194 research outputs found
Molecules in the Circumstellar Disk Orbiting BP Piscium
BP Psc is a puzzling late-type, emission-line field star with large infrared
excess. The star is encircled and enshrouded by a nearly edge-on, dust
circumstellar disk, and displays an extensive jet system similar to those
associated with pre-main sequence (pre-MS) stars. We conducted a mm-wave
molecular line survey of BP Psc with the 30 m telescope of the Institut de
Radio Astronomie Millimetrique (IRAM). We detected lines of 12CO and 13CO and,
possibly, very weak emission from HCO+ and CN; HCN, H2CO, and SiO are not
detected. The CO line profiles of BP Psc are well fit by a model invoking a
disk in Keplerian rotation. The mimumum disk gas mass, inferred from the 12CO
line intensity and 13CO/12CO line ratio, is ~0.1 Jupiter masses. The weakness
of HCO+ and CN (relative to 13CO) stands in sharp contrast to the strong HCO+
and CN emission that characterizes most low-mass, pre-main sequence stars that
have been the subjects of molecular emission-line surveys, and is suggestive of
a very low level of X-ray-induced molecular ionization within the BP Psc disk.
These results lend some support to the notion that BP Psc is an evolved star
whose circumstellar disk has its origins in a catastrophic interaction with a
close companion.Comment: 6 pages, 4 figures; to appear in Astronomy & Astrophysic
Medroxyprogesterone improves nocturnal breathing in postmenopausal women with chronic obstructive pulmonary disease
BACKGROUND: Progestins as respiratory stimulants in chronic obstructive pulmonary disease (COPD) have been investigated in males and during wakefulness. However, sleep and gender may influence therapeutic responses. We investigated the effects of a 2-week medroxyprogesterone acetate (MPA) therapy on sleep and nocturnal breathing in postmenopausal women. METHODS: A single-blind placebo-controlled trial was performed in 15 postmenopausal women with moderate to severe COPD. A 12-week trial included 2-week treatment periods with placebo and MPA (60 mg/d/14 days). All patients underwent a polysomnography with monitoring of SaO(2 )and transcutaneous PCO(2 )(tcCO(2)) at baseline, with placebo, with medroxyprogesterone acetate (MPA 60 mg/d/14 days), and three and six weeks after cessation of MPA. RESULTS: Thirteen patients completed the trial. At baseline, the average ± SD of SaO(2 )mean was 90.6 ± 3.2 % and the median of SaO(2 )nadir 84.8 % (interquartile range, IQR 6.1). MPA improved them by 1.7 ± 1.6 %-units (95 % confidence interval (CI) 0.56, 2.8) and by 3.9 %-units (IQR 4.9; 95% CI 0.24, 10.2), respectively. The average of tcCO(2 )median was 6.0 ± 0.9 kPa and decreased with MPA by 0.9 ± 0.5 kPa (95% CI -1.3, -0.54). MPA improved SaO(2 )nadir and tcCO(2 )median also during REM sleep. Three weeks after cessation of MPA, the SaO(2 )mean remained 1.4 ± 1.8 %-units higher than at baseline, the difference being not significant (95% CI -0.03, 2.8). SaO(2 )nadir was 2.7 %-units (IQR 4.9; 95% CI 0.06, 18.7) higher than at baseline. Increases in SaO(2 )mean and SaO(2 )nadir during sleep with MPA were inversely associated with baseline SaO(2 )mean (r = -0.70, p = 0.032) and baseline SaO(2 )nadir (r = -0.77, p = 0.008), respectively. Treatment response in SaO(2 )mean, SaO(2 )nadir and tcCO(2 )levels did not associate with pack-years smoked, age, BMI, spirometric results or sleep variables. CONCLUSION: MPA-induced respiratory improvement in postmenopausal women seems to be consistent and prolonged. The improvement was greater in patients with lower baseline SaO(2 )values. Long-term studies in females are warranted
Molecules in the disk orbiting the twin young suns of V4046 Sgr
We report the results of a mm-wave molecular line survey of the nearby (D ~
70 pc), 12 Myr-old system V4046 Sgr -- a tight (9 R_sun separation),
short-period (2.42 day) binary with nearly equal component masses of ~0.9 M_sun
-- conducted with the 30 m telescope of the Institut de Radio Astronomie
Millimetrique (IRAM). We detected rotational transitions of 12CO 13CO, HCN, CN,
and HCO+. The double-peaked CO line profiles of V4046 Sgr are well fit by a
model invoking a Keplerian disk with outer radius of ~250 AU that is viewed at
