409 research outputs found
On Smooth Orthogonal and Octilinear Drawings: Relations, Complexity and Kandinsky Drawings
We study two variants of the well-known orthogonal drawing model: (i) the
smooth orthogonal, and (ii) the octilinear. Both models form an extension of
the orthogonal, by supporting one additional type of edge segments (circular
arcs and diagonal segments, respectively).
For planar graphs of max-degree 4, we analyze relationships between the graph
classes that can be drawn bendless in the two models and we also prove
NP-hardness for a restricted version of the bendless drawing problem for both
models. For planar graphs of higher degree, we present an algorithm that
produces bi-monotone smooth orthogonal drawings with at most two segments per
edge, which also guarantees a linear number of edges with exactly one segment.Comment: Appears in the Proceedings of the 25th International Symposium on
Graph Drawing and Network Visualization (GD 2017
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Design and Data Modelling of Fibre Optic Systems to Monitor Reinforced Concrete Structural Elements
Structural monitoring of built assets, performed to ensure safety, usability, and to better understand the assetsâ structural behaviour, is becoming common practice. One method to monitor structural behaviour is to use fibre optic systems to measure temperature and strain in structural elements. Fibre optic systems are relatively inexpensive, easy to install, versatile, and widely applicable. However, all the data acquired by monitoring systems are meaningless if they lack context within the built asset, and they are of little use if they cannot be appropriately exchanged and visualised. This paper presents an extension to the IFC data model standard for structural monitoring systems. The extension allows (1) to model structural monitoring systems, (2) to store and retrieve acquired data, and (3) to visualise the data directly on the BIM model. The James Dyson Building at the University of Cambridge is used as a case study, in which selected reinforced concrete columns, beams, and slabs have been instrumented with two types of fibre optic sensors. The case study demonstrates that the extension is able to fully describe the fibre optic monitoring system and that it can aid in its design, deployment, and further operation.The authors would like to acknowledge funding from the UK Engineering and Physical Sciences Research Council (EPSRC) and Innovate UK. This research was carried out under EPSRC grant no. EP/I019308/1. Acknowledgements also go to several people who contributed to, or facilitated the fibre optic sensor installations in the James Dyson Building: Cedric Kechavarzi, David Rodenas HerrĂĄiz, Jason Shardelow, Jules Birks, Pasquale Ponterosso and Peter Knott from CSIC; Greg Smith and Toby Lucas from Morgan Sindall.This is the author accepted manuscript. The final version is available from American Society of Civil Engineers via https://doi.org/10.1061/9780784479827.22
GiViP: A Visual Profiler for Distributed Graph Processing Systems
Analyzing large-scale graphs provides valuable insights in different
application scenarios. While many graph processing systems working on top of
distributed infrastructures have been proposed to deal with big graphs, the
tasks of profiling and debugging their massive computations remain time
consuming and error-prone. This paper presents GiViP, a visual profiler for
distributed graph processing systems based on a Pregel-like computation model.
GiViP captures the huge amount of messages exchanged throughout a computation
and provides an interactive user interface for the visual analysis of the
collected data. We show how to take advantage of GiViP to detect anomalies
related to the computation and to the infrastructure, such as slow computing
units and anomalous message patterns.Comment: Appears in the Proceedings of the 25th International Symposium on
Graph Drawing and Network Visualization (GD 2017
Efficacy of a strategy for implementing a guideline for the control of cardiovascular risk in a primary healthcare setting: the SIRVA2 study a controlled, blinded community intervention trial randomised by clusters
This work describes the methodology used to assess a strategy for implementing clinical practice guidelines (CPG) for cardiovascular risk control in a health area of Madrid
A hybrid computational approach for efficient Alzheimerâs disease classification based on heterogeneous data
Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and metaâanalyses
This systematic review examined the effect of exercise training interventions on physical fitness in adults with overweight or obesity and compared the effectiveness of different types of exercise training. Four electronic databases were searched. Articles were included if they described randomized controlled trials of exercise training interventions and their effect on maximal oxygen consumption or muscle strength in adults with overweight or obesity. Changes in outcome parameters were analyzed using random effects metaâanalyses for different training types (aerobic, resistance, combined aerobic plus resistance, and highâintensity interval training). Eightyâeight articles satisfied the inclusion criteria of which 66 (3964 participants) could be included in the metaâanalyses. All training types increased VO2max (mean difference 3.82 ml/min/kg (95% CI 3.17, 4.48), Pâ<â0.00001; I2 =â48%). In direct comparisons, resistance training was less effective in improving VO2max than aerobic training, HIIT was slightly more effective than aerobic training, and no difference between aerobic and combined aerobic plus resistance training was found. For muscle strength benefits, incorporation of resistance exercise in the training program is indicated. Exercise training increases VO2max and muscle strength in adults with overweight or obesity. Differences between training types should be weighed with other needs and preferences when health professionals advise on exercise training to improve physical fitness
Effect of exercise training interventions on energy intake and appetite control in adults with overweight or obesity: A systematic review and meta-analysis
