1,211 research outputs found
Geometric Hamilton-Jacobi Theory for Nonholonomic Dynamical Systems
The geometric formulation of Hamilton--Jacobi theory for systems with
nonholonomic constraints is developed, following the ideas of the authors in
previous papers. The relation between the solutions of the Hamilton--Jacobi
problem with the symplectic structure defined from the Lagrangian function and
the constraints is studied. The concept of complete solutions and their
relationship with constants of motion, are also studied in detail. Local
expressions using quasivelocities are provided. As an example, the nonholonomic
free particle is considered.Comment: 22 p
Small-scale magnetic flux emergence in the quiet Sun
Small bipolar magnetic features are observed to appear in the interior of
individual granules in the quiet Sun, signaling the emergence of tiny magnetic
loops from the solar interior. We study the origin of those features as part of
the magnetoconvection process in the top layers of the convection zone. Two
quiet-Sun magnetoconvection models, calculated with the
radiation-magnetohydrodynamic (MHD) Bifrost code and with domain stretching
from the top layers of the convection zone to the corona, are analyzed. Using
3D visualization as well as a posteriori spectral synthesis of Stokes
parameters, we detect the repeated emergence of small magnetic elements in the
interior of granules, as in the observations. Additionally, we identify the
formation of organized horizontal magnetic sheets covering whole granules. Our
approach is twofold, calculating statistical properties of the system, like
joint probability density functions (JPDFs), and pursuing individual events via
visualization tools. We conclude that the small magnetic loops surfacing within
individual granules in the observations may originate from sites at or near the
downflows in the granular and mesogranular levels, probably in the first 1 or
1.5 Mm below the surface. We also document the creation of granule-covering
magnetic sheet-like structures through the sideways expansion of a small
subphotospheric magnetic concentration picked up, and pulled out of the
interior, by a nascent granule. The sheet-like structures we found in the
models may match the recent observations of Centeno et al. (2017).Comment: 9 pages, 5 figures, Published in The Astrophysical Journal Letter
Estudio de las lesiones neoplásicas metacrónicas en el carcinoma colorrectal
Fundamento.
Analizar la frecuencia y las características de las lesiones neoplásicas metacrónicas, carcinomas y adenomas, tras la resección de un cáncer colo-rectal (CCR).
Pacientes y métodos.
Revisamos 382 CCR operados y seguidos mediante colonoscopias completas en dos hospitales de nuestra comunidad. Analizamos las lesiones metacrónicas registradas valorando su localización, momento del diagnóstico, histología, número y tamaño. Estudiamos la frecuencia de adenomas de aparición precoz (12 meses), comparando su tamaño con respecto al resto de lesiones.
Resultados.
La mediana de seguimiento fue de 48 meses (12-112), con 2,74±1,47 colonoscopias/caso. Diagnosticamos 7 cánceres metacrónicos (1,8%), 4 de ellos en estadio I. La mediana de tiempo hasta su diagnóstico fue de 24 meses (13-54). Registramos adenomas metacrónicos en 162 casos (42,4%), sin diferencias entre los dos hospitales: 42,1% vs. 43,8% (p=0,88). Un 6,3% de los pacientes presentaron adenomas avanzados. En 164 casos en que el primer control se efectuó a los 12 meses, la incidencia de adenomas fue del 24%. Los adenomas fueron mayoritariamente únicos (60,8%) y menores de 5 mm (68,5%). En un 55,5% de los casos con pólipos, alguno tenía una localización proximal. El diagnóstico se realizó en la 1ª exploración (56,2%), 2ª (27,8%) ó 3ª (9%). La mediana de tiempo hasta el diagnóstico fue de 21 meses (12-112) para el adenoma simple y de 35 (12-112) para el avanzado.
Conclusiones.
