Lens magnification by CL0024+1654 in the U and R band

[ABRIDGED] We estimate the total mass distribution of the galaxy cluster CL0024+1654 from the measured source depletion due to lens magnification in the R band. Within a radius of 0.54Mpc/h, a total projected mass of (8.1+/-3.2)*10^14 M_sol/h (EdS) is measured, which corresponds to a mass- to-light ratio of M/L(B)=470+/-180. We compute the luminosity function of CL0024+1654 in order to estimate contamination of the background source counts from cluster galaxies. Three different magnification-based reconstruction methods are employed using both local and non-local techniques. We have modified the standard single power-law slope number count theory to incorporate a break and applied this to our observations. Fitting analytical magnification profiles of different cluster models to the observed number counts, we find that the cluster is best described either by a NFW model with scale radius r_s=334+/-191 kpc/h and normalisation kappa_s=0.23+/-0.08 or a power-law profile with slope xi=0.61+/-0.11, central surface mass density kappa_0=1.52+/-0.20 and assuming a core radius of r_core=35 kpc/h. The NFW model predicts that the cumulative projected mass contained within a radius R scales as M(<R)=2.9*10^14*(R/1')^[1.3-0.5lg (R/1')] M_sol/h. Finally, we have exploited the fact that flux magnification effectively enables us to probe deeper than the physical limiting magnitude of our observations in searching for a change of slope in the U band number counts. We rule out both a total flattening of the counts with a break up to U_AB<=26.6 and a change of slope, reported by some studies, from dlog N/dm=0.4->0.15 up to U_AB<=26.4 with 95% confidence.Comment: 19 pages, 12 figures, submitted to A&A. New version includes more robust U band break analysis and contamination estimates, plus new plot

Luminosity Functions of Gamma-Ray Burst Afterglows

Aims: Use the standard fireball model to create virtual populations of gamma-ray burst afterglows and study their luminosity functions. Methods: We randomly vary the parameters of the standard fireball model to create virtual populations of afterglows. We use the luminosity of each burst at an observer's time of 1 day to create a luminosity function and compare our results with available observational data to assess the internal consistency of the standard fireball model. Results: We show that the luminosity functions can be described by a function similar to a log normal distribution with an exponential cutoff. The function parameters are frequency dependent but not very dependent on the model parameter distributions used to create the virtual populations. Comparison with observations shows that while there is good general agreement with the data, it is difficult to explain simultaneously the X-ray and optical data. Possible reasons for this are discussed and the most likely one is that the standard fireball model is incomplete and that decoupling of the X-ray and optical emission mechanism may be needed.Comment: 5 pages, 4 figures; accepted for publication in A&

The Radio Afterglow and Host Galaxy of the Dark GRB 020819

Of the fourteen gamma-ray bursts (GRBs) localized to better than 2' radius with the SXC on HETE-2, only two lack optical afterglow detections, and the high recovery rate among this sample has been used to argue that the fraction of truly dark bursts is ~10%. While a large fraction of earlier dark bursts can be explained by the failure of ground-based searches to reach appropriate limiting magnitudes, suppression of the optical light of these SXC dark bursts seems likely. Here we report the discovery and observation of the radio afterglow of GRB 020819, an SXC dark burst, which enables us to identify the likely host galaxy (probability of 99.2%) and hence the redshift (z=0.41) of the GRB. The radio light curve is qualitatively similar to that of several other radio afterglows, and may include an early-time contribution from the emission of the reverse shock. The proposed host is a bright R = 19.5 mag barred spiral galaxy, with a faint R ~ 24.0 mag "blob'' of emission, 3" from the galaxy core (16 kpc in projection), that is coincident with the radio afterglow. Optical photometry of the galaxy and blob, beginning 3 hours after the burst and extending over more than 100 days, establishes strong upper limits to the optical brightness of any afterglow or associated supernova. Combining the afterglow radio fluxes and our earliest R-band limit, we find that the most likely afterglow model invokes a spherical expansion into a constant-density (rather than stellar wind-like) external environment; within the context of this model, a modest local extinction of A_V ~ 1 mag is sufficient to suppress the optical flux below our limits.Comment: 7 pages, 2 figures. ApJ, in press. For more info on dark bursts, see http://www.astro.ku.dk/~pallja/dark.htm