This systematic review examined the impact of exercise training interventions on energy intake (EI) and appetite control in adults with overweight/obesity (â„18âyears including older adults). Articles were searched up to October 2019. Changes in EI, fasting appetite sensations, and eating behavior traits were examined with random effects meta-analysis, and other outcomes were synthesized qualitatively. Forty-eight articles were included (median [range] BMIâ=â30.6 [27.0â38.4] kg/m2). Study quality was rated as poor, fair, and good in 39, seven, and two studies, respectively. Daily EI was assessed objectively (Nâ=â4), by self-report (Nâ=â22), with a combination of the two (Nâ=â4) or calculated from doubly labeled water (Nâ=â1). In studies rated fair/good, no significant changes in pre-post daily EI were found and a small but negligible (SMDâ<â0.20) postintervention difference when compared with no-exercise control groups was observed (five study arms; MDâ=â102 [1, 203] kcal). There were negligible-to-small pre-post increases in fasting hunger and dietary restraint, decrease in disinhibition, and some positive changes in satiety and food reward/preferences. Within the limitations imposed by the quality of the included studies, exercise training (median duration of 12âweeks) leads to a small increase in fasting hunger and a small change in average EI only in studies rated fair/good. Exercise training may also reduce the susceptibility to overconsumption (PROSPERO: CRD42019157823)
Development of Shuttle Vectors for Transformation of Diverse Rickettsia Species
Plasmids have been identified in most species of Rickettsia examined, with some species maintaining multiple different plasmids. Three distinct plasmids were demonstrated in Rickettsia amblyommii AaR/SC by Southern analysis using plasmid specific probes. Copy numbers of pRAM18, pRAM23 and pRAM32 per chromosome in AaR/SC were estimated by real-time PCR to be 2.0, 1.9 and 1.3 respectively. Cloning and sequencing of R. amblyommii AaR/SC plasmids provided an opportunity to develop shuttle vectors for transformation of rickettsiae. A selection cassette encoding rifampin resistance and a fluorescent marker was inserted into pRAM18 yielding a 27.6 kbp recombinant plasmid, pRAM18/Rif/GFPuv. Electroporation of Rickettsia parkeri and Rickettsia bellii with pRAM18/Rif/GFPuv yielded GFPuv-expressing rickettsiae within 2 weeks. Smaller vectors, pRAM18dRG, pRAM18dRGA and pRAM32dRGA each bearing the same selection cassette, were made by moving the parA and dnaA-like genes from pRAM18 or pRAM32 into a vector backbone. R. bellii maintained the highest numbers of pRAM18dRGA (13.3 â 28.1 copies), and R. parkeri, Rickettsia monacensis and Rickettsia montanensis contained 9.9, 5.5 and 7.5 copies respectively. The same species transformed with pRAM32dRGA maintained 2.6, 2.5, 3.2 and 3.6 copies. pRM, the plasmid native to R. monacensis, was still present in shuttle vector transformed R. monacensis at a level similar to that found in wild type R. monacensis after 15 subcultures. Stable transformation of diverse rickettsiae was achieved with a shuttle vector system based on R. amblyommii plasmids pRAM18 and pRAM32, providing a new research tool that will greatly facilitate genetic and biological studies of rickettsiae
Study of decays to the final state and evidence for the decay
A study of decays is performed for the first time
using data corresponding to an integrated luminosity of 3.0
collected by the LHCb experiment in collisions at centre-of-mass energies
of and TeV. Evidence for the decay
is reported with a significance of 4.0 standard deviations, resulting in the
measurement of
to
be .
Here denotes a branching fraction while and
are the production cross-sections for and mesons.
An indication of weak annihilation is found for the region
, with a significance of
2.4 standard deviations.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-022.html,
link to supplemental material inserted in the reference
Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers
BACKGROUND: Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen, CEA), and antibodies to both can affect tumor cell growth in vitro and in vivo. Here, we compare both antigens as a function of histological phenotype in breast, pancreatic, lung, ovarian, and prostatic cancers, including patient-matched normal, primary tumor, and metastatic breast and colonic cancer specimens. METHODS: Antigen expression was determined by immunohistochemistry (IHC) using tissue microarrays with MN-15 and MN-3 antibodies targeting the A1B1- and N-domains of CEACAM6, respectively, and the MN-14 antibody targeting the A3B3 domain of CEACAM5. IHC was performed using avidin-biotin-diaminobenzide staining. The average score ± SD (0 = negative/8 = highest) for each histotype was recorded. RESULTS: For all tumors, the amount of CEACAM6 expressed was greater than that of CEACAM5, and reflected tumor histotype. In breast tumors, CEACAM6 was highest in papillary > infiltrating ductal > lobular > phyllodes; in pancreatic tumors, moderately-differentiated > well-differentiated > poorly-differentiated tumors; mucinous ovarian adenocarcinomas had almost 3-fold more CEACAM6 than serous ovarian adenocarcinomas; lung adenocarcinomas > squamous tumors; and liver metastases of colonic carcinoma > primary tumors = lymph nodes metastases > normal intestine. However, CEACAM6 expression was similar in prostate cancer and normal tissues. The amount of CEACAM6 in metastatic colon tumors found in liver was higher than in many primary colon tumors. In contrast, CEACAM6 immunostaining of lymph node metastases from breast, colon, or lung tumors was similar to the primary tumor. CONCLUSION: CEACAM6 expression is elevated in many solid tumors, but variable as a function of histotype. Based on previous work demonstrating a role for CEACAM6 in tumor cell migration, invasion and adhesion, and formation of distant metastases (Blumenthal et al., Cancer Res 65: 8809â8817, 2005), it may be a promising target for antibody-based therapy
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