Characteristics of mesospheric gravity waves over Antarctica observed by Antarctic Gravity Wave Instrument Network imagers using 3-D spectral analyses

We have obtained horizontal phase velocity distributions of the gravity waves around 90 km from four Antarctic airglow imagers, which belong to an international airglow imager/instrument network known as ANGWIN (Antarctic Gravity Wave Instrument Network). Results from the airglow imagers at Syowa (69°S, 40°E), Halley (76°S, 27°W), Davis (69°S, 78°E) and McMurdo (78°S, 167°E) were compared, using a new statistical analysis method based on 3-D Fourier transform [Matsuda et al., 2014] for the observation period between 7 April and 21 May 2013. Significant day-to-day and site-to-site differences were found. The averaged phase velocity spectrum during the observation period showed preferential westward direction at Syowa, McMurdo and Halley, but no preferential direction at Davis. Gravity wave energy estimated by I’/I was ~5 times larger at Davis and Syowa than at McMurdo and Halley. We also compared the phase velocity spectrum at Syowa and Davis with the background wind field and found that the directionality only over Syowa could be explained by critical level filtering of the waves. This suggests that the eastward propagating gravity waves over Davis could have been generated above the polar night jet. Comparison of nighttime variations of the phase velocity spectra with background wind measurements suggested that the effect of critical level filtering could not explain the temporal variation of gravity wave directionality well, and other reasons such as variation of wave sources should be taken into account. Directionality was determined to be dependent on the gravity wave periods

Successful Treatment for Hepatic Encephalopathy Aggravated by Portal Vein Thrombosis with Balloon-Occluded Retrograde Transvenous Obliteration

This report presents the case of a 78-year-old female with hepatic encephalopathy due to an inferior mesenteric venous-inferior vena cava shunt. She developed hepatocellular carcinoma affected by hepatitis C virus-related cirrhosis and underwent posterior sectionectomy. Portal vein thrombosis developed and the portal trunk was narrowed after hepatectomy. Portal vein thrombosis resulted in high portal pressure and increased blood flow in an inferior mesenteric venous-inferior vena cava shunt, and hepatic encephalopathy with hyperammonemia was aggravated. The hepatic encephalopathy aggravated by portal vein thrombosis was successfully treated by balloon-occluded retrograde transvenous obliteration via a right transjugular venous approach without the development of other collateral vessels

Role Of the Sun and the Middle atmosphere/thermosphere/ionosphere In Climate (ROSMIC): a retrospective and prospective view

While knowledge of the energy inputs from the Sun (as it is the primary energy source) is important for understanding the solar-terrestrial system, of equal importance is the manner in which the terrestrial part of the system organizes itself in a quasi-equilibrium state to accommodate and re-emit this energy. The ROSMIC project (2014–2018 inclusive) was the component of SCOSTEP’s Variability of the Sun and Its Terrestrial Impact (VarSITI) program which supported research into the terrestrial component of this system. The four themes supported under ROSMIC are solar influence on climate, coupling by dynamics, trends in the mesosphere lower thermosphere, and trends and solar influence in the thermosphere. Over the course of the VarSITI program, scientific advances were made in all four themes. This included improvements in understanding (1) the transport of photochemically produced species from the thermosphere into the lower atmosphere; (2) the manner in which waves produced in the lower atmosphere propagate upward and influence the winds, dynamical variability, and transport of constituents in the mesosphere, ionosphere, and thermosphere; (3) the character of the long-term trends in the mesosphere and lower thermosphere; and (4) the trends and structural changes taking place in the thermosphere. This paper reviews the progress made in these four areas over the past 5 years and summarizes the anticipated research directions in these areas in the future. It also provides a physical context of the elements which maintain the structure of the terrestrial component of this system. The effects that changes to the atmosphere (such as those currently occurring as a result of anthropogenic influences) as well as plausible variations in solar activity may have on the solar terrestrial system need to be understood to support and guide future human activities on Earth

Four-dimensional variational assimilation of ozone profiles from the Microwave Limb Sounder on the Aura satellite

