DINAMIKA KELOMPOK TANI KALELON DI DESA KAUNERAN KECAMATAN SONDER

This study aims to see how the dynamics of the Kalelon farmer groups are examined from the elements of group dynamics. This research took place for 3 months from October to December 2017. The research site was in Kauneran Village, Sonder Sub-district. Data collection techniques carried out in this study were interview techniques. Sample selection using the method purposive sampling. The number of respondents is 15 people who are members of the group. The analysis technique used in this study is a qualitative descriptive analysis technique. The results showed that the Kalelon farmer group was dynamic because of the nine elements of group dynamics consisting of group goals, group structure, group development and coaching, group cohesiveness, group task functions, group atmosphere, group effectiveness, and hidden intentions were dynamic or good dynamic even though there is one element that is not dynamic, namely pressure in the group. *eprm*

An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for the conservative and nonpharmacological management of female pelvic floor dysfunction

There has been an increasing need for the terminology on the conservative management of female pelvic floor dysfunction to be collated in a clinically based consensus report.This Report combines the input of members and elected nominees of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. An extensive process of nine rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Before opening up for comments on the webpages of ICS and IUGA, five experts from physiotherapy, neurology, urology, urogynecology, and nursing were invited to comment on the paper.A Terminology Report on the conservative management of female pelvic floor dysfunction, encompassing over 200 separate definitions, has been developed. It is clinically based, with the most common symptoms, signs, assessments, diagnoses, and treatments defined. Clarity and ease of use have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Ongoing review is not only anticipated, but will be required to keep the document updated and as widely acceptable as possible.A consensus-based terminology report for the conservative management of female pelvic floor dysfunction has been produced, aimed at being a significant aid to clinical practice and a stimulus for research

Investigating global tropical cyclone activity with a hierarchy of AGCMs: the role of model resolution

The ability to run General Circulation Models (GCMs) at ever-higher horizontal resolutions has meant that tropical cyclone simulations are increasingly credible. A hierarchy of atmosphere-only GCMs, based on the Hadley Centre Global Environmental Model (HadGEM1), with horizontal resolution increasing from approximately 270km to 60km (at 50N), is used to systematically investigate the impact of spatial resolution on the simulation of global tropical cyclone activity, independent of model formulation. Tropical cyclones are extracted from ensemble simulations and reanalyses of comparable resolutions using a feature-tracking algorithm. Resolution is critical for simulating storm intensity and convergence to observed storm intensities is not achieved with the model hierarchy. Resolution is less critical for simulating the annual number of tropical cyclones and their geographical distribution, which are well captured at resolutions of 135km or higher, particularly for Northern Hemisphere basins. Simulating the interannual variability of storm occurrence requires resolutions of 100km or higher; however, the level of skill is basin dependent. Higher resolution GCMs are increasingly able to capture the interannual variability of the large-scale environmental conditions that contribute to tropical cyclogenesis. Different environmental factors contribute to the interannual variability of tropical cyclones in the different basins: in the North Atlantic basin the vertical wind shear, potential intensity and low-level absolute vorticity are dominant, while in the North Pacific basins mid-level relative humidity and low-level absolute vorticity are dominant. Model resolution is crucial for a realistic simulation of tropical cyclone behaviour, and high-resolution GCMs are found to be valuable tools for investigating the global location and frequency of tropical cyclones

Dengue: 30 years of cases in an endemic area

The present study aimed to review literature on studies of dengue cases conducted over 30 years in the state of Ceara´. Between November 2015 and January 2016, articles published in Portuguese and English in 7 databases were searched using keywords and a Boolean operator. A total of 191 articles were identified in the databases; 133 were excluded according to the exclusion criteria, and 58 were included in the study. Of the 58 articles analyzed, 6 reported data from Brazil; including the Northeast region and the state of Ceara´; 41 reported data for only the city of Fortaleza; 7 reported data for the state of Ceara´; 4 reported data for cities in the interior of the state; and 3 included only children. The studies adopted different approaches and focused on different aspects of the disease. Study outcomes included the identification of serological, epidemiological, clinical, and laboratory characteristics; potential larvicides and biological predators of mosquitoes; potential antiviral agents; vector density characteristics; and educational dengue prevention and control strategies. Additionally, one vaccine trial was included. Although studies on dengue in the state of Ceara´ are scarce, they are encompassing, including several lines of research, and the number of studies and reports on dengue in the state of Ceara´ continues to increase

‘“For Without Vanity I’m Better Known”: Restoration Actors and Metatheatre on the London Stage.’