an inclination i = 35 degrees. We infer minimum disk gas and dust masses of ~13
and ~20 Earth masses from the V4046 Sgr CO line and submm continuum fluxes,
respectively. The actual disk gas mass could be much larger if the gas-phase CO
is highly depleted and/or 13CO is very optically thick. The overall similarity
of the circumbinary disk of V4046 Sgr to the disk orbiting the single, ~8
Myr-old star TW Hya -- a star/disk system often regarded as representative of
the early solar nebula -- indicates that gas giant planets are likely
commonplace among close binary star systems. Given the relatively advanced age
and proximity of V4046 Sgr, these results provide strong motivation for future
high-resolution imaging designed to ascertain whether a planetary system now
orbits its twin suns.Comment: 5 pages, 3 figures; to appear in Astronomy & Astrophysic
Dense gas in nearby galaxies XVI. The nuclear starburst environment in NGC4945
A multi-line millimeter-wave study of the nearby starburst galaxy NGC 4945
has been carried out using the Swedish-ESO Submillimeter Telescope (SEST). The
study covers the frequency range from 82 GHz to 354 GHz and includes 80
transitions of 19 molecules. 1.3 mm continuum data of the nuclear source are
also presented. A large number of molecular species indicate the presence of a
prominent high density interstellar gas component characterized by cm. Abundances of molecular species are calculated and
compared with abundances observed toward the starburst galaxies NGC 253 and M
82 and galactic sources. Apparent is an `overabundance' of HNC in the nuclear
environment of NGC 4945. While the HNC/HCN =1--0 line intensity ratio is
0.5, the HNC/HCN abundance ratio is 1. While HCN is subthermally
excited (8 K), CN is even less excited (3--4
K), indicating that it arises from a less dense gas component and that its
=2--1 line can be optically thin even though its =1--0 emission is
moderately optically thick. Overall, fractional abundances of NGC 4945 suggest
that the starburst has reached a stage of evolution that is intermediate
between those observed in NGC 253 and M 82. Carbon, nitrogen, oxygen and sulfur
isotope ratios are also determined. Within the limits of uncertainty, carbon
and oxygen isotope ratios appear to be the same in the nuclear regions of NGC
4945 and NGC 253. High O/O, low O/O and
N/N and perhaps also low S/S ratios appear to be
characteristic properties of a starburst environment in which massive stars
have had sufficient time to affect the isotopic composition of the surrounding
interstellar medium.Comment: 26 pages, 16 figures, accepted bt A&
Application of the Occupational Sitting and Physical Activity Questionnaire (OSPAQ) to office based workers
Background
The workplace is a setting where sedentary behaviour is highly prevalent. Accurately measuring physical activity and sedentary behaviour is crucial to assess the impact of behavioural change interventions. This study aimed to evaluate the reliability and criterion validity of the Occupational Sitting and Physical Activity Questionnaire (OSPAQ) and compare with data collected by accelerometers. Methods
A test-retest study was undertaken on 99 participants using the OSPAQ. Data were then compared to accelerometer records of 41 participants. Reliability was assessed by paired t-test and intra-class correlations (ICC) via a two-way mixed model based on absolute agreement. Difference and agreement were measured by comparison of mean self-reported data with accelerometer data using the Pearson’s correlation coefficient and Bland-Altman plots. Results
The ICCs for minutes spent sitting (0.66), standing (0.83) and walking (0.77) showed moderate to strong test-retest reliability. No significant differences were found between the repeated measurements taken seven days apart. Correlations with the accelerometer readings were moderate. The Bland-Altman plots showed moderate agreement for standing time and walking time but systematic variation for sedentary time. Conclusion
The OSPAQ appears to have acceptable reliability and validity measurement properties for application in the office workplace setting
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
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