Nuestro seguimiento permitió aplicar un tratamiento teóricamente curativo en la mayoría de los carcinomas metacrónicos diagnosticados. La alta incidencia de adenomas y su frecuente localización proximal hacen necesario un seguimiento con colonoscopias completas, que debería iniciarse al año de la operación y podría pasar a ser menos estricto tras tres exploraciones consecutivas sin pólipos
The 1989 and 2015 outbursts of V404 Cygni: a global study of wind-related optical features
The black hole transient V404 Cygni exhibited a bright outburst in June 2015
that was intensively followed over a wide range of wavelengths. Our team
obtained high time resolution optical spectroscopy (~90 s), which included a
detailed coverage of the most active phase of the event. We present a database
consisting of 651 optical spectra obtained during this event, that we combine
with 58 spectra gathered during the fainter December 2015 sequel outburst, as
well as with 57 spectra from the 1989 event. We previously reported the
discovery of wind-related features (P-Cygni and broad-wing line profiles)
during both 2015 outbursts. Here, we build diagnostic diagrams that enable us
to study the evolution of typical emission line parameters, such as line fluxes
and equivalent widths, and develop a technique to systematically detect outflow
signatures. We find that these are present throughout the outburst, even at
very low optical fluxes, and that both types of outflow features are observed
simultaneously in some spectra, confirming the idea of a common origin. We also
show that the nebular phases depict loop patterns in many diagnostic diagrams,
while P-Cygni profiles are highly variable on time-scales of minutes. The
comparison between the three outbursts reveals that the spectra obtained during
June and December 2015 share many similarities, while those from 1989 exhibit
narrower emission lines and lower wind terminal velocities. The diagnostic
diagrams presented in this work have been produced using standard measurement
techniques and thus may be applied to other active low-mass X-ray binaries.Comment: Accepted for publication in MNRAS. 23 pages paper, plus a 9 pages
appendix with extra tables and figures. 18 figures are included in the paper
and 8 in the appendi
Exploring the key drivers of riparian woodland successional pathways across three European river reaches
"This is the peer reviewed version of the following article: Muñoz-Mas, R., V. Garófano-Gómez, I. Andrés-Doménech, D. Corenblit, G. Egger, F. Francés, M.T. Ferreira, et al. 2017. ¿Exploring the Key Drivers of Riparian Woodland Successional Pathways across Three European River Reaches.¿ Ecohydrology 10 (8). Wiley: e1888. doi:10.1002/eco.1888, which has been published in final form at https://doi.org/10.1002/eco.1888. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."[EN] Climate change and river regulation are negatively impacting riparian vegetation. To evaluate these impacts, process-based models are preferred over data-driven approaches. However, they require extensive knowledge about ecohydrological processes. To facilitate the implementation of such process-based models, the key drivers of riparian woodland successional pathways across three river reaches, in Austria, Portugal, and Spain, were explored, employing two complementary approaches. The principal component analyses highlighted the importance of the physical gradients determining the placement of the succession phases within the riparian and floodplain zones. The generalized additive models revealed that the initial and pioneer succession phases, characteristic of the colonization stage, appeared in areas highly morphodynamic, close in height and distance to the water table, and with coarse substrate, whereas elder phases within the transitional and mature stages showed incremental differences, occupying less dynamic areas with finer substrate. The Austrian site fitted well the current successional theory (elder phases appearing sequentially further up and distant), but at the Portuguese site, the tolerance of the riparian species to drought and flash flood events governed their placement. Finally, at the Spanish site, the patchy distribution of the elder phases was the remnants of formative events that reshaped the river channel. These results highlight the complex relationships between flow regime, channel morphology, and riparian vegetation. The use of succession phases, which rely on the sequential evolution of riparian vegetation as a response to different drivers, may be potentially better reproducible, within numerical process-based models, and transferable to other geographical regions.This work was supported by the IWRM Era-NET Funding Initiative through the RIPFLOW project (references ERACCT-2005-026025, ERA-IWRM/0001/2008, CGL2008-03076-E/BTE), http://www.old.iwrm-net.eu/spip.php, by the Spanish Ministry of Economy and Competitiveness through the project SCARCE (Consolider¿Ingenio 2010 CSD2009-00065), and by the project ¿Natural and anthropogenic changes in Mediterranean river drainage basins: historical impacts on rivers morphology, sedimentary flows and vegetation¿ of the Spanish MINECO (CGL2013-44917-R). Virginia Garófano-Gómez received a postdoctoral grant from the Université Blaise Pascal (now: Université Clermont Auvergne). Rui Rivaes benefited from a PhD grant (SFRH/BD/52515/2014) sponsored by Fundação para a Ciência e Tecnologia (FCT) under the FCT PhD programme FLUVIO¿River Restoration and Management. Patricia María Rodríguez González was funded by FCT through an SFRH/BPD/47140/2008 postdoctoral fellowship and through an FCT Investigator Programme grant (IF/00059/2015). The authors also thank all the colleagues and master students who contributed enthusiastically to the field campaigns of this study.Muñoz Mas, R.; Garófano-Gómez, V.; Andrés Doménech, I.; Corenblit, D.; Egger, G.; Francés, F.; Ferreira, M.... (2017). Exploring the key drivers of riparian woodland successional pathways across three European river reaches. Ecohydrology. 10(8):1-19. https://doi.org/10.1002/eco.1888S11910
Cosmic Microwave Background anisotropies from second order gravitational perturbations
This paper presents a complete analysis of the effects of second order
gravitational perturbations on Cosmic Microwave Background anisotropies, taking
explicitly into account scalar, vector and tensor modes. We also consider the
second order perturbations of the metric itself obtaining them, for a universe
dominated by a collision-less fluid, in the Poisson gauge, by transforming the
known results in the synchronous gauge. We discuss the resulting second order
anisotropies in the Poisson gauge, and analyse the possible relevance of the
different terms. We expect that, in the simplest scenarios for structure
formation, the main effect comes from the gravitational lensing by scalar
perturbations, that is known to give a few percent contribution to the
anisotropies at small angular scales.Comment: 15 pages, revtex, no figures. Version to be published in Phys. Rev.