Published version of article deposited in accordance with SHERPA Romeo guidelines. © Cambridge University Press, 2011

Carcass characteristics of lambs kept on ryegrass pasture managed at different sward heights

O objetivo deste trabalho foi avaliar as características de carcaça, de cordeiros mantidos em pastagem de azevém anual (Lolium multiflorum Lam.) manejada em diferentes alturas (5, 10, 15 e 20 cm), sob lotação contínua com carga variável, no período de agosto a novembro de 1999. Utilizou-se um delineamento em blocos ao acaso, com três repetições, e as variáveis estudadas foram submetidas à análise de regressão. Os pesos de abate, carcaça quente, filé mignon, paleta e costela diferiram entre os tratamentos e foram inferiores no tratamento relativo à altura de manejo de 5 cm, quando comparados aos tratamentos de 10, 15 e 20 cm, que não diferiram entre si. Não houve diferença entre tratamentos para os pesos de pernil e de carré. O rendimento de carcaça variou entre 42,8±0,29 e 44,1±0,32%. Todas as variáveis apresentaram relação quadrática com os tratamentos. O ganho médio diário influenciou diretamente o peso de abate que, por sua vez, correlacionou fortemente com o rendimento e o peso da carcaça. Os resultados mostram que os melhores rendimentos dos cortes comerciais de cordeiros são obtidos quando a pastagem de azevém é manejada no intervalo entre 12 e 14 cm de altura.The objective of this work was to evaluate the carcass characteristics of lambs maintained on ryegrass (Lolium multiflorum Lam.) pastures managed with different heights (5, 10, 15 and 20 cm), under continuous variable stocking, from August to November 1999. A randomized block design with three replicates was used. The slaughter weight, hot carcass, fillet, palette and rib weights were different among treatments, and those related to the height 5 cm were lower than the ones of 10, 15 and 20 cm, which were not different among them. There were no differences for hind leg and rib loin. Carcass yield ranged from 42.8±0.29 and 44.1±0.32%. All variables showed a quadratic relationship to treatments. The daily liveweight gain determined directly the liveweight at slaughter, the latter being strongly correlated to carcass yield and weight. Better yield of lamb carcass cuts were obtained when ryegrass was managed between 12 and 14 cm height

Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature

<p>Abstract</p> <p>Background</p> <p>Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties.</p> <p>Methods</p> <p>We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm). We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials.</p> <p>Results and discussion</p> <p>Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential.</p> <p>Conclusion</p> <p>The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.</p

Associação entre consumo alimentar e composição corporal de futebolistas ludovicenses