Ozone profiles from the Microwave Limb Sounder (MLS) onboard the Aura satellite of the NASA's Earth Observing System (EOS) were experimentally added to the European Centre for Medium-range Weather Forecasts (ECMWF) four-dimensional variational (4D-var) data assimilation system of version CY30R1, in which total ozone columns from Scanning Imaging Absorption Spectrometer for Atmospheric CHartographY (SCIAMACHY) onboard the Envisat satellite and partial profiles from the Solar Backscatter Ultraviolet (SBUV/2) instrument onboard the NOAA-16 satellite have been operationally assimilated. As shown by results for the autumn of 2005, additional constraints from MLS data significantly improved the agreement of the analyzed ozone fields with independent observations throughout most of the stratosphere, owing to the daily near-global coverage and good vertical resolution of MLS observations. The largest impacts were seen in the middle and lower stratosphere, where model deficiencies could not be effectively corrected by the operational observations without the additional information on the ozone vertical distribution provided by MLS. Even in the upper stratosphere, where ozone concentrations are mainly determined by rapid chemical processes, dense and vertically resolved MLS data helped reduce the biases related to model deficiencies. These improvements resulted in a more realistic and consistent description of spatial and temporal variations in stratospheric ozone, as demonstrated by cases in the dynamically and chemically active regions. However, combined assimilation of the often discrepant ozone observations might lead to underestimation of tropospheric ozone. In addition, model deficiencies induced large biases in the upper stratosphere in the medium-range (5-day) ozone forecasts

Insufficient maintenance DNA methylation is associated with abnormal embryonic development

<p>Abstract</p> <p>Background</p> <p>Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and <it>de novo </it>methylation directed by DNA methyltransferases (DNMTs), is important for embryo development. Abnormal function of these DNMTs may have serious consequences for embryonic development.</p> <p>Methods</p> <p>To evaluate the possible involvement of DNA methylation in human EPL, the expression of DNMT proteins and global methylation of DNA were assessed in villous or decidua from EPL patients. The association of maintenance methylation with embryo implantation and development was also examined.</p> <p>Results</p> <p>We found that DNMT1 and DNMT3A were both expressed in normal human villous and decidua. DNMT1 expression and DNA global methylation levels were significantly down-regulated in villous of EPL. DNMT3A expression was not significantly changed in the EPL group compared to controls in either villous or decidua. We also found that disturbance of maintenance methylation with a DNMT1 inhibitor may result in a decreased global DNA methylation level and impaired embryonic development in the mouse model, and inhibit <it>in vitro </it>embryo attachment to endometrial cells.</p> <p>Conclusions</p> <p>Our results demonstrate that defects in DNA maintenance methylation in the embryo, not in the mother, are associated with abnormal embryonic implantation and development. The findings of the current study provide new insights into the etiology of EPL.</p

The extratropical upper troposphere and lower stratosphere

The extratropical upper troposphere and lower stratosphere (Ex-UTLS) is a transition region between the stratosphere and the troposphere. The Ex-UTLS includes the tropopause, a strong static stability gradient and dynamic barrier to transport. The barrier is reflected in tracer profiles. This region exhibits complex dynamical, radiative, and chemical characteristics that place stringent spatial and temporal requirements on observing and modeling systems. The Ex-UTLS couples the stratosphere to the troposphere through chemical constituent transport (of, e.g., ozone), by dynamically linking the stratospheric circulation with tropospheric wave patterns, and via radiative processes tied to optically thick clouds and clear-sky gradients of radiatively active gases. A comprehensive picture of the Ex-UTLS is presented that brings together different definitions of the tropopause, focusing on observed dynamical and chemical structure and their coupling. This integral view recognizes that thermal gradients and dynamic barriers are necessarily linked, that these barriers inhibit mixing and give rise to specific trace gas distributions, and that there are radiative feedbacks that help maintain this structure. The impacts of 21st century anthropogenic changes to the atmosphere due to ozone recovery and climate change will be felt in the Ex-UTLS, and recent simulations of these effects are summarized and placed in context

Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction

Laminins are key basement membrane molecules that influence several biological activities and are linked to a number of diseases. They are secreted as heterotrimeric proteins consisting of one α, one β, and one γ chain, followed by their assembly into a polymer-like sheet at the basement membrane. Using sedimentation velocity, dynamic light scattering, and surface plasmon resonance experiments, we studied self-association of three laminin (LM) N-terminal fragments α-1 (hLM α-1 N), α-5 (hLM α-5 N) and β-3 (hLM β-3 N) originating from the short arms of the human laminin αβγ heterotrimer. Corresponding studies of the hLM α-1 N C49S mutant, equivalent to the larval lethal C56S mutant in zebrafish, have shown that this mutation causes enhanced self-association behavior, an observation that provides a plausible explanation for the inability of laminin bearing this mutation to fulfill functional roles in vivo, and hence for the deleterious pathological consequences of the mutation on lens function