Circulating brain injury biomarkers increase after endoscopic surgery for pituitary tumors

Pituitary tumors and subsequent treatment with endoscopic transsphenoidal surgery (ETSS) may cause injury to suprasellar structures, causing long-term fatigue and neurocognitive impairment. A method to quantify brain injury after ETSS is not available. In this prospective, exploratory study of patients undergoing ETSS for pituitary tumors, a novel approach to detect possible neuronal damage is presented. Plasma concentrations of brain injury biomarkers (glial fibrillary acidic protein [GFAP], tau, and neurofilament light [NFL]) were measured the day before surgery, immediately after surgery, at day 1 and 5, and at 6 and 12 months after surgery, using enzyme-linked immunosorbent assays. The association between the increase of biomarkers with preoperative tumor extension and postoperative patient-perceived fatigue was evaluated. Suprasellar tumor extension was assessed from MRI scans, and self-perceived fatigue was assessed using the Multidimensional Fatigue Inventory before and 6 months after surgery. Thirty-five patients were included in the analysis. Compared to baseline, GFAP showed a maximal increase at day 1 after surgery (p = 0.0005), tau peaked postoperatively on the day of surgery (p = 0.019), and NFL reached its maximum at day 5 after surgery (p < 0.0001). The increase in GFAP correlated with preoperative chiasmal compression (p = 0.020). The increase in tau was correlated with preoperative chiasmal (p = 0.011) and hypothalamus compression (p = 0.016), and fatigue score 6 months after surgery (p = 0.016). In conclusion, the concentrations of brain injury biomarkers in blood increased after ETSS for pituitary tumors. The results indicate that postoperative plasma GFAP and tau might reflect astroglial and neuronal damage after ETSS

Cerebrospinal fluid proteomics targeted for central nervous system processes in bipolar disorder

The etiopathology of bipolar disorder is largely unknown. We collected cerebrospinal fluid (CSF) samples from two independent case-control cohorts (total n = 351) to identify proteins associated with bipolar disorder. A panel of 92 proteins targeted towards central nervous system processes identified two proteins that replicated across the cohorts: the CSF concentrations of testican-1 were lower, and the CSF concentrations of C-type lectin domain family 1 member B (CLEC1B) were higher, in cases than controls. In a restricted subgroup analysis, we compared only bipolar type 1 with controls and identified two additional proteins that replicated in both cohorts: draxin and tumor necrosis factor receptor superfamily member 21 (TNFRSF21), both lower in cases than controls. This analysis additionally revealed several proteins significantly associated with bipolar type 1 in one cohort, falling just short of replicated statistical significance in the other (tenascin-R, disintegrin and metalloproteinase domain-containing protein 23, cell adhesion molecule 3, RGM domain family member B, plexin-B1, and brorin). Next, we conducted genome-wide association analyses of the case-control-associated proteins. In these analyses, we found associations with the voltage-gated calcium channel subunit CACNG4, and the lipid-droplet-associated gene PLIN5 with CSF concentrations of TNFRSF21 and CLEC1B, respectively. The reported proteins are involved in neuronal cell-cell and cell-matrix interactions, particularly in the developing brain, and in pathways of importance for lithium’s mechanism of action. In summary, we report four novel CSF protein associations with bipolar disorder that replicated in two independent case-control cohorts, shedding new light on the central nervous system processes implicated in bipolar disorder

The early X-ray afterglows of optically bright and dark Gamma-Ray Bursts

A systematical study on the early X-ray afterglows of both optically bright and dark gamma-ray bursts (B-GRBs and D-GRBs) observed by Swift has been presented. Our sample includes 25 GRBs. Among them 13 are B-GRBs and 12 are D-GRBs. Our results show that the distributions of the X-ray afterglow fluxes ($F_{X}$), the gamma-ray fluxes ($S_{\gamma}$), and the ratio ($R_{\gamma, X}$) for both the D-GRBs and B-GRBs are similar. The differences of these distributions for the two kinds of GRBs should be statistical fluctuation. These results indicate that the progenitors of the two kinds of GRBs are the same population. Their total energy explosions are comparable. The suppression of the optical emissions from D-GRBs should results from circumburst but not their central engine.Comment: 10 pages, 3 figures, 1 table; accepted by ChJA

