Losing faith : the process of converting to atheism

The current study examines the process of converting to atheism and the counseling issues associated with it. It is argued that conversion to atheism can be conceptualized according to the model of religious conversion that Paloutzian, Richardson, and Rambo (1999) suggested. Research on atheism is reviewed in terms of how it fits into the stages of this model, and implications for counseling are discussed

Examining associations between classroom environment and processes and early mathematics performance from pre-kindergarten to kindergarten.

One benefit of the No Child Left Behind legislation (2001) has been the increasing attention on the importance of the skills learned in the pre-kindergarten period for later academic achievement. There is a growing awareness that mathematics skills in kindergarten and beyond are influenced by the formal and informal mathematics skills acquired in the pre-kindergarten classroom. In recent years, a body of research has emerged pointing to the contributions to children’s learning from pre-kindergarten program quality as indexed by structure and process elements in the classroom. Results from this study point to three major findings. First, the growth of mathematics skills from pre-kindergarten to kindergarten for the full sample varied between classes but was not significantly associated with the elements of the classroom environment selected for study. Second, classroom elements were differentially related to growth of mathematics scores depending on children’s scores at pre-kindergarten entry. Third, overall differences between high- and low-performing children at pre-kindergarten entry are evident in their growth through kindergarten

Differential Temporal Dynamics of Axial and Appendicular Ataxia in SCA3

Background: Disease severity in spinocerebellar ataxia type 3 (SCA3) is commonly defined by the Scale for the Assessment and Rating of Ataxia (SARA) sum score, but little is known about the contributions and progression patterns of individual items. Objectives: To investigate the temporal dynamics of SARA item scores in SCA3 patients and evaluate if clinical and demographic factors are differentially associated with evolution of axial and appendicular ataxia. Methods: In a prospective, multinational cohort study involving 11 European and 2 US sites, SARA scores were determined longitudinally in 223 SCA3 patients with a follow-up assessment after 1 year. Results: An increase in SARA score from 10 to 20 points was mainly driven by axial and speech items, with a markedly smaller contribution of appendicular items. Finger chase and nose-finger test scores not only showed the lowest variability at baseline, but also the least deterioration at follow-up. Compared with the full set of SARA items, omission of both tests would result in lower sample size requirements for therapeutic trials. Sex was associated with change in SARA sum score and appendicular, but not axial, subscore, with a significantly faster progression in men. Despite considerable interindividual variability, the average annual progression rate of SARA score was approximately three times higher in subjects with a disease duration over 10 years than in those within 10 years from onset. Conclusion: Our findings provide evidence for a difference in temporal dynamics between axial and appendicular ataxia in SCA3 patients, which will help inform the design of clinical trials and development of new (etiology-specific) outcome measures. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Funding agencies: This publication is an outcome of ESMI, an EU Joint Programme — Neurodegenerative Disease Research (JPND) Project (www.jpnd.eu). The project is supported through the following funding organizations under the aegis of JPND: Germany, Federal Ministry of Education and Research (BMBF; funding codes 01ED1602A/B); Netherlands, The Netherlands Organization for Health Research and Development; Portugal, Foundation for Science and Technology and Regional Fund for Science and Technology of the Azores; United Kingdom, Medical Research Council. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 643417. At the United States sites this work was in part supported by the National Ataxia Foundation.Spinocerebellar ataxia type 3Natural historyScale for the Assessment and Rating of AtaxiaDisease progressio

Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3

Background: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity. Objective: The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease. Methods: We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers and 63 healthy controls. In addition, cervical cord cross-sectional areas were determined at 2 levels. Results: The metrics of cervical spinal cord segments C3 and C2, medulla oblongata, pons, and pallidum, and the cerebellar anterior lobe were reduced in preataxic mutation carriers compared with controls. Those of cervical spinal cord segments C2 and C3, medulla oblongata, pons, midbrain, cerebellar lobules crus II and X, cerebellar white matter, and pallidum were reduced in ataxic compared with nonataxic carriers. Of all metrics studied, pontine volume showed the steepest decline across the disease course. It covaried with ataxia severity, CAG repeat length, and age. The multivariate model derived from this analysis explained 46.33% of the variance of pontine volume. Conclusion: Regional brain and spinal cord tissue loss in spinocerebellar ataxia type 3 starts before ataxia onset. Pontine volume appears to be the most promising imaging biomarker candidate for interventional trials that aim at slowing the progression of spinocerebellar ataxia type 3. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): illuminating the functional diversity of eukaryotic life in the oceans through transcriptome sequencing

International audienceCurrent sampling of genomic sequence data from eukaryotes is relatively poor, biased, and inadequate to address important questions about their biology, evolution, and ecology; this Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans

Infant Temperament, Maternal Personality, and Parenting Stress as Contributors to Infant Developmental Outcomes

This study examined contributions of maternal personality and infant temperament to infant vocabulary and cognitive development both directly and indirectly through parental stress. Participants were recruited at birth and included 63 infant twin pairs and their mothers. Assessments were completed at 6, 9, 12, and 18 months of age and included Dimensions of Temperament–Revised (maternal personality), Parenting Stress Index (parental stress), Infant Behavior Questionnaire–Revised (infant temperament), Bayley Scales of Infant Development II: Mental Development Index, and MacArthur-Bates Total Vocabulary. Structural equation modeling with a jackknife approach was used to analyze data separately for each twin in the pair. At 12 months, maternal personality and infant temperament contributed indirectly to MacArthur-Bates Total Vocabulary and Bayley Mental Development Index scores through parental stress. In addition, infant temperament directly contributed to 12-month MacArthur-Bates Total Vocabulary. At 18 months, these relationships were no longer significant. The different findings at 12 months compared to 18 months may reflect important developmental and environmental shifts, as well as possible differences in the method and measurements used at each age

Examining Associations between Classroom Environment and Processes and Early Mathematics Performance from Pre-Kindergarten to Kindergarten

One benefit of the No Child Left Behind legislation (2001) has been the increasing attention on the importance of the skills learned in the pre-kindergarten period for later academic achievement. There is a growing awareness that mathematics skills in kindergarten and beyond are influenced by the formal and informal mathematics skills acquired in the pre-kindergarten classroom. In recent years, a body of research has emerged pointing to the contributions to children’s learning from pre-kindergarten program quality as indexed by structure and process elements in the classroom. Results from this study point to three major findings. First, the growth of mathematics skills from pre-kindergarten to kindergarten for the full sample varied between classes but was not significantly associated with the elements of the classroom environment selected for study. Second, classroom elements were differentially related to growth of mathematics scores depending on children’s scores at pre-kindergarten entry. Third, overall differences between high- and low-performing children at pre-kindergarten entry are evident in their growth through kindergarten