Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia

Objective Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in thi

Common Genetic Variation And Age at Onset Of Anorexia Nervosa

Background Genetics and biology may influence the age at onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to AN age at onset and to investigate the genetic associations between age at onset of AN and age at menarche. Methods A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed which included 9,335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age at onset, early-onset AN (< 13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses. Results Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (SNP-h2) were 0.01-0.04 for age at onset, 0.16-0.25 for early-onset AN, and 0.17-0.25 for typical-onset AN. Early- and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age at onset and early-onset AN estimated from independent GWASs significantly predicted age at onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early-onset AN. Conclusions Our results provide evidence consistent with a common variant genetic basis for age at onset and implicate biological pathways regulating menarche and reproduction.Peer reviewe

Shared genetic risk between eating disorder- and substance-use-related phenotypes:Evidence from genome-wide association studies

First published: 16 February 202

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified the variance in liability to disease explained

De minimalisatie van het totale energieverbruik van de omzetting van fermentatie-ethanol in benzinekomponenten

Document uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science

Multi-stakeholder analysis of fire risk reduction in a densely populated area in the Netherlands: a case-study in the Veluwe area

Reducing the climate change-induced risk of uncontrollable fires in landscapes under nature management, with severe impacts on landscape and society, is particularly urgent in densely-populated and fragmented areas. Reducing fire risk in such areas requires active involvement of a wide diversity of stakeholders. This research letter investigates stakeholders’ needs with regard to fire risk reduction in the Veluwe area in the Netherlands. This densely populated landscape is a popular tourist attraction, and it is one of the most fire-prone landscapes of the Netherlands, with abundant fuels and human ignition sources. We draw upon seven in-depth qualitative interviews with key stakeholders in the Veluwe area, which we situate in a wider review of existing literature. Our analysis demonstrates that the rising incidence of uncontrollable fires poses four types of new challenges to these stakeholders in the Veluwe area. First, stakeholders express the need to reshape existing policy tools and develop novel ones that create synergies between existing policy-priorities (e.g. biodiversity conservation) and fire risk reduction. Second, stakeholders argue for a critical rethinking of the value of landscapes in society, and the diverse roles that fire may play in landscape management research and practice. Third, developing such policy tools requires new modalities and platforms for multi-stakeholder and multi-level collaboration, which are currently lacking because the current and expected future risk of uncontrollable fire is unprecedented. And fourth, the development of effective policy tools requires new knowledge that is interdisciplinary, sensitive towards the local social and ecological characteristics of the area, and which approaches current fire risk challenges and their possible solutions dynamically. While our stakeholder analysis is specific to the Veluwe area in the Netherlands, our findings are also likely to be relevant to other fire-prone nature areas in fragmented landscapes, particularly in Northwestern Europe

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia

Developmen