Variable Ly alpha sheds light on the environment surrounding GRB 090426

Long duration gamma-ray bursts are commonly associated with the deaths of massive stars. Spectroscopic studies using the afterglow as a light source provide a unique opportunity to unveil the medium surrounding it, probing the densest region of their galaxies. This material is usually in a low ionisation state and at large distances from the burst site, hence representing the normal interstellar medium in the galaxy. Here we present the case of GRB 090426 at z=2.609, whose optical spectrum indicates an almost fully ionised medium together with a low column density of neutral hydrogen. For the first time, we also observe variations in the Ly alpha absorption line. Photoionisation modeling shows that we are probing material from the vicinity of the burst (~80 pc). The host galaxy is a complex of two luminous interacting galaxies, which might suggest that this burst could have occurred in an isolated star-forming region outside its host galaxy created in the interaction of the two galaxies.Comment: 11 pages, 9 figures, submitted to MNRA

Loss of endothelial endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signaling

Rationale: ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and is strongly expressed in endothelial cells. Mutations in ENG lead to the inherited vascular disorder hereditary hemorrhagic telangiectasia characterized by local telangiectases and larger arteriovenous malformations (AVMs); but how ENG functions to regulate the adult vasculature is not understood. Objective: The goal of the work was to determine how ENG maintains vessel caliber in adult life to prevent AVM formation and thereby protect heart function. Methods and Results: Genetic depletion of endothelial Eng in adult mice led to a significant reduction in mean aortic blood pressure. There was no evidence of hemorrhage, anemia, or AVMs in major organs to explain the reduced aortic pressure. However, large AVMs developed in the peripheral vasculature intimately associated with the pelvic cartilaginous symphysis—a noncapsulated cartilage with a naturally high endogenous expression of VEGF (vascular endothelial growth factor). The increased blood flow through these peripheral AVMs explained the drop in aortic blood pressure and led to increased cardiac preload, and high stroke volumes, ultimately resulting in high-output heart failure. Development of pelvic AVMs in this region of high VEGF expression occurred because loss of ENG in endothelial cells leads to increased sensitivity to VEGF and a hyperproliferative response. Development of AVMs and associated progression to high-output heart failure in the absence of endothelial ENG was attenuated by targeting VEGF signaling with an anti-VEGFR2 (VEGF receptor 2) antibody. Conclusions: ENG promotes the normal balance of VEGF signaling in quiescent endothelial cells to maintain vessel caliber—an essential function in conditions of increased VEGF expression such as local hypoxia or inflammation. In the absence of endothelial ENG, increased sensitivity to VEGF drives abnormal endothelial proliferation in local regions of high VEGF expression, leading to AVM formation and a rapid injurious impact on heart function

Looking Into the Fireball: ROTSE-III and Swift Observations of Early GRB Afterglows

We report on a complete set of early optical afterglows of gamma-ray bursts (GRBs) obtained with the ROTSE-III telescope network from March 2005 through June 2007. This set is comprised of 12 afterglows with early optical and Swift/XRT observations, with a median ROTSE-III response time of 45 s after the start of gamma-ray emission (8 s after the GCN notice time). These afterglows span four orders of magnitude in optical luminosity, and the contemporaneous X-ray detections allow multi-wavelength spectral analysis. Excluding X-ray flares, the broadband synchrotron spectra show that the optical and X-ray emission originate in a common region, consistent with predictions of the external forward shock in the fireball model. However, the fireball model is inadequate to predict the temporal decay indices of the early afterglows, even after accounting for possible long-duration continuous energy injection. We find that the optical afterglow is a clean tracer of the forward shock, and we use the peak time of the forward shock to estimate the initial bulk Lorentz factor of the GRB outflow, and find 100<Gamma_0<1000, consistent with expectations.Comment: 31 pages, 5 figures, submitted to Ap