Adiabatic compression and indirect detection of supersymmetric dark matter
Recent developments in the modelling of the dark matter distribution in our
Galaxy point out the necessity to consider some physical processes to satisfy
observational data. In particular, models with adiabatic compression, which
include the effect of the baryonic gas in the halo, increase significantly the
dark matter density in the central region of the Milky Way. On the other hand,
the non-universality in scalar and gaugino sectors of supergravity models can
also increase significantly the neutralino annihilation cross section. We show
that the combination of both effects gives rise to a gamma-ray flux arising
from the Galactic Center largely reachable by future experiments like GLAST. We
also analyse in this framework the EGRET excess data above 1 GeV, as well as
the recent data from CANGAROO and HESS. The analysis has been carried out
imposing the most recent experimental constraints, such as the lower bound on
the Higgs mass, the \bsg branching ratio, and the muon . In addition, the
recently improved upper bound on has also been taken
into account. The astrophysical (WMAP) bounds on the dark matter density have
also been imposed on the theoretical computation of the relic neutralino
density through thermal production.Comment: 32 pages, 11 figures, final version to appear in JCA
Randomized phase II trial of FOLFIRI-panitumumab compared with FOLFIRI alone in patients with RAS wild-type circulating tumor DNA metastatic colorectal cancer beyond progression to first-line FOLFOX-panitumumab : the BEYOND study (GEMCAD 17-01)
Altres ajuts: Fundació la Marató de TV3 (201330.10); Fundacion Olga Torres (Modalitat A. 2019/2020); Spanish Association Against Cancer (AECC, PROYE19040POST_001).Purpose: Panitumumab plus FOLFOX (P-FOLFOX) is standard first-line treatment for RAS wild-type (WT) metastatic colorectal cancer. The value of panitumumab rechallenge is currently unknown. We assessed addition of panitumumab to FOLFIRI (P-FOLFIRI) beyond progression to P-FOLFOX in patients with no RAS mutations in liquid biopsy (LB). Methods: In this randomized phase II trial, patients were assigned (3:2 ratio) to second-line P-FOLFIRI (arm A) or FOLFIRI alone (arm B). LB for circulating tumor DNA analysis was collected at study entry and at disease progression. Primary endpoint was 6-month progression-free survival. Two-stage Simon design required 85 patients to be included (EudraCT 2017-004519-38). Results: Between February 2019 and November 2020, 49 patients were screened (16 RAS mutations in LB detected) and 31 included (18 assigned to arm A and 13 to arm B). The study was prematurely closed due to inadequate recruitment. Serious adverse events were more frequent in arm A (44% vs. 23%). Overall response rate was 33% (arm A) vs. 7.7% (arm B). Six-month progression-free survival rate was 66.7% (arm A) and 38.5% (arm B). Median progression-free survival was 11.0 months (arm A) and 4.0 months (arm B) (hazard ratio, 0.58). At disease progression, RAS or BRAF mutations in LB were found in 4/11 patients (36%) in arm A and 2/10 (20%) in arm B. Conclusions: The BEYOND study suggests a meaningful benefit of P-FOLFIRI beyond progression to P-FOLFOX in metastatic colorectal cancer patients with WT RAS status selected by LB. This strategy deserves further investigation
The confining-Higgs phase transition in U(1)-Higgs LGT
Abstract We simulate the compact U(1)-Higgs model in a four-dimensional lattice. We present a numerical study for the behaviour around the region where the transition between the confining and Higgs phases disappears. The transition line is found to be first order and to end in a second-order point. We measure the critical exponents of the endpoint obtaining the mean field ones within errors
Observations of Milky Way Dwarf Spheroidal galaxies with the Fermi-LAT detector and constraints on Dark Matter models
We report on the observations of 14 dwarf spheroidal galaxies with the Fermi
Gamma-Ray Space Telescope taken during the first 11 months of survey mode
operations. The Fermi telescope provides a new opportunity to test particle
dark matter models through the expected gamma-ray emission produced by pair
annihilation of weakly interacting massive particles (WIMPs). Local Group dwarf
spheroidal galaxies, the largest galactic substructures predicted by the cold
dark matter scenario, are attractive targets for such indirect searches for
dark matter because they are nearby and among the most extreme dark matter
dominated environments. No significant gamma-ray emission was detected above
100 MeV from the candidate dwarf galaxies. We determine upper limits to the
gamma-ray flux assuming both power-law spectra and representative spectra from
WIMP annihilation. The resulting integral flux above 100 MeV is constrained to
be at a level below around 10^-9 photons cm^-2 s^-1. Using recent stellar
kinematic data, the gamma-ray flux limits are combined with improved
determinations of the dark matter density profile in 8 of the 14 candidate
dwarfs to place limits on the pair annihilation cross-section of WIMPs in
several widely studied extensions of the standard model. With the present data,
we are able to rule out large parts of the parameter space where the thermal
relic density is below the observed cosmological dark matter density and WIMPs
(neutralinos here) are dominantly produced non-thermally, e.g. in models where
supersymmetry breaking occurs via anomaly mediation. The gamma-ray limits
presented here also constrain some WIMP models proposed to explain the Fermi
and PAMELA e^+e^- data, including low-mass wino-like neutralinos and models
with TeV masses pair-annihilating into muon-antimuon pairs. (Abridged)Comment: 25 pages, 4 figures, accepted to ApJ, Corresponding authors: J.
Cohen-Tanugi, C. Farnier, T.E. Jeltema, E. Nuss, and S. Profum
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