185 research outputs found

    Fluid Physics in a Fluctuating Acceleration Environment

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    We summarize several aspects of an ongoing investigation of the effects that stochastic residual accelerations (g-jitter) onboard spacecraft can have on experiments conducted in a microgravity environment. The residual acceleration field is modeled as a narrow band noise, characterized by three independent parameters: intensity (g(exp 2)), dominant angular frequency Omega, and characteristic correlation time tau. Realistic values for these parameters are obtained from an analysis of acceleration data corresponding to the SL-J mission, as recorded by the SAMS instruments. We then use the model to address the random motion of a solid particle suspended in an incompressible fluid subjected to such random accelerations. As an extension, the effect of jitter on coarsening of a solid-liquid mixture is briefly discussed, and corrections to diffusion controlled coarsening evaluated. We conclude that jitter will not be significant in the experiment 'Coarsening of solid-liquid mixtures' to be conducted in microgravity. Finally, modifications to the location of onset of instability in systems driven by a random force are discussed by extending the standard reduction to the center manifold to the stochastic case. Results pertaining to time-modulated oscillatory convection are briefly discussed

    Quaternary structure of a G-protein coupled receptor heterotetramer in complex with Gi and Gs

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    Background: G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of extracellular stimuli to intracellular signaling pathways. Different GPCRs may also interact to form heteromers that are novel signaling units. Despite the exponential growth in the number of solved GPCR crystal structures, the structural properties of heteromers remain unknown. Results: We used single-particle tracking experiments in cells expressing functional adenosine A1-A2A receptors fused to fluorescent proteins to show the loss of Brownian movement of the A1 receptor in the presence of the A2A receptor, and a preponderance of cell surface 2:2 receptor heteromers (dimer of dimers). Using computer modeling, aided by bioluminescence resonance energy transfer assays to monitor receptor homomerization and heteromerization and G-protein coupling, we predict the interacting interfaces and propose a quaternary structure of the GPCR tetramer in complex with two G proteins. Conclusions: The combination of results points to a molecular architecture formed by a rhombus-shaped heterotetramer, which is bound to two different interacting heterotrimeric G proteins (Gi and Gs). These novel results constitute an important advance in understanding the molecular intricacies involved in GPCR function

    Probing proton halo effects in the 8B+64Zn collision around the Coulomb barrier

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    Proton halo effects in the 8B+64Zn reaction at an energy around 1.5 times the Coulomb barrier have been studied at HIE-ISOLDE CERN using, for the first time, the only existing postaccelerated 8B beam. This, together with the use of a high granularity and large solid angle detection system, allowed for a careful mapping of the elastic angular distribution, especially in the Coulomb-nuclear interference region. Contrary to what is observed for the one-neutron halo nucleus 11Be on the same target in a similar energy range, the analysis of the elastic scattering angular distribution shows only a modest suppression of the Coulomb-nuclear interference peak, with no remarkable enhancement of the total reaction cross-section. Inclusive angular and energy distributions of 7Be produced in direct reaction processes have also been measured. The comparison of these data with the results of theoretical calculations for the elastic and non-elastic breakup contributions indicate that both processes are important. Overall, the experimental data suggest a 8B collision dynamics at the barrier very different from the one of neutron halo nuclei, showing only modest effects of coupling to continuum. This behaviour can be interpreted as due to the presence of the additional Coulomb interactions halo-core and halo-target together with the presence of the centrifugal barrier felt by the valence proton of 8B

    Spatial and temporal spectra of noise driven stripe patterns

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    Spatial and temporal noise power spectra of stripe patterns are investigated, using as a model a Swift-Hohenberg equation with a stochastic term. In particular, the analytical and numerical investigations show: 1) the temporal noise spectra are of 1/f^alpha form, where alpha=1+(3-D)/4 with D the spatial dimension of the system; 2) that the stochastic fluctuations of the stripe position are sub-diffusive.Comment: Submitted to PR

    Coulomb excitation of 222Rn

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    The nature of quadrupole and octupole collectivity in 222Rn was investigated by determining the electricquadrupole (E2) and octupole (E3) matrix elements using subbarrier, multistep Coulomb excitation. The radioactive 222Rn beam, accelerated to 4.23 MeV/u, was provided by the HIE-ISOLDE facility at CERN. Data were collected in the Miniball gamma -ray spectrometer following the bombardment of two targets, 120Sn and 60Ni. Transition E2 matrix elements within the ground-state and octupole bands were measured up to 10 h over bar and the results were consistent with a constant intrinsic electric-quadrupole moment, 518(11) e fm2. The values of the intrinsic electric-octupole moment for the 0+ -> 3- and 2+ -> 5- transitions were found to be respectively -210 e fm3 and 2300+300-500 e fm3 while a smaller value, 1200+500-900 e fm3, was found for the 2+ -> 1- transition. In addition, four excited non-yrast states were identified in this work via gamma -gamma coincidences.Peer reviewe
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