc.
Publication date: 01/01/2012
Field of study

AbstractGlobin gene switching is a complex, highly regulated process allowing expression of distinct globin genes at specific developmental stages. Here, for the first time, we have characterized all of the zebrafish globins based on the completed genomic sequence. Two distinct chromosomal loci, termed major (chromosome 3) and minor (chromosome 12), harbor the globin genes containing α/β pairs in a 5′–3′ to 3′–5′ orientation. Both these loci share synteny with the mammalian α-globin locus. Zebrafish globin expression was assayed during development and demonstrated two globin switches, similar to human development. A conserved regulatory element, the locus control region (LCR), was revealed by analyzing DNase I hypersensitive sites, H3K4 trimethylation marks and GATA1 binding sites. Surprisingly, the position of these sites with relation to the globin genes is evolutionarily conserved, despite a lack of overall sequence conservation. Motifs within the zebrafish LCR include CACCC, GATA, and NFE2 sites, suggesting functional interactions with known transcription factors but not the same LCR architecture. Functional homology to the mammalian α-LCR MCS-R2 region was confirmed by robust and specific reporter expression in erythrocytes of transgenic zebrafish. Our studies provide a comprehensive characterization of the zebrafish globin loci and clarify the regulation of globin switching

Elsevier - Publisher Connector

PubMed Central

MPG.PuRe

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

Author: Cheng Jan-Fang
Demmers Jeroen A. A.
Fisher Christopher A.
Ganis Jared J.
Gibbons Richard J.
Gillemans Nynke
Grosveld Frank
Higgs Douglas R.
Hockman Dorit
Hou Jun
Miyata Masato
Mulugeta Eskeatnaf
Philipsen Sjaak
Salminen Matti
Sauka-Spengler Tatjana
Taylor Stephen
Zon Leonard I.
Publication venue: 'American Society of Hematology'
Publication date: 01/01/2020
Field of study

202

Jukuri

PubMed Central

EUR Research Repository

Oxford University Research Archive

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

Author: Buitenhuis
Carpten
Chen
Cullion
D. Gary Gilliland
Gutierrez
Horn
Jared J. Ganis
Kelly
Kharas
Kira Gritsman
Kohn
Kornblau
Mahnaz Paktinat
Malstrom
Manning
Maricel Gozo
Martelli
Mende
Michael G. Kharas
Moore
Nyakern
Paik
Park
Rachel Okabe
Recher
Rocnik
Samuels
Tamburini
Tibes
Tothova
Tothova
Tulasi Khandan
Vivanco
Xu
Xu
Yilmaz
Yilmaz
Zenz
Zhang
Publication venue: American Society of Hematology
Publication date
Field of study

Human cancers, including acute myeloid leukemia (AML), commonly display constitutive phosphoinositide 3-kinase (PI3K) AKT signaling. However, the exact role of AKT activation in leukemia and its effects on hematopoietic stem cells (HSCs) are poorly understood. Several members of the PI3K pathway, phosphatase and tensin homolog (Pten), the forkhead box, subgroup O (FOXO) transcription factors, and TSC1, have demonstrated functions in normal and leukemic stem cells but are rarely mutated in leukemia. We developed an activated allele of AKT1 that models increased signaling in normal and leukemic stem cells. In our murine bone marrow transplantation model using a myristoylated AKT1 (myr-AKT), recipients develop myeloproliferative disease, T-cell lymphoma, or AML. Analysis of the HSCs in myr-AKT mice reveals transient expansion and increased cycling, associated with impaired engraftment. myr-AKT–expressing bone marrow cells are unable to form cobblestones in long-term cocultures. Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR) rescues cobblestone formation in myr-AKT–expressing bone marrow cells and increases the survival of myr-AKT mice. This study demonstrates that enhanced AKT activation is an important mechanism of transformation in AML and that HSCs are highly sensitive to excess AKT/mTOR signaling

Crossref

PubMed Central