Introduction: Football is a sport that favors the improvement of physical conditioning, maintenance of performance and health of individuals, so this study aimed to evaluate the association between body composition and factors such as food consumption at resting metabolic rate and the position occupied by athletes from a football team from Maranhão. Materials and Methods: Cross-sectional study carried out with 23 players, in a competitive period, distributed in the positions of striker, goalkeeper, side, midfielder, midfielder and defender. Body composition was obtained through the measurement of skin folds and food consumption through a 24-hour recall. Indirect calorimetry was also performed in the form of a closed circuit, with the calorimeter. Student's t test was performed to reject the null hypothesis, considering p &lt;0.05 as a statistically significant value. Results: The fat percentage of the players was not influenced by the position occupied on the field. The higher consumption of energy and protein was associated with the lower percentage of body fat. Among macronutrients, only the consumption of carbohydrate and saturated fat were within the parameters, the protein was low and the total fat below the recommendation. As for micronutrients, only the average consumption of iron was adequate. Conclusion: The percentage of body fat was influenced only by total caloric and protein consumption. Only carbohydrate, saturated fat and iron were within the established parameters. Athletes who were overweight, according to the BMI, had more fat-free mass.Introdução: O futebol é um esporte que favorece aprimoramento do condicionamento físico, manutenção da performance e saúde dos indivíduos, logo este trabalho objetivou avaliar a associação entre composição corporal e fatores como o consumo alimentar à taxa metabólica em repouso e a posição ocupada pelos atletas de um time de futebol do Maranhão. Materiais e Métodos: Estudo transversal realizado com 23 jogadores, em período competitivo, distribuídos nas posições de atacante, goleiro, lateral, meia, volante e zagueiro. A composição corporal foi obtida através da aferição das dobras cutâneas e o consumo alimentar através de um Recordatório de 24 horas. Realizou-se também a calorimetria indireta na forma de circuito fechado, com o calorímetro. Foi realizado o teste t student para rejeitar a hipótese nula, considerando p&lt;0,05 como valor estatisticamente significante. Resultados: O percentual de gordura dos jogadores não sofreu influência da posição ocupada em campo. O maior consumo de energia e proteína esteve associado ao menor percentual de gordura corporal. Dentre os macronutrientes, somente o consumo de carboidrato e de gordura saturada estiveram dentro dos parâmetros, a proteína esteve pouco elevada e a gordura total abaixo da recomendação. Quanto aos micronutrientes, apenas a média do consumo de ferro esteve adequado. Conclusão: O percentual de gordura corporal sofreu influência apenas do consumo calórico total e proteico. Somente o carboidrato, a gordura saturada e o ferro estiveram dentro dos parâmetros estabelecidos. Os atletas que apresentaram excesso de peso, segundo o IMC, possuíam mais massa livre de gordura

Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial-Efficacy and Biomarker Discovery.

PURPOSE: The neutralizing peptibody trebananib prevents angiopoietin-1 and angiopoietin-2 from binding with Tie2 receptors, inhibiting angiogenesis and proliferation. Trebananib was combined with paclitaxel±trastuzumab in the I-SPY2 breast cancer trial. PATIENTS AND METHODS: I-SPY2, a phase II neoadjuvant trial, adaptively randomizes patients with high-risk, early-stage breast cancer to one of several experimental therapies or control based on receptor subtypes as defined by hormone receptor (HR) and HER2 status and MammaPrint risk (MP1, MP2). The primary endpoint is pathologic complete response (pCR). A therapy graduates if/when it achieves 85% Bayesian probability of success in a phase III trial within a given subtype. Patients received weekly paclitaxel (plus trastuzumab if HER2-positive) without (control) or with weekly intravenous trebananib, followed by doxorubicin/cyclophosphamide and surgery. Pathway-specific biomarkers were assessed for response prediction. RESULTS: There were 134 participants randomized to trebananib and 133 to control. Although trebananib did not graduate in any signature [phase III probabilities: Hazard ratio (HR)-negative (78%), HR-negative/HER2-positive (74%), HR-negative/HER2-negative (77%), and MP2 (79%)], it demonstrated high probability of superior pCR rates over control (92%-99%) among these subtypes. Trebananib improved 3-year event-free survival (HR 0.67), with no significant increase in adverse events. Activation levels of the Tie2 receptor and downstream signaling partners predicted trebananib response in HER2-positive disease; high expression of a CD8 T-cell gene signature predicted response in HR-negative/HER2-negative disease. CONCLUSIONS: The angiopoietin (Ang)/Tie2 axis inhibitor trebananib combined with standard neoadjuvant therapy increased estimated pCR rates across HR-negative and MP2 subtypes, with probabilities of superiority &gt;90%. Further study of Ang/Tie2 receptor axis inhibitors in validated, biomarker-predicted sensitive subtypes is warranted